Danio rerio (zebrafish): 100126126 Help Entry 100126126         CDS       T01004                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism dre  Danio rerio (zebrafish) Pathway dre04020   Calcium signaling pathway dre04260   Cardiac muscle contraction dre04261   Adrenergic signaling in cardiomyocytes dre04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:dre00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     100126126 (ryr2a)    04020 Calcium signaling pathway     100126126 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     100126126 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     100126126 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:dre04040]     100126126 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:dre04990]     100126126 (ryr2a) Ion channels [BR:dre04040]  Voltage-gated cation channels   Ryanodine receptor    100126126 (ryr2a) Domain-containing proteins not elsewhere classified [BR:dre04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    100126126 (ryr2a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  100126126 NCBI-ProteinID:  XP_068080773 ZFIN:  ZDB-GENE-071001-1 Ensembl:  ENSDARG00000098856 UniProt:  A0AB32U380 LinkDB All DBs Position 12:47117822..47364953 Genome browser AA seq 4550 aa AA seqDB search MTDGEAEDEIQFLRTDDEVVLQCSATLHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPD LSICTFVLEQSLSVRALQEMLANTEERAEGLIDMEKWKFMMKTAQGGGHRTLLYGHAVLL RHSYSGMYLCCLSTARSSTDKLAFDVGLQEDATGEACWWTIHPASKQRSEGEKVRVGDDL ILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVVPICSGSEVAQGFLIGGDVLRLLHGHM DECLTVPSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQPFRLRHVT TGKYLSMMDDQGLLLMDKEKADVKSTAFCFRSSKEKLDFGLRKEMDGMGVPDIKYGDSVC YIQHVDAGLWLTYQSVDAKCARMGGVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIRS TVFLFNRFIRGLDTLSKKGKTSTLDLPIESVSLSLQDLIGYFQPPDEHLEHEDKQNRLRA LKSRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGKEAGESWKSILNSLYELLAALI RGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLL DKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFL GVSEGSAQYKKWYYELIVDHVDPFVTAEATHLRVGWASTQGYGPYPGGGEGWGGNGVGDD LYSYGFDGLHLWAGCVARSVSSPNQHLLRAEDVVSCCLDLSAPSISFRINGQPVQGMFEN FNSDGLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPSGYAPCFEAVLPREKLRVEHSQEYK QDHGNTRDLLGPTVTLSQAAFTPTPVDTSQIVLPPHLERIREKLAENIHELWVMNKIDLG WTYGAVRDDNKRQHPCLVEFSRLPEQERSYNLQMSQETLKTLLALGCHVGVADERAAEKV KNLKLSAKYELSSGYKPAPMDLCHIKLASTQEAMVDKLAENAHNVWARDRIRQGWTYGIQ QDIKNKRNPRLVPYVLLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAREDVGNLSA ERFRIFRAEKTYCVNGGKWYFELEVVTAGEMRVGWARPGCLPDQELGADEQAFVFDGFKA QRWHQGNEHFGRSWQSGDVVGCMVDMNERTMMFTLNGEVLLDDSGSELAFKDFEVWEGFI PVCSLGVSQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNMNRDLTMWISKRLPQFTPVP LIHEHIEVTRIDGTVESPPCLKVTQRSFGSQNSHTDIMFYRLSMPIECSEAFARSPGGTL AANGSFFSPKRDLEDFETVSDFEVLMKTPHSHMSSNGPDRERDEFNNHKDHNQEKPSKIK QRFMLKRTKPDMNSSSSSARLSEEVLADEKDDCENLIQTSTYYYSVRIFPGQEPSSVWVG WVTSDFHQYDTAFEISNVRTVTVTLGDEKGKVHESIKRSNCYMVWAGECTSPGQGRSNNG LEIGCLVDTANGLLTFTSNGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKSIM PLSAGLFKSERKNVVPQCPPRLHVQFLTPVLWSRVPNQFLRSEVTRVNERLGWMVQSLEP LQFMTLHIPEENRSVDILELTEQQDLLKFHYHTLRLYSAICALGNNRVAHALCSHVDEAQ LLYAIQNKYMPGLLRTGYYDLLIDIHLSSYATARLMMNSEYIVPMTPETKSITLFPNEKK KHGLPGIGLSTSLQPRMRFSSPSFVGFNGSGGVDCFQYSPEFPLETLKSRTMEMLTEAVR EGSLHVRDPVGGSTEFLFVPLIKLFYTLLIMGIFHNGDLKTILQLIEPSVFSQDSGADGG GGSVGDGCGRGQLEGGVVDDGLRGKMPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVRHRI EAVVAFSDDFVANLQENQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDE KQDCPCPEDIREQLLDFHEDLMTHCGIETDDDKSGDGDSDFTIRGRLMSLVEKVTYLKKK MTDLPKKKKSKKPSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGQVRAL PKTYTINAVSVEDTISLLASLGQIRSLLSVRMGREEEKLMIHGLSDIMNNKVFYQHPNLM RALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLL ENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCVMLMS KGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNG LLAAIEEAIKISEDPSRDGPSPTTEESRTLNDVMEEEEDDTIHMGNAIMTFYAALIDLLG RCAPEMHLIHAGKGEAIRIRAILRSLIPIEDLVGVISIPFLMPTLAKDGSVIEPDMSAGF CPDHKAAMVLFLDRVYGIEDQNFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYL CTAVLPLLTKCAPLFAGTEPFASLIDSLLHTVYRLSKGCCLTKAQRDAIEECLLAVCGKL RPSMMQHLLRRLVFDVPVLNEHTKMPLKLLTNHYERCWKYYCLSGGWGSFGAASEEELHL SRKLFWGIFDALARKKYDPELFKLALPCLSAVGGALPPDYMESNYVAMMEKQSSMDAEGN FNPQPADTSSVVVPEKLDHFINKYAEYSHEKWSMEKFAVGWVHGEQMCESSKVHPLLKPY KCLSEKDKEVYRWPIRESLKTMLSWGWSIERMRESDASTLHNRTRRISLSSQRSIEGAHG FSPRPVDMSNVTLSRDLHSMAELLAENYHNIWAQKKKLELESKGGGSHPLLVPYDTLTAK EKSKDREKAQDILKFFQINGYSVSRAMKEQDLDTPSIEKRFAYTFLQQLITYVDEAHGHM LEFDAGIRPKGEKIPHEQQIKFFGKVVLPLVDQYFKNHRLYFLSTAVRPISSGGHASNKE KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGQDSVKAALRAF FDNAAEDLEKTMENLRQGQFTHTRSQPKGVTQIINYTTVALLPVLSSLFEHIGQNLFGED LILDDVQVSCYRILNNLYSLGTSKSIYVERQRPAIGECLAAFSSAFPVAFLEPSLNKHNT YSIYNCKGSRERAGATHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLEKPGVEEPPEEDE MTKNIDPLHQLIQLFSRTALTEKCKLEEDHLYMAYADIMAKSCHDEEEEDEVKSFEEKEM EKQKLLYQQARLHDRGAAEMVLQTISASKGEMGPMVASTLKLGIAILNGGNSTVQQKMLD YLKDKRDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVMQDDEFTCDL FRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVID EQGQRNFSKAINVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLS QDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDM FLKLKDLTSSDAFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENELLD YEEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDSRLQTFLELAESVLNYFQPYLGRIEIM GSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFE MQLAARMSDAGERSASKEDSEREKPEEETPEMGFFSITTVRTALFALRYNVMLLMKVLSM KSLKKQVKKAKKMTVKDMVTTLVSFYWSVLLGLLHFAFSVARGFFRIIYNSFLGGSLVEG AKTMKVSELLANMPDPTQDEVRGEMEDGEKKPVDKTSPEEDLADLTVATDETDLLSDIFG LDLKREGGQYKLMPHNPNASLTDLLNTPVPPPPTPSPELRRRHHTKGSSSSTDNNDAAEE TKSVPEKAEGENVEKAQKKKEEAVKRKVRQHYEPDLQESAFWKKIIAYQRKLLNYFARNF YNMRMLALFVAFAINFILLFYKVSTSSAVTEGKEVLFSASSDTSVQWDPLSGSSSRPVTV HFVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYI TEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRISELLGMDKAAL DFSDAHEKKKPKRDSSLAAVLNSVDVKYQIWKLGVVFTDNSFLYLAWYMSMSILGHYNNF FFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSE DGESPDMKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFFFFVIVI LLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLAN YLFFFMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 13653 nt NT seq  +upstreamnt  +downstreamnt atgacggacggagaagccgaagacgagatccagttcctgcggactgatgatgaggtggtc ctccagtgctcggcgacgctccataaggagcagcagaagctctgtctggccgccgagggc ttcgggaacagactgtgttttctggagtccacatcaaactcaaagaatgttcctccagat ctgtccatctgcacgttcgttctggagcagtctctgtcagtgcgagcgctgcaggagatg ctggccaacaccgaggagagagcagaggggctcatagacatggagaaatggaaattcatg atgaagacagcacaaggcggaggtcaccggacgctgctctatggtcatgcagtcttactg agacactcctacagcggaatgtatctgtgctgtctctctacggctcgctcgtccaccgac aaactggcttttgacgtgggactacaggaagacgcaacaggtgaggcatgttggtggacg atccatcctgcatccaaacaacggtccgagggtgagaaggtgcgggtgggtgatgatctc attctggtcagtgtgtcttctgaacgttacctgcacttgtcgtatgggaacggcagttta cacgtggacgcagctttccagcagacgctctggagtgtggtgcccatctgctcggggagt gaagtggctcagggcttcctgattggtggagatgttttacgactgctgcatggtcacatg gacgagtgtttgaccgtcccatctggagaacatggagaggaacagcgcaggacggtgcat tatgaaggtggagcagtgtccatccatgccagatccctctggaggctggagacgcttcga gtcgcgtggagtggcagtcatatccgctggggtcaaccgttccgcctgcgtcacgtgacc accggcaaatatctcagcatgatggacgatcaagggctcctgttaatggacaaggagaaa gcggatgttaaatccacggctttctgcttccgctcctcaaaagagaagctggacttcggc ctcaggaaagagatggacggtatgggcgtcccggacatcaaatacggtgactctgtctgt tacatccagcacgtggatgctggactctggctcacctaccagtctgtggatgccaagtgt gctcgcatgggtggcgttcagaggaaggccatcatgcatcacgagggtcacatggatgat ggtttgacgctctcacgatcacaacacgaggagtcgcgcactgctagagtcattcgcagc accgttttcctcttcaatcgcttcatcaggggtttggacactctcagtaaaaagggaaag acatccaccctcgatctgcccatcgagtcggtcagtctgagtcttcaggatctgattggg tatttccagccacccgatgaacatctggagcacgaggacaagcagaaccgtctgcgagca ctcaagagcagacagaaccttttccaggaggagggaatgatcaacctggtgctggagtgt atcgatcgtttgcatgtgtacagcagcgcggctcattttgcagatgtagctggtaaagag gctggagaatcctggaagtccatcctgaactccctctacgagctcctggctgctctgatc agaggaaacaggaagaactgcgcccagttctccggctctctggattggctgatcagtcgt ctggagaggttggaagcgtcgtctgggattctggaggttctgcattgcgttctggtggag