KEGG   Canis lupus dingo (dingo): 112666294
Entry
112666294         CDS       T08371                                 
Symbol
MAP2K2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2 isoform X1
  KO
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
clud  Canis lupus dingo (dingo)
Pathway
clud01521  EGFR tyrosine kinase inhibitor resistance
clud01522  Endocrine resistance
clud04010  MAPK signaling pathway
clud04012  ErbB signaling pathway
clud04014  Ras signaling pathway
clud04015  Rap1 signaling pathway
clud04022  cGMP-PKG signaling pathway
clud04024  cAMP signaling pathway
clud04066  HIF-1 signaling pathway
clud04068  FoxO signaling pathway
clud04071  Sphingolipid signaling pathway
clud04072  Phospholipase D signaling pathway
clud04140  Autophagy - animal
clud04148  Efferocytosis
clud04150  mTOR signaling pathway
clud04151  PI3K-Akt signaling pathway
clud04210  Apoptosis
clud04218  Cellular senescence
clud04270  Vascular smooth muscle contraction
clud04370  VEGF signaling pathway
clud04371  Apelin signaling pathway
clud04517  IgSF CAM signaling
clud04519  Cadherin signaling
clud04540  Gap junction
clud04550  Signaling pathways regulating pluripotency of stem cells
clud04613  Neutrophil extracellular trap formation
clud04620  Toll-like receptor signaling pathway
clud04650  Natural killer cell mediated cytotoxicity
clud04660  T cell receptor signaling pathway
clud04662  B cell receptor signaling pathway
clud04664  Fc epsilon RI signaling pathway
clud04720  Long-term potentiation
clud04722  Neurotrophin signaling pathway
clud04730  Long-term depression
clud04810  Regulation of actin cytoskeleton
clud04910  Insulin signaling pathway
clud04912  GnRH signaling pathway
clud04915  Estrogen signaling pathway
clud04916  Melanogenesis
clud04917  Prolactin signaling pathway
clud04919  Thyroid hormone signaling pathway
clud04921  Oxytocin signaling pathway
clud04926  Relaxin signaling pathway
clud04929  GnRH secretion
clud04934  Cushing syndrome
clud04935  Growth hormone synthesis, secretion and action
clud05010  Alzheimer disease
clud05022  Pathways of neurodegeneration - multiple diseases
clud05132  Salmonella infection
clud05135  Yersinia infection
clud05160  Hepatitis C
clud05161  Hepatitis B
clud05163  Human cytomegalovirus infection
clud05164  Influenza A
clud05165  Human papillomavirus infection
clud05166  Human T-cell leukemia virus 1 infection
clud05167  Kaposi sarcoma-associated herpesvirus infection
clud05170  Human immunodeficiency virus 1 infection
clud05200  Pathways in cancer
clud05205  Proteoglycans in cancer
clud05206  MicroRNAs in cancer
clud05207  Chemical carcinogenesis - receptor activation
clud05208  Chemical carcinogenesis - reactive oxygen species
clud05210  Colorectal cancer
clud05211  Renal cell carcinoma
clud05213  Endometrial cancer
clud05214  Glioma
clud05215  Prostate cancer
clud05216  Thyroid cancer
clud05218  Melanoma
clud05219  Bladder cancer
clud05220  Chronic myeloid leukemia
clud05221  Acute myeloid leukemia
clud05223  Non-small cell lung cancer
clud05224  Breast cancer
clud05225  Hepatocellular carcinoma
clud05226  Gastric cancer
clud05230  Central carbon metabolism in cancer
clud05231  Choline metabolism in cancer
clud05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:clud00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    112666294 (MAP2K2)
   04012 ErbB signaling pathway
    112666294 (MAP2K2)
   04014 Ras signaling pathway
