Cyclopterus lumpus (lumpfish): 117741370 Help Entry 117741370         CDS       T09199                                  Symbol ryr1b Name (RefSeq) ryanodine receptor 1b   KO K04961   ryanodine receptor 1 Organism clum  Cyclopterus lumpus (lumpfish) Pathway clum04020   Calcium signaling pathway clum04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:clum00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     117741370 (ryr1b)    04020 Calcium signaling pathway     117741370 (ryr1b)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:clum01009]     117741370 (ryr1b)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:clum04147]     117741370 (ryr1b)    04040 Ion channels [BR:clum04040]     117741370 (ryr1b) Protein phosphatases and associated proteins [BR:clum01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      117741370 (ryr1b) Exosome [BR:clum04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    117741370 (ryr1b) Ion channels [BR:clum04040]  Voltage-gated cation channels   Ryanodine receptor    117741370 (ryr1b) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec MIR SPRY RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  117741370 NCBI-ProteinID:  XP_034404271 Ensembl:  ENSCLMG00005010926 LinkDB All DBs Position 13:12322610..12393494 Genome browser AA seq 5029 aa AA seqDB search MAEGGEGEEEIQFLRTDDQVVLQCTASILKEQQIKLCLSCEGFGNRLCFLETTSNAQNVP PDLAICSFVLVQSLSVRALQEMLANTVEMTESSQGGGHRTLLYGHAILLRHYHSSMYLSC LTTSRSLTDKLAFDVGLQEDATGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSYASGDLMVDASFMQTLWNMNPITSGCELAEGFLTGGHVLRLFHGHMDECLAIAAPEE GEDKRRMAHYEGGAVCSQARSLWRLEPLRISWSGSHMKWGQSFRIRHITTGRYLCLDEDK GLLVVDPERANTKLSAFCFRATKEKVEVAQKRDVEGMGIPEIKYGESMCFVTHVSTGLWL TYAALDAKAARLGMMKRKVILHQEGHMDDALTVSRSQNEESQAARMIFSTMGLFRQFNKG LDALNGKNKSPGAVSLPLEGVILSLQDLIFYFHPPEEELEHEEKQTKLRSLRNRQNLFQE EGMITIVLECIDRLNVYNTAAHFSEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALF CDNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVL DVLRSLCVCNGVAVRSNQNLITENLLPGRDLLLQTNIVNYVTSLRPNIFLGTCEGSTQYK KWYFEMMVDYVEPFVTAQASHLRVGWAMTEGYSPYPGGGEGWGGNGVGDDLYSYGYDGLD LWSGTVPRQVASPSAHALAADDVVSCCLDLSVPSISFRINGHPVQGMFENFNVDGLFFPV ISFSAGVKVRFLLGGRHGDFKFMPPPGYAPCYEALLPRDRMRIEPIKEYKHDFHGVRNLL GPTLSLTHTSFTPCPVDTVQIVLPPHLERIREKLAENIHELWAVTRIEQGWTYGSFRDDN KKLHPCLVDFQSLPEPERNYNLQMSGETLKTLLALGCHVGMGDEKAEENLKKIKLPKTYV MSNAYKPAPLDLNHVKLTPNQNQLVEKLAENGHNVWARDRVRQGWTYSIVQDIMNKRNPR LVPYNLLDEKTKKTNRDSVNNAVRTLIGYGYNIEPPDQESSKSKFIYLILNLIDISNNTR GDKVRIFRAERSYAITQGKWYFEFEAATTGEMRVGWARPSVRSDTELGADELAYVFNGNK AQRWHIGNDPFGRQWLSGDVVGCMIDLTEMNIMFTLNGEMLISDSGSDMAFKDIEIGEGF IPVCALGLSQVGRINLGQNVSSLRYFAICGLQEGFEPFAINMKRDTTMWFSKSLPQFVPL PTDHNHVEVSRVDGTVDSAPCLKLTHRTFGSQNANTDMMFLRLSMPVQFHETFKFQAGTT PLTRALTIPEEEVVVVEPDSEFEVLKKSASRKEQDDDKTEPSVAKELSVENEKDTVSEKG