KEGG   Chlorocebus sabaeus (green monkey): 103233717
Entry
103233717         CDS       T04361                                 
Symbol
MAP2K2
Name
(RefSeq) mitogen-activated protein kinase kinase 2
  KO
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
csab  Chlorocebus sabaeus (green monkey)
Pathway
csab01521  EGFR tyrosine kinase inhibitor resistance
csab01522  Endocrine resistance
csab04010  MAPK signaling pathway
csab04012  ErbB signaling pathway
csab04014  Ras signaling pathway
csab04015  Rap1 signaling pathway
csab04022  cGMP-PKG signaling pathway
csab04024  cAMP signaling pathway
csab04066  HIF-1 signaling pathway
csab04068  FoxO signaling pathway
csab04071  Sphingolipid signaling pathway
csab04072  Phospholipase D signaling pathway
csab04140  Autophagy - animal
csab04148  Efferocytosis
csab04150  mTOR signaling pathway
csab04151  PI3K-Akt signaling pathway
csab04210  Apoptosis
csab04218  Cellular senescence
csab04270  Vascular smooth muscle contraction
csab04370  VEGF signaling pathway
csab04371  Apelin signaling pathway
csab04540  Gap junction
csab04550  Signaling pathways regulating pluripotency of stem cells
csab04613  Neutrophil extracellular trap formation
csab04620  Toll-like receptor signaling pathway
csab04650  Natural killer cell mediated cytotoxicity
csab04660  T cell receptor signaling pathway
csab04662  B cell receptor signaling pathway
csab04664  Fc epsilon RI signaling pathway
csab04720  Long-term potentiation
csab04722  Neurotrophin signaling pathway
csab04730  Long-term depression
csab04810  Regulation of actin cytoskeleton
csab04910  Insulin signaling pathway
csab04912  GnRH signaling pathway
csab04915  Estrogen signaling pathway
csab04916  Melanogenesis
csab04917  Prolactin signaling pathway
csab04919  Thyroid hormone signaling pathway
csab04921  Oxytocin signaling pathway
csab04926  Relaxin signaling pathway
csab04929  GnRH secretion
csab04934  Cushing syndrome
csab04935  Growth hormone synthesis, secretion and action
csab05010  Alzheimer disease
csab05022  Pathways of neurodegeneration - multiple diseases
csab05132  Salmonella infection
csab05135  Yersinia infection
csab05160  Hepatitis C
csab05161  Hepatitis B
csab05163  Human cytomegalovirus infection
csab05164  Influenza A
csab05165  Human papillomavirus infection
csab05166  Human T-cell leukemia virus 1 infection
csab05167  Kaposi sarcoma-associated herpesvirus infection
csab05170  Human immunodeficiency virus 1 infection
csab05200  Pathways in cancer
csab05205  Proteoglycans in cancer
csab05206  MicroRNAs in cancer
csab05207  Chemical carcinogenesis - receptor activation
csab05208  Chemical carcinogenesis - reactive oxygen species
csab05210  Colorectal cancer
csab05211  Renal cell carcinoma
csab05213  Endometrial cancer
csab05214  Glioma
csab05215  Prostate cancer
csab05216  Thyroid cancer
csab05218  Melanoma
csab05219  Bladder cancer
csab05220  Chronic myeloid leukemia
csab05221  Acute myeloid leukemia
csab05223  Non-small cell lung cancer
csab05224  Breast cancer
csab05225  Hepatocellular carcinoma
csab05226  Gastric cancer
csab05230  Central carbon metabolism in cancer
csab05231  Choline metabolism in cancer
csab05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:csab00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    103233717 (MAP2K2)
   04012 ErbB signaling pathway
    103233717 (MAP2K2)
   04014 Ras signaling pathway
    103233717 (MAP2K2)
   04015 Rap1 signaling pathway
    103233717 (MAP2K2)
   04370 VEGF signaling pathway
    103233717 (MAP2K2)
   04371 Apelin signaling pathway
    103233717 (MAP2K2)
   04066 HIF-1 signaling pathway
    103233717 (MAP2K2)
   04068 FoxO signaling pathway
    103233717 (MAP2K2)
   04072 Phospholipase D signaling pathway
    103233717 (MAP2K2)
   04071 Sphingolipid signaling pathway
    103233717 (MAP2K2)
   04024 cAMP signaling pathway
    103233717 (MAP2K2)
   04022 cGMP-PKG signaling pathway
    103233717 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    103233717 (MAP2K2)
   04150 mTOR signaling pathway
    103233717 (MAP2K2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    103233717 (MAP2K2)
   04148 Efferocytosis
    103233717 (MAP2K2)
  09143 Cell growth and death
   04210 Apoptosis
    103233717 (MAP2K2)
   04218 Cellular senescence
    103233717 (MAP2K2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    103233717 (MAP2K2)
   04550 Signaling pathways regulating pluripotency of stem cells
    103233717 (MAP2K2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    103233717 (MAP2K2)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    103233717 (MAP2K2)
   04620 Toll-like receptor signaling pathway
    103233717 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    103233717 (MAP2K2)
   04660 T cell receptor signaling pathway
    103233717 (MAP2K2)
   04662 B cell receptor signaling pathway
    103233717 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    103233717 (MAP2K2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    103233717 (MAP2K2)
   04929 GnRH secretion
    103233717 (MAP2K2)