    112666294 (MAP2K2)
   04015 Rap1 signaling pathway
    112666294 (MAP2K2)
   04370 VEGF signaling pathway
    112666294 (MAP2K2)
   04371 Apelin signaling pathway
    112666294 (MAP2K2)
   04066 HIF-1 signaling pathway
    112666294 (MAP2K2)
   04068 FoxO signaling pathway
    112666294 (MAP2K2)
   04072 Phospholipase D signaling pathway
    112666294 (MAP2K2)
   04071 Sphingolipid signaling pathway
    112666294 (MAP2K2)
   04024 cAMP signaling pathway
    112666294 (MAP2K2)
   04022 cGMP-PKG signaling pathway
    112666294 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    112666294 (MAP2K2)
   04150 mTOR signaling pathway
    112666294 (MAP2K2)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    112666294 (MAP2K2)
   04519 Cadherin signaling
    112666294 (MAP2K2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    112666294 (MAP2K2)
   04148 Efferocytosis
    112666294 (MAP2K2)
  09143 Cell growth and death
   04210 Apoptosis
    112666294 (MAP2K2)
   04218 Cellular senescence
    112666294 (MAP2K2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    112666294 (MAP2K2)
   04550 Signaling pathways regulating pluripotency of stem cells
    112666294 (MAP2K2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    112666294 (MAP2K2)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    112666294 (MAP2K2)
   04620 Toll-like receptor signaling pathway
    112666294 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    112666294 (MAP2K2)
   04660 T cell receptor signaling pathway
    112666294 (MAP2K2)
   04662 B cell receptor signaling pathway
    112666294 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    112666294 (MAP2K2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    112666294 (MAP2K2)
   04929 GnRH secretion
    112666294 (MAP2K2)
   04912 GnRH signaling pathway
    112666294 (MAP2K2)
   04915 Estrogen signaling pathway
    112666294 (MAP2K2)
   04917 Prolactin signaling pathway
    112666294 (MAP2K2)
   04921 Oxytocin signaling pathway
    112666294 (MAP2K2)
   04926 Relaxin signaling pathway
    112666294 (MAP2K2)
   04935 Growth hormone synthesis, secretion and action
    112666294 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    112666294 (MAP2K2)
   04916 Melanogenesis
    112666294 (MAP2K2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    112666294 (MAP2K2)
  09156 Nervous system
   04720 Long-term potentiation
    112666294 (MAP2K2)
   04730 Long-term depression
    112666294 (MAP2K2)
   04722 Neurotrophin signaling pathway
    112666294 (MAP2K2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112666294 (MAP2K2)
   05206 MicroRNAs in cancer
    112666294 (MAP2K2)
   05205 Proteoglycans in cancer
    112666294 (MAP2K2)
   05207 Chemical carcinogenesis - receptor activation
    112666294 (MAP2K2)
   05208 Chemical carcinogenesis - reactive oxygen species
    112666294 (MAP2K2)
   05230 Central carbon metabolism in cancer
    112666294 (MAP2K2)
   05231 Choline metabolism in cancer
    112666294 (MAP2K2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    112666294 (MAP2K2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    112666294 (MAP2K2)
   05225 Hepatocellular carcinoma
    112666294 (MAP2K2)
   05226 Gastric cancer
    112666294 (MAP2K2)
   05214 Glioma
    112666294 (MAP2K2)
   05216 Thyroid cancer
    112666294 (MAP2K2)
   05221 Acute myeloid leukemia
    112666294 (MAP2K2)