KKKGFFSKAKKVAMTPLAPPPAPPMVPRLVEDVVPDDRDDPEFILNTTTYYYSLRIFAGQ EPSGVWVGWVTPDYHQYDPTFDLSKVRSVTVTVGDDRGNIHDSMKHSNCYMVWGGDLVSN HQTRFSQEDMVVGCLVDLATGLMTFTANGKEINAFYQVEPNTKLFPAVFVQPSNQNMVQL ELGKLKNIMPISAAMFHSERNNPVPQCPPRLDVQMLTPVIWSRMPNHFLNPEVGKVSERL GWMVECTEPLIMMALHIPEENRCIDILELSERQDLMKFHYHTLMLYCAVCALGNNRVAHA LCSHVDESQLFYSTENTYLPGPLRSGYYDLLISIHLESAKRARLGTNREFIVPMSAETLS IHLYPDAKKAHSLPGVGLTTCLRPKLHFSSINFVGTDPDLYTISPVFPLQELKTRAISML TEAVLDGSQAMRDPVGGSVEFHFVPILKLISTLLMMGIFNDEDTKHILKMIDPHVFSGKK EEEEEKEDAEPKDEREVDEKEEGETKGVKVDGEKAEEEKEAEAVEVEVKDEEEGLEEGLL QMKLPESVKLQMCTLLQYFCDCELRHRVEGIVAYSDQFVNDIQKNQRVRYNLLMRAFTMS AAETARKTREFRSPPQDQVILLTNFKHSPEDENSPVPEEVRDTLAEFHNDLLLHCGIHIE EEAEEEEVDTSLRGRLISLADKIKSLRKKKEEEEKPEVEEEAKPSSLQELISHTMIHWAQ ESFIQNPELVRLMFSLLHRQYDGLGELIRALPKAYAINAVSVQDTMDLLECLGQIRSLLI VQMGPEEERLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGGDSKEIRFP QMVTNCCRFLCYFCRISRQNQRSMFDHLSYLLQNSGIGLGMRGSTPLDVAAASCIDNNEL ALALQEQDLEMVVTYLAGCGLQMCPMLLSKGYPDIGWNPCGGERYLDFLRFAVFVNGESV EENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIKISEDPARDGPTVKKDRRFMFG GEEQQEENRVHLGNAIMSFYSALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPIEDL VGVISLSVQIPAYGKDGQIIEPKMSASFVPDHKASMVLFLDRVYGIDNQDFLLHVLEVGF LPDMRAAASLDTVSFSTTEMALALNRYLCSAVLPLLTKCAPLFAGTEHRAIMIDSMLHTI YRLSRGRALTKAQRDVIEECLMSLCKFLRPSMLQHLLRRLVFDVPILNEYAKMPLKLLTN HYERCWKYYCLPNGWANFGVTSEEELHLSRKLFWGILESLAHKKYDTELFKIAMPCLCAI AGAIPPDYVDATYSSHVEKKASVDAEGNFDPKPVETTNTIIPERLDAFINKFAEHTHDKW AFEKIQNNWTYGEVLDENAKSHPMLRPYKTFSEKDKEIYRWPIKESVKAMLAWEWTLDKA RDGEVEVEKKAATRKISQTAQATYDPSHGYNPQPIDIAGMALSRELQSMAEQLAENYHNT WGRKKKLELQAKGAGTHPLLVPYDTLTAKEKARDREKAQDLLKFLQLNGYAVTRGLKDME QDISSIEKRFAYGFLQKLLKWMDIAQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPL VNQYFKNHCLYFLSTPAKVLGSGGHSSNKEKEMIASIFCKLAALVRHRVSLFGTDAGAVV NCLHILSRSLDARTVMKSGPEIVKAVLRQFFESAADDIEKMVENLKLGKVSSRNQVKGVA QNINYTTNALLPVLTSLFDHIAQHQFGDDVMLDDLQISCYRLMCSIYSLGTVKTPHVDKQ RPALGECLAHLAAAMPVAFLEPSLNEFNMFSVYTTKTPRERTILGLPNQVEELCTDIPEL EVLMKEIHNLAESGARYKEMPHVIEITLPMLCNYLPRWWERGLENFPELEGQLCTSITSE QLNQLLGSIMKIVVNNLGIDEASWMKRLAVFAQPIVSRAKPEMLKSHFIPTMEKLKKRTG KVVAEEDQLRMEGKIEVDSENGTIRDEFAVLCRDLYALYPLLIRYVDNNRARWLTCPDPD AEELFRMVGEVFIFWSKSHNFKREEQNFVVMNEINNMSFLTADSKSKMSKAGDGESGGSE QERTKKKRRGDRYSVQTSLIVAALKKMLPIGLNMCSPADQELINLAKIRYSLRDTDEEVR EFLHNNLHLQGKVEDPAMRWQMSLYKELSGKAEDAEEPEKVVKRVQEVSAVLYHIEVTEH PFKSKKMVWHKLLSKQRRRAVVACFRMTPLYNVPAHRATNMFLDAYKRNWLETEGYSFED KMIDDLSKAMEVEEEEEEETETKPDPLHQLILHFSRTALTEKMKLDVDHLYMSYADIMAK SCHMGEEDEGGDQEGEEPAFEDKEMEKQRLLYQQSRLHNRGTAEMVLQMISACKGEPGAM VSSTLKLGISILNGGNCDVQQRMLDYLKDKKDVGFFLSVQALMQTCSVLDLNAFERQNKA EGLGMVSEEGTNEKVMADDEFTCDLLRFLQLLCEGHNNDFQNYLRTQTGSTTTINIIICT VDYLLRLQESISDFYWYYSGKDIIDEPGKRNFSKAMTVAKQVFNSLTEYIQGPCTGNQQS LAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIGLLKELLDLQKDMVVMLLSLLEGNVVNGT IARQMVDMLVESSSNVEMILKFFDMFLKLKDIVASDAFRDYVTDPRGLISKKDFSKAMDS QKQYSPSEIQFLLSCSEADENEMINFEEFADRFQEPAKDIGFNIAVLLTNLSEHVPHDTR LQNFLGQAESVLNYFRPYLGRIEIMGASRKIERIYFEISEANRNQWEMPQVRESKRQFIF DVVNEIGESEKMEMFVNFCEDTIFEMNIAASISEPEGDGAEEEDDEEEEESGGDQVEALE GDEENGEEAAPVSASAFADFLKSVGDFFNMFTFRNLRRRYRKLRKMTVKEMVIGLATFIF TVVMGILMFVYGICKGFFTLIWKVLFGGGLVEGAKKMTVTEILASMPDPTQDEVHGDLPP EPGAREIQDADGVSDLLDAVGGEEEEEDSEERGEGGRLPGFNAPGGLGDFGETTAEEPPT PEGTPLLKRKLMEAAVGEPGEEQQPVQPEEEAPQETEKADTENGEKEKEEKAKPEPEVKE EEPEVKEEKTVKTKAKKDKKVAEEGFELWNELEVLRIKYMNYLSRNFYNLRFLALFIAFA LNFILLFYKVSESPPGEEDPSEGSGLFEGSGLFEGSGAEEDGSGLDDVGGEDDEEEGTLY YFLEESTGYMEPAMAFFGFIHTIISFLCIIGYNCLKVPLVIFKREKELARKLEFDGVYVT EQPEEDDIKGQWDRLVLNTPSFPNNYWDKFVKRKVLDKYGDIYGRERIAELLGMDLASLD VSAMTHEKKPEPDTSMLSWVTAIDIKYQIWKFGVIFTDNTFLYLVWYMLMSLLGHYNNFF FAAHLLDIAMGVKTLRTILSSVTHNGKQLMMTVGLLAVVVYLYTVVAFNFFRKFYNMSED EDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVIL LAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANY MFFLMYLINKDETEHTGQESYVWKLYQERCWDFYPAGDCFRKQYEDQLG NT seq 15090 nt NT seq  +upstreamnt  +downstreamnt atggccgaagggggagagggagaggaggagatccagttcctgcgaacggatgaccaggtt gttctgcagtgcactgcctccatcctgaaggagcagcagattaagctctgtctgtcctgc gagggcttcgggaaccgtctctgcttcctggaaaccacatccaacgctcagaatgtgccc ccggacctggccatatgcagctttgttctggtgcagtccctgtcggtccgcgctctacag gagatgctggccaacacggtggagatgactgagtcgtcccaaggtgggggtcatcgcacc ttactgtacggtcacgccatccttctgagacactaccactcaagcatgtacctgagctgt ttgactacctctcggtcgctcacagacaagctggcctttgacgtgggcttacaagaagac gccactggtgaagcatgttggtggaccatccatccagcctccaagcaaaggtcagaaggt gaaaaggtcagggtgggtgatgacctcatcctggtcagcgtgtcctctgagagatacctg cacctgtcctacgccagtggggatctgatggtggatgcctccttcatgcagactctgtgg aacatgaatccaatcacttcaggatgcgaactcgctgaggggtttctgacaggaggccac gttctcaggctgttccacggccacatggacgagtgtctggccatcgctgctccagaggaa ggagaggacaagcgcaggatggctcactatgaaggcggtgctgtgtgcagtcaggctcgt tcactgtggaggttggagcctctcagaatcagctggagcggtagccacatgaagtggggt cagtctttccgtatccgtcacatcacaacaggccggtacctgtgtctggatgaggataag ggtctgttggtggtcgacccagagagggccaacaccaaactctccgctttctgcttccgt gctacaaaggagaaggtggaggtggctcagaagcgcgatgttgaggggatgggcattcca gagatcaaatacggagagtccatgtgctttgtcacgcatgtgtccacaggcctgtggctc acatatgccgccctggatgccaaagcggctcgtttggggatgatgaagagaaaggtcatt ctgcaccaggagggccacatggacgatgccctcactgtgtcccgctcccaaaatgaagag tctcaggctgctcgaatgattttcagcactatgggcctcttcaggcagttcaacaagggc ttggacgccctgaatgggaagaacaagtcaccaggggctgtgtctcttcctctggagggg gtcatcctctctcttcaggatctcatcttctactttcatcctcccgaggaggaactggag cacgaggagaagcagaccaaacttcgctccctccgcaaccggcagaacctcttccaagag gaggggatgatcaccatcgtgctggagtgcatcgaccgcctcaacgtctataacactgct gcccacttctctgaatttgccggggaggaagccgcagagtcctggaaggagattgtcaac cttctttacgagctgctggcttctctaatcagggggaaccgctccaattgtgcgttgttc