Callorhinchus milii (elephant shark): 103190328 Help Entry 103190328         CDS       T03088                                  Name (RefSeq) ryanodine receptor 1 isoform X1   KO K04961   ryanodine receptor 1 Organism cmk  Callorhinchus milii (elephant shark) Pathway cmk04020   Calcium signaling pathway cmk04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:cmk00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     103190328    04020 Calcium signaling pathway     103190328  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:cmk01009]     103190328   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:cmk04147]     103190328    04040 Ion channels [BR:cmk04040]     103190328 Protein phosphatases and associated proteins [BR:cmk01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      103190328 Exosome [BR:cmk04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    103190328 Ion channels [BR:cmk04040]  Voltage-gated cation channels   Ryanodine receptor    103190328 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR Ins145_P3_rec SPRY RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  103190328 NCBI-ProteinID:  XP_007909255 LinkDB All DBs Position Unknown AA seq 5008 aa AA seqDB search MAEGAEGEEEIQFLRTGDEVVLQCTATVVKQQIKLCLAAEGFGNRLCFLESTSNAKNVPP DLAICSFVLQQSLSVRALQEMLANTVQGNESSQGGGHRTLLYGHAILLQHSHSGMYLCCL TTSRSMTDKLAFDVGLQEDATGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLH LSYASGDLQVDASFMQTLWNMNPICSGCELAEGYVTGGHVLRLFHGHMDECLTIVAFDQG EDQRRLVHFEGGAVCSHARSLWRLEPLRISWSGSHMKWGQPFRIRHVTTGKYLALDEEKG LLLFDQEKSNTKATAFCFRISKDKIDMPHKRDVEGMGTPEIKYGESMCFVQHVNSGLWLT YAALESKTARLGPLKRKAILHQEGHMDDALPLSRSQQEESQASRMIYSTVGLFNQFISCL DHLTGKNKASSHQNSLPIDTVVLSLQDLISYFQHPDEELEHEEKQTKLRSLKNRQNLFQE EGKIQLVLNCIDRLNVYNSAAHFAEIAGEEAAESWKEIVNLLYELLASLIRGNRRICALF SDNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIITESHIKSIISLLDKHGRNHKVL DVLRSLCVCNGVAVRSNQNLITENLLPGRDLLLQTNLINYVTSIRPNIFVGSYEGSTQYK KWYFEMMVDYVDSFVTPQVTHLRVGWALTEGYSPYPGGGEGWGSNGVGDDLYSYGFDGIH LWSGRVAKVVASPDPHILAADDVVSCCLDLSVPSISFRVNGHPVQGMFENFNLDGLFFPV ISFSAGVRARFLLGGRHGDFKFLPPPGYAPCYEALLPKERMRLEPIKEYKFDFGGVRNLL GPTQCLSHSEFAPCPVDTAQIVLPPHLERIREKLAENIHELWALTKIETSWTYGTIRDDN KKLHPCLVEFNRLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEENLKKIKMAKSYL MSSGYKPAPLDLSHVKLTPAQNTLVDKLAENGHNVWARDRVRQGWTYSILQDIMNKRNPR LVPYNLLDERTKKTNRDSLCEAVRTLIGYGYNIEPPDQEATAHTGKGSIDKVRLFRAEKS YAVKTGKWYFEFEAVTVGEMRVGWALPECRPDIELGGDDLAFVFNGFKGQRWHIGSEPFG RTWLPGDVVGCMIDLSEMSIMFTLNGEMLISDSGSELAFKDIEVGDGFLPVCSLGLSQVG RINLGQDVSSLRYFTICGLQEGFEPFAVNMKRDITMWFSKSLPQFVPTPLDHSHIEVTRI DGTVDSPPCIKLSHKTFGSQNSNTDMLFFRLSMPVEFHDTFKCTPGTTPLIRMSRPEEEV EDIDVDSEFEVLKKSASRTQTETTNDKEGHKEVVKTENEKDVSSEKSKPKSRFLFKKKPA FIAPPPVIPTVPRLIQDVVPDDRDDPEIILNTTTYYYSVKIFAGQDPGGVWVGWVTPDFH