Chlorocebus sabaeus (green monkey): 103224109
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Entry
103224109 CDS
T04361
Symbol
HSD3B2
Name
(RefSeq) hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
KO
K00070
3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:
1.1.1.145
5.3.3.1
]
Organism
csab
Chlorocebus sabaeus (green monkey)
Pathway
csab00140
Steroid hormone biosynthesis
csab01100
Metabolic pathways
csab04913
Ovarian steroidogenesis
csab04925
Aldosterone synthesis and secretion
csab04927
Cortisol synthesis and secretion
csab04934
Cushing syndrome
Module
csab_M00107
Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
csab_M00110
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
csab_M00976
C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
csab_M00977
C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:
csab00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
103224109 (HSD3B2)
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
103224109 (HSD3B2)
04925 Aldosterone synthesis and secretion
103224109 (HSD3B2)
04927 Cortisol synthesis and secretion
103224109 (HSD3B2)
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
103224109 (HSD3B2)
Enzymes [BR:
csab01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.145 3beta-hydroxy-Delta5-steroid dehydrogenase
103224109 (HSD3B2)
5. Isomerases
5.3 Intramolecular oxidoreductases
5.3.3 Transposing C=C bonds
5.3.3.1 steroid Delta-isomerase
103224109 (HSD3B2)
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GFIT
Motif
Pfam:
3Beta_HSD
Epimerase
NAD_binding_4
GDP_Man_Dehyd
Polysacc_synt_2
NAD_binding_10
RmlD_sub_bind
NmrA
KR
Ldh_1_N
Sacchrp_dh_NADP
Semialdhyde_dh
Motif
Other DBs
NCBI-GeneID:
103224109
NCBI-ProteinID:
XP_007975564
Ensembl:
ENSCSAG00000001716
UniProt:
A0A0D9S624
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All DBs
Position
20:complement(14351189..14359146)
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AA seq
447 aa
AA seq
DB search
MSMWQEFKVTRAEPEATEHKAPVLPPGMRQRGLRLLCPVFNNLTYALFWVTLESDLLPSI
FCFLVSDSCYFGLAMTGWSCLVTGAGGFLGQRIVRLLVEEKELKEIRVLDKAFRPELREE
FSKLQNKTKLTVLEGDILDEPFLKRACQDVSVVIHTACIIDVFGVTHRESIMNVNVKGTQ
LLLEACVQASVPVFIYTSTLEVAGPNSYKEIIQNGHEEEPLENTWPAPYPYSKKLAEKAV
LAANGWTLKNGGTLYTCALRPMYIYGEGGPFLSASINEALNNNGILSSVGKFSTVNPVYV
GNVAWAHILALRALRDPKKAPSVQGQFYYISDDTPHQSYDNLNYILSKEFGLCLDSRWSL
PLSLMYWIGFLLEVVSFLLSPVYSYQPPFNRHTVTLSNSVFTFSYKKAQQDLAYKPLYSW
EEAKQKTVEWVGSLVDRHKKTLKSKTH
NT seq
1344 nt
NT seq
+upstream
nt +downstream
nt
atgagtatgtggcaggagttcaaggtgacaagggctgagccagaagccacagagcataaa
gctccagtccttcctccagggatgaggcaacgaggactccgactcctctgtccagttttt
aacaatctaacttacgccctcttctgggtcacactagaatcagatctgctccccagcatc
ttctgtttcctggtgagtgattcctgctactttggattggccatgacgggctggagttgc
cttgtgacaggagcaggagggtttctgggtcagaggatcgtccgcctcttggtggaggag
aaggagctgaaggagatcagggtcttggacaaggccttcagaccagagctgagggaggaa
ttttccaagctccagaacaagaccaagctgactgtactggaaggagacattctggatgag
ccattcctgaagagagcctgccaggacgtctcggttgtcatccacaccgcctgtatcatt
gatgtctttggtgtcactcacagagagtccatcatgaatgtcaatgtgaaaggtacccag
ctcctgttggaggcttgtgtccaagccagtgtgccagtcttcatctacaccagtacccta
gaggtagccgggcccaactcctacaaggaaatcatccagaacggccacgaagaagagcct
ctggaaaacacatggcccgctccatacccatacagcaaaaaacttgctgagaaggctgtg
ctggcagccaatgggtggactctgaaaaatggtggcaccttgtacacttgtgccttaaga
cccatgtatatctatggggaaggaggcccattcctttctgccagtataaatgaggccctg
aacaacaatgggatcctgtcaagtgttggcaagttctccactgtcaacccagtctatgtt
ggcaacgtggcctgggctcacattctggccttgagggccctgcgggaccccaagaaggcc
ccaagtgtccaaggacagttctattacatctcagatgacacacctcaccaaagctatgat
aaccttaattacatcctgagcaaagagtttggcctctgccttgattccagatggagcctt
cctttatccctgatgtactggattggcttcctgctggaagtagtgagcttcctactcagc
ccagtttactcctatcaaccgcccttcaaccgccacacggtgactttgtcaaatagcgtg
ttcaccttctcttacaagaaggctcagcaagatctggcatataagccgctctacagctgg
gaggaagccaagcagaaaaccgtggagtgggttggttcccttgtggaccggcacaagaag
accctgaagtccaagactcactga
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