tgtgacaacctggactggctggtcagcaagctggaccgcctggaggcctcctcaggtatt cttgaggtgctgtactgtgtgctaattgaaagccctgaggttctgaacatcatccaggag aaccacatcaaatccatcatctctctcctcgacaagcatggaaggaaccacaaggtcctg gatgtcctgcgctctctttgtgtgtgtaatggtgtcgctgtgaggtccaaccagaacctc atcactgaaaacctgcttccgggtcgtgacctcttgctgcagaccaacattgtaaactat gtcaccagtttgagacccaacatcttcctgggtacatgtgagggttccacgcagtataag aaatggtactttgagatgatggtagactacgtggaacccttcgtgacggcacaggccagc cacctgcgtgtgggctgggctatgaccgagggctacagcccctaccctggaggaggagaa ggctggggaggcaacggtgtgggagatgacctctactcctatggctacgatggactggat ctctggtcaggcaccgtaccccgccaggtggcttcacccagtgcacacgccctggctgca gacgacgtcgtcagctgctgcctggacctgagtgtgcccagcatctccttccgtattaac ggccacccggttcagggcatgtttgaaaacttcaatgtggacggcctctttttccctgtc atcagcttctctgctggagtcaaggttcggttcctccttggcggtcgtcatggcgacttc aagttcatgcccccgcctggctacgccccatgctacgaggccctgctgcccagagatagg atgcgtattgaacccatcaaggagtacaagcatgacttccacggcgtgcgcaacctgctg ggtcccacgctgtccctcacccacacctcgttcaccccctgccccgtggacactgttcag attgtgttgccaccccacttggagcgcattcgagagaagctggcagagaatattcatgag ctctgggctgtcacccgcattgaacagggctggacctacgggagcttcagagatgataat aagaaactccatccttgtctggtggacttccagagtctccctgaaccagagaggaactac aacctgcagatgtctggcgagactctcaagactctcctggctctgggttgccacgtcggt atgggtgacgagaaagcagaggagaatctcaagaagatcaagctgcccaagacctatgtg atgagcaatgcatacaagcctgccccccttgacctcaaccatgtcaaactgacaccaaac cagaaccagcttgtagaaaaactggcagaaaatggacataacgtttgggcaagggaccgg gtacgacaaggatggacctacagtattgttcaggacatcatgaataagcgaaaccctcgt ctggtaccttacaacctgctggacgagaaaactaagaaaaccaaccgagacagcgtcaac aacgccgtccgcaccctcatcggctacggctacaacatcgagcctccggatcaggagagc agtaagtcgaaatttatttatttaatcctgaatctcattgacatctcaaacaacacccgc ggagacaaggtgcggatcttcagggcggagaggtcgtacgccatcacccaagggaagtgg tactttgagttcgaggctgcgaccacaggggagatgcgagtgggctgggcacgacctagt gtccgctctgacactgaactgggagcagatgaactggcctacgtctttaacggcaacaag gctcaaagatggcatattggcaatgatccctttggtcgccagtggctgtctggcgatgtc gtcggctgtatgattgacctgactgagatgaacatcatgttcacactcaacggagaaatg ctgatcagtgactcgggctcggacatggcgttcaaagatatcgaaattggggaaggtttt attccggtgtgtgccctgggcctgtctcaggttggaaggattaatcttgggcagaacgtc agcagcctgcgctactttgccatctgtggcctgcaggaaggattcgagccttttgccatc aacatgaagcgagacacgaccatgtggttcagtaaaagtttgccccagttcgtgccttta cccaccgatcacaaccatgttgaggtctcccgcgtggacggaactgtggacagcgccccg tgcctgaagctgacccatcggacctttggctcgcagaatgccaacacagatatgatgttc ctccgactcagcatgcctgtccagttccacgagaccttcaagttccaggcaggcacgacc cctctcacccgtgccctcaccatacccgaggaggaagtggtagtggtggagcccgactcc gagtttgaggttctgaagaagtcggccagccgcaaagagcaggacgatgacaagacggag ccgtctgtagcgaaggagctctctgtggaaaatgagaaggacacagtgtcagaaaaggga aagaaaaaaggattcttctccaaggccaagaaggttgccatgacgcctcttgcccctcct cctgctcctccgatggtgccacgtttggtggaagatgtggtccctgacgacagagatgac cctgagttcatcctgaataccaccacttattactactcattgaggatctttgctgggcag