   05220 Chronic myeloid leukemia
    112666294 (MAP2K2)
   05218 Melanoma
    112666294 (MAP2K2)
   05211 Renal cell carcinoma
    112666294 (MAP2K2)
   05219 Bladder cancer
    112666294 (MAP2K2)
   05215 Prostate cancer
    112666294 (MAP2K2)
   05213 Endometrial cancer
    112666294 (MAP2K2)
   05224 Breast cancer
    112666294 (MAP2K2)
   05223 Non-small cell lung cancer
    112666294 (MAP2K2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    112666294 (MAP2K2)
   05170 Human immunodeficiency virus 1 infection
    112666294 (MAP2K2)
   05161 Hepatitis B
    112666294 (MAP2K2)
   05160 Hepatitis C
    112666294 (MAP2K2)
   05164 Influenza A
    112666294 (MAP2K2)
   05163 Human cytomegalovirus infection
    112666294 (MAP2K2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    112666294 (MAP2K2)
   05165 Human papillomavirus infection
    112666294 (MAP2K2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    112666294 (MAP2K2)
   05135 Yersinia infection
    112666294 (MAP2K2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112666294 (MAP2K2)
   05022 Pathways of neurodegeneration - multiple diseases
    112666294 (MAP2K2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    112666294 (MAP2K2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    112666294 (MAP2K2)
   01522 Endocrine resistance
    112666294 (MAP2K2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:clud01001]
    112666294 (MAP2K2)
Enzymes [BR:clud01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     112666294 (MAP2K2)
Protein kinases [BR:clud01001]
 Serine/threonine kinases: STE group
  STE7 family
   112666294 (MAP2K2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7 APH
Other DBs
NCBI-GeneID: 112666294
NCBI-ProteinID: XP_025312752
Ensembl: ENSCAFG00020018484
UniProt: A0A8C0L1A1
LinkDB
Position
20:55756834..55779819
AA seq 400 aa
MLARRKPVLPALTINPAIAEGPSPTSEGASEANLVDLQKKLAELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDAKELEAIFGRPMVDGIEGEPHSISPRPRP
PGRPISGHGTDSRPAMAIFELLDYIVNEPPPKLPNGVFTQDFQEFVNKCLIKNPAERADL
KMLMSHTFIKRSEVEEVDFAGWLCKTLRLNQPSTPTRTAV
NT seq 1203 nt   +upstreamnt  +downstreamnt
atgctggcccggaggaagccggtgctgccggcgctcactatcaaccccgccatcgccgag
ggcccgtcccccaccagcgagggcgcctccgaagcaaacttggtggacctccagaagaag
ctagcagagctagaacttgatgagcagcagaagaagcgactggaagccttcctcacccag
aaggccaaggtcggggaactcaaggatgatgacttcgaacggatctcagagctgggagcc
gggaacggcggggtggtcaccaaggtccagcacagaccttctggcctcatcatggcgaga
aagctgatccacctggaaatcaagccggccatccggaaccagatcatccgcgagctgcag
gtgctgcacgagtgtaactccccgtacatcgtgggcttctacggggccttctacagcgac
ggcgagatcagcatctgcatggagcatatggatggcggctctctggaccaggtgttgaag
gaagccaagagaatccctgaggagatcctggggaaggtcagcattgcggttctccggggt
ttggcgtatctccgggagaagcaccagatcatgcaccgagacgtgaaaccatccaacatc
ctcgtcaactcccgaggggagattaagctgtgtgattttggggtgagcggccagctcatc
gactccatggccaactccttcgtgggaactcggtcctacatgtctccagagcggttgcag
ggcactcattactcagtgcagtcggacatctggagcatgggcctgtccctggtggagctg
tccattggaaggtaccccatcccgccaccagatgccaaggagctagaggccatcttcggc
cggcccatggttgacgggatagaaggagagcctcacagcatctcaccacggccgagaccc
cctggacgccccatcagcggtcatgggacggacagccggccagctatggccatctttgag
ctgctggactatattgtgaacgagccgcctcccaagctgcccaatggtgtcttcacccag
gacttccaggagtttgtaaataaatgcctaataaagaacccagcagagcgagcagatctg
aagatgctcatgagccacacgttcatcaagcggtccgaggtggaagaggtggattttgcc
ggctggttgtgtaaaacgctgcggctgaatcagcccagtacgcccacgcgcaccgccgtg
tga

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