QYDKSFDLFKVRTVTVTVGDDRGKVHDSMKRSNCYMVWGGEFSNSSQQASRSNVDLDIGC LVDLATGLMTFTANGKDINTYFQVEPNTKLFPAVFVQPFSQNMFQFELGKLKNIMPISAA MFRSERKNNIPQCPPRLNVQIITPVVWSRMPNEFLQIEMARVSERHGWMLECVDPLIMMA LHIPEENRCIDILELTECKDLQKFHYHTLKLYCAVCALGNNRVAHALCSHVDESQLLYTI ENTYLPGLLRSGYYDLLISIHLESAKRNRLMMNNEFIVPMTEETRQITLFPDRRKIHGLP GVGLSSCLRPPLHFASLCFIGTSDDRFQFSPEIPLDILKTKAINMLTEGVKDGGQHTRDP VGGSVEFQFVPVLKLVSTLLIMGVFGDEDVKHVLKMIEPEVFAEAKEESSEKNEDEKAKT EEATKADEEQEEEEEKAEEDEQGVEEAEEVKEEEMEDGLLQMKLPESVKLQMCKLLQFFC DCELRHRVEAITSFADKFVDNMQVDQKQRYRELMLNFSMSAAETARKTREFRSPPQEQIN MLMHFKMDPSKEVNPMPDKVRNVLIDFHAELLLHCGIQIEEEEEEEEKDTSLKGRLLSLV EKVKSLRKKEDTEDLQGEEEETKPSTLQELISHTVVHWAQEAFIQNPELVRLMFSLLHRQ YDGVGELIRAMPKAYIINGTSVEDTMNLLECLGQIRSLLIVQMGPEEERLMIQSIGNIMN NKVFYQHPNLMRALGMHETVMEVMVNVLGGRDSKEIRFPRMVTNCCRFLCYFCRISRQNQ RSMFDHLSYLLDNSGIGLGMRGSTPLDVAAASVIDNNELALALQEPDLEKVVTYLAGRGL QSCPMLLAKGYPDIGWNPVGGERYLDFLRFAVFVNGESVEENANVVVRLLIRRPECFGPA LRGEGGSGLLGAIEEAIKISEDPARDGPTVKKDRRREMFTEEGHEDNRVHLGNAIMSFYA ALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPIDDLVGVISLPVQMPAFGKDGHIVE PKMAASFVPDHKASMVLFLDRVYGIENQDFLLHVLEVGFLPDMRAGASLDTVAFSTTEMA LALNRYLCSAVLPLITKCAPLFAGTEHRAIMIDSMLHTIYRLSRGRSLTKAQRDVIEECL MALCRYLRPSMLQHLLRRLVFDVPILNEYAKMPLKLLTNHYERCWKYYCLPSGWANYGVT SEEELHLTRKLFWGIFESVSHKKFDVELFKIVMPCLCGIAGALPPDYVDASYSSQVEKKA SVDAEGNFDPKPVETMNVIIPEKLDSFINKYAEYTHDKWAFEKLQNNWTYGENIDEEAMT HPWLRPYKTFSEKDKEIYRWPIKESLKAMIAWEWTVEKAREGEGMEKSDKGEKKTRKISQ SAQVMYDPSQGYSPQPPEMLVAALSRELQAMAEQLAENYHNTWGRKKKLELQAKGGGSHP LLVPYDTLTAKEKARDREKAQELLKFLQMQGYSVTRGMKDMELDTSSIEKRFAYGFLKKL LQWMDIAQEFVAHIEAVVSSGRVEKSPHEQEIKFFAKILLPLINQSFKNHCLYFLSTPAK LLGSGGHASNKEKEMIASIFCKMAALVRHRVSLFGTDAPTIINCLHILARSLDARTVMKS GPEIVKAGLRSFFEGASEDIEKTVENLKLGKVSQKTQVKGVAQNVNYTTVALLPVLTSLF EHIAQHQFGDDVILDDVQVSCYRILSSIYSLGTTKNPYVERHRPSLGECLARLAAAMPVA FLEHHLNEHNIYSVYNTKSSRERTILGLPNTVEEMCSDIPDLDCLMKEISDLAESGARYT EMPHVIEITLPMLCNYLPRWWDRGPENNSEEITVSSTTVTSEQMNTLLGNILKIVVNNLG IDEASWMKRLAVFAQPIISKAKPELLKSHFIPTMEKLKKRSGKVVAEEDQLRMEGKGDNV ESELLIRDEFSVLCRDLYALYPLLIRYVDNNRAKWLTEPDPDAEELFRMVGDIFILWSKS HNFKREEQNFVVQNEINNMSFLTADSKSKMSKSGDDGQSGGSDQERMKKQRRGDRYSVQT SLIVATLKKMLPIGLNMCSPADQELINIAKTRYSLKDTDEEVQEFLQSNLYLQEKCENSS SMRWQMALYRDTAGKAEDSNNPEKIVKRVQEVSAVLFHLEQTEHPYKSKKMAWHKLLSKQ RRRAVVACFRMTPLYNLPRHRASNLFIEGYRTSWIETEEHSFEDKLIDDLAKSGEEEEEE EEAKETKPDPLHQLILHFSRTALTEKSKLEEDHLYMSYADIMAKSCHIEEEGGGDEDEES VELTFEEKEMEKQRLLYQQSRLHSRGAAEMVLQMISACKGEPGAMVSSTLKLGISILNGG NCEVQQKMLDYLKEKKEIGFFHSVQSLMQTCSVLDLNAFERQNKAEGLGMVTEEGTIIKR ESAGKQNSSGEKVMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVD YLLRLQESISDFYWYYSGKDVVDEQGKRNFSKAMAVAKQVFNSLTEYIQGPCTGNQQSLA HSRLWDAVVGFLHIFAHMMMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGTIA KQMVDMLVESSSNVEMILKFFDMFLKLKDIVASDAFKDYVTDPRGLISKKDFQKAMDSQK