gagccgtccggtgtttgggttggctgggtcactcctgactaccaccagtatgatccgacc tttgacctctccaaagtgcgcagtgtcaccgttactgtgggagatgacagaggcaacata catgacagtatgaagcacagtaactgttacatggtgtggggcggggacctggtcagcaat catcagactcgcttcagccaggaggacatggtagtcggctgcttggtcgacctggccaca ggcctcatgacctttacagccaacggaaaagagattaacgccttctaccaggtggagccc aacaccaagctgtttcctgccgtctttgttcagccctccaaccagaacatggtgcagctg gagctgggcaaactcaagaacattatgcccatctcggctgcaatgttccacagcgagcgc aacaacccggtcccccagtgccctcccaggctggatgtccagatgctgaccccggttatc tggagtcgtatgcccaatcacttcctcaacccggaggtgggcaaagtgagcgagcggttg ggctggatggtggagtgcactgagcctctcatcatgatggctttgcacatcccggaggag aacaggtgtatcgacatcctggagctgtcggagcgtcaggatctgatgaagttccactac cacaccctcatgctctactgcgccgtgtgtgctctcggcaacaaccgggtggcccacgcc ctgtgcagccacgtggatgagtcccagcttttctactccaccgagaacacgtacctgccc ggaccgctccgcagcggctactacgacctgctcatcagcattcacctggagtctgccaag cgggcacgcctgggcaccaaccgggagtttatcgtcccaatgtctgctgagacgctcagc attcacctctatcccgatgcaaaaaaggcccactctctccccggcgttggcctaaccacc tgcttgcggcccaagctgcatttctcctccatcaacttcgttggcactgaccctgacttg tacaccatcagtcccgttttccccctacaggagctgaagaccagggcgattagcatgtta acagaggctgtgctggatgggagccaggccatgagggatccagtaggaggcagcgtggag ttccactttgtcccaatcctgaagctgatcagtacactactcatgatgggcatcttcaac gatgaggacacaaagcacatcctcaagatgatcgatccacatgttttcagtggaaagaag gaggaggaggaggagaaagaagatgctgagcctaaggatgaaagagaggtggatgagaag gaggagggagagaccaaaggagtaaaggtggatggagagaaggcagaggaggagaaggag gccgaggcagtggaggtagaagtgaaagatgaagaggagggtctggaggaaggattgctt cagatgaagctaccagagtccgtcaaactgcagatgtgcacactgctgcagtacttctgc gactgcgagctgcgtcacagagtggagggcatcgtggcctattccgaccagtttgtcaat gatattcaaaagaaccaacgtgtgcgctacaacctgttaatgagagccttcaccatgtcg gctgctgagactgcacgcaagacccgcgagttccgttcaccaccgcaggaccaggttatc ttgctgaccaacttcaagcacagtccagaggatgagaacagtccagtgcccgaggaggtg cgggacactctggcagagtttcacaatgacctcctgcttcactgcggtatacatatcgag gaggaggcggaggaggaggaggtggacacctcgctgaggggcagactcatcagtttagct gataagatcaagagcttgcgcaagaagaaggaggaggaggagaagccggaggtcgaggag gaagcaaagcccagcagccttcaggaactaatctcccacaccatgatccactgggcccag gagtcgttcattcagaaccctgagctggtgcgcttgatgttcagcctgctccaccggcag tacgacggcctcggcgagctgatccgagcgctgcccaaagcctacgccatcaacgccgtg tctgtccaggacaccatggacctactcgagtgcttgggacagatccgttcactgctcatc gtccagatgggcccagaggaggagcggctcatgatccagagcatcgggaacatcatgaac aacaaggtgttctaccaacaccccaatctgatgagagctcttggtatgcacgagactgtc atggaagtgatggtcaatgtgctgggcggaggaggagactccaaggagattcgattcccc caaatggtgaccaactgctgccgtttcctgtgctacttctgtcgcatcagccgacagaac cagcgctccatgtttgaccatctgagctacctgctgcagaatagcggcatcggcttgggc atgcgtgggtccacacctttggatgtggctgcggcttcttgcattgacaacaatgagctg gccttggcgctacaagagcaggacctggaaatggtggtgacgtacctggcgggctgcggc ctccagatgtgtccaatgctcctctctaagggctaccctgacatcggctggaacccctgt ggaggagagagatacctggacttcctccgctttgctgtctttgttaacggggagagcgtg