KEGG   Cavia porcellus (domestic guinea pig): 100734044
Entry
100734044         CDS       T07777                                 
Symbol
Pik3r2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
cpoc  Cavia porcellus (domestic guinea pig)
Pathway
cpoc01521  EGFR tyrosine kinase inhibitor resistance
cpoc01522  Endocrine resistance
cpoc01524  Platinum drug resistance
cpoc04012  ErbB signaling pathway
cpoc04014  Ras signaling pathway
cpoc04015  Rap1 signaling pathway
cpoc04024  cAMP signaling pathway
cpoc04062  Chemokine signaling pathway
cpoc04066  HIF-1 signaling pathway
cpoc04068  FoxO signaling pathway
cpoc04070  Phosphatidylinositol signaling system
cpoc04071  Sphingolipid signaling pathway
cpoc04072  Phospholipase D signaling pathway
cpoc04081  Hormone signaling
cpoc04140  Autophagy - animal
cpoc04150  mTOR signaling pathway
cpoc04151  PI3K-Akt signaling pathway
cpoc04152  AMPK signaling pathway
cpoc04210  Apoptosis
cpoc04211  Longevity regulating pathway
cpoc04213  Longevity regulating pathway - multiple species
cpoc04218  Cellular senescence
cpoc04360  Axon guidance
cpoc04370  VEGF signaling pathway
cpoc04380  Osteoclast differentiation
cpoc04510  Focal adhesion
cpoc04550  Signaling pathways regulating pluripotency of stem cells
cpoc04611  Platelet activation
cpoc04613  Neutrophil extracellular trap formation
cpoc04620  Toll-like receptor signaling pathway
cpoc04625  C-type lectin receptor signaling pathway
cpoc04630  JAK-STAT signaling pathway
cpoc04650  Natural killer cell mediated cytotoxicity
cpoc04660  T cell receptor signaling pathway
cpoc04662  B cell receptor signaling pathway
cpoc04664  Fc epsilon RI signaling pathway
cpoc04666  Fc gamma R-mediated phagocytosis
cpoc04668  TNF signaling pathway
cpoc04670  Leukocyte transendothelial migration
cpoc04722  Neurotrophin signaling pathway
cpoc04725  Cholinergic synapse
cpoc04750  Inflammatory mediator regulation of TRP channels
cpoc04810  Regulation of actin cytoskeleton
cpoc04910  Insulin signaling pathway
cpoc04914  Progesterone-mediated oocyte maturation
cpoc04915  Estrogen signaling pathway
cpoc04917  Prolactin signaling pathway
cpoc04919  Thyroid hormone signaling pathway
cpoc04923  Regulation of lipolysis in adipocytes
cpoc04926  Relaxin signaling pathway
cpoc04929  GnRH secretion
cpoc04930  Type II diabetes mellitus
cpoc04931  Insulin resistance
cpoc04932  Non-alcoholic fatty liver disease
cpoc04933  AGE-RAGE signaling pathway in diabetic complications
cpoc04935  Growth hormone synthesis, secretion and action
cpoc04960  Aldosterone-regulated sodium reabsorption
cpoc04973  Carbohydrate digestion and absorption
cpoc05010  Alzheimer disease
cpoc05017  Spinocerebellar ataxia
cpoc05020  Prion disease
cpoc05100  Bacterial invasion of epithelial cells
cpoc05135  Yersinia infection
cpoc05142  Chagas disease
cpoc05146  Amoebiasis
cpoc05160  Hepatitis C
cpoc05161  Hepatitis B
cpoc05162  Measles
cpoc05163  Human cytomegalovirus infection
cpoc05164  Influenza A
cpoc05165  Human papillomavirus infection
cpoc05166  Human T-cell leukemia virus 1 infection
cpoc05167  Kaposi sarcoma-associated herpesvirus infection
cpoc05168  Herpes simplex virus 1 infection
cpoc05169  Epstein-Barr virus infection
cpoc05170  Human immunodeficiency virus 1 infection
cpoc05171  Coronavirus disease - COVID-19
cpoc05200  Pathways in cancer
cpoc05203  Viral carcinogenesis
cpoc05205  Proteoglycans in cancer
cpoc05206  MicroRNAs in cancer
cpoc05207  Chemical carcinogenesis - receptor activation
cpoc05208  Chemical carcinogenesis - reactive oxygen species
cpoc05210  Colorectal cancer
