KEGG   DRUG: コハク酸メトプロロール
エントリ  
D00635                      Drug                                   

一般名   
コハク酸メトプロロール;
Metoprolol succinate (USP)
米国の商品 
  後発品
METOPROLOL SUCCINATE (A-S Medication Solutions), METOPROLOL SUCCINATE (A-S Medication Solutions), METOPROLOL SUCCINATE (A-S Medication Solutions), METOPROLOL SUCCINATE (A-S Medication Solutions), METOPROLOL SUCCINATE (A-S Medication Solutions), METOPROLOL SUCCINATE (A-S Medication Solutions), METOPROLOL SUCCINATE (A-S Medication Solutions), METOPROLOL SUCCINATE (A-S Medication Solutions), METOPROLOL SUCCINATE (A-S Medication Solutions), METOPROLOL SUCCINATE (A-S Medication Solutions), METOPROLOL SUCCINATE (A-S Medication Solutions), METOPROLOL SUCCINATE (A-S Medication Solutions), METOPROLOL SUCCINATE (A-S Medication Solutions), METOPROLOL SUCCINATE (A-S Medication Solutions), METOPROLOL SUCCINATE (A-S Medication Solutions), METOPROLOL SUCCINATE (A-S Medication Solutions), METOPROLOL SUCCINATE (A-S Medication Solutions), METOPROLOL SUCCINATE (A-S Medication Solutions), METOPROLOL SUCCINATE (Actavis Pharma), METOPROLOL SUCCINATE (Actavis Pharma), METOPROLOL SUCCINATE (American Health Packaging), METOPROLOL SUCCINATE (Aphena Pharma Solutions - Tennessee), METOPROLOL SUCCINATE (Aphena Pharma Solutions - Tennessee), METOPROLOL SUCCINATE (Aphena Pharma Solutions - Tennessee), METOPROLOL SUCCINATE (Aphena Pharma Solutions - Tennessee), METOPROLOL SUCCINATE (Aphena Pharma Solutions - Tennessee), METOPROLOL SUCCINATE (Aphena Pharma Solutions - Tennessee), METOPROLOL SUCCINATE (AvPAK), METOPROLOL SUCCINATE (BluePoint Laboratories), METOPROLOL SUCCINATE (BluePoint Laboratories), METOPROLOL SUCCINATE (BluePoint Laboratories), METOPROLOL SUCCINATE (BluePoint Laboratories), METOPROLOL SUCCINATE (Bryant Ranch Prepack), METOPROLOL SUCCINATE (Bryant Ranch Prepack), METOPROLOL SUCCINATE (Bryant Ranch Prepack), METOPROLOL SUCCINATE (Bryant Ranch Prepack), METOPROLOL SUCCINATE (Bryant Ranch Prepack), METOPROLOL SUCCINATE (Bryant Ranch Prepack), METOPROLOL SUCCINATE (Bryant Ranch Prepack), METOPROLOL SUCCINATE (Bryant Ranch Prepack), METOPROLOL SUCCINATE (Bryant Ranch Prepack), METOPROLOL SUCCINATE (Bryant Ranch Prepack), METOPROLOL SUCCINATE ER (Bryant Ranch Prepack), METOPROLOL SUCCINATE (Bryant Ranch Prepack), METOPROLOL SUCCINATE (Cadila Healthcare Limited), METOPROLOL SUCCINATE (Camber Pharmaceuticals), METOPROLOL SUCCINATE (Cardinal Health), METOPROLOL SUCCINATE (Cardinal Health), METOPROLOL SUCCINATE (Cardinal Health), METOPROLOL SUCCINATE (Cardinal Health), METOPROLOL SUCCINATE (Cipla USA), METOPROLOL SUCCINATE (Denton Pharma), METOPROLOL SUCCINATE (Denton Pharma), METOPROLOL SUCCINATE (Denton Pharma), METOPROLOL SUCCINATE (Denton Pharma), METOPROLOL SUCCINATE (Denton Pharma), METOPROLOL SUCCINATE (Denton Pharma), METOPROLOL SUCCINATE (Denton Pharma), METOPROLOL SUCCINATE (Direct_Rx), METOPROLOL SUCCINATE (Dr. Reddy's Laboratories Limited), METOPROLOL SUCCINATE (Dr. Reddy's Laboratories Limited), METOPROLOL SUCCINATE (Golden State Medical Supply), METOPROLOL SUCCINATE (Ingenus Pharmaceuticals), METOPROLOL SUCCINATE (Lake Erie Medical DBA Quality Care Products LLC), METOPROLOL SUCCINATE (Lake Erie Medical DBA Quality Care Products LLC), METOPROLOL SUCCINATE (Lake Erie Medical DBA Quality Care Products LLC), METOPROLOL SUCCINATE (Lannett Company), METOPROLOL SUCCINATE (Legacy Pharmaceutical Packaging), METOPROLOL SUCCINATE (Legacy Pharmaceutical Packaging), METOPROLOL SUCCINATE (Major Pharmaceuticals), METOPROLOL SUCCINATE (Major Pharmaceuticals), METOPROLOL SUCCINATE (Mylan Institutional), METOPROLOL SUCCINATE (Mylan Pharmaceuticals), METOPROLOL SUCCINATE (NCS HealthCare of KY), METOPROLOL SUCCINATE (NCS HealthCare of KY), METOPROLOL SUCCINATE (New American Therapeutics), METOPROLOL SUCCINATE (Northstar Rx LLC), METOPROLOL SUCCINATE (Northwind Pharmaceuticals), METOPROLOL SUCCINATE (Northwind Pharmaceuticals), METOPROLOL SUCCINATE (Northwind Pharmaceuticals), METOPROLOL SUCCINATE (NuCare Pharmaceuticals), METOPROLOL SUCCINATE (NuCare Pharmaceuticals), METOPROLOL SUCCINATE (NuCare Pharmaceuticals), METOPROLOL SUCCINATE (NuCare Pharmaceuticals), METOPROLOL SUCCINATE (NuCare Pharmaceuticals), METOPROLOL SUCCINATE (NuCare Pharmaceuticals), METOPROLOL SUCCINATE (NuCare Pharmaceuticals), METOPROLOL SUCCINATE (NuCare Pharmaceuticals), METOPROLOL SUCCINATE (NuCare Pharmaceuticals), METOPROLOL SUCCINATE (NuCare Pharmaceuticals), METOPROLOL SUCCINATE (PD-Rx Pharmaceuticals), METOPROLOL SUCCINATE (PD-Rx Pharmaceuticals), METOPROLOL SUCCINATE (PD-Rx Pharmaceuticals), METOPROLOL SUCCINATE (PD-Rx Pharmaceuticals), METOPROLOL SUCCINATE (PD-Rx Pharmaceuticals), METOPROLOL SUCCINATE (PD-Rx Pharmaceuticals), METOPROLOL SUCCINATE (Pharmadax), METOPROLOL SUCCINATE (Pharmadax), METOPROLOL SUCCINATE (Preferred Pharmaceuticals), METOPROLOL SUCCINATE (Preferred Pharmaceuticals), METOPROLOL SUCCINATE (Preferred Pharmaceuticals), METOPROLOL SUCCINATE (Preferred Pharmaceuticals), METOPROLOL SUCCINATE (Preferred Pharmaceuticals), METOPROLOL SUCCINATE (Preferred Pharmaceuticals), METOPROLOL SUCCINATE (Proficient Rx LP), METOPROLOL SUCCINATE (Proficient Rx LP), METOPROLOL SUCCINATE (Proficient Rx LP), METOPROLOL SUCCINATE (Proficient Rx LP), METOPROLOL SUCCINATE (Proficient Rx LP), METOPROLOL SUCCINATE (Proficient Rx LP), METOPROLOL SUCCINATE (REMEDYREPACK), METOPROLOL SUCCINATE (REMEDYREPACK), METOPROLOL SUCCINATE (REMEDYREPACK), METOPROLOL SUCCINATE (REMEDYREPACK), METOPROLOL SUCCINATE (REMEDYREPACK), METOPROLOL SUCCINATE (REMEDYREPACK), METOPROLOL SUCCINATE (REMEDYREPACK), METOPROLOL SUCCINATE (REMEDYREPACK), METOPROLOL SUCCINATE (REMEDYREPACK), METOPROLOL SUCCINATE (REMEDYREPACK), METOPROLOL SUCCINATE (RPK Pharmaceuticals), METOPROLOL SUCCINATE (RPK Pharmaceuticals), METOPROLOL SUCCINATE (RedPharm Drug), METOPROLOL SUCCINATE (RedPharm Drug), METOPROLOL SUCCINATE (Slate Run Pharmaceuticals), METOPROLOL SUCCINATE (St. Mary's Medical Park Pharmacy), METOPROLOL SUCCINATE (St. Mary's Medical Park Pharmacy), METOPROLOL SUCCINATE (St. Mary's Medical Park Pharmacy), METOPROLOL SUCCINATE (St. Mary's Medical Park Pharmacy), METOPROLOL SUCCINATE (St. Mary's Medical Park Pharmacy), METOPROLOL SUCCINATE (St. Mary's Medical Park Pharmacy), METOPROLOL SUCCINATE (St. Mary's Medical Park Pharmacy), METOPROLOL SUCCINATE (TWi Pharmaceuticals), METOPROLOL SUCCINATE (Wockhardt USA LLC.), METOPROLOL SUCCINATE (Wockhardt USA LLC.), METOPROLOL SUCCINATE (Wockhardt USA LLC.), METOPROLOL SUCCINATE (Zydus Pharmaceuticals (USA)), METOPROLOL SUCCINATE ER (Direct_Rx), METOPROLOL SUCCINATE (A-S Medication Solutions), METOPROLOL SUCCINATE (A-S Medication Solutions), METOPROLOL SUCCINATE (A-S Medication Solutions), METOPROLOL SUCCINATE (Ascend Laboratories), METOPROLOL SUCCINATE (BluePoint Laboratories), METOPROLOL SUCCINATE (Bryant Ranch Prepack), METOPROLOL SUCCINATE (Bryant Ranch Prepack), METOPROLOL SUCCINATE (Bryant Ranch Prepack), METOPROLOL SUCCINATE (Bryant Ranch Prepack)
組成式   
(C15H25NO3)2. C4H6O4
質量    
652.3935
分子量   
652.8158
構造式   
Simcomp   
クラス   
心血管系用薬
 DG01466  アドレナリン受容体拮抗薬
  DG01464  β-アドレナリン受容体拮抗薬 (β遮断薬)
   DG01461  β1-アドレナリン受容体拮抗薬
 DG01653  抗不整脈薬
  DG01806  クラスII抗不整脈薬
代謝酵素基質薬
 DG01644  CYP2D6基質薬
コード   
ATCコード: C07AB02
化学構造グループ: DG00313
商品 (DG00313): D00601<JP/US> D00635<US>
商品 (mixture): D10273<US>
効能    
血圧降下薬, 血管拡張薬, β1遮断薬
コメント  
プロプラノロール誘導体
β1選択性遮断剤
ターゲット 
ADRB1 [HSA:153] [KO:K04141]
  パスウェイ
hsa04080  神経刺激性リガンドとレセプターの相互作用
hsa04261  心筋細胞におけるアドレナリンシグナル伝達
代謝    
Enzyme: CYP2D6 [HSA:1565]
相互作用  

構造マップ 
map07037  抗不整脈薬
map07048  抗片頭痛薬
map07214  β-アドレナリン受容体の作動薬と拮抗薬
階層分類  
医療用医薬品のATC分類 [BR:jp08303]
 C 循環器系
  C07 ベータ遮断薬
   C07A ベータ遮断薬
    C07AB ベータ遮断薬、選択型
     C07AB02 メトプロロール
      D00635  コハク酸メトプロロール <US>
医療用医薬品のUSP分類 [BR:jp08302]
 心血管治療薬
  ベータアドレナリン遮断薬
   ベータ1選択的
    メトプロロール
     D00635  コハク酸メトプロロール
ターゲットに基づく医薬品分類 [BR:jp08310]
 Gタンパク質共役受容体
  ロドプシンファミリー
   アドレナリン
    ADRB1
     D00635  コハク酸メトプロロール <US>
薬物代謝酵素とトランスポーター [jp08309.html]
 薬物代謝酵素
  D00635
リンク   
CAS: 98418-47-4
PubChem: 7847701
ChEBI: 6905
ChEMBL: CHEMBL2356097
LigandBox: D00635
LinkDB    

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