agtccagaagctctgaacattattaaagaaggacacatcaaatccatcatctcactgctg gacaaacacggacgcaaccacaaggttctggatgtcctgtgttctctgtgtgtgtgtcac ggggtggccgtccgctccaatcagcacctgatctgtgataatctgctgcccggcagagac ctgctgcttcagacgcgcctcgttaatcacgtcagcagcatgaggcccaatatcttcctg ggtgtgagcgaaggctccgcgcagtacaagaagtggtattatgagctgatcgtggaccat gtggatccgttcgtgacggctgaagccacgcacctgcgagtgggctgggcgtccactcag ggctacgggccatatccgggtggaggagagggatggggcggcaacggcgtgggggatgat ctctactcatacggctttgatggactgcacctttgggcaggctgtgtggcgcggtcagtc agctcacccaatcagcacctgctgcgggccgaggatgtggtgagctgctgtctggacctc agcgctcccagcatctccttccgcatcaacggccagccggtgcagggaatgttcgagaac ttcaactcggatggactcttcttcccagtcgtctccttttctgctggagtcaaagttcgc ttcttgttgggtggtcgtcatggtgagttcaagttcctgcctccgtccggttacgccccg tgtttcgaggctgttttaccacgagagaagctgagagtggagcacagccaggagtacaag caggaccatggcaacacacgggaccttctcggacccacggtcacactctcacaggcagcc ttcactccaacacctgtggacaccagtcagattgttttgccgccacatcttgagcggatc cgagaaaaactggccgaaaacatccatgagctgtgggtgatgaacaagatagatctgggc tggacttacggagctgtgagagatgacaacaaacgtcagcatccgtgtctggtggagttt tccagacttcccgaacaagagcgcagctacaacctacagatgtctcaggagacgctcaag actcttctggcactgggatgtcacgtcggagtggcagacgaacgagcggcagaaaaagtc aaaaatctcaagctttcagcaaaatatgagctctctagtgggtataaacctgcaccgatg gacctgtgccacatcaaactggcgtctacccaggaggccatggtggacaagctggcagag aacgctcacaatgtctgggccagagaccgcatacgacagggctggacgtacggcatacag caggacattaagaacaagagaaaccctcgtctcgttccttacgttcttctggatgagaga accaagaagtctaataaggacagtctgcgggaagccgttaggacactgttgggttacgga tacaacctagaggctccagatcaagatcacgctcgagaggatgtaggtaatctgtcagca gagcgtttccggatattccgtgcagaaaagacgtactgtgtgaatggagggaagtggtac tttgagctggaggtggtgacggcgggcgagatgcgggtgggctgggcgagacccggctgt ctgccagaccaggagctcggagcagacgaacaggccttcgtattcgatggattcaaggcg cagcgctggcatcagggaaacgagcacttcggccgctcctggcagtctggagatgtggtg ggctgcatggtggacatgaacgaacgcaccatgatgttcacactgaacggagaagtgctg ctcgacgactccggctctgagctggcctttaaagactttgaggtgtgggaaggcttcatc ccggtctgcagtctgggggtcagtcaggtgggccgcatgaactttgggaaggacgtgagc acgctgaagtacttcaccatctgcggcctgcaggagggatacgagcccttcgctgtcaac atgaaccgagatctgaccatgtggatcagcaaacgcctgccgcagttcacccctgtcccg ctcatccacgagcacatagaggtcacacggatcgacgggacggtggagagcccgccgtgc ctaaaggtcacccagaggtcattcggctcacagaacagtcacacagacatcatgttttac cggctcagcatgcccatcgagtgctcggaggcgttcgcccgctcgcctggtgggacgcta gcagccaacggcagcttcttctcccctaagagagacctggaggattttgagacggtgtcg gattttgaggtccttatgaaaacaccacacagccacatgagctccaacggaccagacaga gaacgggacgaattcaacaaccacaaagatcataaccaggagaagccatccaaaatcaaa cagaggttcatgttgaaaagaacgaagccggacatgaacagcagcagctccagcgctcgt ctgtcagaggaggttttggctgatgagaaagacgactgtgagaatcttatacaaacatca acgtattattactcagtgaggatcttccccgggcaggagccctccagtgtctgggtcgga tgggtgacctcagactttcaccaatacgacactgcattcgagatcagcaatgtccggacg