   04912 GnRH signaling pathway
    103233717 (MAP2K2)
   04915 Estrogen signaling pathway
    103233717 (MAP2K2)
   04917 Prolactin signaling pathway
    103233717 (MAP2K2)
   04921 Oxytocin signaling pathway
    103233717 (MAP2K2)
   04926 Relaxin signaling pathway
    103233717 (MAP2K2)
   04935 Growth hormone synthesis, secretion and action
    103233717 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    103233717 (MAP2K2)
   04916 Melanogenesis
    103233717 (MAP2K2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    103233717 (MAP2K2)
  09156 Nervous system
   04720 Long-term potentiation
    103233717 (MAP2K2)
   04730 Long-term depression
    103233717 (MAP2K2)
   04722 Neurotrophin signaling pathway
    103233717 (MAP2K2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103233717 (MAP2K2)
   05206 MicroRNAs in cancer
    103233717 (MAP2K2)
   05205 Proteoglycans in cancer
    103233717 (MAP2K2)
   05207 Chemical carcinogenesis - receptor activation
    103233717 (MAP2K2)
   05208 Chemical carcinogenesis - reactive oxygen species
    103233717 (MAP2K2)
   05230 Central carbon metabolism in cancer
    103233717 (MAP2K2)
   05231 Choline metabolism in cancer
    103233717 (MAP2K2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103233717 (MAP2K2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    103233717 (MAP2K2)
   05225 Hepatocellular carcinoma
    103233717 (MAP2K2)
   05226 Gastric cancer
    103233717 (MAP2K2)
   05214 Glioma
    103233717 (MAP2K2)
   05216 Thyroid cancer
    103233717 (MAP2K2)
   05221 Acute myeloid leukemia
    103233717 (MAP2K2)
   05220 Chronic myeloid leukemia
    103233717 (MAP2K2)
   05218 Melanoma
    103233717 (MAP2K2)
   05211 Renal cell carcinoma
    103233717 (MAP2K2)
   05219 Bladder cancer
    103233717 (MAP2K2)
   05215 Prostate cancer
    103233717 (MAP2K2)
   05213 Endometrial cancer
    103233717 (MAP2K2)
   05224 Breast cancer
    103233717 (MAP2K2)
   05223 Non-small cell lung cancer
    103233717 (MAP2K2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    103233717 (MAP2K2)
   05170 Human immunodeficiency virus 1 infection
    103233717 (MAP2K2)
   05161 Hepatitis B
    103233717 (MAP2K2)
   05160 Hepatitis C
    103233717 (MAP2K2)
   05164 Influenza A
    103233717 (MAP2K2)
   05163 Human cytomegalovirus infection
    103233717 (MAP2K2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103233717 (MAP2K2)
   05165 Human papillomavirus infection
    103233717 (MAP2K2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    103233717 (MAP2K2)
   05135 Yersinia infection
    103233717 (MAP2K2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103233717 (MAP2K2)
   05022 Pathways of neurodegeneration - multiple diseases
    103233717 (MAP2K2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    103233717 (MAP2K2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103233717 (MAP2K2)
   01522 Endocrine resistance
    103233717 (MAP2K2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:csab01001]
    103233717 (MAP2K2)
Enzymes [BR:csab01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     103233717 (MAP2K2)
Protein kinases [BR:csab01001]
 Serine/threonine kinases: STE group
  STE7 family
   103233717 (MAP2K2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase CAMSAP_CC1 Kdo Seadorna_VP7 APH
Other DBs
NCBI-GeneID: 103233717
NCBI-ProteinID: XP_007993057
Ensembl: ENSCSAG00000010771
UniProt: A0A0D9REF2
LinkDB
Position
6:complement(3848441..3881367)
AA seq 400 aa
MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQ
GTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRP
PGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADL
KMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV
NT seq 1203 nt   +upstreamnt  +downstreamnt
atgctggcccggaggaagccggtgctgccggcgctcaccatcaaccctaccatcgccgag
ggcccgtcccctaccagcgagggcgcctccgaggcaaacctggtggacctgcagaagaag
ctggaggagctggaacttgacgagcagcagaagaagcgtctggaagcctttctcacccag
aaagccaaggtcggcgaactcaaagacgatgacttcgaaaggatctcagagctgggcgcg
ggcaatggcggggtggtcaccaaagtccagcacagaccctcaggcctcatcatggccagg
aagctgatccaccttgagatcaagccggccatccggaaccagatcatccgcgagctgcag
gtcctgcatgagtgcaactcgccatacatcgtgggcttctacggggccttctacagcgac
ggggagatcagcatctgcatggagcacatggatggcggctccctggaccaggtgctgaag
gaggccaagaggatccccgaggagatcctggggaaagtcagcattgcggttctccgcggc
ttggcgtatctccgagagaagcaccagatcatgcaccgagatgtgaagccctccaacatc
cttgtgaactccagaggggagatcaagctgtgtgacttcggggtgagcggccagctcatc
gactccatggccaactccttcgtgggcacacgctcctacatggctccggagcggttgcag
ggcacacattactcggtgcagtcggacatctggagcatgggcctgtccctggtggagctg
gccatcggaaggtaccccatccccccgcccgacgccaaggagctggaggccatctttggc
aggccagtggtcgacggggaagaaggagagcctcacagcatctcgcctcggccgagaccc
cctgggcgccccatcagcggtcacgggatggacagccggcccgccatggccatcttcgaa
ctgctggactatattgtgaatgagccgcctcctaagctgcccaacggtgtgttcaccccc
gacttccaggagtttgtcaataaatgcctcatcaagaacccagcagagcgggcagacctg
aagatgctcacgaaccacaccttcatcaagcggtccgaggtggaagaagtggattttgcc
gggtggttgtgtaaaaccctgcgactgaaccagcccggcacacccacgcgcaccgccgtg
tga

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