Chlorocebus sabaeus (green monkey): 103234633 Help Entry 103234633         CDS       T04361                                  Symbol RYR1 Name (RefSeq) ryanodine receptor 1   KO K04961   ryanodine receptor 1 Organism csab  Chlorocebus sabaeus (green monkey) Pathway csab04020   Calcium signaling pathway csab04371   Apelin signaling pathway csab04713   Circadian entrainment csab04730   Long-term depression csab04921   Oxytocin signaling pathway csab05017   Spinocerebellar ataxia csab05020   Prion disease csab05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:csab00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     103234633 (RYR1)    04020 Calcium signaling pathway     103234633 (RYR1)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     103234633 (RYR1)   09156 Nervous system    04730 Long-term depression     103234633 (RYR1)   09159 Environmental adaptation    04713 Circadian entrainment     103234633 (RYR1)  09160 Human Diseases   09164 Neurodegenerative disease    05017 Spinocerebellar ataxia     103234633 (RYR1)    05020 Prion disease     103234633 (RYR1)    05022 Pathways of neurodegeneration - multiple diseases     103234633 (RYR1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:csab01009]     103234633 (RYR1)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:csab04147]     103234633 (RYR1)    04040 Ion channels [BR:csab04040]     103234633 (RYR1) Protein phosphatases and associated proteins [BR:csab01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      103234633 (RYR1) Exosome [BR:csab04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    103234633 (RYR1) Ion channels [BR:csab04040]  Voltage-gated cation channels   Ryanodine receptor    103234633 (RYR1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  103234633 NCBI-ProteinID:  XP_007994881 Ensembl:  ENSCSAG00000004047 LinkDB All DBs Position 6:33080443..33234478 Genome browser AA seq 5042 aa AA seqDB search MGDAEGEDDVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPD LAICCFVLEQSLSVRALQEMLANTVEAGVEALNLDKWSSQGGGHRTLLYGHAILLRHAHS RMYLSCLTTSRSMTDKLAFDVGLQEDAIGEACWWTTHPASKQRSEGEKVRVGDDIILVSV SSERYLHLSTASGELQVDASFMQTLWNMNPICSRCEEGFVTGGHVLRLFHGHMDECLTIS PADSDDQRRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRVRHVTTGRYLALT EDQGLVVVDASKAHTKATSFCFRISKEKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASG LWLTYAAPDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQF IKSLDSFSGKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNR QSLFQEEGMLSLVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNR SNCALFSTNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHG RNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAE GTTQYSKWYFEVMVDEVAPFLTAQATHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSY GFDGLHLWTGHVARLVTSPGQHLLAPEDVVSCCLDLSVPSISFRINGCPVQGVFESFNLD GLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGP RGPHLVGPSRCLSHTDFVPCPVDTIQIVLPPHLERIREKLAENIHELWALTRIEQGWTYG PVRDDNKRLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTK LPKTYMMSNGYKPAPLDLSHVRLTPAQMTLVDRLAENGHNVWARDRVGQGWSYSAVQDIP ARRNPRLVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQSRWDRVRI FRAEKSYAVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHL GSEPFGRPWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCSL GPGQVGHLNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKSLPQFEPVPLEHPH YEVARVDGTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLAPPG LQPPAEDEARAAEPDPDYENLRRSAGGWGEAENGKEGTAKEGAPGSTPQAGGEAQPARAE NEKDATTEKNKKRGFLFKAKKVAMMTQPPATPTLPRLPHDVVPADNRDDPEIILNTTTYY YSVRVFAGQEPSCVWVGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGNIHSSLKCSNCYM VWGGDFVSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFV LPTHQNVIQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMPVSWSRMPNHFLQ VETRRAGERLGWAVQCREPLTMMALHVPEENRCMDILELSERLDLQRFHSHTLRLYRAVC ALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEY IVPLTPETRAITLFPPGRSTENGHPRHGLPGVGVSTSLRPPHHFSAPCFVAALPVAGAAE APARLSPAIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGI FGDEDVKQILKMIEPEVFTEEEEEEEEEEEEEEEEDEEEKEEDEEETAQEKEDEEKEEEE AAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQAN QRSRYGLLMKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLL DFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERPAEESKPR SLQELVSHMVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDT MSLLECLGQIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMV NVLGGGESKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTP LDVAAASVIDNNELALALQEQDLEKVVSYLAGCGLQSCPMLVAKGYPDIGWNPCGGERYL DFLRFAVFVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPAR DGPGIRRDRRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQACKGEALR IRAILRSLVPLEDLVGIISLPLQMPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGI ENQDFLLHVLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGT EHRAIMVDSMLHTVYRLSRGRSLTKAQRDVIEDCLMALCRYIRPSMLQHLLRRLVFDVPI LNEFAKMPLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYD PELYRMAMPCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIPEKLD SFINKFAEYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKES LKAMIAWEWTIEKAREGEEEKTEKKKTRKISQSAQTYDPREGYNPQPPDLSAVTLSRELQ AMAEQLAENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQM NGYAVTRGLKDMELDSSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHE QEIKFFAKILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRH RVSLFGTDAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRL GKVSQARTQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSI YSLGTTKNIYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGL PNSVEEMCPDIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAP PPALPAGAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPE LLQSHFIPTIGRLRKRAGKVVSEEEQLRLEAKAEAQEGELLVRDEFSVLCRDLYALYPLL IRYVDNNRAQWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTA DNKSKMAKAGDTQSGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDL ITLAKTRYALKDTDEEVREFLNNNLHLQGKVEGSPSLRWQMALYRGVPGREEDADDPEKI VRRVQEVSAVLYHLDQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNM FLESYKAAWILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTE KSKLDEDYLYMAYADIMAKSCHLEEGGENGEGEEEVEVSFEEKEMEKQRLLYQQARLHTR GAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQ ALMQTCSVLDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCE GHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSK AMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELL KELLDLQKDMVVMLLSLLEGNVVNGTIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVG SEAFQDYVTDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMINCEEFANRFQ EPARDIGFNVAVLLTNLSEHVPHDPRLHNFLELAESILEYFRPYLGRIEIMGASRRIERI YFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISE PEGEPETDEDEGAAEAGVEGAEESAAGPEGTAATAAAGATARVAAAMGRALRGLSYRSLR RRVRRLRRLTAREAATAVAALLWAAVTRAGAAGAGAAAGALGLLWGSLFGGGLVEGAKKV TVTELLAGMPDPTSDEVHGEQPAGPGGDADGEGASEGAGDAAEGAGDEEEAVDEAGPGGA DGAVAVTDGGPFRPEGAGGLGDMGDTTPAEPPTPEGSPILKRKLGVDGVEEELPPEPEPE PELEPEKADAENGEKEEVPEPPPEPPKKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYL SRNFYTLRFLALFLAFAINFILLFYKVSDSPPGEDDMEGSAAGDVSGAGSGGGSGWGLGA GEEAEGDEDENMVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREK ELARKLEFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRE RIAELLGMDLATLEITAHNERKPDPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWY MVMSLLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVA FNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVV FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGF ETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQ LS NT seq 15129 nt NT seq  +upstreamnt  +downstreamnt atgggtgacgcagaaggcgaggacgacgtccagttcctgcggacggatgatgaggtggtc ctgcagtgcagcgccaccgtgctcaaggagcagctcaagctctgcctggccgccgagggt ttcggtaaccgcctgtgcttcctggagcccaccagcaacgcccagaatgtgccccctgat ctggccatctgttgcttcgtcctggagcagtccctgtccgtgcgagccctgcaggagatg ctggccaacacggtggaggccggcgtggaggccctcaatttggataagtggtcatcccag ggcgggggacacaggacgctcctgtatggccatgccatcttactccggcacgcacacagc cgcatgtatctgagctgcctcaccacctcccgctccatgactgacaagctggccttcgat gtgggactgcaggaggacgcaataggagaggcttgctggtggaccacacacccagcctcc aagcagaggtctgaaggagaaaaggtccgtgttggggatgacatcatccttgtcagtgtc tcctccgaacgctacctgcacctgtcgactgccagcggggagctccaggttgacgcttcc ttcatgcagacgctgtggaacatgaaccccatctgctcccgctgcgaagagggcttcgtg acaggaggtcacgtcctccgcctctttcatggacatatggatgagtgtctgaccatttcc cctgctgacagtgacgaccagcgcagacttgtctactatgaggggggagctgtgtgcacc cacgcccgctccctctggaggctggagccactaagaatcagctggagtgggagccaccta cgctggggccagccactccgagtccggcatgtcaccaccgggcggtacctggcactcacc gaggaccagggcctcgtggtggttgacgccagcaaggcccataccaaggctacgtccttc tgcttccgcatctccaaggagaagctggatgtggcccccaagcgggatgtggaaggcatg ggcccccctgagatcaagtacggggagtcactgtgctttgtacagcatgtggcctcagga