QYTLSEIQFLLSCSEADENEMINYEEFANRFQEPAKDIGFNIAVLLTNLSEHVPHDTRLQ NFLTLAESILNYFQPFLGRIEIMGASRKIERIYFEISEANKTQWEMPQVKESKRQFIFDV VNEGGESEKMEMFVNFCEDTIFEMQIASKISEPDEEEKSEDEEEQGENAEGGEVERASPL AESPSAFAAFLGSIVDFFHLFTLKNIRKQYRKLKKMTIKEMVMALVSFFWTLLVGIVLFF YNICRGFFLIVWNTLFGGGLVEEAKKMTVADLLASMPDPTQDEVHADLPDLSKVEVENLE TPSEFEDQVKEQEDSDQAEAKRESGCPRTSSPDSNLGLGDIVESASAEPPTPEGTPPSFR KLGEQIEATIEAQSHEKQVEPEKADTENGEKAEKDMKEKEVEEEEAAPEEEMAPVRRARK KAKRERKREEPEAVMEFWNEFENYKTKLLNYLSRNFYNLRFLALFVAFAINFILLFYKVS VLEDEESFEEAGFEDDSGGSGFGNGNGGEEEEEEDDNSLVYFVLEESTGYMAPTLKFLSV LHTLISFLCIIGYNCLKVPLVIFKREKELARKLEFDGVYITEQPADDDIKGQWDRLVLNT PSFPNNYWDKFVKRKVLDKYGDIYGRERIAELLGMDMSALDVSVPQKKPVSDNSILSWFT SLDIKYQIWKFGVIFTDNSFLYLVWYLVMSALGHYNNFFFAAHLLDIAMGVKTLRTILSS VTHNGKQLMMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYV GVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQ VKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESY VWKMYQERCWDFFPAGDCFRKQYEDQLA NT seq 15027 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggggcagaaggagaagaggagattcagttcctcagaactggtgatgaagtg gttctacaatgcactgcaactgttgtcaaacagcaaataaaactctgccttgccgctgaa ggatttggtaatcgactctgcttccttgaatctacatcaaacgcaaagaatgttcctcca gaccttgcaatttgcagcttcgtgcttcagcaatctctctctgtgcgagccttgcaagag atgctggcaaacactgtccaaggcaatgagtcatctcagggaggaggtcatcgaaccctc ttgtatggtcatgcaattctactccaacattcccacagtggtatgtatttatgctgtttg acgacatcgaggtctatgacggacaaattagcctttgatgttggactgcaggaagatgca acaggggaagcatgttggtggaccattcacccagcctctaaacaaaggtctgagggtgag aaagtgcgtgtgggtgatgacctcatccttgtcagtgtttcctcagagcgatatctgcat ttatcttacgccagtggagatttacaagtggatgcctcctttatgcagacgctctggaat atgaatcccatctgttcaggctgtgaactggctgaaggatatgtgaccggtggccatgtt ctgcgtctctttcatggtcatatggacgagtgcctcacgatagtagcatttgaccaagga gaagaccagcgcaggttggttcactttgaaggaggagcagtgtgcagccatgcaagatct ctgtggagactggaacctctgcgcatcagttggagtggtagccacatgaaatggggccag ccctttcgtatccgtcacgtaacaaccggtaaatacttggccctagatgaggagaaaggg ctgcttctttttgatcaagagaaatcgaacaccaaagctactgccttttgtttccgaatc tcaaaggataagattgatatgcctcataaacgagatgtagaggggatgggaaccccagaa atcaagtatggggagtccatgtgtttcgtgcagcacgtcaacagtggactctggttgaca tacgcagcactcgagagtaaaactgctcggctcggacctttaaagagaaaagctatactg caccaagagggacacatggatgatgctcttccactgtcacgctcccaacaagaggaatcc caggcctctcgaatgatctacagcacagttggtctcttcaaccaattcatcagctgtctt gatcatcttactggaaagaacaaagcttcatcgcatcagaacagtttacctattgataca gtggttctcagtctccaggatctgatcagctacttccagcatccagatgaagaacttgaa cacgaagagaaacaaaccaaactgcgctcactcaaaaaccgacagaatctattccaagaa gaagggaagatccagctagtgctgaactgcattgacaggctcaatgtatacaacagtgcc gctcactttgcagagattgcaggagaggaggccgctgaatcctggaaggaaattgtgaac ctgctttacgagctgctggcctccctcatccgaggtaatcgcaggatatgtgcactattc tctgacaatttggattggctggtcagtaaactggaccgactggaagcttcctcaggtatt