gaagagaacgccaacgtagtggtgcgtctgctcatccggcggcccgagtgcttcggcccg gccctgagaggagagggcgggaatggtctgctggctgccatggaggaggccatcaagatc tcagaggatccagcgagggatggacccacagtcaagaaagacaggcgcttcatgttcggt ggcgaggaacagcaagaggagaaccgtgtacatctgggaaatgcaatcatgtccttctac tcggccctcatcgatctgctgggtcgctgcgcccctgagatgcacctgatccaagcaggt aagggtgaagctctcaggatcagggccatcctgaggtctctggttcccatagaggatctg gtgggagtcatcagcctatccgtccagattcctgcatacgggaaagatgggcagatcatt gagcctaagatgtccgccagttttgtgccagaccacaaggcctccatggtgctgttcctc gacagagtgtacggcatcgacaaccaggacttcttgcttcatgtgctagaggtcggcttc ctgcctgacatgagagctgcagcctctctggacacggtgtcatttagtacgactgaaatg gccctggcgctgaaccgctacctctgttcggctgtactacctctcctcaccaagtgcgcc ccgttgtttgctgggaccgaacaccgggccatcatgatcgactccatgctccacaccatc taccgcctgtcccgcggccgagccctcaccaaggctcagagggacgtcatcgaggagtgc ctcatgtcactctgcaagttccttcgaccctccatgctgcagcatctgctgagacggctg gtgtttgatgtgcccatcctcaacgaatatgcaaagatgcctctcaagctgttgaccaat cactacgagcgttgctggaagtactactgcttgcctaatggatgggctaatttcggggtg acctcagaggaggagctacatctgtctcgtaaactcttttggggaatcttggaatctctg gcgcacaagaaatacgacacagagctcttcaagatcgccatgccgtgcctctgtgctata gcaggagccatcccgcccgactacgtggatgccacctactcctctcacgtggagaagaag gcctctgtggatgcggaaggcaactttgaccccaaaccagtggagaccaccaacaccatc atcccagagaggctggatgccttcatcaacaagtttgcagagcacactcatgacaaatgg gcctttgagaagattcagaacaactggacctacggagaggtgttggatgagaacgcgaag tctcacccaatgctgcggccctacaaaaccttctctgaaaaggacaaggagatttatcgg tggcctatcaaagagtccgtcaaagccatgctggcctgggagtggaccttggataaagcc agggacggggaggtagaagtggagaagaaggccgccacacgcaagatctcccaaactgct caggccacttatgatcccagtcacggctacaaccctcagccaatagatatcgcaggaatg gccctgtccagagagctgcagtctatggccgagcagctggctgagaactaccacaacacc tggggcaggaagaagaagctggagcttcaggccaaaggtgctggcacccatcctctgctg gtgccgtatgacaccctgaccgccaaggagaaggccagggacagggagaaggcccaggac ctgctcaagttcctccagctcaatggatatgctgtgacaaggggactgaaggacatggag caggacatttcctccattgagaagcgcttcgcctatggcttcctccagaagcttcttaaa tggatggacattgcccaggagttcattgctcatctcgaggctgtggtcagcagtggaaga gtggagaagtcgccacatgaacaagagatcaaattctttgccaagatcctcttgccgcta gtcaatcaatacttcaagaaccactgcctgtacttcctctccactcccgctaaagtcttg gggagtggagggcattcctccaacaaggagaaggagatgattgcaagtatcttctgtaag ttggctgctttggtgaggcacagagtttctctttttggaacggatgcaggcgcagtggta aactgtctgcacatcctctcacgctcgctggatgccaggactgttatgaaatcgggccct gagattgtgaaggccgtcctgcgccagttctttgagagtgctgccgatgacattgagaag atggtcgagaacctgaaactgggcaaagtgtccagtcggaaccaggttaagggtgtggcc cagaacatcaactacaccaccaatgccctgctgccagtcctcacctcactgttcgaccac attgcccagcaccagtttggggacgacgtcatgttggacgacctgcaaatatcctgctac cgtttgatgtgcagtatctactctctgggcacagtgaagactccacatgtagataaacag cgaccggctcttggcgagtgtctggcccacttagcagcggctatgccggtggccttcctt gagccatcactgaatgagttcaacatgttttctgtatataccaccaagactcccagagag agaaccattctgggtcttcccaaccaagtagaggagctgtgcacggacatcccagagctg