Dipodomys ordii (Ord's kangaroo rat): 105993062 Help Entry 105993062         CDS       T07834                                  Symbol Ryr1 Name (RefSeq) ryanodine receptor 1   KO K04961   ryanodine receptor 1 Organism dord  Dipodomys ordii (Ord's kangaroo rat) Pathway dord04020   Calcium signaling pathway dord04371   Apelin signaling pathway dord04713   Circadian entrainment dord04730   Long-term depression dord04921   Oxytocin signaling pathway dord05017   Spinocerebellar ataxia dord05020   Prion disease dord05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:dord00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     105993062 (Ryr1)    04020 Calcium signaling pathway     105993062 (Ryr1)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     105993062 (Ryr1)   09156 Nervous system    04730 Long-term depression     105993062 (Ryr1)   09159 Environmental adaptation    04713 Circadian entrainment     105993062 (Ryr1)  09160 Human Diseases   09164 Neurodegenerative disease    05017 Spinocerebellar ataxia     105993062 (Ryr1)    05020 Prion disease     105993062 (Ryr1)    05022 Pathways of neurodegeneration - multiple diseases     105993062 (Ryr1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:dord01009]     105993062 (Ryr1)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:dord04147]     105993062 (Ryr1)    04040 Ion channels [BR:dord04040]     105993062 (Ryr1) Protein phosphatases and associated proteins [BR:dord01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      105993062 (Ryr1) Exosome [BR:dord04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    105993062 (Ryr1) Ion channels [BR:dord04040]  Voltage-gated cation channels   Ryanodine receptor    105993062 (Ryr1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec MIR SPRY RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  105993062 NCBI-ProteinID:  XP_012881649 Ensembl:  ENSDORG00000006887 UniProt:  A0A1S3G026 LinkDB All DBs Position Unknown AA seq 4821 aa AA seqDB search MGDGGEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPP DLAICCFILEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHAHSRMYLSC LTTSRSLTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSTASGELQVDASFMQTLWNMNPICSCCEEGYVTGGHVLRLFHGHMDECLTISPSDSDD QRRLVYYEGGSVCTHARSLWRLEPLRISWSGSHLRWGQPLRIRHVTTGRYLALTEDQGLV VVDASKAHTKATSFCFRISKEKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYA APDTKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIYSTAGLYNQFIKGLDS FSGKPRGSGPPVGSALPIEGVILSLQDLIGYFEPPSEELQHEEKQSKLRSLRNRQSLFQE EGMLSLVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRTNCALF STNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVL DVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTDLINYVTSIRPNIFVGRAEGSTQYG KWYFEVMVDEVVPFLTAQATHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLH LWTGHVARPVTSPGQHLLAPEDVVSCCLDLSVPSISFRINGCPVQGVFEAFNLDGLFFPV VSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHLV GPSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGQVRDDN KRLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYM MSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVAQGWSYSAVQDIPARRNPR LVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQAENQSRGDRTRIFRAEKS YVVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRVSRMDGTVDTPP CLRLTHRTWGSQNSLVEMLFLRLSLPVQFYQHFRCTAGATPLAPPGLQPPAEDEARAAEP DPDYENLRRSAGGWGEAEAGKEGTAKDGGTPQPGMEAQPVRAENEKDATTEKNKKRGFLF KAKKAAMMTQPPATPVLPRLPREVVPTDNRDDPEIILNTTTYYYSVRVFAGQEPSCVWVG WVTPDYHQHDMTFDLTKVRAVTVTMGDEQGNVHSSLKCSNCYMVWGGDFVSPGQQGRISH TDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNVIQFELGKLKN IMPLSAAMFLSERKNPAPQCPPRLEVQMLMPVSWSRMPNHFLQVDTRRAGERLGWAVQCQ EPLTMMALHIPEENRCMDILELSERLDLQRFHSHTLSLYRAVCALGNNRVAHALCSHVDQ AQLLHTLEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPETRSITLFPPG RSAEDGPRRHGLPGVGVTTSLRPPHHFSPPCFVAALPAAGGTEAPARLSPAIPLEALRDK ALRMLGEAVRDGGQHARDPIGGSVEFQFVPVLKLVSTLLVMGVFSDEDVKQILKMIEPEV FTEIEEEEEEAEEEEEEDEEEKEEDEEEEAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMK LPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQGNQRGRYGLLMKAFTMSAAE TARRTREFRSPPQEQSLQELVSHMVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRA LPRAYTISPSSVADTMSLLECLGQIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNL MRALGMHETVMEVMVNVLGGGESKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYL LENSGIGLGMQGSTPLDVAAASVIDNNELALALQEQDLEKVVSYLAGCGLQSCPMLLAKG YPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLL AAIEEAIRISEDPARDGPGVRRDRRPHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAP EMHLIQAGKGEALRIRAILRSLVPLDDLVGIISLPLQMPTLGKDGALVQPKMSASFVPDH KASIVLFLDRVYGIDNQDFLLHVLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAV LPLITKCAPLFAGTEHRAIMVDSMLHTVYRLSRGRSLTKAQRDVIEDCLMALCRYIRPSM LQHLLRRLVFDVPILNEFAKMPLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKL FWGIFDSLAHKKYDQELYRIAMPCLCAIAGALPPDYVDASFSSKTEKKATVDAEGNFDPR PVETLNVIIPEKLDSFINKFAEYSHEKWAFDKIQNSWSYGENIDEEQKTHPMLRPYKTFS EKDKEIYRWPIKESLKAMIAWEWTIEKAREGEEEKTEKKKTRKISQTAQTYDPREGYSPQ PPDLSGVTLSRELQAMAEQLAENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKAR DREKAQELLKFLQMNGYAVTRGLKDMELDTSSIEKRFAFGFLQQLLRWMDISQEFIAHLE AVVSSGRVEKSPHEQEIKFFAKILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEM ITSLFCKLAALVRHRVSLFGTDAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFES ASEDIEKMVENLRLGKVSQARTQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVIL DDVQVSCYRTLCSIYSLGTTRNPYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSV YTTKSPRERAILGLPNSVEEMCPDIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLC SYLPRWWERGPEAPPPALPAGAPPPCTEVTSDHLNSLLGNILRIIVNNLGIDEASWMKRL AVFAQPIVSRARPELLRSHFIPTIGRLRKRAGKVVAEEEQLRLEAKAEAEEGELLVRDEF SVLCRDLYALYPLLIRYVDNNRAHWLTEPNPNAEELFRMVGEIFIYWSKSHNFKREEQNF VVQNEINNMSFLTADNKSKMAKAGDVQSGGSDQERTKKKRRGDRYSVQTSLIVATLKKML PIGLNMCAPTDQDLIGLAKARYALKDTDEEVREFLQNNLNLQGKVEGSPSLRWQMALYRG LPGREEDADDPEKIVRRVQEVSAVLYHLEQTEHPYKSKKAVWHKLLSKQRRRAVVACFRM TPLYNLPTHRACNMFLESYKASWILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPL HQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHMEEGGENGEAEGEEEAEVSFEEKE MEKQRLLYQQSRLHNRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKML DYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMAD DEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYY SGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFA HMMMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEM ILKFFDMFLKLKDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFTGPEIQFLLSCSEA DENEMINCEEFANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLRTFLELAESILEYFRPY LGRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGESEKMELFVSF CEDTIFEMQIAAQISEPEGEPEESEDEGATEAGTEVPEEGSAGPEGTTGAVAAGVTARLA AAMSRALRGLSYRSLRRRVRKLRRLTAREAATAVVALLWAVVTQAGSAGAGAAAGTLRLL WGSLFGGGLVDSAKKVTVTELLAGMPDPTGDEVHGQQPTGPGGDADGEGEGEGEGDTQEG AGEEEAASDEARQGGADRAVAVADGSPFRPEGAGGLGDMGDTTPVEPPTPEGSPILKRKP GVEGEEEEEQPPEPEPEPEPEKADTENGEKEEVQEPPPEEPPTKTAPPPPPPKKEEAGGA GLEFWGELEVQRVKFLNYLSRNFYTLRFLALFLAFAINFILLFYKVSDSPPGEDDMEGSA AGEMSGAGSGGGSGWGSGAGEEVEGDEDENMVYYFLEESTGYMEPALRCLSLLHTLVAFL CIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYW DKFVKRKVLDKHGDIFGRERIAELLGMDLASLEITAHSGRKPEPPPGLLTWLMSIDVKYQ IWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQ LVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGG IGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMET KCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQE RCWDFFPAGDCFRKQYEDQLS NT seq 14466 nt NT seq  +upstreamnt  +downstreamnt atgggagacggaggagaaggcgaggacgaagtccagttcctgcggacggatgacgaggtg gtcctgcagtgcagcgccaccgtgctcaaggagcagctcaagctctgcctggcggctgag ggcttcggcaaccgcctctgcttcctggagcccaccagcaacgcgcagaatgtgccccct gacctggccatctgctgcttcatcctggagcagtctctgtcagtccgagccttgcaggag atgctggctaacactgtagaggctggcgtagagtcatcccagggtggaggacatagaaca cttctgtatggccatgccatcctgctccggcatgcacacagtcgcatgtacctgagttgt cttactacctcccgctccttgactgacaagctggctttcgatgtgggactacaggaggat gcaacaggagaagcctgttggtggacaatgcacccagcctccaaacaaaggtctgaagga gagaaggttcgagttggagatgatctcattcttgtcagtgtctcctccgagcgctacctg cacctgtccacagccagtggggagctccaggttgatgcttccttcatgcagactctgtgg aacatgaaccctatctgttcctgctgtgaagagggctatgtgacagggggacatgtcctc cgtctgtttcacggacacatggatgaatgtctgaccatttctccttctgacagtgatgac cagcgcagacttgtctactacgagggaggatctgtgtgtacccatgctcgctctctctgg aggctggagccgctgagaatcagttggagtgggagccacctacgctggggccagcctctg