Chlorocebus sabaeus (green monkey): 103245987 Help Entry 103245987         CDS       T04361                                  Symbol PLCG1 Name (RefSeq) phospholipase C gamma 1   KO K01116   phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11] Organism csab  Chlorocebus sabaeus (green monkey) Pathway csab00562   Inositol phosphate metabolism csab01100   Metabolic pathways csab01521   EGFR tyrosine kinase inhibitor resistance csab04012   ErbB signaling pathway csab04014   Ras signaling pathway csab04015   Rap1 signaling pathway csab04020   Calcium signaling pathway csab04062   Chemokine signaling pathway csab04064   NF-kappa B signaling pathway csab04066   HIF-1 signaling pathway csab04070   Phosphatidylinositol signaling system csab04072   Phospholipase D signaling pathway csab04360   Axon guidance csab04370   VEGF signaling pathway csab04613   Neutrophil extracellular trap formation csab04650   Natural killer cell mediated cytotoxicity csab04658   Th1 and Th2 cell differentiation csab04659   Th17 cell differentiation csab04660   T cell receptor signaling pathway csab04664   Fc epsilon RI signaling pathway csab04666   Fc gamma R-mediated phagocytosis csab04670   Leukocyte transendothelial migration csab04722   Neurotrophin signaling pathway csab04750   Inflammatory mediator regulation of TRP channels csab04919   Thyroid hormone signaling pathway csab04933   AGE-RAGE signaling pathway in diabetic complications csab04935   Growth hormone synthesis, secretion and action csab05012   Parkinson disease csab05022   Pathways of neurodegeneration - multiple diseases csab05135   Yersinia infection csab05167   Kaposi sarcoma-associated herpesvirus infection csab05170   Human immunodeficiency virus 1 infection csab05171   Coronavirus disease - COVID-19 csab05200   Pathways in cancer csab05205   Proteoglycans in cancer csab05206   MicroRNAs in cancer csab05214   Glioma csab05223   Non-small cell lung cancer csab05225   Hepatocellular carcinoma csab05231   Choline metabolism in cancer csab05235   PD-L1 expression and PD-1 checkpoint pathway in cancer csab05417   Lipid and atherosclerosis Module csab_M00130   Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Brite KEGG Orthology (KO) [BR:csab00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     103245987 (PLCG1)  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     103245987 (PLCG1)    04015 Rap1 signaling pathway     103245987 (PLCG1)    04064 NF-kappa B signaling pathway     103245987 (PLCG1)    04066 HIF-1 signaling pathway     103245987 (PLCG1)    04070 Phosphatidylinositol signaling system     103245987 (PLCG1)    04072 Phospholipase D signaling pathway     103245987 (PLCG1)  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     103245987 (PLCG1)    04650 Natural killer cell mediated cytotoxicity     103245987 (PLCG1)    04660 T cell receptor signaling pathway     103245987 (PLCG1)    04658 Th1 and Th2 cell differentiation     103245987 (PLCG1)    04659 Th17 cell differentiation     103245987 (PLCG1)    04664 Fc epsilon RI signaling pathway     103245987 (PLCG1)    04666 Fc gamma R-mediated phagocytosis     103245987 (PLCG1)    04670 Leukocyte transendothelial migration     103245987 (PLCG1)    04062 Chemokine signaling pathway     103245987 (PLCG1)   09152 Endocrine system    04935 Growth hormone synthesis, secretion and action     103245987 (PLCG1)    04919 Thyroid hormone signaling pathway     103245987 (PLCG1)   09156 Nervous system    