gtcactgtgaccctgggggacgagaagggcaaagttcacgagagcatcaagcgcagtaac tgttatatggtgtgggccggcgagtgcactagtcccggtcagggtcgcagtaataacggg ctggagatcggctgtctggtcgatacggctaacggcctcctcaccttcacctctaacggc aaagagctcagcacttactaccaggtggagcccagtactaaactcttccctgcagtgttt gcgcaggccaccagtccaaacgtcttccagttcgaactgggtcgcatcaagagcatcatg ccgctctctgctggactgtttaagagcgagcgtaagaatgtggttcctcagtgtccgccg agactacatgtgcagttcctcacaccggtgctgtggagccgtgtgcccaatcagttcctg aggtcagaggtcactagggtcaatgagagactgggttggatggtgcagagtttagaacca ctgcagttcatgaccctccatatacccgaggagaacaggtctgtggatattctggagctg acggagcagcaagatcttctgaagttccactatcacacactgcgcttatattcggctatc tgcgcgctgggaaataaccgtgtggctcacgcgctctgcagtcacgtagacgaggcgcag ctcctctacgccatccagaacaaatacatgcccggcctgctgcgcaccggatactacgac ctgctgatcgacatccacctgagcagctacgccaccgcacgcctcatgatgaactccgag tacatcgtccccatgacgcccgaaaccaagagcatcacactgttccctaatgagaagaag aaacacggtctgccgggtatcggtctgagcacatctctgcagccacgcatgcgcttctcc tctcccagttttgtaggttttaatggcagtggaggtgtcgactgtttccagtacagccct gagtttcctctggagacgctgaagagtcgtacgatggagatgctgacggaggcagtgcga gagggcagtctgcatgtgcgggatccagtagggggcagcactgagttcctgttcgtcccg ctcattaaactcttctacacgctgctcatcatgggcatcttccacaacggagacctgaag accatcctgcagctgatcgagcctagtgtattctcgcaggactctggagccgatggtgga ggcgggtcggtgggggatgggtgtgggcggggccaattggaagggggcgtggtcgatgat ggcctgagaggaaagatgcccaaagaaggacttttacagatgaagcttcctgagcctgtc aaactccagatgtgtcacctgctccagtacctgtgtgactgtcaggttcgtcaccgtatc gaggccgtggtcgcgttctctgacgactttgtggcgaatcttcaggagaaccagcgtttc cgctataacgaagtgatgcaggcgttaaacatgtccgccgctctgacggcacgcaaaacc aaagagttccgctctcctccacaggaacagatcaacatgctgctgaattttaaggatgag aagcaggattgtccgtgtcctgaagacatccgtgaacaactgctggatttccatgaagat ctcatgacacactgtggcattgagactgatgatgataaatcaggagatggagacagcgat ttcaccatcagaggtcgtctgatgtctctggtggagaaggtgacgtacctgaagaagaaa atgacagatcttccaaagaagaagaagtcaaagaagcccagtacactccagcagctgatc tctgagacgatggtccgctgggctcaggagtctgtcatcgaggacccagagctggttcgg gccatgttcgtgctgctccaccggcagtatgacggcattgggggtcaggtgcgagcgctg cccaaaacctacacaatcaacgctgtttctgtggaggacaccatcagcctgctggcgtct ctgggtcagattcgctcgctgctcagtgtcaggatgggccgcgaggaggagaaactcatg atccatgggctcagtgacatcatgaataataaggtgttttaccagcatccaaacctgatg cgggcactgggcatgcatgagactgtcatggaggtgatggtgaacgttctgggtggagga gagtctaaggagatcacgtttcctaagatggtggcgaactgctgccggttcctgtgctac ttctgtcggatcagccgtcagaatcagaaggccatgttcgatcatctgagttacctgctg gagaacagcagcgtgggcctcgcgtctccatcgatgagaggctccactccgctggatgtg gccgctgcgtctgtgatggacaataatgaactggctctggcgctgagagaaccagacctc gagaaggtggtgcagtatctggccggctgtggtcttcagagctgtgtgatgctgatgtct aaaggatatcccgacatcggctggaatccggtggagggtgaacgatacctggacttcctt cgattcgctgtattctgtaacggcgagagtgtggaggagaatgctaatgtggtggtgcgg ctcctgattcgccggccggagtgttttggccccgccctgcgtggagaaggtggaaacggc ctgctggcggccattgaggaagccataaagatctctgaggatcccagcagagacggacca