KEGG   Delphinapterus leucas (beluga whale): 111184170
Entry
111184170         CDS       T05885                                 
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
dle  Delphinapterus leucas (beluga whale)
Pathway
dle00562  Inositol phosphate metabolism
dle01100  Metabolic pathways
dle01521  EGFR tyrosine kinase inhibitor resistance
dle04012  ErbB signaling pathway
dle04014  Ras signaling pathway
dle04015  Rap1 signaling pathway
dle04020  Calcium signaling pathway
dle04062  Chemokine signaling pathway
dle04064  NF-kappa B signaling pathway
dle04066  HIF-1 signaling pathway
dle04070  Phosphatidylinositol signaling system
dle04072  Phospholipase D signaling pathway
dle04360  Axon guidance
dle04370  VEGF signaling pathway
dle04613  Neutrophil extracellular trap formation
dle04650  Natural killer cell mediated cytotoxicity
dle04658  Th1 and Th2 cell differentiation
dle04659  Th17 cell differentiation
dle04660  T cell receptor signaling pathway
dle04664  Fc epsilon RI signaling pathway
dle04666  Fc gamma R-mediated phagocytosis
dle04670  Leukocyte transendothelial migration
dle04722  Neurotrophin signaling pathway
dle04750  Inflammatory mediator regulation of TRP channels
dle04919  Thyroid hormone signaling pathway
dle04933  AGE-RAGE signaling pathway in diabetic complications
dle04935  Growth hormone synthesis, secretion and action
dle05012  Parkinson disease
dle05022  Pathways of neurodegeneration - multiple diseases
dle05135  Yersinia infection
dle05167  Kaposi sarcoma-associated herpesvirus infection
dle05170  Human immunodeficiency virus 1 infection
dle05171  Coronavirus disease - COVID-19
dle05200  Pathways in cancer
dle05205  Proteoglycans in cancer
dle05206  MicroRNAs in cancer
dle05214  Glioma
dle05223  Non-small cell lung cancer
dle05225  Hepatocellular carcinoma
dle05231  Choline metabolism in cancer
dle05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
dle05417  Lipid and atherosclerosis
Module
dle_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:dle00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    111184170 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    111184170 (PLCG1)
   04014 Ras signaling pathway
    111184170 (PLCG1)
   04015 Rap1 signaling pathway
    111184170 (PLCG1)
   04370 VEGF signaling pathway
    111184170 (PLCG1)
   04064 NF-kappa B signaling pathway
    111184170 (PLCG1)
   04066 HIF-1 signaling pathway
    111184170 (PLCG1)
   04020 Calcium signaling pathway
    111184170 (PLCG1)
   04070 Phosphatidylinositol signaling system
    111184170 (PLCG1)
   04072 Phospholipase D signaling pathway
    111184170 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    111184170 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    111184170 (PLCG1)
   04660 T cell receptor signaling pathway
    111184170 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    111184170 (PLCG1)
   04659 Th17 cell differentiation
    111184170 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    111184170 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    111184170 (PLCG1)
   04670 Leukocyte transendothelial migration
    111184170 (PLCG1)
   04062 Chemokine signaling pathway
    111184170 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    111184170 (PLCG1)
   04919 Thyroid hormone signaling pathway
    111184170 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    111184170 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    111184170 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    111184170 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    111184170 (PLCG1)
   05206 MicroRNAs in cancer
    111184170 (PLCG1)
   05205 Proteoglycans in cancer
    111184170 (PLCG1)
   05231 Choline metabolism in cancer
    111184170 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    111184170 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    111184170 (PLCG1)
   05214 Glioma
    111184170 (PLCG1)
   05223 Non-small cell lung cancer
    111184170 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    111184170 (PLCG1)
   05171 Coronavirus disease - COVID-19
    111184170 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    111184170 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    111184170 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    111184170 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    111184170 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    111184170 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    111184170 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    111184170 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:dle04131]
    111184170 (PLCG1)
Enzymes [BR:dle01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     111184170 (PLCG1)
Membrane trafficking [BR:dle04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    111184170 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    111184170 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH SH3_1 C2 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD PH_9 EF-hand_6 EF-hand_7
