KEGG   Chlorocebus sabaeus (green monkey): 103222594
Entry
103222594         CDS       T04361                                 
Symbol
PIK3R1
Name
(RefSeq) phosphoinositide-3-kinase regulatory subunit 1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
csab  Chlorocebus sabaeus (green monkey)
Pathway
csab01521  EGFR tyrosine kinase inhibitor resistance
csab01522  Endocrine resistance
csab01524  Platinum drug resistance
csab04012  ErbB signaling pathway
csab04014  Ras signaling pathway
csab04015  Rap1 signaling pathway
csab04024  cAMP signaling pathway
csab04062  Chemokine signaling pathway
csab04066  HIF-1 signaling pathway
csab04068  FoxO signaling pathway
csab04070  Phosphatidylinositol signaling system
csab04071  Sphingolipid signaling pathway
csab04072  Phospholipase D signaling pathway
csab04081  Hormone signaling
csab04140  Autophagy - animal
csab04150  mTOR signaling pathway
csab04151  PI3K-Akt signaling pathway
csab04152  AMPK signaling pathway
csab04210  Apoptosis
csab04211  Longevity regulating pathway
csab04213  Longevity regulating pathway - multiple species
csab04218  Cellular senescence
csab04360  Axon guidance
csab04370  VEGF signaling pathway
csab04380  Osteoclast differentiation
csab04510  Focal adhesion
csab04550  Signaling pathways regulating pluripotency of stem cells
csab04611  Platelet activation
csab04613  Neutrophil extracellular trap formation
csab04620  Toll-like receptor signaling pathway
csab04625  C-type lectin receptor signaling pathway
csab04630  JAK-STAT signaling pathway
csab04650  Natural killer cell mediated cytotoxicity
csab04660  T cell receptor signaling pathway
csab04662  B cell receptor signaling pathway
csab04664  Fc epsilon RI signaling pathway
csab04666  Fc gamma R-mediated phagocytosis
csab04668  TNF signaling pathway
csab04670  Leukocyte transendothelial migration
csab04722  Neurotrophin signaling pathway
csab04725  Cholinergic synapse
csab04750  Inflammatory mediator regulation of TRP channels
csab04810  Regulation of actin cytoskeleton
csab04910  Insulin signaling pathway
csab04914  Progesterone-mediated oocyte maturation
csab04915  Estrogen signaling pathway
csab04917  Prolactin signaling pathway
csab04919  Thyroid hormone signaling pathway
csab04923  Regulation of lipolysis in adipocytes
csab04926  Relaxin signaling pathway
csab04929  GnRH secretion
csab04930  Type II diabetes mellitus
csab04931  Insulin resistance
csab04932  Non-alcoholic fatty liver disease
csab04933  AGE-RAGE signaling pathway in diabetic complications
csab04935  Growth hormone synthesis, secretion and action
csab04960  Aldosterone-regulated sodium reabsorption
csab04973  Carbohydrate digestion and absorption
csab05010  Alzheimer disease
csab05017  Spinocerebellar ataxia
csab05020  Prion disease
csab05100  Bacterial invasion of epithelial cells
csab05135  Yersinia infection
csab05142  Chagas disease
csab05146  Amoebiasis
csab05160  Hepatitis C
csab05161  Hepatitis B
csab05162  Measles
csab05163  Human cytomegalovirus infection
csab05164  Influenza A
csab05165  Human papillomavirus infection
csab05166  Human T-cell leukemia virus 1 infection
csab05167  Kaposi sarcoma-associated herpesvirus infection
csab05168  Herpes simplex virus 1 infection
csab05169  Epstein-Barr virus infection
csab05170  Human immunodeficiency virus 1 infection
csab05171  Coronavirus disease - COVID-19
csab05200  Pathways in cancer
csab05203  Viral carcinogenesis
csab05205  Proteoglycans in cancer
csab05206  MicroRNAs in cancer
csab05207  Chemical carcinogenesis - receptor activation
csab05208  Chemical carcinogenesis - reactive oxygen species
csab05210  Colorectal cancer
csab05211  Renal cell carcinoma
csab05212  Pancreatic cancer
csab05213  Endometrial cancer
csab05214  Glioma
csab05215  Prostate cancer
csab05218  Melanoma
csab05220  Chronic myeloid leukemia
csab05221  Acute myeloid leukemia
csab05222  Small cell lung cancer
csab05223  Non-small cell lung cancer
csab05224  Breast cancer
csab05225  Hepatocellular carcinoma
csab05226  Gastric cancer
csab05230  Central carbon metabolism in cancer
csab05231  Choline metabolism in cancer
csab05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
csab05415  Diabetic cardiomyopathy
csab05417  Lipid and atherosclerosis
csab05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:csab00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    103222594 (PIK3R1)
   04014 Ras signaling pathway
    103222594 (PIK3R1)
   04015 Rap1 signaling pathway
    103222594 (PIK3R1)
   04370 VEGF signaling pathway