cgaatccggcatgtgaccactgggcggtacctggcactcactgaggaccagggcctggtc gtggtggatgccagcaaggcccacaccaaggccacttccttttgcttccgtatctccaag gagaagctggatgtggcccccaagcgagatgtggaaggcatgggcccccctgagatcaag tacggagaatcgttgtgctttgtgcagcatgtggcttcaggcctgtggctcacttatgct gcccctgataccaaggccttgcggcttggtgtgctcaagaagaaggccatgctacatcag gaaggtcacatggatgatgccctgtcactgacccgctgccagcaggaggagtcacaggct gcccggatgatttacagcacggctggcctgtacaaccagttcatcaagggcctggatagc ttcagcgggaagccacggggctcaggaccgcctgttggctctgcgctgcccatcgagggt gtcattctgagcctgcaggacctcatcggctactttgagcctccctcagaggagcttcag catgaggagaagcagagcaagctgcgcagtttacgcaaccgccagagcctcttccaggag gaggggatgctctccctggtcctgaattgcattgaccgcctgaatgtctacaccaccgct gcccacttcgccgaatttgcaggggaggaggcggctgagtcctggaaagagattgtgaac ctgctgtatgaactcctggcctctttgatccgtggcaatcgtaccaactgtgccctcttc tccaccaacttggactggctggtcagcaagctggatcggctagaggcctcatctggaatc ctggaggtgctgtactgcgtccttatcgagagtcctgaagtcctgaatatcatccaagag aaccacatcaagtccattatctccctcctcgacaagcatgggagaaaccacaaggtcctg gatgtgctatgttctctgtgtgtgtgtaatggtgtggccgtgcgctccaaccaagatctc attactgagaacttgctcccaggtcgtgagcttctgttgcagacagatctgatcaactac gttaccagtatccgccccaacatctttgtgggacgagcagagggttccacacagtatgga aaatggtactttgaggtgatggtggatgaggtggttccattcctgacagctcaggccacc cacctgcgggtgggatgggccctcactgagggctatagcccctaccctggaggcggcgag ggctggggaggcaatggagtcggcgatgacctctattcctatggctttgatgggctgcat ctctggacaggtcatgtggcacgcccagtgacttctccaggacaacaccttctagcccca gaggatgtggtcagctgctgcctggatcttagtgtaccatccatatccttccgcatcaat ggctgtcctgttcaaggtgtctttgaagccttcaaccttgatgggctcttcttcccagtt gtcagcttctcagcgggtgtcaaagtccggtttctccttggtggccgccatggggaattt aaattcctccccccacctggctatgccccatgccatgaggctgtgctacctcgagagcga ctccatcttgaacccatcaaggagtatcgacgggaaggtccccggggaccccacctggtg ggacccagtcgctgcctctcacacactgacttcgtgccctgtcctgtggacactgtccag attgtcctgcctcctcatctggaacgcattcgggagaagctagcagaaaacatccatgaa ctctgggcgctgactcgcatcgagcagggctggacctatggccaggttcgagatgacaac aagaggctgcatccgtgtcttgtggatttccacagcctgccagagcctgagagaaattac aacctgcagatgtcaggggagacgctcaagactctgctggcgctgggctgccatgtgggc atggctgatgagaaggcagaggacaacctgaagaagacaaaactccccaaaacgtatatg atgagcaatgggtacaagcctgcccccctggacctgagccacgtgcgtctgacaccagca cagacgacactggtggatcggctagcagagaatggacacaatgtgtgggcaagagaccgt gtggcccagggctggagctatagtgctgtgcaggacatccctgctcgcagaaaccctcgc ctagtaccctaccgcctgcttgatgaggccaccaagcgcagcaaccgagacagcctctgc caggctgtgcgtaccctgctgggttatggttacaacattgaaccacctgaccaggagccc agccaagcagagaaccagtctcgaggagaccggacacgcatcttcagggcagaaaaatcc tatgtggtacagagtggccgctggtactttgagttcgaggcagttaccacgggcgagatg cgagtgggctgggcgaggcctgaactgcgaccggatgtagagctgggagctgatgagttg gcctatgtcttcaatgggcatagggtatcccgcatggatggcactgtggacacgcccccc tgcctacgactgacccaccgtacctggggctcccaaaacagtctggtagagatgcttttt ctccgactgagtcttccagttcaattctaccagcatttccgctgcactgctggggccact cctctggcaccccctggcctacagccccctgccgaagatgaggccagagccgcagaacca