tcgccaaccacagaggagagcaggacgctgaatgatgtgatggaggaagaggaagacgac accattcacatgggaaacgccatcatgaccttctatgctgccctgatcgacctgttgggc cgctgcgctccagagatgcatctgattcacgcaggaaagggagaagccatccgtatccga gccatcctgcgctctctgattcctattgaggatctggtgggagtgatcagcatcccgttc ctgatgcccacgctggctaaagacggctctgtgatcgagcctgacatgtcagcaggattc tgtcctgatcacaaagcagccatggttctgtttctggaccgggtttacggcatcgaagac cagaacttcctcctgcacctcctggaagtgggtttcctgcctgacctcagagccgccgcc tcattggacacggcggctctgagtgccacagacatggcgttggctctgaaccggtatctg tgtacagccgtgctgccgctgctcactaaatgtgctcctctgtttgcgggaacggaaccg ttcgcatctctcatcgactctctgctgcacaccgtctaccggctgtccaaaggctgctgt ctcaccaaagctcagagagacgccatcgaggagtgtctgctggccgtctgcgggaaactg cgtccgtcgatgatgcagcatctgttgaggcgtctggtgtttgacgttcctgtgctcaat gaacacactaagatgcctctgaagctcctgaccaatcactacgagcgctgctggaagtat tactgcctgtctggtggatgggggagctttggagccgcgtcagaggaggagctgcatctg tccagaaaactcttctggggaatttttgacgctctggccagaaagaagtatgacccagag ttgtttaagctggcattgccgtgtctgagtgccgttggtggagctttacctccagattac atggagtcaaactacgtggccatgatggagaaacagtcatcgatggatgcagagggaaac ttcaacccgcagccagccgacaccagcagtgttgttgttcctgagaaactcgatcatttc atcaataagtacgctgaatattcccatgagaaatggtccatggagaagtttgcggtcggc tgggttcatggagagcagatgtgtgaatcatcaaaagttcatccactgcttaagccttac aaatgtctgtctgagaaggataaggaggtttaccgatggccaatcagagagagtctgaag acgatgctgtcttggggttggagcatcgagcggatgagagagagtgatgcgtcgaccctt cacaaccgcacacgccggatctcactgtccagtcagcgctccatagagggagctcatggc ttcagcccacggcctgtagacatgagcaacgtcacgctgtccagagacctgcactcgatg gcggagctgctggctgagaactaccacaacatttgggctcagaagaaaaagctggagctg gaatccaaaggaggaggaagtcatccattgctggttccttatgacactttaactgccaaa gagaaatccaaagatagagagaaagcacaagacatcctcaagttctttcagatcaacgga tacagcgtttcaagggctatgaaagaacaggatctggacactccgtccatagagaagcgc ttcgcctacacgtttctgcagcagctgatcacgtatgtggatgaagctcacggacacatg ctggagtttgatgcaggaatacgaccaaaaggagagaaaatccctcatgagcagcagatt aagttcttcgggaaggttgttctgccactagtggatcagtacttcaagaaccaccggctg tacttcctgtccactgcggttcgaccaatcagcagcggcggccacgcctccaataaagag aaagagatggtgaccagcctgttctgtaagctgggtgtgctggtgcgacaccggatctca ttgtttggaaatgatgccacgtctatcgtcaactgcctgcacatcctgggacagacgctg gatgccaggactgtgatgaagacgggtcaggactcggtcaaagcggctctcagggccttc tttgataatgcagcagaggatctggagaagacgatggagaacctgcgccagggtcagttc acgcacacacgcagtcaacccaaaggagtcacgcagatcatcaactacaccaccgtggct ctgctgccggtgctctcctcgctcttcgagcacatcggacagaacctgtttggagaggat ctgatactggatgatgtccaggtctcctgctatcgcatattgaacaacttgtactcgctc ggaaccagtaaaagtatttatgttgagaggcagcgtccagccatcggcgagtgtttggct gcattctccagcgcatttcctgtggctttcctggagcccagtctgaacaagcacaacaca tactccatatacaactgtaaagggtcccgggagagagcaggtgcgacgcacagggcagtg aatttgttcctgcagggttatgagaagtcctggattgagaccgaagagcattacttcgag gacaagctgattgaggatttagagaaaccaggtgtagaggagccaccagaagaggatgag