ctgtggctcacctatgccgctccagaccccaaggccctgaggctcggcgtgctcaaaaag aaggccatgctgcaccaggaaggccacatggacgacgcactgtcactgacccgctgccag caggaggagtcccaggccgcccgcatgatccacagcaccaatggcctgtacaaccagttc atcaagagcctggacagcttcagcgggaagccacggggctcggggccgccggctggcacg gcgctgcccatcgagggcgttatcctgagcctgcaggacctcatcatctacttcgagccg ccctccgaggacttgcagcatgaggagaagcagagcaagctgcgaagcctgcgcaaccgc cagagtctcttccaggaggaggggatgctctccctggtcctgaattgcattgaccgccta aatgtctacaccaccgctgcccactttgccgagtttgcaggggaggaggcagccgagtcc tggaaagagattgtgaatcttctctatgaactcctggcttctctgatccgtggcaatcgt agcaactgtgccctcttctccacaaacttggactggctggtcagcaagctggatcggctg gaggcctcatctggcatcctggaggtcctgtactgtgtcctcattgagagtccagaggtt ctgaacatcatccaggagaatcacatcaagtccatcatctccctcctggacaagcatggg aggaaccacaaggtcctggacgtgctatgctccctgtgtgtgtgtaatggtgtggctgta cgctccaaccaagatcttattactgagaacttgctgcctggccgtgagcttctgctgcag acaaacctcatcaactatgtcaccagcatccggcccaacatctttgtgggccgagcggag ggcaccacgcagtacagcaaatggtactttgaggtgatggtggacgaggtggctccattt ctgacagctcaggccacccacttgcgggtgggctgggccctcaccgagggctacagcccc taccctgggggcggcgagggctggggcggcaacggggtcggcgatgacctctattcctac ggctttgatggactgcatctctggacaggacacgtggcacgcctggtgacttccccaggg cagcacctcctggcccctgaagacgtagtcagctgctgtctggacctcagcgtgccgtcc atctccttccgcatcaatggctgccctgtgcagggtgtctttgagtccttcaacctggac gggcttttcttccctgttgtcagcttctcggctggtgtcaaggtacggttcctccttggt ggccgccatggcgaattcaagttcctgcccccacctggctatgccccatgccatgaggct gtgctccctcgagagcgactccatcttgaacccatcaaggagtatcgacgggaggggccc cgggggcctcacctggtgggccccagtcgctgcctgtcacacaccgactttgtgccctgc cctgtggacaccattcagatcgtcctgccaccccatctggagcgcattcgggagaagctg gcggagaacatccatgagctctgggcactgacccgcattgaacaaggctggacctacggc ccggttcgggatgacaacaagaggctgcatccgtgtcttgtggacttccacagccttcca gagcccgagaggaactacaacctgcagatgtcgggggagacgctcaagactctgctggct ctgggctgccacgtgggtatggcagacgagaaggcggaggacaacctgaagaagacaaaa ctccccaagacgtatatgatgagcaatgggtacaagccggctccgctggacctgagccac gtgcggctgacgccggcgcagatgacactggtggaccgtctggcagaaaatgggcacaac gtgtgggcccgagaccgtgtgggccagggctggagctacagtgcggtgcaggacatcccc gcgcgccgaaacccacggctcgtgccctaccgcctcctggacgaggccaccaagcgcagc aaccgggacagcctctgccaggccgtgcgcaccctcctaggttacggctacaacatcgag cctcctgaccaggagcccagtcaggtggagaaccagtctcgttgggaccgggtgcgcatc ttccgggcagagaaatcctatgcagtgcagagcggccgctggtacttcgagtttgaagca gtcaccacaggcgagatgcgagtgggctgggcgaggcccgagctgaggcctgatgtagag ctgggagctgatgagctggcctatgtcttcaatgggcaccgcggccagcgctggcacttg ggtagtgagccatttgggcgcccctggcagccaggcgatgtcgttggctgtatgatcgac ctcacagagaacaccattatcttcaccctcaatggcgaggtcctcatgtctgactcgggc tccgaaacagccttccgggagattgagattggggacggcttcctgcccgtctgcagcttg ggacctggccaggtgggtcacctgaacctgggccaggacgtgagctccctgcggttcttt gccatctgtggcctccaggaaggcttcgagccatttgccatcaacatgcagcgcccagtc accacctggttcagcaaaagcctgccccagtttgaaccagtgccccttgaacaccctcac tatgaggtagcccgagtggacggcactgtggacacgcccccctgtctgcgtctgacccac cgcacctggggctcccagaacagcctggtggagatgctcttcctgcggctgagcctccca