ctggaagtgctgtactgtgttttgatagaaagcccagaggtcctgaatatcataacagaa agccacatcaaatcgattatttctctgctggacaagcacgggcgaaatcacaaggtgctg gatgtgctacgttctctgtgtgtgtgtaacggtgtcgctgtcagatccaatcagaatctg ataactgagaatctacttccaggccgtgatctgctgctacagaccaacctgatcaactat gtcaccagcatcaggccaaacatctttgtgggctcgtacgaaggttctactcaatacaag aagtggtactttgagatgatggtggattacgttgattcattcgttacaccccaagtcact catttgcgagtgggctgggcattgacagaaggctatagcccttacccaggaggaggtgaa ggctggggaagcaatggagtgggagatgatttgtactcgtatggttttgatggtattcat ctgtggtcggggcgtgtggctaaggtcgttgcctcacctgacccacacattctggcagcg gatgatgttgtcagctgttgccttgatttgagtgtgccaagtatctccttccgggtaaat ggccatcccgttcaaggcatgttcgagaactttaaccttgatggtctcttctttcctgtt atcagcttctctgcaggagtcagggctcgattcttacttggtggcaggcatggtgatttc aagttcctgcctcccccgggttacgctccctgttacgaagctctgctaccaaaggaaagg atgagactggaacccatcaaggaatacaagtttgattttggtggggtgcgaaatctcctg ggcccgacacaatgcttgtcccattctgaatttgctccatgccctgtggatacagctcag attgtgcttccacctcatttggaacggatacgggagaaattggcggaaaacatccatgag ctttgggctttgacaaagattgagacaagctggacatatggaacaattcgagatgacaat aagaaactacatccgtgtcttgtggaatttaatagactaccagaaccagagagaaattac aatttacagatgtctggcgaaacgctgaagactttgctggcgttggggtgtcacgtcgga atggccgatgaaaaagcagaggaaaatctgaagaaaatcaaaatggccaaatcgtaccta atgtctagtggatataaacctgctccccttgacctttcccacgtcaaactgaccccagcc cagaacactctggtggataaattggctgaaaacggacacaacgtatgggcaagggatcgt gttcggcagggctggacatacagtattttgcaggacattatgaacaagagaaatccgcgg ctcgtaccttacaacctgctggatgagcgcaccaagaaaacaaaccgagacagcctgtgt gaggctgtccgcaccctgattggttatggctacaacatcgagcccccggatcaggaagct actgcccacacaggcaagggttccattgataaagtgcgcctattccgtgcagagaagtcg tacgcagtgaagaccgggaaatggtattttgaatttgaagccgtgactgtaggagaaatg cgagtagggtgggccctacccgagtgcaggcctgatattgaattgggtggcgatgacctg gctttcgttttcaatggattcaagggtcagcggtggcacataggcagtgagccatttggc cggacctggctgcctggtgatgtggttggttgtatgatcgacttaagtgaaatgagcatc atgttcacattgaacggagagatgctcatcagcgactctggttctgagctggcttttaaa gacattgaagtgggtgatggctttctccctgtgtgcagcttgggcctttcccaggttggg cgtattaatcttgggcaggacgttagcagtctgagatacttcaccatctgtggtttgcag gaaggctttgagcctttcgctgtaaacatgaagcgggacatcacaatgtggttcagcaaa agtttgcctcaattcgttcctactcctttggaccatagccatattgaggtgacaaggatc gatggaactgttgacagcccaccttgcattaagttgtctcataaaacctttggatctcag aacagcaacactgatatgctattcttccgactcagcatgcctgtcgagtttcatgacacg ttcaaatgtaccccgggcacaacacccctgattaggatgtctagacccgaagaagaagta gaagatatagacgtagattcagagtttgaagtcctgaagaagtcagccagccggactcaa accgaaacaacaaatgacaaagagggtcataaggaagtcgtgaagacggagaatgaaaag gatgtttcctctgagaaaagtaaacccaaatctaggttcttgttcaaaaagaagccagcc ttcattgctcctccgccagtgattcccaccgtgccccgcctgatccaggatgtggtacca gatgatcgggatgatccagagattattttgaatacaacaacgtattactattcagtgaag atatttgctggacaggatccaggaggtgtgtgggttggctgggttaccccagacttccat cagtatgacaaaagctttgatctgttcaaagttcgcacggtcactgtcacagtaggagac