Other DBs
NCBI-GeneID: 111184170
NCBI-ProteinID: XP_022448104
UniProt: A0A2Y9PMG8
LinkDB
Position
Unknown
AA seq 1291 aa
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRTSDITYGQFAQLYRSLMYSAQKTMDLPFLEASALRA
GERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSIWNSQLDAVCPDAMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPSQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLVSYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRPFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFLAGGHCGYVLQPSIMREEAFDPFDKS
SLRGLEPCAICIEVLGARHLPKNGRGIVCPFVELEVAGAEYDSAKQKTEFVVDNGLNPMW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLVKVDVFPAKQENGDLSPFGGASLRERGCDASGQLFHGRAREGSFEARYQQPFED
FRISQEHLADHFDSRERRAPRRTRVNGDNRL
NT seq 3876 nt   +upstreamnt  +downstreamnt
atggcgggcgccgcgtccccctgcgccaacggctgcgggcccggcgcgccctcggacgcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgttatgactttgttctactcc
aagaagtcgcagcggcccgagcggaagaccttccaggtcaagctggagacgcggcagatc
acgtggagccgtggcgccgacaagatcgagggggccattgacattcgagaaatcaaggag
atccgcccggggaagacctcacgggacttcgatcgctaccaagaggatcctgcttttcga
ccggaccagtcacactgctttgtcatcctgtatggaatggaattccgcctgaagaccctg
agcctgcaagctacgtctgaggacgaagtgaacatgtggatcaagggcctgacttggctg
atggaggatacgttgcaggcagccacacccttgcagattgagaggtggctgcggaagcag
ttctactcagtggaccggaatcgtgaggatcgtatatcagccaaggacctgaagaacatg
ctgtcccaggtcaactaccgggtccccaacatgcgcttcctccgagagcggctgacggac
ctggagcagcgcaccagcgacatcacctacgggcagtttgctcagctgtaccgcagcctt
atgtacagcgcccagaagacgatggacctccccttcctggaagccagtgccctgagggcg
ggggagcggccggagctctgccgggtgtcccttcctgagttccagcagttcctcctcgag
taccagggggagctatgggctgtcgaccggctccaggtgcaggagttcatgctcagcttc
cttcgagaccccttgcgagagatcgaggagccttacttcttcctggatgagttcgtcacc
ttcctgttctccaaggagaacagcatatggaattcgcagctggacgccgtgtgccccgac
gccatgaacaaccccctgtcccactactggatctcctcctcgcacaacacgtacctgacc
ggggaccagttttccagcgagtcctccctggaagcctacgcccgctgcctgcggatgggc
tgccgctgcatcgagttggactgctgggatggtccagacgggatgccagtcatttaccac
ggacacaccctgaccaccaagatcaagttctcagacgtcctgcacaccatcaaggagcac
gcctttgtggcctcagagtacccggtcatcttgtccatcgaggaccattgcagcatcgcc
cagcagaggaacatggcccagtacttcaagaaggtgctcggggacacactcctcaccaag
cccgtggacattgctgctgacgggctcccctcacccagccagctcaagaggaagatcctc
atcaagcacaagaagctggctgagggcagtgcctatgaagaggtgcctacgtccgtgatg
tactctgagaacgacatcagcaactccatcaagaatggcatcctctacctggaggacccc
gtgaatcacgagtggtatccccactacttcgttctgaccagtagcaagatctactactcc
gaggagaccagcagtgaccagggcaacgaggacgaggaggagcccaaggaggccagtggc
agcacagagctgcactccaatgagaagtggtttcacgggaagctcggggcaggacgggat
gggcggcacattgccgagcgcctgctcacagagtactgcatcgagaccggggcccccgac
ggctccttcctcgtgcgcgagagcgagaccttcgtgggcgactacaccctctccttctgg
cggaacggcaaagtccagcactgccggatccactcccggcaggacgcagggacccccaag
ttcttcctgactgacaacctcgtcttcgactcactctatgacctcatcacacactaccag
caggtgcccctgcgctgcaacgaatttgagatgcgcctctcagagcccgtcccgcagacc
aacgcccacgagagcaaagagtggtaccacgcgagcctgaccagagcgcaggccgagcac
atgctgatgcgcgtcccccgggacggggccttcctggtgcggaaacggaatgagcccaac
tcctacgccatctccttccgggctgagggcaagatcaagcactgccgcgtacagcaggag
ggccagaccgtgatgctgggcaactcagagtttgacagcctcgtggacctcgtcagctac
tacgagaagcatcccctgtaccgcaagatgaagctacgctatcccatcaacgaggaggca
ctggagaagatcggcacagcggagcctgactatggggccctgtatgagggccgcaacccc
ggcttctacgtggaggcgaaccccatgccaactttcaagtgcgccgtcaaagctctcttc
gactacaaggcccagagagaggacgagctgactttcaccaagagcgccatcatccagaac
gtggagaagcaggaaggaggctggtggcgtggtgactatggtgggaagaagcagctgtgg
ttcccgtcgaactacgtggaagagatggtcagccctgcggccctggaacctgagagggag
cacttggacgagaacagccccctgggggacttgctgcggggggtcttggatgtgccggct
tgtcagatagccatccgtcctgagggcaagaacaaccggcccttcgtcttctccatcagc
atggcatcggtggcacactggtccctagatgtggctgccgactcacaggaggagctgcag
gactgggtgaaaaagatccgggaagtggcccagaccgcggatgccaggctcactgagggg
aagatgatggagcggaggaagaagatcgccctggagctctccgagcttgtcgtctactgc
cggcctgttcccttcgacgaagagaagatcggcacagaacgcgcctgctaccgggacatg
tcgtccttcccggaaaccaaggctgagaagtacgtgaacaaggccaaaggcaagaagttc
ctccagtacaaccggctgcagctctcccgcatctaccccaagggccagcggctggactcc
tccaattacgaccccttgcccatgtggatctgtggcagtcagctggtagccctcaacttc
caaaccccagacaagcctatgcagatgaaccaggccctcttcctggccggcgggcactgt
ggctacgtgctgcagccgagcatcatgcgcgaggaggccttcgacccctttgacaagagc
agcctccgtgggctggagccgtgcgccatctgcatcgaggtgctgggggcccggcacctg
ccgaagaacggccgaggcatcgtgtgtccgttcgtggagcttgaggtggccggtgctgag
tatgacagcgccaagcagaagaccgagtttgtggtggacaacggactgaaccccatgtgg
ccagccaagcccttccacttccagatcagtaaccccgaattcgccttcctgcgctttgtg
gtgtatgaggaagacatgtttagtgaccagaacttcctggctcaggccaccttcccggtg
aagggcctgaagacaggatacagagctgtgcctttgaagaacaactatagtgaggacctg
gagttggcctccctgctcgtcaaggtcgacgttttccctgccaagcaggagaacggcgac
ctcagtccctttgggggtgcgtccctgcgggagcggggctgcgacgcctcgggccagctg
tttcacggccgggcccgggaaggctccttcgaagctcgctaccagcagccatttgaggac
ttccgcatctcccaggagcatctcgccgaccattttgacagtcgggaacgaagggccccg
cgaaggactcgggtcaatggagacaaccgcctctag

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