04722 Neurotrophin signaling pathway     103245987 (PLCG1)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     103245987 (PLCG1)   09158 Development and regeneration    04360 Axon guidance     103245987 (PLCG1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103245987 (PLCG1)    05206 MicroRNAs in cancer     103245987 (PLCG1)    05205 Proteoglycans in cancer     103245987 (PLCG1)    05231 Choline metabolism in cancer     103245987 (PLCG1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     103245987 (PLCG1)   09162 Cancer: specific types    05225 Hepatocellular carcinoma     103245987 (PLCG1)    05214 Glioma     103245987 (PLCG1)    05223 Non-small cell lung cancer     103245987 (PLCG1)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     103245987 (PLCG1)    05171 Coronavirus disease - COVID-19     103245987 (PLCG1)    05167 Kaposi sarcoma-associated herpesvirus infection     103245987 (PLCG1)   09171 Infectious disease: bacterial    05135 Yersinia infection     103245987 (PLCG1)   09164 Neurodegenerative disease    05012 Parkinson disease     103245987 (PLCG1)    05022 Pathways of neurodegeneration - multiple diseases     103245987 (PLCG1)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     103245987 (PLCG1)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     103245987 (PLCG1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     103245987 (PLCG1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:csab04131]     103245987 (PLCG1) Enzymes [BR:csab01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.4  Phosphoric-diester hydrolases     3.1.4.11  phosphoinositide phospholipase C      103245987 (PLCG1) Membrane trafficking [BR:csab04131]  Exocytosis   Calcium ion-dependent exocytosis    Phospholipases     103245987 (PLCG1)  Endocytosis   Macropinocytosis    Phospholipase C     103245987 (PLCG1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH C2 SH3_1 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 PH_9 EF-hand_7 Motif Other DBs NCBI-GeneID:  103245987 NCBI-ProteinID:  XP_008015491 LinkDB All DBs Position 2:complement(22599547..22638394) Genome browser AA seq 1291 aa AA seqDB search MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL SLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNM LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRA GERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLQTIKEHAFVASEYPVILSIEDHCSIA QQRNMAQHFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMM YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSS STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW FPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYC RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKS SLRGLEPCAISVEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL ELASLLIKIDIFPAKQENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFED FRISQEHLADHFDSRERRAPRRTRVNGDNRL NT seq 3876 nt NT seq  +upstreamnt  +downstreamnt atggcgggcgccgcgtccccctgcgccaacggctgcgggcccggcgcgccctcggacgcc gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc aagaagtcgcagcgacccgagcggaagaccttccaggtcaagctggagacgcgccagatc acgtggagccggggcgccgacaagatagagggggccattgatattcgagaaatcaaggag attcgcccagggaagacctcacgagactttgatcgctatcaagaggaccccgctttccgg ccagaccagtcacactgctttgtcattctctatggaatggaattccgtctgaagacgctg agcctgcaagccacatctgaggatgaagtgaacatgtggatcaagggcttaacttggctg atggaggatacattgcaggcacctacacccctgcagattgagaggtggctccggaagcag ttttactcagtggatcggaatcgtgaggatcgtatatcagccaaggacctaaagaacatg