cpoc05211  Renal cell carcinoma
cpoc05212  Pancreatic cancer
cpoc05213  Endometrial cancer
cpoc05214  Glioma
cpoc05215  Prostate cancer
cpoc05218  Melanoma
cpoc05220  Chronic myeloid leukemia
cpoc05221  Acute myeloid leukemia
cpoc05222  Small cell lung cancer
cpoc05223  Non-small cell lung cancer
cpoc05224  Breast cancer
cpoc05225  Hepatocellular carcinoma
cpoc05226  Gastric cancer
cpoc05230  Central carbon metabolism in cancer
cpoc05231  Choline metabolism in cancer
cpoc05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
cpoc05415  Diabetic cardiomyopathy
cpoc05417  Lipid and atherosclerosis
cpoc05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:cpoc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100734044 (Pik3r2)
   04014 Ras signaling pathway
    100734044 (Pik3r2)
   04015 Rap1 signaling pathway
    100734044 (Pik3r2)
   04370 VEGF signaling pathway
    100734044 (Pik3r2)
   04630 JAK-STAT signaling pathway
    100734044 (Pik3r2)
   04668 TNF signaling pathway
    100734044 (Pik3r2)
   04066 HIF-1 signaling pathway
    100734044 (Pik3r2)
   04068 FoxO signaling pathway
    100734044 (Pik3r2)
   04070 Phosphatidylinositol signaling system
    100734044 (Pik3r2)
   04072 Phospholipase D signaling pathway
    100734044 (Pik3r2)
   04071 Sphingolipid signaling pathway
    100734044 (Pik3r2)
   04024 cAMP signaling pathway
    100734044 (Pik3r2)
   04151 PI3K-Akt signaling pathway
    100734044 (Pik3r2)
   04152 AMPK signaling pathway
    100734044 (Pik3r2)
   04150 mTOR signaling pathway
    100734044 (Pik3r2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    100734044 (Pik3r2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100734044 (Pik3r2)
  09143 Cell growth and death
   04210 Apoptosis
    100734044 (Pik3r2)
   04218 Cellular senescence
    100734044 (Pik3r2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100734044 (Pik3r2)
   04550 Signaling pathways regulating pluripotency of stem cells
    100734044 (Pik3r2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100734044 (Pik3r2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100734044 (Pik3r2)
   04613 Neutrophil extracellular trap formation
    100734044 (Pik3r2)
   04620 Toll-like receptor signaling pathway
    100734044 (Pik3r2)
   04625 C-type lectin receptor signaling pathway
    100734044 (Pik3r2)
   04650 Natural killer cell mediated cytotoxicity
    100734044 (Pik3r2)
   04660 T cell receptor signaling pathway
    100734044 (Pik3r2)
   04662 B cell receptor signaling pathway
    100734044 (Pik3r2)
   04664 Fc epsilon RI signaling pathway
    100734044 (Pik3r2)
   04666 Fc gamma R-mediated phagocytosis
    100734044 (Pik3r2)
   04670 Leukocyte transendothelial migration
    100734044 (Pik3r2)
   04062 Chemokine signaling pathway
    100734044 (Pik3r2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100734044 (Pik3r2)
   04923 Regulation of lipolysis in adipocytes
    100734044 (Pik3r2)
   04929 GnRH secretion
    100734044 (Pik3r2)
   04915 Estrogen signaling pathway
    100734044 (Pik3r2)
   04914 Progesterone-mediated oocyte maturation
    100734044 (Pik3r2)
   04917 Prolactin signaling pathway
    100734044 (Pik3r2)
   04926 Relaxin signaling pathway
    100734044 (Pik3r2)
   04935 Growth hormone synthesis, secretion and action
    100734044 (Pik3r2)
   04919 Thyroid hormone signaling pathway
    100734044 (Pik3r2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100734044 (Pik3r2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100734044 (Pik3r2)
  09156 Nervous system