gaccctgactatgaaaacctacgccgttcagctggaggctggggtgaagctgaggcgggc aaggaaggaactgctaaggatgggggcactcctcagcctgggatggaggcccagcctgta agggcagaaaatgaaaaggatgccaccacagagaagaacaagaaaagagggttcctcttt aaggccaagaaggctgccatgatgacccagccaccggctactcctgttctgccccgactc cctcgtgaggtggtacccactgacaaccgtgatgatcctgagattatcctgaacactacc acgtactactactccgtgagggtcttcgctggccaggagcctagctgtgtatgggtgggt tgggtcactcctgactaccatcagcacgacatgaccttcgacttgaccaaagtccgggca gtgacagtgaccatgggggatgaacaaggcaatgtccacagcagcctcaaatgcagcaac tgctatatggtatggggcggggactttgtgagccctgggcagcagggccggatcagccac acagaccttgtcattggctgcctggtggacttggccactggtttaatgacctttacagcc aatggcaaagagagcaacacctttttccaggtggaacccaacacgaagttgtttcctgcc gtctttgtcctgcccacccaccagaacgtcatccagtttgaattggggaagctaaagaac atcatgccactgtcagcagctatgttcctgagtgagcgcaagaatccggccccacagtgc ccaccgaggttggaggtacagatgctcatgccggtctcctggagccgaatgcccaaccac ttcctgcaggtggacacccggcgtgcgggtgagcggctcggctgggctgttcagtgccag gaaccgttgactatgatggcgcttcacatccccgaggagaacaggtgcatggacatcctg gagctctccgaacgcctggatctgcagcgcttccactcacacaccctgtccctttaccga gccgtgtgcgctctgggcaacaaccgcgtggcacatgctctgtgcagccacgtggaccag gcccagttattgcacacgctggaggatgcgcacctaccggggcctcttcgtgcaggctac tacgacctcctcatcagcatccacctggaaagtgcctgccgcagccggcgctccatgctt tctgaatacattgtgcccctcaccccggagacccggtccatcaccctcttcccacctgga agaagtgcagaagatggtccccgccgccacggcctgcctggcgttggagtcacgacttcc ctgaggcccccgcaccatttctcacccccctgtttcgtggctgccctgccagctgctgga ggaacagaagctcctgctcgcctcagccctgccatccctctggaggccctgcgggacaag gctctgagaatgctgggtgaggcggtgcgagacggtgggcagcatgctcgagaccccatt ggaggctccgtggagttccagtttgtgcctgtcctcaaacttgtgtctactttgctggtg atgggtgtctttagtgatgaggatgtgaaacagatcttgaagatgattgaacccgaagtg ttcactgagatagaagaagaggaggaggaggcagaagaggaggaagaagaagatgaggag gagaaggaagaggacgaagaggaagaggcacaggagaaggaagatgaggagaaagaggaa gaggaagcagcagaaggagagaaagaagaaggcttggaggaggggctgctccagatgaag ctgccagagtctgtgaagttacagatgtgtcacctcctggagtatttctgtgatcaagag ctgcagcaccgtgtagagtccctggctgccttcgcagagcgctatgtagacaagctgcaa ggcaaccagagaggtcgctatggactcctcatgaaagccttcaccatgagtgcagcggag actgcaagacgcacccgcgagttccgctcgccaccccaggagcagtccttacaggagtta gtatcccacatggtggtgcgctgggcccaggaggactttgtgcagagccccgagctagtc cgggccatgttcagccttctgcatcggcagtatgatgggctgggtgagctgctgcgtgcc ctgccacgggcatataccatttcaccgtcttctgtggcggacaccatgagcctgttggaa tgcctcggccagatccgctcgctgctgattgtgcagatggggccccaggaggagaatctt atgatccagagcattgggaacattatgaacaacaaggtcttttaccaacacccaaacctg atgagggccctgggtatgcatgagaccgtcatggaggtcatggtgaacgtccttgggggc ggtgaatctaaggagatccgcttccccaagatggtgaccagctgctgccgctttctctgc tacttctgccgcattagccggcaaaaccagcgctccatgtttgaccacctgagctacctg ctggagaacagtggcattggcctgggcatgcagggttccacgcccctggatgtggcagct gcctctgtcattgacaacaatgagctggcattggcattgcaggagcaagacctggaaaag gtcgtatcctacctggcaggctgtggcctccaaagctgccccatgctgctggccaagggg