Cronobacter sakazakii ES15: ES15_0376
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Entry
ES15_0376 CDS
T02119
Symbol
metH
Name
(GenBank) B12-dependent methionine synthase
KO
K00548
5-methyltetrahydrofolate--homocysteine methyltransferase [EC:
2.1.1.13
]
Organism
csk
Cronobacter sakazakii ES15
Pathway
csk00270
Cysteine and methionine metabolism
csk00450
Selenocompound metabolism
csk00670
One carbon pool by folate
csk01100
Metabolic pathways
csk01110
Biosynthesis of secondary metabolites
csk01230
Biosynthesis of amino acids
csk04981
Folate transport and metabolism
Module
csk_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:
csk00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
ES15_0376 (metH)
09106 Metabolism of other amino acids
00450 Selenocompound metabolism
ES15_0376 (metH)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
ES15_0376 (metH)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
ES15_0376 (metH)
04980 Cobalamin transport and metabolism
ES15_0376 (metH)
Enzymes [BR:
csk01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.13 methionine synthase
ES15_0376 (metH)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Met_synt_B12
S-methyl_trans
Pterin_bind
B12-binding_2
B12-binding
Motif
Other DBs
NCBI-ProteinID:
AFJ97949
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Position
400522..404205
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AA seq
1227 aa
AA seq
DB search
MSSKSEQLHRQLAERIMVLDGGMGTMIQSYRLDEEDFRGERFADWPCDLKGNNDLLVLTK
PDIIAAIHYAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINYEAAKLARACADEWTA
RTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVEAYRESTRALIEGGADLILI
ETVFDTLNAKAAIFAVKAEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHADA
LTFGLNCALGPDELRQYVAELSRIAECYVTAHPNAGLPNAFGEYDLDADVMAAQIREWAE
SGFLNIVGGCCGTTPEHIAAMSRAVEGLPPRKLPDIPVACRLAGLEPLNIGDDSLFVNVG
ERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLI
AGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVEAFVHHAKLVRRYGAAV
VVMAFDEVGQADTRERKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIDEHNNYAQ
DFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAG
QLAIYDDLPTELRDAVEDVILNRRADGTERLLALAEKYRGSKADNAADAQQAEWRTWDVK
KRLEYSLVKGITEFIEQDTEEARQQAARPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
SARVMKQAVAYLEPYIQASKEVGKSNGKIVLATVKGDVHDIGKNIVGVVLQCNNYEIIDL
GVMVPTDKILKTAREVNADIIGLSGLITPSLDEMVNVAKEMERQGFTLPLLIGGATTSKA
HTAVKIEQNYSGPTVYVQNASRTVGVVSALLSDTLRDDFVARTRKEYETVRIQHGRKKPR
TPPVTLAAARENDLAFDWESYTPPAAHRLGVEEVTASIETLRNYIDWTPFFMTWSLAGKY
PRILEDEVVGEEAQRLFKDANEMLDKLSAEKSLTPRGVVGLFPANRVGDDIEIYRDETRT
HVLSVSHHLRQQTEKVGFANYCLADFVAPKHSGKADYLGAFAVTGGLEEDALAEAFDAQH
DDYNKIMVKAVADRLAEAFAEYLHERVRKVLWGYAPYENLSNEELIRENYQGIRPAPGYP
ACPEHTEKSVIWDLLDVENRIGMKLTESYAMWPGASVSGWYFSHPESKYFAVAQIQRDQV
EDYAQRKGMSVSEVERWLAANLGYDTD
NT seq
3684 nt
NT seq
+upstream
nt +downstream
nt
gtgagtagcaaatctgaacagctgcaccggcaattagcggaacgcattatggtgctggac
ggcggtatgggcaccatgatccagagctaccgtctggatgaagaggatttccgcggcgag
cgtttcgccgactggccgtgcgatcttaaaggtaacaatgacctgctggtactcactaag
ccagatatcatcgccgctatccactacgcctactttgaagcgggcgccgatatcatcgag
accaacacctttaactcgacgaccatcgcgatggccgattaccagatggaatcgctgtcg
gcggaaatcaactacgaagccgcgaagctggcccgcgcctgcgccgatgaatggacggcg
cgcacaccggaaaaaccgcgttacgtggcaggtgtgttagggcctactaaccgtacagcg
tcgatttctcctgatgttaacgacccggccttccgtaatattacttttgatcagctagtg