gaggtcctgatgaaggagatccacaacctggctgagtccggggctcgctacaaagaaatg ccccacgtgattgagatcaccctgcccatgttgtgcaattacctcccccgctggtgggag aggggcctggagaacttccccgagctggagggccagctgtgcacctccataacctccgag cagctgaaccagctgctgggaagcatcatgaagattgtggttaacaacctgggcatagac gaggcctcctggatgaagaggttggcagtgttcgcccagcccattgtcagccgggctaaa ccggagatgcttaaatcccacttcatccccaccatggaaaagctgaagaagcgcacaggc aaagtggtggctgaggaggatcagctgcgcatggagggcaagatagaggtggacagcgaa aacgggaccatcagggacgagttcgctgtgctgtgtcgggacctgtatgctctctacccc ttgctcatccgctacgtggacaataacagggcaaggtggttgacctgtccagacccagat gcagaggagcttttcaggatggtgggagaggtcttcattttctggtccaaatctcacaac tttaagagggaggagcagaactttgtggtgatgaatgagatcaacaacatgtccttcctg accgctgacagtaagagcaagatgagcaaggccggagatggagagtctggaggatcagag caggagcgtaccaagaagaagcggcgtggggatcgctactccgtgcagacctccctcatc gttgcagcgttaaagaagatgcttcctatcggcctcaacatgtgctcccctgccgaccag gagctcatcaacctcgccaagatcagatactcactgagagacacagatgaagaagtgagg gagttcttgcacaacaatctgcatctgcagggcaaggtggaggaccccgctatgcgctgg caaatgtccctgtataaggagttatccggaaaggctgaggatgccgaggagcctgagaag gtggtaaagagggttcaagaggtgtctgctgtcctttaccacattgaggtgacggagcat cccttcaagtcgaagaaaatggtgtggcacaagctgctgtccaaacagcgccgcagggcc gtggtggcctgtttcaggatgacgcccctgtacaacgtccccgcgcacagggcaaccaac atgttcttagacgcctacaaacgcaactggctagaaactgaaggttactcatttgaggac aagatgatcgacgacttgtcaaaagccatggaggtagaggaggaagaggaagaggagacc gagaccaagcctgacccccttcatcagctgattcttcatttcagccgcacagctctcaca gagaagatgaaacttgacgttgaccatctctatatgtcttatgctgatattatggcaaag agctgccatatgggtgaggaggacgaagggggagatcaggagggggaggagccagccttt gaggacaaggagatggagaaacagaggcttctgtaccagcagtcgcgcctacacaaccga gggactgcagagatggtgctgcagatgatcagtgcctgtaaaggtgaacctggagccatg gtttcttccacactcaaactgggaatctccatcctcaatggaggtaactgtgatgtgcag cagagaatgctggactatctgaaggataaaaaggatgtgggattcttcctgagcgttcag gctctgatgcagacctgcagcgttttggatttgaatgcctttgagagacaaaacaaggcc gagggacttgggatggtttcagaggaaggcacgaatgagaaagtgatggcggacgatgaa ttcacgtgtgacctcttacgtttcctgcagcttctttgtgagggccacaataatgatttc cagaactacttgagaactcagacaggcagcaccacgaccatcaacatcatcatctgcact gtggactacctgctgcgacttcaggagtcgatcagtgacttttactggtactactcagga aaagacattatcgatgaacccgggaagaggaatttctccaaagcaatgacggtggccaag caggtcttcaacagcttgactgagtacatccagggtccctgtactgggaaccagcagtct ctggcccacagcaggttgtgggacgccgtcgtgggcttcctgcacgtcttcgctcacatg atgatgaaacttgctcaggactccagtcaaattggactgttgaaggagctgttggatctg cagaaggacatggtggtgatgcttctgtctctgcttgagggcaacgtggtgaacggcacc atcgcccggcagatggtggacatgctggtggagtcctccagcaacgtggagatgatcctc aagttcttcgacatgttcctcaagctcaaggacatcgtcgcgtccgacgccttccgggac tacgtgaccgacccccgagggctcatctccaagaaggacttctccaaggccatggacagc cagaagcagtactctccctcagaaatccagttcctcctctcctgctcggaggccgacgag aacgagatgatcaactttgaggaattcgccgatcgtttccaagagccggcgaaagacatc ggcttcaatatcgccgtactgctcacaaacctgtcggagcacgtgccccacgacacccgc