gatcgaggaaaagttcatgacagtatgaagcgcagcaattgttacatggtctggggaggc gagttcagtaacagctcccagcaggcaagccgcagtaatgtggatttggatattggctgc cttgttgatttggcaacaggtctcatgacttttaccgccaacggaaaggacatcaatacc tatttccaggttgaaccgaatactaagctattccctgcagtcttcgtgcagccttttagt cagaatatgttccagtttgagcttggcaagctgaagaatatcatgccaatttcagccgcc atgtttcggagtgaacggaagaacaacattccccagtgtcctccacggctcaatgtccaa ataatcaccccagtcgtgtggagccgaatgcccaacgagttcttgcagatcgagatggca cgtgtgagtgagcgtcacggctggatgttagaatgcgtggacccacttatcatgatggca ctgcacattccagaggagaacagatgtatcgacattttggagctcaccgagtgcaaagat ctgcagaaattccactatcacacgttaaagctgtactgcgctgtgtgtgcattgggcaac aatcgggtcgcccatgccctgtgtagtcatgttgatgaatcccagttgctctacactatc gagaacacatacctgccgggcctcctacgcagtggctattatgatctactgatcagcatt cacctggagtcagccaaacgcaacagactcatgatgaacaatgagttcattgtcccgatg actgaagaaaccagacagatcacattatttccagacaggcgcaaaattcatgggctgcca ggtgtcggtctcagctcttgcttgagacccccactccattttgcttccttgtgttttatc ggcacaagtgatgaccgctttcagttcagtcccgaaatccccctggacattctcaagacc aaagccatcaacatgttgaccgagggagtcaaagacggtgggcagcacacaagggaccct gtgggggggagtgtagaattccagttcgtacccgtgctaaaacttgtaagcaccctcctc atcatgggtgtgtttggtgatgaagatgtgaagcacgtgttgaagatgatcgagccagaa gtgtttgccgaggccaaagaggagagcagtgagaagaatgaagatgagaaggcaaagacg gaagaagccacgaaagcagatgaagaacaggaagaagaagaagaaaaggccgaggaggat gagcagggagtggaagaagcagaagaagtgaaagaggaagaaatggaggatggacttctg caaatgaaactgccagagtctgtcaaattacagatgtgcaaactgctgcaattcttctgc gactgtgagctccgtcaccgcgtcgaagcaatcacttcgttcgctgataaatttgttgac aacatgcaagtggatcagaagcaacgctaccgggaactgatgctgaacttcagcatgtct gcagcagagaccgccaggaagacacgagagtttcgctctccgccacaggagcagatcaac atgttgatgcatttcaaaatggatccaagtaaagaagttaacccaatgccagataaagtg aggaacgtgttgattgacttccatgctgaacttctcttgcattgtggcattcagattgag gaggaagaggaagaagaggagaaggacacgtctctgaaaggccgcttgctgagtctcgtt gagaaggttaaaagtttaagaaagaaggaggacactgaggacttgcagggcgaagaggaa gaaacgaagcccagtacactccaggagctgatctctcacacagtggtgcactgggctcag gaggcttttatccagaaccctgaactggtccgactgatgttcagtttgctgcataggcag tatgatggtgtcggagagcttatccgtgctatgcccaaggcttacatcatcaacggcacc tctgtggaggacactatgaatttgctggaatgcctagggcagatccgctcattgctcatt gtccaaatgggcccagaagaagagaggctcatgatccaaagcatcggaaacatcatgaac aacaaagtcttctatcagcatccaaacctgatgcgtgccttgggaatgcatgaaactgtt atggaagtcatggtgaatgtgttgggaggtagagattccaaggagattcgcttccccaga atggtgaccaactgctgtcgattcttgtgctacttctgtcgtatcagccgtcaaaatcag aggtccatgtttgatcacttaagctacttgctggataacagtggcattggactgggtatg cgcggttccacaccgctggatgtggcagctgcttcggtcattgacaacaatgagcttgca ttggctctgcaggaaccagatctagagaaggtcgtcacctacctcgccgggcgtgggcta cagagctgcccgatgctactggcgaaaggctacccagacatagggtggaaccctgtagga ggagagcgttacctggatttcctgcggtttgcagtatttgtgaatggggaaagtgttgag gaaaatgccaatgttgttgtccgtttgctgatccgtcgccctgagtgctttgggccagct