   04725 Cholinergic synapse
    100734044 (Pik3r2)
   04722 Neurotrophin signaling pathway
    100734044 (Pik3r2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100734044 (Pik3r2)
  09158 Development and regeneration
   04360 Axon guidance
    100734044 (Pik3r2)
   04380 Osteoclast differentiation
    100734044 (Pik3r2)
  09149 Aging
   04211 Longevity regulating pathway
    100734044 (Pik3r2)
   04213 Longevity regulating pathway - multiple species
    100734044 (Pik3r2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100734044 (Pik3r2)
   05206 MicroRNAs in cancer
    100734044 (Pik3r2)
   05205 Proteoglycans in cancer
    100734044 (Pik3r2)
   05207 Chemical carcinogenesis - receptor activation
    100734044 (Pik3r2)
   05208 Chemical carcinogenesis - reactive oxygen species
    100734044 (Pik3r2)
   05203 Viral carcinogenesis
    100734044 (Pik3r2)
   05230 Central carbon metabolism in cancer
    100734044 (Pik3r2)
   05231 Choline metabolism in cancer
    100734044 (Pik3r2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100734044 (Pik3r2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100734044 (Pik3r2)
   05212 Pancreatic cancer
    100734044 (Pik3r2)
   05225 Hepatocellular carcinoma
    100734044 (Pik3r2)
   05226 Gastric cancer
    100734044 (Pik3r2)
   05214 Glioma
    100734044 (Pik3r2)
   05221 Acute myeloid leukemia
    100734044 (Pik3r2)
   05220 Chronic myeloid leukemia
    100734044 (Pik3r2)
   05218 Melanoma
    100734044 (Pik3r2)
   05211 Renal cell carcinoma
    100734044 (Pik3r2)
   05215 Prostate cancer
    100734044 (Pik3r2)
   05213 Endometrial cancer
    100734044 (Pik3r2)
   05224 Breast cancer
    100734044 (Pik3r2)
   05222 Small cell lung cancer
    100734044 (Pik3r2)
   05223 Non-small cell lung cancer
    100734044 (Pik3r2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100734044 (Pik3r2)
   05170 Human immunodeficiency virus 1 infection
    100734044 (Pik3r2)
   05161 Hepatitis B
    100734044 (Pik3r2)
   05160 Hepatitis C
    100734044 (Pik3r2)
   05171 Coronavirus disease - COVID-19
    100734044 (Pik3r2)
   05164 Influenza A
    100734044 (Pik3r2)
   05162 Measles
    100734044 (Pik3r2)
   05168 Herpes simplex virus 1 infection
    100734044 (Pik3r2)
   05163 Human cytomegalovirus infection
    100734044 (Pik3r2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100734044 (Pik3r2)
   05169 Epstein-Barr virus infection
    100734044 (Pik3r2)
   05165 Human papillomavirus infection
    100734044 (Pik3r2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100734044 (Pik3r2)
   05100 Bacterial invasion of epithelial cells
    100734044 (Pik3r2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100734044 (Pik3r2)
   05142 Chagas disease
    100734044 (Pik3r2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100734044 (Pik3r2)
   05017 Spinocerebellar ataxia
    100734044 (Pik3r2)
   05020 Prion disease
    100734044 (Pik3r2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100734044 (Pik3r2)
   05418 Fluid shear stress and atherosclerosis
    100734044 (Pik3r2)
   05415 Diabetic cardiomyopathy
    100734044 (Pik3r2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100734044 (Pik3r2)
   04932 Non-alcoholic fatty liver disease
    100734044 (Pik3r2)
   04931 Insulin resistance
    100734044 (Pik3r2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100734044 (Pik3r2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100734044 (Pik3r2)
   01524 Platinum drug resistance
    100734044 (Pik3r2)
   01522 Endocrine resistance