cttcagaacttcctggggcaggccgagagcgtgctcaactacttccgcccttacctcggc cgcattgagatcatgggagccagcaggaagattgagcgcatctactttgaaatcagcgag gcgaaccgcaaccagtgggaaatgccgcaggtccgagagtccaagcggcagttcatcttc gacgtggtcaacgaaatcggggagagcgagaagatggagatgtttgtgaacttctgcgag gacactatctttgagatgaacatcgccgcttcgatctctgagcccgagggagacggggca gaagaggaggatgacgaggaggaagaggagagcggcggagatcaggtcgaggctctggag ggcgatgaggaaaatggagaagaagcagctccagtgtccgcctcggcctttgcggacttc ctgaagagcgtgggtgacttcttcaacatgttcaccttccgtaacctgcggcgtcgctac cgcaaactaagaaaaatgaccgtgaaggagatggtgatcggcctggccacgtttatcttc acggtcgtgatgggtatcctgatgttcgtgtatggcatatgcaagggcttcttcacgctc atatggaaggtgctgttcggcggaggcttagtggagggcgccaagaagatgacggtgacg gagatcctagccagcatgccagatcccacgcaggacgaagttcacggggatctgccacct gaaccgggggcgcgagaaatacaagacgcagatggagtgtcggacctcttggatgctgtg gggggagaggaggaagaggaggatagcgaggagcgaggagaaggtggacgcctgcccggt ttcaatgctcccggaggactcggagactttggcgagacgacagcagaggagcctccgact cccgagggcacgccgctgctgaagaggaaattgatggaagccgcggtgggagaaccagga gaggaacagcaacctgttcagcctgaagaagaggctcctcaggaaaccgagaaagcagac accgagaatggagagaaggagaaggaagagaaggccaagcctgaacccgaggtaaaggag gaggagcccgaggtgaaagaggaaaagacagtgaagacgaaggcgaagaaggacaagaag gtggctgaggagggcttcgagctgtggaatgagctggaggttctgaggattaaatatatg aactacctttctcgcaacttttacaaccttcggttcttggccctgtttatcgccttcgct ctcaatttcatcctgctcttctacaaggtgtctgaaagtcctccaggtgaggaggacccg tctgagggttctggtctgtttgagggctctggcctgtttgaaggctccggtgccgaggag gatgggtccggattagatgacgtaggaggagaagatgacgaagaggagggtactttgtac tacttcctggaagagagcacaggctacatggagccggctatggctttctttggcttcatc cacactattatctccttcctctgcatcatcggctacaactgcctcaaggtccctctggtt atcttcaagagagagaaggagctggccagaaagctggagtttgatggtgtctacgtcact gagcagcctgaggaagacgacatcaagggccagtgggaccgactggtgctcaacactcca tctttcccaaacaattactgggacaagtttgtgaaaagaaaggtgctggataaatatggt gacatctacggcagagagaggatcgcggagctgctcggtatggacttggcttctctggac gtcagtgccatgactcatgaaaagaagcctgaacccgacacctcaatgttgagctgggtc acggctattgacatcaagtaccagatctggaagtttggtgttattttcaccgacaatacc ttcctctacctcgtctggtacatgttgatgtctctgctcggacactacaacaacttcttc ttcgcggctcatcttctggacatcgccatgggggtcaaaaccctgcgcaccattctgtcc tccgtcacccacaacggcaaacagctgatgatgacggtgggtttgctggccgtggtggtg tacctgtacaccgtggtggcgtttaacttcttccgcaagttctacaacatgagcgaggac gaggacgagccggacatgaagtgtgacgacatgatgacgtgttacctgttccacatgtac gttggcgtgcgcgctggtggtggcatcggagatgaaattgaggacccggccggtgacgaa tacgagctctaccgagtggtctttgacattaccttcttcttcttcgtcatcgtcatcctg ctggctatcatccagggtttgatcatcgacgcctttggagagctgagagaccagcaggag caggtcagggaggacatggagacaaagtgcttcatctgtggaattggaagcgactacttt gacacgacgccgcacggcttcgagacgcacaccttagaagaacataacttagccaactac atgttcttcctgatgtatctcataaataaagatgaaacggaacacacagggcaggagtcc tacgtgtggaagctataccaggagcgatgctgggacttctacccggctggagactgcttc cggaagcagtatgaggatcagctcggataa

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