ctgcggggtgaaggtggcagcgggttgctgggggccattgaggaagccatcaagatctca gaggacccggcccgtgatggaccaacagtcaaaaaagaccgtcgtcgagaaatgtttacc gaggaaggccacgaggacaatcgtgtccatctgggcaatgccatcatgtctttctacgct gcattgattgacctactgggacgctgtgctccggagatgcatctgatccaagctggaaaa ggtgaagcattgagaatccgagcgatcctgcgctccctggtgcccattgatgacctggtc ggtgtaatcagcctcccagtgcagatgcctgcctttgggaaagatggtcacattgttgag cctaaaatggcggccagctttgttcctgatcacaaagcctccatggttctgttcctggat cgtgtctatgggatagaaaatcaggatttccttcttcacgtactggaggtcggattcctg cctgatatgagggctggtgcctccttagatactgttgctttcagtaccaccgagatggca ctggctttaaaccggtacctctgttctgcagtgctgcctcttatcactaaatgtgctcca ctgtttgcgggaacagagcaccgagcaattatgatcgactccatgctgcacacaatctac cgtctctccaggggccgctctctgaccaaggcacagcgagacgttattgaggagtgcctc atggcactgtgcaggtatctccgaccttccatgctgcagcatttactgcgtcgcttggtc tttgatgtaccaatattgaatgagtacgccaagatgccactgaagttgctaactaaccac tacgagagatgctggaaatattactgcctgccatccggatgggctaattacggagtcact tcggaggaagaactccatctgactcggaaactcttctggggaatcttcgagtcggtgtct cataagaaatttgacgtagaacttttcaagatcgtcatgccatgtctgtgcgggatagct ggagcattgccaccggattacgttgatgccagctactcttcccaggtggagaaaaaagcc tcagtagatgcagaaggcaacttcgaccctaaacctgtggaaactatgaatgtcatcatt cctgaaaaactggacagctttattaacaagtatgcagagtatacgcatgacaagtgggct tttgagaagttacaaaataactggacttatggtgaaaatattgacgaggaagcaatgact cacccatggttgagaccttacaaaacgttctctgagaaggacaaagaaatctatagatgg ccaattaaagagtccttgaaggctatgatcgcctgggaatggacagtggaaaaggcgaga gagggagaaggaatggagaagagtgataagggggagaaaaagacccgcaagatttcccag tcggctcaggttatgtacgatcctagtcaaggctactctccgcagccccctgaaatgctg gtggcagcgctatcccgagaactgcaggcaatggcggagcaactcgcagaaaactaccac aacacctggggccgaaagaagaagctggagctacaggccaaaggtgggggaagccatcca cttttggtgccgtacgatacactgaccgccaaagagaaagcccgggacagggagaaagct caggagctgctcaaattcctccaaatgcaaggctactcagtgaccagaggcatgaaggat atggaactggacacgtcctcgattgagaagagatttgcctatggcttcctgaagaaactg ctgcaatggatggatatagctcaggagtttgttgctcatatagaggcagttgtaagcagt ggaagagttgagaaatctcctcacgaacaggagatcaagttctttgcaaagattttgctc cctttgatcaatcaatctttcaagaaccactgcttgtacttcctgtccactccggccaaa ttgctgggcagcggtggacatgcctccaacaaagagaaagagatgatagccagtatcttc tgcaaaatggcagctttggtcaggcatagagtctccctctttggtactgatgcccccaca attataaactgtttgcacattttggcacggtctctggatgcgaggactgtgatgaaatct ggccctgagattgtaaaggcaggtctgcggtcattctttgaaggagcgtctgaggacatt gagaaaaccgtggaaaatctgaaacttggcaaagtctctcagaaaacacaagtgaaggga gtggctcagaacgtcaactacaccactgtggcccttttgcctgtacttacctccctgttt gagcatatcgcacagcatcagtttggagacgacgtgatcctggatgatgtgcaagtctcg tgttaccgaatcctatccagtatttattctcttggaaccacaaagaatccttacgtggaa agacatcgaccctccctgggtgagtgtctggccagactggcggctgcaatgccggtggcc tttcttgaacatcatcttaacgagcacaatatctactccgtttacaatacgaaatcgtca cgtgaacgcaccattctgggtctgccgaacactgtggaggaaatgtgttccgatattccc gacctggactgcctcatgaaagaaattagtgacttggcggaatctggagcccgctacact