gaggcttaccgcgaatccacgcgtgcgctgattgagggcggcgcagatctgattctcatc
gaaacggtcttcgatacgcttaacgccaaggccgcgattttcgccgtgaaggcggagttc
gaggcgctcggcgtcgagctgcccatcatgatctccggcacaatcaccgacgcctcgggc
cgcacgctgtcgggccagaccaccgaggcgttttataactcgctgcgccacgctgacgcg
ctcaccttcggccttaactgtgcgctgggcccggacgagctgcgccagtacgtggcggag
ctgtcgcgcatcgccgagtgctacgtcaccgcgcaccccaacgcgggcctgcccaacgcc
ttcggggaatatgatttagacgccgatgtgatggctgcgcaaatccgcgagtgggcggag
tcgggcttcttaaatatcgtcggcggctgctgcggcaccacgccggagcatatcgctgcg
atgagccgcgcggtggaaggtttaccgccgcgtaaattgccggatattcccgtcgcctgc
cgtctggcgggccttgagccgctcaacatcggcgacgattcgctgtttgtaaacgtcggc
gagcgtaccaacgtcaccggctcggccaaatttaagcgcttaatcaaagaagagaaatac
agcgaagcgctggacgtggcgcgccagcaggtcgaaaacggcgcgcagattatcgatatc
aacatggatgaggggatgctcgacgccgaagcggcgatggtgcgtttcctcaaccttatc
gcgggtgagccagacatcgcccgcgtgccgattatgatcgactcctcgaagtgggacgtt
atcgaaaaaggcctgaaatgcattcagggcaaaggcatcgttaactcgatctccatgaaa
gagggcgtcgaggcgtttgtgcatcacgcgaagctggtgcgccgctatggcgcggcggtg
gtggtgatggcgtttgacgaagtgggccaggccgacacccgcgagcgtaaaattgaaatt
tgccgccgcgcctacaaaatcctcaccgaagaggttggcttcccgccggaagatattatt
ttcgacccgaacattttcgcggtcgcaacgggcatcgatgagcacaacaactacgcgcag
gattttatcggcgcgtgtgaagacattaaacgcgagctgccgcatgcgctgatctccggc
ggcgtctctaacgtctcgttctcgtttcgcggcaacgacccggtgcgcgaggcgatccac
gccgtgttcctctactacgccatccgcaacggcatggacatgggtatcgttaacgccggg
cagctggcgatttacgacgatctgcccaccgagctgcgcgacgcggtagaagacgtcatc
cttaaccgccgcgccgatggcaccgagcggctgctggcgcttgccgaaaagtaccgcggc
agcaaagcggataacgcggcagatgcccagcaggcggaatggcgcacgtgggatgtcaaa
aagcgccttgagtattcactggtcaaaggcattaccgagtttatcgagcaggataccgaa
gaggcgcgccagcaggcggcccgcccgattgaggtaattgaaggcccgctgatggacggc
atgaacgtggtcggcgatctgttcggcgagggcaaaatgttcctgccacaggtggtgaaa
tcggcccgcgtgatgaaacaagcggtggcgtatcttgagccgtacatccaggccagtaaa
gaagtgggcaagagcaacggcaaaatcgtgcttgcgaccgtgaaaggcgatgtccacgac
atcggcaaaaatatcgtcggcgtggtgctccagtgcaacaactacgagattatcgatctc
ggcgtgatggtgccgacggataaaatcctcaaaaccgcgcgtgaagtgaacgccgatatt
atcggactttccgggcttatcacgccgtcgcttgatgagatggtcaacgtggcgaaagag
atggagcgccagggctttacgctgccgctgcttatcggtggcgcgaccacgtctaaagcc
catacggcggtgaaaatcgagcagaactacagcgggccgacggtctatgtccagaacgcc
tcacgtaccgtgggcgtggtctctgcgctgctctccgacacgctgcgtgacgatttcgtc
gcgcgcacccgcaaagagtatgaaaccgtgcgcattcagcacgggcgtaaaaaaccgcgc
acgccgccggtgacgctcgccgccgcgcgtgaaaacgatctggcgtttgactgggaaagc
tacacgccgcccgccgcacaccgtctgggcgtcgaagaagtaacagcaagcattgagacg
ctgcgtaattacatcgactggacgccgttctttatgacctggtcacttgccgggaaatac
ccgcgcattctggaagatgaggttgtgggcgaagaggctcagcgcctgtttaaagacgcc
aacgagatgctcgacaaactgagcgccgaaaaatccctgacgccgcgcggcgtggtaggg
cttttcccggcgaaccgcgtgggtgacgacatcgaaatctaccgcgacgagacccgcaca
catgtgttgtcagtaagtcatcacttacgtcagcagaccgagaaagtgggctttgcgaac
tactgtctggccgatttcgtcgcgccaaaacacagcggcaaagcagactacctcggcgcg
ttcgccgtgaccggcgggctggaggaagacgcgctggcggaggccttcgacgcgcagcat
gatgattacaataaaatcatggtcaaagcggtggccgaccgtctggcggaagcgttcgcc
gagtatctgcatgagcgcgtgcgtaaagtgctgtggggctacgcgccgtatgaaaacctc
agcaatgaggagctcatccgtgaaaattatcagggcattcgcccggcgccgggttatccc
gcctgcccggagcacaccgagaaatcggttatctgggatctgctggacgtggaaaaccgc
atcggcatgaaactcacggagtcctacgccatgtggccaggcgcgtcagtctccggctgg
tatttcagccacccggaaagcaaatatttcgccgtggcgcagatccagcgcgaccaggtg
gaagattacgcgcagcgcaaagggatgagcgtgagcgaggtagagcggtggctcgcggcg
aaccttggttacgacaccgattag
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