    100734044 (Pik3r2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cpoc04131]
    100734044 (Pik3r2)
Membrane trafficking [BR:cpoc04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100734044 (Pik3r2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 SH3_1 RhoGAP SH2_1 Ribosomal_L22e ATG11 SH3_9
Other DBs
NCBI-GeneID: 100734044
NCBI-ProteinID: XP_023418820
Ensembl: ENSCPOG00000024452
LinkDB
Position
Unknown
AA seq 733 aa
MAGTDGFQYRALYPFRRERPEDLELLPGDLLVVSRAALQALGVTDGGERCPQAVGWMPGF
NERTRQRGDFPGTYVEFLGPVSLARLGPRTRGPRPLPARPRDEPPEPGLTLPDLPEQFTP
PDVAPPILAKLVEAIELTGLDTECHCRPELPAPRTDWSLIDLDQWDASALSDAIKSFLLA
LPAPLVLPEAAAEAHRACGMLGDPWGRCWSPPRCHCTGRSRCASCSGTWAGRADVLLPGA
PRTCPGHGLWATPAARTPSPGSSLCAADRGALSEGTEPSPDFPVLLLEKLLQEHLEEQEA
APPALPPKPSKAKPAAPVLANGGSAPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDA
SSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFRSVVDLITHYRHESLAQYNAKL
DTRLLYPVSRLQQDQVVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMK
RTAIEAFNETIKIFEEQGQTQERCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHE
SRTKLEQDLRAQASDNREIDKRMNSLKPDLLQLRKIRDQYLLWLTQKGTRQKKINEWLGI
RNETEDQYALMMEDEEDLPHHEERTWYVGKINRTQAEGMLSGKRDGTFLIRESSQRGCYA
CSVVVDGDTKHCVIYRTASGFGFAEPYNLYGSLKELVLHYQRASLVQHNDALPVTLAHPV
RAPGPGPPPPAAR
NT seq 2202 nt   +upstreamnt  +downstreamnt
atggcgggcaccgatggcttccaataccgcgcgctgtacccgttccggcgcgagcggccg
gaggatctggagctgctgcccggtgacctgctggtggtgagccgagcagccctacaggcg
ctgggcgtgacagatggcggcgagcgctgcccacaggctgtgggctggatgcctggcttc
aatgagcgaacacggcagcggggcgacttcccaggcacctacgtggaattcctggggccc
gtgtccctagccagactcggcccccgtacccgtggcccccgccccctgcctgccaggccc
cgagatgaacctccagagccaggcctcaccctccccgacctgcccgagcagttcacccct
ccggatgtggcaccccccatcctggcgaagctggtggaggcaatcgagcttacaggactg
gacaccgagtgccactgccggcctgagctgccggcgccgcgcacagactggtccctgatc
gacctggaccagtgggatgccagtgccctgtccgacgccatcaagagcttcctgctggcc
ctgcctgcacctctggttttgcctgaggctgctgccgaggcacaccgggcctgcgggatg
ctcggggacccttggggccggtgctggagccccccacgctgccactgcaccgggcgatca
cgctgcgcttcctgctccggcacctgggccgggcgcgccgacgtgctcctgcccggggcc
ccacgtacatgccctggccacggcctttgggccactcctgctgcgcgcacccccagccct
ggttccagcctctgtgcagccgacaggggcgccctgtctgagggtaccgagcccagcccc
gacttcccagtgctgctgctggagaagctgctgcaggaacatctggaagagcaggaggct
gcgcccccagccttgccgccgaagccctccaaggcgaagcctgcagcccctgtcctagcc
aatgggggcagcgcgccctccctgcaggatgcggagtggtactggggtgacatctctagg
gaggaggtgaacgagaaattgcgagacacaccggatgggaccttcctggttcgagatgca
tccagcaagatccagggagagtacacactcaccctcaggaaaggcggcaataacaaactc
atcaaggtcttccaccgcgacggccactacggcttctcagagccgctgaccttccgatcc
gtggtggacctcattacacactaccgtcacgagtcactggcccagtacaatgccaagctg
gacacaaggctgctgtaccctgtgtcacggctgcagcaggaccaggtggtcaaggaggac
agcgtggaggccgtgggcgcccagctcaaggtctaccaccagcagtaccaggacaagagc
cgcgagtacgaccagctctatgaggagtacacacgtacctcgcaggagctgcagatgaag
cgcacggcaatcgaagccttcaacgagacgatcaagatcttcgaagagcagggccagacc
caggagaggtgcagcaaggagtatctggagcgcttccggcgtgagggcaacgagaaggag
atgcagaggatcctgctcaactccgagcgcctcaagtcccgcatcgccgagatccatgag
agccgtacaaagctggagcaggacctgcgggcccaggcctcagacaaccgggagatcgac
aagcgcatgaacagcctcaagcccgacctcctgcagctgcgcaagatccgtgatcagtac
ctcctgtggcttacccagaaaggaacccggcagaagaagatcaatgagtggctggggatc
agaaacgagaccgaggaccagtatgcgctgatgatggaggatgaggaagacctgccccac
cacgaggagcgcacgtggtacgtgggcaagatcaaccgcacgcaggccgagggcatgctg
agcggcaagcgagacggcaccttcctcatccgggagagcagccagcgcggctgctatgcc
tgctctgtggtggtggacggcgacacgaagcactgcgtcatctaccgcacagccagcggc
tttggctttgccgagccctacaatctgtatggctccctcaaggagctggtgctgcactac
cagcgtgcatccctggtgcagcacaatgatgcgctgcccgtcacactggcgcacccagtg
cgagcgcctgggccagggcccccgccacctgctgcccgctga

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