KEGG   PATHWAY: csab03060
Entry
csab03060                   Pathway                                
Name
Protein export - Chlorocebus sabaeus (green monkey)
Description
The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
csab03060  Protein export
csab03060

Other DBs
GO: 0043952 0043953
Organism
Chlorocebus sabaeus (green monkey) [GN:csab]
Gene
103218992  WRB; tryptophan rich basic protein [KO:K22384]
103219137  SEC61B; Sec61 translocon beta subunit [KO:K09481]
103221273  SEC62; SEC62 homolog, preprotein translocation factor [KO:K12275]
103224260  UBL4B; ubiquitin like 4B [KO:K23388]
103226057  SEC61G; Sec61 translocon gamma subunit [KO:K07342]
103226745  IMMP2L; inner mitochondrial membrane peptidase subunit 2 [KO:K09648] [EC:3.4.21.-]
103227739  SPCS1; signal peptidase complex subunit 1 [KO:K12946] [EC:3.4.-.-]
103228100  SEC61A1; Sec61 translocon alpha 1 subunit [KO:K10956]
103228813  SRP54; signal recognition particle 54 [KO:K03106] [EC:3.6.5.4]
103231108  SEC11A; SEC11 homolog A, signal peptidase complex subunit [KO:K13280] [EC:3.4.21.89]
103231443  OXA1L; OXA1L, mitochondrial inner membrane protein [KO:K03217]
103232300  [KO:K03104]
103232828  UBL4A; ubiquitin like 4A [KO:K23388]
103233288  TMEM208; transmembrane protein 208 [KO:K27164]
103233657  SGTA; small glutamine rich tetratricopeptide repeat containing alpha [KO:K16365]
103233986  ASNA1; arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) [KO:K01551] [EC:7.3.2.7 7.3.-.-]
103235715  SRP72; signal recognition particle 72 [KO:K03108]
103236563  SPCS3; signal peptidase complex subunit 3 [KO:K12948] [EC:3.4.-.-]
103237891  [KO:K10956]
103238250  IMMP1L; inner mitochondrial membrane peptidase subunit 1 [KO:K09647] [EC:3.4.21.-]
103239874  HSPA5; heat shock protein family A (Hsp70) member 5 [KO:K09490] [EC:3.6.4.10]
103239946  [KO:K03104]
103241021  SEC63; SEC63 homolog, protein translocation regulator [KO:K09540]
103241651  SRPRB; SRP receptor beta subunit [KO:K12272]
103243015  SRP68; signal recognition particle 68 [KO:K03107]
103244204  SEC11C; SEC11 homolog C, signal peptidase complex subunit [KO:K13280] [EC:3.4.21.89]
103244343  SRP19; signal recognition particle 19 [KO:K03105]
103245852  SRP14; signal recognition particle 14 [KO:K03104]
103246895  GET4; golgi to ER traffic protein 4 [KO:K23387]
103248041  SPCS2; signal peptidase complex subunit 2 [KO:K12947] [EC:3.4.-.-]
103248787  SRPRA; SRP receptor alpha subunit [KO:K13431]
Reference
  Authors
Dalbey RE, Robinson C.
  Title
Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane.
  Journal
Trends Biochem Sci 24:17-22 (1999)
DOI:10.1016/S0968-0004(98)01333-4
Reference
  Authors
Berks BC, Sargent F, Palmer T.
  Title
The Tat protein export pathway.
  Journal
Mol Microbiol 35:260-74 (2000)
DOI:10.1046/j.1365-2958.2000.01719.x
Reference
  Authors
Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T.
  Title
TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.
  Journal
J Biol Chem 275:16717-22 (2000)
DOI:10.1074/jbc.M000800200
Reference
  Authors
Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J.
  Title
TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.
  Journal
J Biol Chem 275:41350-7 (2000)
DOI:10.1074/jbc.M004887200
Reference
  Authors
Rapoport TA
  Title
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
  Journal
Nature 450:663-9 (2007)
DOI:10.1038/nature06384
Reference
  Authors
Flower AM
  Title
The SecY translocation complex: convergence of genetics and structure.
  Journal
Trends Microbiol 15:203-10 (2007)
DOI:10.1016/j.tim.2007.03.001
Reference
  Authors
Osborne AR, Rapoport TA, van den Berg B
  Title
Protein translocation by the Sec61/SecY channel.
  Journal
Annu Rev Cell Dev Biol 21:529-50 (2005)
DOI:10.1146/annurev.cellbio.21.012704.133214
Reference
  Authors
Paetzel M, Karla A, Strynadka NC, Dalbey RE
  Title
Signal peptidases.
  Journal
Chem Rev 102:4549-80 (2002)
DOI:10.1021/cr010166y
Reference
  Authors
Paetzel M, Dalbey RE, Strynadka NC
  Title
The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.
  Journal
Pharmacol Ther 87:27-49 (2000)
DOI:10.1016/S0163-7258(00)00064-4
Reference
  Authors
Ng SY, Chaban B, VanDyke DJ, Jarrell KF
  Title
Archaeal signal peptidases.
  Journal
Microbiology 153:305-14 (2007)
DOI:10.1099/mic.0.2006/003087-0
Reference
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03060   

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