tacccagatatcggctggaacccctgtggtggtgagcggtacctggacttcctgcgcttt gctgtcttcgtcaatggtgagagtgtggaagagaatgccaatgtggtggtacgactgctc attcgtaagcctgagtgcttcggccccgccctgcgtggtgagggcggctcagggctgctg gctgccattgaggaagccatccgcatctctgaggatcctgccagggatggcccaggtgtc cgcagggaccggcgaccgcactttggtgaggagccccctgaggaaaaccgggtacacctg ggacatgccatcatgtccttctatgccgccttgatcgacctgctgggacgctgtgcacca gagatgcatctaatccaagctggcaagggggaggctctgaggatccgggctatcttacga tctcttgtgcccttggatgaccttgtgggcatcatcagcctcccactgcagatgcctaca ctgggcaaagatggggcactggtccagccaaagatgtctgcatccttcgtgcctgaccac aaggcatccatagtgctcttcctggaccgagtgtatggtattgataaccaggacttcttg ttacatgtactggatgtgggcttccttcctgacatgagggcagctgcctctctggacacg gccactttcagcaccacagagatggcgctggctctgaaccgttacctgtgcctggcggtg cttcctttgattaccaagtgtgcacccctgtttgcgggaactgagcaccgggccattatg gtggactccatgctgcacactgtgtaccgcctgtcccggggccgctccctcaccaaggct caacgcgacgtcatcgaggactgcctcatggcactctgcaggtacatccgcccatccatg ctacagcacctgctgcggcgcctggtgtttgatgtacccatcttgaacgagttcgccaag atgccactcaagcttctcaccaaccactatgagcgctgctggaagtattactgccttccc acgggctgggccaactttggagtcacctctgaggaagagctgcacctcacacgcaaactc ttctggggcatctttgactctctggcacataagaagtatgaccaggagctgtaccgcata gccatgccttgtctatgcgccatcgcaggggccctgcctcccgattacgtggacgcttcc ttctcatccaagacagagaaaaaagccacagtggatgctgaaggcaactttgatccccgg cctgtggagaccctcaatgtgatcatcccagagaagctcgactccttcattaacaagttt gcagagtactcacatgagaagtgggccttcgacaagatccaaaacagctggtcctatgga gagaacatagatgaggagcaaaagacccatcccatgctgagaccctacaagaccttttct gaaaaggacaaagagatttatcgctggcctatcaaagagtccttgaaggccatgattgcc tgggagtggaccatagagaaggccagggagggcgaagaggagaagacagaaaagaagaaa acaaggaagatttcccaaactgcccagacctatgatcccagagaaggctacagtccacag cctcctgatctcagtggggttaccttgtcccgagagctgcaggctatggcagaacaactg gcagagaattaccacaatacctgggggcggaagaagaagcaagaattggaagccaaaggg ggtgggacgcatcccctgctggtcccctatgacacactcactgccaaggagaaggcacga gatagagagaaggcccaggagctgctgaagttcctacaaatgaacggctatgctgttacc agaggtcttaaggacatggagctggacacatcttccattgagaagcggttcgcgtttggc ttcctgcagcagctactacgatggatggacatttcccaagagttcattgcccacctggag gctgtggtcagcagtgggcgagtggagaaatccccacacgaacaggagatcaaatttttt gcaaagatcctgcttcccttgatcaaccaatacttcaccaaccactgcctctatttcctg tccactccagccaaagtcttgggcagtggtggccatgcctccaacaaggagaaagaaatg atcaccagccttttctgcaaactggctgcccttgtccgccaccgtgtctctctctttggg acagatgctcctgctgtggtcaactgtcttcacattctggcacgttccctggatgccagg acggtgatgaagtcaggccccgaaatcgtgaaggctggcctccgctccttctttgaaagc gcctcggaggacatcgagaagatggtggagaacctgcggctgggcaaggtgtcccaagca cgcacacaagtgaagggcgtgggccagaacctcacctacaccactgtggccctgctgcct gtccttaccaccctcttccagcacattgcccagcatcagtttggagatgatgtcatcttg gatgatgtccaggtctcttgctaccgaacactgtgcagtatctactcactgggaaccacc aggaacccgtatgtggaaaagctacggccagcccttggggagtgtctggcccgcttggct gcagccatgccagtggcatttttggaacctcagctgaatgagtacaatgcctgctccgtg tacacgacaaagtcaccgcgggagagggccatcctggggctccctaacagcgtggaggaa