gtccagttccaccagcacttccgctgcaccgcaggggccaccccgctggcaccccccggc ctgcagccccctgccgaggacgaggcccgggcggcggaacccgaccctgactacgaaaac ctgcgccgctcagctgggggctggggcgaggccgagaatggcaaagaagggactgcgaag gagggcgcccccgggagcaccccgcaggcggggggagaggcacagcccgccagggctgag aatgagaaggacgccaccaccgagaagaacaagaagagaggcttcttattcaaggccaag aaggtcgccatgatgacccaaccaccggccacccccacgctgcctcggctccctcacgat gtggtgcctgcagacaaccgcgatgaccctgagatcatcctcaacaccaccacgtactat tactccgtgagggtctttgccggacaggagcccagctgcgtgtgggtgggctgggtcact cctgactaccatcagcacgacatgagcttcgacctcagcaaggtccgggtcgtgacggtg accatgggggatgaacaaggcaacatccacagcagcctcaagtgcagcaattgctacatg gtatggggtggggactttgtgagtcccggacagcagggccggatcagccacacggatctt gtcattgggtgcctggtggacttggccactggcttaatgacctttacagccaatggcaaa gagagcaacacctttttccaggtggaacccaacacaaagctatttcctgctgtcttcgtc ctgcccacccaccagaacgtcatccagtttgagctggggaagcagaagaacatcatgccg ttgtcagccgccatgttccagagcgagcgcaagaacccggccccgcagtgcccgccacgg ctggagatgcagatgctgatgccagtgtcctggagccgcatgcccaaccacttcctgcag gtggagacgaggcgcgccggcgagcggctgggctgggccgtgcagtgccgggagccgctg accatgatggcgctgcacgtccctgaggagaaccgatgcatggacatactggagctgtcg gagcgcctggacctgcagcgcttccactcgcacaccctgcgcctctaccgcgctgtgtgc gccctgggcaacaatcgcgtggcgcacgctctgtgcagccacgtggaccaggctcagctg ctgcacgccctggaggacgcgcacctgccaggcccactgcgtgcaggctactacgacctc ctcattagcatccacctcgaaagtgcctgccgcagccgccgctccatgctctctgaatac atcgtgcccctcacgcctgagacccgcgccatcacgctcttcccacctggaaggagcaca gaaaatggtcacccccggcacggcctgccgggagttggagtcagcacttcgctgcggccc ccgcatcatttctcggccccctgtttcgtggccgctctgccagttgctggggcagcagag gctccggcccgcctcagccccgccatcccgctggaggccctacgggacaaggcactgagg atgctgggggaggcggtgcgcgacggtgggcagcacgctcgcgaccccgtcgggggctcc gtggagttccagtttgtgcctgtgctcaagctcgtgtccaccctgctggtgatgggcatc tttggcgatgaggatgtgaaacagatcttgaagatgattgagcctgaagtcttcactgag gaagaagaggaggaggaggaggaggaagaagaggaggaagaggaagatgaggaggagaag gaggaggatgaggaggaaacagcacaggaaaaggaagatgaagaaaaagaggaagaggag gcagcagaaggggagaaggaagaaggcttggaggaggggctgctccagatgaagttgcca gagtctgtgaagttacagatgtgccacctgctggaatatttctgtgaccaagagttgcag caccgtgtggagtccctggcagcctttgcggagcgctatgtggacaagctccaggccaac cagcggagccgctatggcctcctcatgaaagccttcagcatgacggcagcggagactgcc agacgcacccgcgagttccgctccccgccccaggagcagatcaatatgctattgcaattc aaagatggtacagatgaggaagactgtcctctccctgaagagatacgacaggatttgctt gactttcatcaagacctgctggcacactgtggaattcagctggatggagaggaggaggaa ccagaggaagagaccaccctgggcagccgcctcatgagccttttggagaaagtgcggcta gtgaagaagaaggaggagaaacctgaggaggagcggccagcagaggagagcaaaccccgg tccctgcaggaactggtgtcccacatggtggtgcgctgggcccaagaggacttcgtgcag agccccgagctggtgcgggccatgttcagcctcctgcaccggcagtacgacgggctgggt gagctgctgcgtgccctgccacgggcgtacaccatctcaccgtcctccgtggaagacacc atgagcctacttgagtgcctcggccagatccgctccctgctcatcgtgcagatgggccct caggaggagaacctcatgatccagagcatcgggaacatcatgaacaacaaagtcttctac caacacccgaacctgatgagggcgctgggcatgcatgagacggtcatggaggtcatggtc aatgtcctcgggggcggcgagtccaaggagatccgcttccccaagatggtgacaagctgc