    103222594 (PIK3R1)
   04630 JAK-STAT signaling pathway
    103222594 (PIK3R1)
   04668 TNF signaling pathway
    103222594 (PIK3R1)
   04066 HIF-1 signaling pathway
    103222594 (PIK3R1)
   04068 FoxO signaling pathway
    103222594 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    103222594 (PIK3R1)
   04072 Phospholipase D signaling pathway
    103222594 (PIK3R1)
   04071 Sphingolipid signaling pathway
    103222594 (PIK3R1)
   04024 cAMP signaling pathway
    103222594 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    103222594 (PIK3R1)
   04152 AMPK signaling pathway
    103222594 (PIK3R1)
   04150 mTOR signaling pathway
    103222594 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    103222594 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    103222594 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    103222594 (PIK3R1)
   04218 Cellular senescence
    103222594 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    103222594 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    103222594 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    103222594 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    103222594 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    103222594 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    103222594 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    103222594 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    103222594 (PIK3R1)
   04660 T cell receptor signaling pathway
    103222594 (PIK3R1)
   04662 B cell receptor signaling pathway
    103222594 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    103222594 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    103222594 (PIK3R1)
   04670 Leukocyte transendothelial migration
    103222594 (PIK3R1)
   04062 Chemokine signaling pathway
    103222594 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    103222594 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    103222594 (PIK3R1)
   04929 GnRH secretion
    103222594 (PIK3R1)
   04915 Estrogen signaling pathway
    103222594 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    103222594 (PIK3R1)
   04917 Prolactin signaling pathway
    103222594 (PIK3R1)
   04926 Relaxin signaling pathway
    103222594 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    103222594 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    103222594 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    103222594 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    103222594 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    103222594 (PIK3R1)
   04722 Neurotrophin signaling pathway
    103222594 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    103222594 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    103222594 (PIK3R1)
   04380 Osteoclast differentiation
    103222594 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    103222594 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    103222594 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103222594 (PIK3R1)
   05206 MicroRNAs in cancer
    103222594 (PIK3R1)
   05205 Proteoglycans in cancer
    103222594 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    103222594 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    103222594 (PIK3R1)
   05203 Viral carcinogenesis
    103222594 (PIK3R1)
   05230 Central carbon metabolism in cancer
    103222594 (PIK3R1)
   05231 Choline metabolism in cancer
    103222594 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103222594 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    103222594 (PIK3R1)
   05212 Pancreatic cancer
    103222594 (PIK3R1)
   05225 Hepatocellular carcinoma
    103222594 (PIK3R1)
   05226 Gastric cancer
    103222594 (PIK3R1)
   05214 Glioma
    103222594 (PIK3R1)
   05221 Acute myeloid leukemia
    103222594 (PIK3R1)
   05220 Chronic myeloid leukemia
    103222594 (PIK3R1)
   05218 Melanoma
    103222594 (PIK3R1)
   05211 Renal cell carcinoma
    103222594 (PIK3R1)
   05215 Prostate cancer
    103222594 (PIK3R1)
   05213 Endometrial cancer
    103222594 (PIK3R1)
   05224 Breast cancer
    103222594 (PIK3R1)
   05222 Small cell lung cancer
    103222594 (PIK3R1)
   05223 Non-small cell lung cancer
    103222594 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    103222594 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    103222594 (PIK3R1)
   05161 Hepatitis B
    103222594 (PIK3R1)
   05160 Hepatitis C