atgtgtcctgacatcccagtgttggagcggctcatggcagatattggaggactggccgag tcgggggcccgctacacagagatgccacacgtcattgagatcaccctccccatgctctgt agctacctgccccgctggtgggaacgtgggcccgaggctcccccaccagccctgcctgcc ggggccccgcctccctgcacagaggtcacctctgaccacctcaactctctgctggggaac atcctgcgaatcattgtcaacaacctggggatcgatgaggcctcatggatgaagcgactt gctgtgtttgctcagcccatcgtgagccgtgctcggccggagctgcttcgctcccacttc atccccaccatagggcggctgcgcaagcgggcagggaaggtggtggctgaggaggagcaa ctgcgcctggaagccaaggccgaagcagaggagggcgagctcctggtgcgagatgagttc tcagtcctctgccgggacctgtatgccctctacccactgctcatccgctatgtggacaac aacagggcgcactggttgacagagcccaatcccaacgcagaggagctattcaggatggtg ggcgaaatcttcatctattggtccaagtcccacaacttcaagcgtgaggagcagaacttc gtggtccagaatgagatcaataacatgtccttcctgactgctgacaacaaaagcaaaatg gccaaggcgggagatgtacagtcaggtggctcggaccaggaacggaccaagaaaaagcgc cggggggaccggtactctgtgcagacctcactgatcgtggctacactcaagaagatgtta cccattggcctgaacatgtgtgcccccactgaccaggacctcattgggctggccaaggcc cgctatgccctgaaagacacagatgaggaggtccgagaattcctacaaaacaacctcaac ctgcagggaaaggttgaaggctccccatctctacgctggcagatggccctgtatcggggc ctcccaggccgggaggaggatgctgatgacccagagaaaattgtacgcagagtccaggaa gtatctgcagttctctaccacctcgagcagaccgagcacccttacaagtccaagaaggca gtgtggcacaagctcttgtccaaacaacgtcggcgggcagttgtggcctgttttcgcatg acacccctgtacaatctgcccacacaccgggcatgtaacatgttcttggagagctacaag gcttcatggatcctgactgaggaccacagttttgaggaccgcatgatagatgacctttca aaagctggggagcaggaggaagaggaggaagaagtagaggagaagaagccagaccccttg caccagttggtcctgcactttagccgcactgctctgactgaaaagagtaaactagacgag gattacctatacatggcatacgctgacatcatggcaaagagctgccatatggaggaggga ggggagaatggcgaagctgaaggagaagaagaggctgaggtgtcttttgaggagaaggag atggagaagcagaggctgttgtatcaacagtcacggctgcacaaccggggggccgctgag atggtactacagatgatcagtgcctgcaaaggtgaaacgggcgccatggtgtcctccacc ctgaagttgggcatctccatccttaatggaggcaatgcagaggtgcagcagaaaatgctg gactacctgaaggataagaaggaagtgggcttcttccagagtatccaggcactcatgcaa acatgcagtgtcctggacctcaatgcctttgagaggcagaacaaggcagaggggctaggc atggtgaatgaggatggcactgtcatcaatcgccagaacggagagaaggtcatggctgat gatgaattcacacaagatctcttccggttcctacagctgctctgtgagggacataacaat gatttccagaactatcttaggacacagacaggaaacacaactactattaacatcatcatt tgcacagtggactatctcttgcggttgcaggaatccatcagcgatttctactggtactac tcaggcaaggatgtcattgaggaacagggcaagagaaacttctccaaggctatgtcagtg gctaaacaggtgttcaatagccttacagagtacattcagggcccctgcactgggaaccag cagagcctggcacatagccgtctctgggacgccgtggtaggattcctacacgtgtttgcc cacatgatgatgaagcttgctcaggactccagccagattgagctgttgaaggagctgctc gatctacagaaggacatggtggtgatgctgctgtccctactggaagggaacgtggtgaat ggcatgatcgcccggcagatggtagacatgctcgtggagtcctcatccaacgtggagatg atcctcaagttcttcgacatgttcctgaaactcaaggacattgtgggctccgaggccttc caggactatgtcactgatccccggggcctcatctctaagaaggacttccagaaggctatg gatagtcagaagcagttcactggcccggagatccagttcctgctttcctgctctgaagca gatgagaatgagatgatcaactgtgaggagtttgccaaccgcttccaggaaccagctcgt