tgccgcttcctctgctatttctgccgcatcagccggcagaaccagcgctccatgtttgac cacctgagctacctgctggagaacagtggcatcggcctgggcatgcagggctccacgccc ctggacgtggctgctgcctccgtcattgacaacaatgagctggccttggcgttgcaggag caggacctggaaaaggtggtgtcctacctggcaggctgtggcctccaaagctgccccatg cttgtggccaagggatacccagatattggctggaacccctgcggtggagagcgctacctg gacttcctgcgcttcgctgtcttcgtcaacggcgagagcgtggaggagaacgccaacgtg gtggtgcggctgctcatccggaagcctgagtgctttggacccgccctgcggggtgagggt ggctcagggctgctggctgccatcgaagaggccatccgcatctccgaggaccctgcgagg gatggcccaggcatccgcagggaccggcggcgtgagcacttcggtgaggaaccacctgaa gaaaaccgggtgcacctgggacacgccatcatgtccttctatgccgccttgattgacctg ctcggacgctgtgcgccagagatgcatctaatccaagcctgcaagggtgaggccctgcgg atccgtgccatcctccgctcccttgtgcccttggaggacctcgtgggcatcatcagcctc ccactgcagatgcccaccctgggcaaagacggggctctggtgcagccaaagatgtcagca tccttcgtgccggaccacaaggcgtccatggtgctcttcctggaccgtgtgtatggcatt gagaaccaggacttcttgctgcacgtgctggacgtgggattcctgcccgacatgagggca gccgcctcgctggacacggccactttcagcaccaccgaaatggcactggcactgaaccgc tacctgtgcctggccgtgctgcctctcatcaccaagtgtgcgccgctctttgcgggcacg gaacaccgcgccatcatggtggactccatgctgcacacggtgtaccgcctgtcccggggt cgctcactcaccaaggcgcagcgcgacgtcatcgaggactgcctcatggctctctgcagg tacatccgcccgtcgatgctgcagcacctcctgcggcgtctggtgttcgacgtgcccatc ttaaacgagttcgccaagatgccactcaagctcctcaccaaccactatgagcgttgttgg aagtactactgcctacccacaggctgggccaacttcggggtcacctcggaggaggagctg cacctcacccggaaactcttctggggcatctttgactctctggcccataagaaatacgac ccggagctttaccgaatggccatgccttgtctgtgtgccatcgctggggctctgcccccc gactacgtggacgcctcatactcatctaaggcggagaaaaaggccacagtggatgctgaa ggcaactttgatccccggcctgtggaaaccctcaatgtgatcatcccggagaagctggac tccttcattaacaagtttgcggagtatacacatgagaagtgggccttcgacaagatccag aacaactggtcctatggagagaacatagatgaggagttgaagacccaccccatgctgagg ccctacaagaccttttcagagaaggacaaagagatttaccgctggcccatcaaggagtcc ctgaaggccatgattgcctgggaatggaccatagagaaggccagggagggtgaggaggag aagacggaaaagaaaaaaacgcggaagatatcacaaagtgcccagacctacgatcctcga gaaggctacaacccccagccccccgaccttagcgcagttaccctgtcccgggagctgcag gccatggcagaacaactggcggaaaattaccacaacacgtggggaaggaagaagaagcag gagctggaagccaaaggcggtgggacccaccccctgctggtcccctacgacacgctaaca gccaaggagaaggcacgagatcgagagaaggcccaggagctgctgaaattcctgcagatg aatggctacgcggttacaagaggccttaaggacatggaactggactcgtcttccattgaa aagcggtttgcctttggcttcctgcagcagctgctgcgctggatggacatttctcaggag ttcattgcccacctggaggctgtggtcagcagcgggcgagtggaaaagtccccacatgaa caggagattaaattctttgccaagatcctgctccctttgatcaaccagtacttcaccaac cactgcctctatttcctgtccactccagctaaagtgctgggcagtggcggccacgcctcc aacaaggagaaggaaatgatcaccagcctcttctgcaaacttgctgctcttgtccgccac cgagtctctctctttgggacggacgccccggctgtggttaactgtcttcacatcctggcc cgctccctggatgccaggacggtgatgaagtcaggccctgagatcgtgaaggctggcctc cgctccttcttcgagagtgcctcggaggacatcgagaagatggtggagaacctgcggctg ggcaaggtgtcacaggcgcgcacccaggtgaagggcgtgggccagaacctcacctacacc accgtggcgctgctgccggtcctcaccaccctcttccagcacatcgcccagcaccagttc ggagatgacgtcatcctggacgacgtccaggtctcttgctaccgaacgctgtgcagtatc