gagatgccgcacgtcattgagatcactctgccaatgttgtgtaactacctgccccgatgg tgggatcgaggaccagagaacaattccgaggaaatcactgtgagctccaccaccgtcaca tcggaacagatgaacaccttgctgggaaacattttgaaaatcgtggttaataacttgggc atcgacgaggcttcctggatgaagagactggcagtatttgcacagcccatcattagcaaa gccaaacccgagctgctgaagtcccattttatccccaccatggagaagctgaagaagcga tcggggaaggtggtggctgaggaggaccagcttcgcatggaggggaagggtgacaacgtg gagtctgagctactcattcgagatgagttttccgtcctctgccgggacctgtacgctctg tacccactgctgattcgctatgtagacaataatcgagccaaatggttgactgaaccagac cccgatgctgaggagctcttcaggatggttggagacatctttatcctgtggtcaaagtca cacaatttcaaaagggaagaacagaactttgtggtccaaaatgaaatcaacaacatgtcc ttcctaactgcagacagcaaaagcaagatgtccaagtctggagatgatggacagtctgga ggttctgaccaggaaaggatgaaaaagcagaggcgaggggaccgttactccgttcagacg tcgctgattgtcgcaacccttaagaaaatgcttcctatcggcctcaacatgtgttctcct gctgatcaagaacttattaacatagccaagaccagatacagtctgaaagatacagatgaa gaggtacaagagtttcttcagagcaatctctacttgcaagaaaagtgtgaaaattcctcg tccatgcgatggcaaatggcgttgtaccgggacacggctggcaaagctgaagacagcaac aaccctgagaaaatcgtaaagagggtacaagaggtttccgccgtcctgttccacctggag cagactgagcacccttacaagtccaaaaagatggcctggcacaaactattatccaagcag cgcaggcgggcagtggttgcctgtttcagaatgactccactgtataacttacccaggcac cgcgcatctaacctcttcatcgaaggttatagaacttcctggattgagaccgaggagcac tcgtttgaagataaactaatagatgatctggctaaatcaggtgaagaggaggaggaggaa gaggaggcgaaggaaactaagcccgaccctcttcaccagctgatcctgcacttcagccgc acagctctcactgagaaaagcaaactggaagaggatcatctgtacatgtcatacgcagac atcatggccaagagttgtcacatcgaagaggagggtggtggtgatgaagatgaagagagc gtagagcttacctttgaagaaaaggagatggaaaagcagagattgctttaccagcagtcc aggctacacagccgtggggcagctgagatggtcctgcagatgattagcgcgtgcaaaggt gaaccaggtgctatggtttcttcaaccctgaaacttggcatctccattctgaatgggggt aactgtgaagttcagcagaaaatgctggactatctgaaagagaagaaggaaattggtttc ttccacagtgtgcagtccctcatgcaaacctgcagtgttctggatctgaatgcctttgag agacagaacaaggcagaaggcctgggaatggtcactgaagagggaacaatcatcaaacgt gaaagtgcaggcaaacaaaacagttctggtgagaaggtgatggccgatgatgaattcaca caagatcttttccggttcctgcagttactctgtgaaggacacaataacgatttccagaat tacctgcgcacccagacaggtaacaccaccaccatcaacatcattatctgcaccgtcgac tacctgcttcgcctacaggaatcgatcagcgatttctactggtattactctggcaaagat gttgttgacgaacaaggaaaacgaaacttttccaaggctatggccgtggctaagcaagtc ttcaacagtctcactgaatatatccagggtccttgcaccgggaatcagcagagcctggct catagcagactatgggatgcagttgtcggtttcctgcatatctttgcacatatgatgatg aaacttgctcaggattcaagccagattgagttgttgaaggagctgctggacttgcagaaa gacatggtggtgatgctgctctctctgctggaagggaatgtggtgaacggaaccattgct aaacagatggtggacatgttggtcgagtcgtccagcaatgttgaaatgatcttgaagttc tttgacatgttcctgaagctgaaggatattgtggcttccgatgcattcaaagactatgtg acggacccgagggggctgatttcaaagaaggatttccagaaggcgatggacagtcagaaa cagtacaccttgtctgagatccagttcctactctcgtgttctgaggcagacgagaacgag atgataaactatgaggaatttgctaaccggtttcaggaaccagccaaggacatcggcttt aacatagccgtgctgctcaccaatctctccgaacatgtgcctcacgacaccaggcttcag