gacatcggcttcaatgtggcagtgctgctgaccaacctgtccgagcatgtgccacatgac ccacgcctgcgcaccttcttggagctggctgagagtatccttgagtacttccggccctac ctgggccgcatcgagatcatgggagcctcacgacgcattgagaggatctacttcgagatc tcagagaccaaccgcgcccagtgggagatgccccaggtgaaggagtccaagcgccagttc atcttcgacgtggtgaatgagggcggtgagtcggagaagatggagctgttcgtgagcttc tgtgaggacaccatctttgagatgcagattgcagcacagatctcggagcctgagggggag ccagaggagtcggaggacgagggtgccactgaggctggcacagaagttcccgaggaggga tcggcaggtcccgagggcaccacaggcgcagtggcagctggtgtcactgcgaggttggca gctgccatgagccgggcgctgcggggtcttagttaccgcagcctgcggcggcgggtgcgg aagctgcgacggctgacagcgagggaggcggccacggcggtggtggcactgctctgggcg gtggtaacccaggcaggatcagcaggtgctggggcagcagcaggcacactgcgcctcctc tggggctccctctttggcggtggcttggtagacagtgccaagaaagtgaccgtcactgag ctcctggcgggcatgcctgaccccactggtgatgaggtgcatggccagcagcccacaggg ccaggtggtgatgcagatggtgaaggcgagggtgagggcgagggtgacacccaggagggt gcaggtgaagaagaggcggcatcggatgaggcccgacagggcggtgcagaccgggctgtg gctgtggccgatgggagtcctttccggcctgaaggggctggtggtctcggggacatgggg gatacgactccagtggagccacctacgcctgagggttccccgatcctcaagaggaagccg ggggtggagggagaagaggaagaagaacagcctccagaaccagagccagagcctgaacca gagaaagctgatactgagaacggggagaaggaagaagtccaagaacccccaccagaggag cctcccacgaagacagcaccccctccaccccctccgaaaaaggaggaagctggaggtgca ggcttggaattctggggggagctggaagtgcagagggtgaagttcttgaattacctctcc cggaacttttacactctgcggttccttgccctcttcttggcatttgccatcaacttcatt ctgctgttttataaggtctcagattcaccaccaggagaggatgacatggagggctcagcg gctggagagatgtcgggagcagggtctggcggtggctctggctggggctcaggggctggt gaggaggtagaaggtgatgaggatgaaaacatggtatactatttcctggaagagagtaca ggctacatggaacctgctctgcggtgcttgagtctgttacacacactggtggccttcctc tgcatcattggctacaactgtcttaaggtgcccctggtgatctttaaacgggaaaaggag ctagcccgcaagctggagttcgatggcctttacatcacagaacagcctgaagatgacgat gtgaagggacagtgggaccgcctggtactgaacacaccgtctttccccagcaactactgg gacaaatttgtcaagcggaaggttctggataaacatggggacatctttgggcgagagcgg atagcagagctgctgggcatggacctggcctcactggagatcactgcccacagtgggcgc aaacctgagcctccaccggggctgctcacctggctcatgtccatcgatgtcaaataccag atatggaagtttggagtcatattcacagacaactctttcctatacctcggctggtacatg gtaatgtctctcctgggtcactacaacaacttcttcttcgctgcccacctcctggacatc gctatgggggtgaagacactgcgaaccatcctttcctccgttacccacaatgggaagcag ctggtgatgaccgtgggcctcctggctgtggtagtctatctgtacaccgtggtggccttc aacttcttccgcaagttctacaacaagagcgaggatgaggacgaaccggacatgaaatgt gatgacatgatgacgtgttatctatttcatatgtatgtgggtgtccgggccggcggaggc ataggagacgagatcgaggacccggcaggggatgagtacgagctctatcgtgtggtcttc gacatcaccttcttcttcttcgtcatcgtcatcctgctggccatcatccagggtctgatt attgacgcttttggggagctccgagaccaacaagaacaagtgaaggaggatatggagacc aagtgcttcatctgtggaataggcagtgactacttcgatacaacaccacatgggtttgag acccacacactagaggaacacaacctggccaattacatgtttttcctgatgtatttgata aacaaggatgagactgaacacacagggcaggaatcttacgtctggaagatgtaccaagag agatgttgggacttcttcccagctggcgactgtttccgcaagcagtatgaggaccagctt agctga

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