tattccctgggaaccaccaagaacatttacgtggaaaagcttcggccagcccttggggag tgcctggcccgtctggcagcagccatgccggtggcgttcctggagccccagctgaacgag tacaacgcctgctcggtgtacaccaccaagtctccccgagagcgagccatcctggggctc cccaacagtgtggaggagatgtgtcctgacatcccggtgctggagcggctcatggcagac atcggggggctggccgagtcaggggcccgctacacagagatgccgcacgtcatcgagatc acgctgcccatgctatgcagctacctgccccgatggtgggagcgcgggcccgaggcaccc cctcctgccctgcccgccggcgcccccccaccctgcacagctgtcacctctgaccacctc aactccctgctggggaatatcctgagaatcatcgtcaacaacctgggcattgatgaggcc tcctggatgaagcggctggctgtgttcgcacagcccatcgtgagccgtgcgcggccggag ctcctgcagtcccacttcatccccaccatcgggcggctgcgcaagagggcagggaaggtg gtgtccgaggaggagcagctgcggctggaggccaaggccgaggcccaggagggcgagctg ctggtgcgagacgagttctccgtgctctgccgggacctgtacgccctgtatccgctgctc atccgctatgtggacaacaacagggcacagtggctgacggagccgaatcccagcgcggag gagctgttcaggatggtgggcgagattttcatctactggtccaagtcccacaacttcaag cgcgaggagcagaactttgtggtccagaacgagatcaacaacatgtccttcctgactgcg gacaacaagagcaaaatggctaaggcgggagatacacagtccggtggctcggaccaggag cgcaccaagaagaagcgccgtggggaccggtactccgtgcagacgtcgctgatcgtggcc acgctgaagaagatgctgcccatcggcctgaacatgtgcgcgcccaccgaccaggacctc atcacgctggccaagacccgctacgccctgaaagacacagatgaggaggtccgggaattt ctgaacaacaaccttcaccttcagggaaaggtcgaaggctccccgtctctgcgctggcag atggccctgtaccggggcgtcccaggtcgtgaggaggacgccgacgaccccgagaaaatc gtgcgcagagtccaggaagtgtcagccgtgctctaccacctggaccagaccgagcaccct tacaagtctaagaaggccgtgtggcacaagcttttgtccaagcagcgccggcgggcagtc gtggcctgtttccgtatgacgcccctgtacaacctgcccacgcaccgggcatgtaacatg ttcctggagagctacaaggctgcatggatcctgactgaagaccacagttttgaggaccgc atgatagatgacctttcaaaagctggggagcaggaggaggaggaggaagaggtggaagaa aagaagccagaccccctgcaccagttggtcctgcacttcagccgcactgccctgacggaa aagagcaaactggacgaggattacctgtacatggcctatgccgacatcatggcaaagagc tgccacctggaggagggaggggagaacggcgaaggtgaagaggaggttgaggtctccttt gaggagaaagagatggagaaacagcggctcctataccagcaagcacggctgcacacccgg ggggcggccgagatggtgctgcagatgatcagtgcctgcaaaggagagacaggtgccatg gtgtcctccaccctgaagctgggcatctccatcctcaatggaggcaatgctgaggtccag cagaaaatgctggattatcttaaggacaagaaggaagttggcttcttccagagtatccag gcactgatgcaaacatgcagcgtactggatctcaatgcctttgagagacagaacaaggcc gaggggctgggcatggtgaacgaggatggcactgtcatcaatcgccagaacggagagaag gtcatggcggatgatgaattcacacaagacctgttccgattcctacaattgctctgtgag gggcacaataatgatttccagaactacctacggacacagacagggaacacaaccactatt aacatcatcatctgcacggtggactacctcctgcggctgcaggaatccatcagcgacttc tactggtactactcaggcaaggatgtcattgaagagcagggcaagaggaacttctccaaa gccatgtcggtggctaagcaggtgttcaacagcctcactgagtacatccagggcccctgc actgggaaccagcagagcctggcgcacagccgcctttgggacgcagtggtgggattcctg cacgtgttcgcccatatgatgatgaagctcgctcaggactcaagccagatcgagctgctg aaggagctgctggatctgcagaaggacatggtggtgatgctgctgtcgctactagaaggg aacgtggtaaacggcacgatcgcccggcagatggtggacatgctcgtggaatcctcgtcc aatgtggagatgattctcaagttcttcgacatgttcctgaaactcaaggacattgtgggc tctgaagccttccaggactatgtaacggatccccgtggcctcatctccaagaaggacttc cagaaggccatggacagccagaagcagttcagcggtccagaaatccagttcctgctttcg