ctgtcccaggtcaactaccgggtccccaacatgcgcttcctccgagagcggctgacggac ctggagcagcgcagcggggacattacctacgggcagtttgctcagctgtaccgcagcctc atgtacagcgcccagaagacgatggacctccctttcttggaagccagtactctgagggct ggggagcggccggagctttgccgagtgtcccttcctgagttccagcagttccttcttgac taccagggggagctgtgggctgttgatcgcctccaggtgcaggagttcatgctcagcttc ctccgagaccccttgcgagagatcgaggagccatacttcttcctggatgagtttgtcacc ttcctgttctccaaagagaatagtgtgtggaactcacagctggatgcagtatgcccggac accatgaacaaccccctttcccactattggatctcctcctcacacaacacgtacctgacc ggggaccagttctctagtgagtcctccttggaagcctatgctcgctgcctgcggatgggc tgtcgctgcattgagttggactgctgggacggcccagatgggatgccagttatttaccat gggcacacccttaccaccaagatcaagttctcagatgtcctgcaaaccatcaaggagcat gcctttgtggcctcagagtacccagtcatcctgtccattgaggaccactgcagcattgcc cagcagaggaacatggcccagcacttcaagaaggtgctaggggacacactcctcaccaag cctgtggagatctccgctgatgggctcccctcacccaaccagcttaagaggaagatcctc atcaagcacaagaagctggctgagggcagtgcctacgaggaggtgcctacatccatgatg tactctgagaacgacatcagcaactccatcaagaatggcatcctctacctggaggaccct gtgaaccatgaatggtatccccactacttcgttctgaccagcagcaagatctactactct gaggagaccagcagtgaccagggcaacgaggatgaggaggagcccaaggaggtcagcagc agcacagagctgcactccaatgagaagtggttccatgggaagctaggggcagggcgtgac gggcggcacatcgctgagcgcctgctcactgagtactgcatcgagaccggggcccctgat ggctccttcctcgtgcgagagagtgagaccttcgtgggcgactacacgctctctttctgg cggaacgggaaagtccagcactgccgtatccactcacggcaagatgctgggacccccaag ttcttcttgacagacaacctcgtctttgactccctctatgacctcatcacacactaccag caggtgcccctgcgctgcaatgagtttgagatgcgactttcagagcctgtcccacagacc aatgcccatgagagcaaagagtggtaccacgcgagcctgaccagagcacaggctgagcac atgctgatgcgtgtccctcgtgatggggccttcctggtgcggaagcggaatgagcccaac tcatatgccatctctttccgggctgaaggcaagatcaagcattgccgtgtccagcaagag ggccagactgtgatgctagggaactcggagttcgacagccttgttgacctcatcagctac tatgagaagcacccgctataccgcaagatgaagctgcgctatccaatcaatgaggaggcg ctggagaagattggcacagctgagcctgactacggggccctgtatgagggacgcaaccct ggcttctatgtagaggcaaaccctatgccaactttcaagtgtgcagtcaaagccctcttt gactacaaggcccagagggaggatgagctgaccttcaccaagagcgccatcatccagaat gtggagaagcaagagggaggctggtggcgaggggactacggagggaagaagcagctgtgg ttcccatcaaactacgtggaagagatggtcaaccccgtggccctggagccagagagggag cacttggacgagaacagccccctaggggacttgctgcggggggtcttggatgtgccggct tgtcagattgccatccgtcctgagggcaagaacaaccggctcttcgtcttctccatcagc atggcgtcggtggcccactggtccctggatgttgctgccgactcacaggaggagctgcag gactgggtgaaaaagatccgtgaagtggcccagaccgcagatgccaggctcactgaaggg aagataatggaacggaggaagaagatcgccctggagctctctgaacttgttgtctactgc cggcctgttcccttcgatgaagagaagattggcacagaacgtgcttgctaccgggacatg tcatccttcccggagaccaaggctgagaaatacgtgaacaaggccaaaggcaagaagttc cttcagtacaatcgactgcagctctcccgcatctaccccaagggccagcgactggattcc tccaactacgatcctttgcccatgtggatctgtggtagtcagctggtggccctcaacttc cagacccctgacaagcctatgcagatgaaccaggctctcttcatgacgggcaggcactgt ggctacgtgctgcagccaagcaccatgcgggatgaggccttcgacccctttgacaagagc agcctccgtgggctggagccatgtgccatctctgttgaggtgctgggtgcccgacatttg ccaaagaatggccgaggcattgtgtgcccttttgtggagattgaggtggctggagctgag tatgacagcaccaagcagaagacagagtttgtggtggacaatggactcaaccctgtatgg ccagccaagcccttccacttccagatcagtaaccctgaatttgcctttctgcgctttgtg gtgtatgaggaagacatgtttagtgaccagaatttcctggctcaggctactttcccggta aaaggcctgaagacaggatacagagcagtgcctttgaagaacaactacagtgaggacctg gagttggcctccctgctgatcaagattgacatattccctgccaagcaggagaatggtgac ctcagtcccttcagtggtacgtccctgcgggagcggggctcagatgcctcaggccagctg tttcacggccgagcccgggaaggctcctttgaatcccgctaccagcagccatttgaggac ttccgcatctcccaggaacatcttgcagaccattttgacagtcgagaacgaagggcccca agaaggactcgggtcaatggagacaaccgcctctag

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