    103222594 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    103222594 (PIK3R1)
   05164 Influenza A
    103222594 (PIK3R1)
   05162 Measles
    103222594 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    103222594 (PIK3R1)
   05163 Human cytomegalovirus infection
    103222594 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103222594 (PIK3R1)
   05169 Epstein-Barr virus infection
    103222594 (PIK3R1)
   05165 Human papillomavirus infection
    103222594 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    103222594 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    103222594 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    103222594 (PIK3R1)
   05142 Chagas disease
    103222594 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103222594 (PIK3R1)
   05017 Spinocerebellar ataxia
    103222594 (PIK3R1)
   05020 Prion disease
    103222594 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    103222594 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    103222594 (PIK3R1)
   05415 Diabetic cardiomyopathy
    103222594 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    103222594 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    103222594 (PIK3R1)
   04931 Insulin resistance
    103222594 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    103222594 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103222594 (PIK3R1)
   01524 Platinum drug resistance
    103222594 (PIK3R1)
   01522 Endocrine resistance
    103222594 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:csab04131]
    103222594 (PIK3R1)
Membrane trafficking [BR:csab04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    103222594 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 SH3_2 Laminin_I SH3_9 FANCI_S2 Exonuc_VII_L
Other DBs
NCBI-GeneID: 103222594
NCBI-ProteinID: XP_007972574
Ensembl: ENSCSAG00000015888
UniProt: A0A0D9RTM6
LinkDB
Position
4:64321296..64406188
AA seq 724 aa
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAE
QFAPPDVAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTASVDLEMIDVH
VLADAFKRYLLDLPNPVIPAAVYSEMISLAQEVQSSEEYIQLLKKLIRSPSIPHQYWLTL
QYLLKHFFKLSQTSSKNLLNARVLSEIFGPMLFRFSAASSDNTENLIKVIEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
NT seq 2175 nt   +upstreamnt  +downstreamnt
atgagtgctgaggggtaccagtacagagcgctgtatgattataaaaaggaaagagaagaa
gatattgacttgcacttgggtgacatattgactgtgaataaagggtccttagtagctctt
ggattcagtgatggacaggaagccaggcctgaagaaattggctggttaaatggctataat
gaaaccacaggggaaaggggggactttccgggaacttatgtagaatatattggaaggaaa
aaaatctcacctcccacgccaaagccccggccgcctcggcctcttcctgttgcacccggt
tcttcgaaaactgaagcagatgttgaacaacaagctttgactctcccggatcttgcagag
cagtttgcccctcctgacgttgccccgcctcttcttatcaagctcgtggaagccattgaa
aagaaaggtctggaatgttcaactctatacagaacacagagctccagcaacctggcggaa
ttacgacagcttcttgattgtgatacagcctctgtggacttggaaatgatcgatgtgcac
gttttggctgacgctttcaaacgctatctcctggacttaccaaatcctgtcattccagca
gccgtttacagtgaaatgatttctttagctcaagaagtacaaagctccgaagaatatatt
cagctattgaagaagcttattaggtcgcctagcatacctcatcagtattggcttacgctt
cagtatttgttaaaacatttcttcaagctctctcaaacctccagcaaaaatctgttgaat
gcaagagtactctctgaaattttcggccctatgcttttcagattctcagcagccagctct
gataatactgaaaacctcataaaagttatagaaattttaatctcaactgaatggaatgaa
cgacagcctgcaccagcactgcctcctaaaccaccaaaacccactactgtagccaacaac
ggtatgaataacaatatgtccttacaagatgctgaatggtactggggagatatctcgagg
gaagaagtgaatgaaaaacttcgagatacagcagatgggacctttttggtacgagatgcg
tctactaaaatgcatggtgattatactcttacactaaggaaagggggaaataacaaatta
atcaaaatatttcatcgagatgggaaatatggcttctctgacccattaaccttcaattct
gtggttgaattaataaaccactaccggaatgaatctctagctcagtataatcccaagctg
gatgtgaaattactttatccagtatccaaataccaacaggatcaagttgtcaaagaagat
aatattgaagctgtagggaaaaaattacatgaatataacactcagtttcaagaaaaaagt
agagaatatgatagattatatgaagaatatacccgtacatcccaggaaatccaaatgaaa
aggacagctattgaagcatttaatgaaaccataaaaatatttgaagagcagtgccagacc
caggagcgctacagcaaagaatacatagaaaagtttaaacgtgagggcaatgagaaagaa
atacaaaggattatgcataattatgataagttgaagtctcgaatcagtgaaattattgac
agtagaagaagattggaagaagacttgaagaagcaggcagctgagtatcgagaaattgac
aaacgtatgaacagcattaaaccagaccttatccagctgagaaagacgagagaccaatac
ttgatgtggttgactcaaaaaggtgttcggcaaaagaagttgaacgagtggttgggcaat
gaaaacactgaagaccaatattcgctggtggaagatgatgaagatttaccccatcatgat
gagaagacgtggaatgttggaagcagcaaccgaaacaaagctgaaaacctgttgcgaggg
aagcgagatggcacttttcttgtccgggagagcagtaaacagggctgctacgcctgctct
gtagtggtggacggcgaagtaaagcattgtgtcataaacaaaacagcgactggctatggc
tttgccgagccctataacttgtacagctctctgaaagaactggtgctacattaccaacac
acctccctcgtgcagcacaacgactccctcaatgtcacactagcctacccagtatatgca
cagcagaggcgatga

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