tgctccgaagcggatgagaacgagatgatcaactgcgaggagttcgccaaccgcttccag gagccagctcgcgacatcggcttcaacgtggcggtgctgctgaccaacctgtcggagcat gtgccgcatgacccgcgcctgcacaacttcctggagctggccgagagcatcctcgagtac ttccgcccctacctgggccgcatcgagatcatgggcgcctcgcgccgcatcgagcgcatc tacttcgagatctcggagaccaaccgcgcccagtgggagatgccccaggtgaaggagtcc aagcgccagttcatcttcgacgtggtgaacgagggcggcgaggccgagaagatggagctc ttcgtgagtttctgcgaggacaccatcttcgagatgcagatcgccgcgcagatctcggag cccgagggcgagccggagaccgacgaggacgagggcgcggcggaggcgggcgtggagggc gcggaggagagcgcggcgggccccgagggcacggcggccacggcagctgcaggggcgaca gcgcgggtggcggcggccatgggccgggccctgcgcggcctcagctaccgcagcctgcgg cggcgcgtgcggcggctgcggcggctcacggcccgcgaggcggccaccgcggtggcggcg ctgctctgggcagccgtgacgcgcgcaggggccgcgggcgcgggggcggcggcgggcgcg ctgggcctgctgtggggctcgctgttcggcggcggcctggtggaaggcgccaagaaggtg acggtgaccgagctcctggcgggcatgcccgaccccaccagcgacgaggtgcacggcgag cagccggccgggcccggcggagacgcagacggcgagggtgccagcgagggcgcaggagac gccgcggagggagctggagacgaggaggaggcggtggacgaggctgggccgggcggcgca gacggggcggtggccgtgacggatgggggccccttccgacccgaaggggctggcggtctc ggggacatgggggacacgacgcctgcggaaccgcccactcccgagggctctcccatcctc aagaggaagctgggggtggatggagtggaggaggagctcccgccagaaccggagccggaa ccagaactggagccggagaaagcagatgccgagaatggggagaaagaagaagttcccgaa cccccaccagagccccccaagaagcaagcacctccctcaccccctccaaagaaagaggaa gctgggggcgaattctggggagaactggaggtgcagagggtgaagttcctgaactacctg tcccggaacttttacaccctgcggttccttgccctcttcttggcatttgccatcaacttc atcttgctgttttataaggtctcagactctccaccaggggaagacgacatggaaggctca gctgctggggatgtgtcaggtgcaggctctggtggcggctctggctggggcttgggggcc ggagaggaggcagagggcgatgaggatgagaacatggtgtactacttcctggaggagagc acaggctacatggagcccgccctgcgttgtctgagcctcctgcatacactggtggccttt ctctgcatcattggctataactgtctcaaggtgcccctggtaatctttaagcgggagaag gagctggcccggaagctggagtttgacggcctatacatcacagagcagcccgaggacgat gacgtgaaggggcagtgggaccgactggtgctcaacacaccgtctttccccagcaactac tgggacaagtttgtcaagcgcaaggtcctggacaaacatggggacatctacgggcgggag cggattgctgagctactgggcatggacctggccacactagagatcaccgcccacaacgag cgcaagcccgacccgccaccagggctgctgacgtggctcatgtccatcgatgtcaagtac cagatctggaagttcggggtcatcttcacagacaactccttcctgtacctgggctggtat atggtgatgtccctcttggggcactacaacaacttcttcttcgctgcccatctcctggac atcgccatgggggtcaagacactgcgcaccatcctctcctccgtcacccacaatgggaaa cagctggtgatgaccgtgggccttctggcggtggtcgtctacctgtacaccgtagtggcc ttcaacttcttccgcaagttctacaacaagagcgaggatgaggatgagcctgacatgaaa tgtgacgacatgatgacgtgttacctgtttcacatgtacgtgggtgtccgggctggtgga ggcattggggacgagatcgaggaccccgcgggtgacgaatacgagctctacagggtggtc ttcgacatcaccttcttcttcttcgtcatcgtcatcctgttggccatcatccagggtctg atcatcgacgcttttggtgagctccgagaccaacaagagcaagtgaaggaggatatggag accaagtgcttcatctgcggaatcggcagtgactactttgatacgacaccgcatggcttc gagactcacacgctggaggagcacaacctggccaattacatgtttttcctgatgtatttg ataaacaaggatgagacagaacacacaggtcaggagtcttatgtctggaagatgtaccaa gagagatgttgggatttcttcccggctggcgattgtttccgcaagcagtatgaggaccag cttagctga

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