aacttcctaacgttggcagagagcattctgaactacttccagcctttcctgggccgcatc gagatcatgggagccagtcggaaaatcgagcgaatttactttgagattagcgaggccaac aagacccagtgggagatgcctcaagtcaaggagtccaagaggcagtttatcttcgacgtg gtgaacgaagggggggagtccgagaagatggaaatgttcgtcaacttctgcgaggacacc atctttgagatgcagatcgcctccaagatttccgaaccggacgaggaagagaagtcggag gacgaggaggagcagggagagaacgccgagggaggcgaggtcgagagagcctcgcctttg gccgagtcgccctccgccttcgcggctttcctcggcagcatcgtggactttttccacctg ttcaccctgaaaaacatacggaagcaatataggaagttgaagaagatgaccatcaaagag atggtgatggccttggtgtccttcttctggaccttgttggtaggaattgtgctcttcttc tataatatctgtcgtggtttcttcctgatcgtgtggaacaccttattcggaggcggcttg gtcgaagaggccaaaaagatgacggtggcagacctgttggccagtatgccggacccaaca caagatgaggttcacgccgatcttcctgacctcagcaaggtggaggtggagaacctggaa actccctcggagtttgaggatcaggttaaagagcaggaggattcagaccaggccgaggcc aagagggagagtggctgccccaggacaagctcgcctgactctaacctggggctcggtgac attgtggagagcgcatcagcagagccacccactcctgagggcacaccaccctccttcagg aagctgggagagcagattgaagctacaattgaggcccagtcacatgaaaagcaggttgaa cccgagaaagccgacacagagaacggggagaaggcagagaaggacatgaaggagaaagaa gtggaggaggaggaggcggccccagaagaagagatggcgcctgtgaggagagcgaggaag aaagccaagcgggagaggaagcgggaggagccagaggcggtcatggaattctggaacgag tttgaaaattacaagaccaaactcctgaattacctgtcgaggaatttctataacctgcgt ttcctggctctcttcgtggcgtttgccatcaactttatcctgctcttctataaggtttct gtgcttgaagatgaagaaagctttgaagaagcaggttttgaggatgactcgggaggatct ggttttggaaatggaaatggaggtgaagaggaggaagaggaggatgacaactcgttggtt tattttgtccttgaggagagtacgggttacatggcgccaacactgaagttcctgtctgtt ctgcacaccctcatctcgttcctctgcatcattggctacaactgtttaaaggtgcctctg gtcatctttaaacgggagaaggaactggccaggaagctggagttcgacggtgtgtacatc acggagcagcccgcagacgacgacataaaaggccagtgggatcgtctggttctcaacacc ccatcgttcccaaataactactgggacaagtttgtcaaacgaaaggtgttggataaatac ggtgatatctacggcagggaacgtattgcagagcttctgggaatggatatgagtgcctta gacgtcagtgtacctcagaagaaaccagtgtctgacaactccattctgtcctggttcaca tcgttggacatcaagtaccagatctggaagtttggagtgattttcactgacaattcgttc ctgtacctggtctggtatctcgtcatgtctgctctcggtcattacaacaacttcttcttc gctgctcacctgctggacattgccatgggagtcaagacccttcgcaccatcctgtcctcc gtaactcacaacggcaaacagctgatgatgacggtggggctgctggcagtggtggtttat ctatacacagtcgtggccttcaactttttccgcaagttctataacaagagcgaggatgag gatgagcctgacatgaagtgtgacgatatgatgacgtgctacctgttccacatgtacgtg ggcgtgcgagctggaggtggcattggcgacgagattgaagacccggctggggacgaatat gagctataccgagttgtcttcgacatcactttcttcttcttcgtcattgtcatccttctg gccatcatccagggtctgatcatagacgcctttggagaactgagagatcaacaggagcaa gtcaaagaggacatggagaccaagtgcttcatttgtggaatcggcagcgattacttcgac acaacgccacacgggtttgaaactcacactttggaagagcacaatttggcaaattacatg tttttcctcatgtacctgatcaacaaggatgagacggagcacacgggtcaggaatcttac gtgtggaagatgtatcaggaacgttgctgggatttcttcccggccggggattgcttccgg aaacagtacgaggaccagctggcataa

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