atgaccaaaaacattgacccgttacaccagctcattcagctgttcagccggaccgcactg accgagaaatgtaaactagaggaggatcatctctacatggcttacgctgatatcatggcc aaaagctgccatgatgaagaggaagaggacgaggtgaagagttttgaggagaaggagatg gagaagcagaagctgctgtatcagcaggccagacttcacgaccgcggagctgctgagatg gtgctgcagaccatcagcgccagcaaaggagagatggggccgatggtggcctccacgctg aagctgggaatcgccatcctcaacgggggaaactcaaccgttcagcagaaaatgctggac tacctgaaggacaagcgtgatgtgggcttcttccagagtctggcgggtctgatgcagtca tgcagtgttctggatctcaacgctttcgagcgtcagaataaagctgaaggtctggggatg gtgaccgaggaaggatcaggtgaaaaggtcatgcaagatgacgaattcacctgtgacctc ttccgcttcctgcagctgctctgtgagggacacaattcagattttcagaactacctgcga acgcagacgggtaacaacaccacggtcaatatcatcatctccacggtggattatctgctc agagtccaggaatccatcagtgatttctactggtactactctgggaaagacgtcattgac gaacaaggacaacgcaatttctccaaagcaatcaatgtagccaaacaagtcttcaacact cttacagagtacattcagggtccctgcaccgggaatcagcagagtctggctcacagtcgc ctgtgggatgcggttgttggtttcctgcatgtttttgcacatatgcagatgaagctctct caggactcaagccaaatcgagctactgaaggagctgatggatcttcagaaggacatggtc gtgatgcttttgtccatgttggaaggaaatgttgtgaatggcactattggcaagcagatg gtggacatgttagtggagtcctcgaataacgtggagatgatcctgaagttctttgacatg ttcctcaaactaaaagacctgacgtcgtcggacgccttcaaagagtacgaccccgatggc aaaggcgtcatttccaaacgagatttccacaaggcaatggagagccataagcactacacc caatccgagacggagttcctgctctcctgtgcggaaacagatgagaatgagctcttagac tacgaagagttcgtcgaacgatttcacgaaccggcgaaggatatcggttttaacgtggca gttcttctaaccaatctctcagagcacatgccgcatgattctcgcctccaaacgttcctg gagttggcggagagcgtgctgaattatttccagccctatctagggcgcatcgagatcatg ggcagcgccaagagaatcgagcgagtgtacttcgagattagcgaatcgagtcgcacacaa tgggaaaaaccccaagtcaaagagtctaagcgacagttcatctttgatgtggtcaatgaa ggcggtgaaaaggagaaaatggagctcttcgtgaacttctgtgaagacaccatctttgag atgcagttagcagcgcggatgtctgacgccggtgaacgatccgctagcaaagaggacagc gagagggagaaacctgaagaggagactccagaaatgggcttcttctccatcaccactgtg agaacggctctgtttgcgctacgttacaatgtgatgctgttaatgaaagtgctgtccatg aaaagtctgaagaaacaagtgaagaaggccaagaagatgactgtgaaggacatggtgacc actctggtgtccttctactggagtgtcctactcggcctgctgcactttgcattcagtgtt gcgcgagggtttttcaggatcatatacaacagctttcttggagggagtctcgtagaggga gcaaagaccatgaaggtgtcggagctcctggccaacatgcctgacccgacacaagatgag gtgagaggagagatggaagatggcgagaagaaacctgtggataaaacttcacctgaggaa gacctggccgacctgactgtagccaccgatgaaacagatctgctgtctgatatctttggt ctggatctgaagagagaaggaggacagtataagctgatgcctcacaatcccaacgccagc ctgacggatctgctcaacacacccgtccctccgccacccacaccctcacctgaactccgc agacgacaccatacgaagggctcttcctcttcaacggacaacaatgatgctgcagaggag accaaatcagtgcctgagaaagcggaaggtgaaaatgtagagaaagcacagaagaagaag gaggaagcggtgaagcggaaggtcagacagcactatgagccggatctacaggagtcggcc ttctggaagaagatcatcgcttaccaacgcaagctgctgaactattttgcacgaaatttc tacaacatgagaatgttggcgttgtttgtggcctttgcgattaacttcattctgctgttt tacaaggtatccacatcctctgccgtgacggaggggaaggaggtgttgttcagcgcgtcc tcagacaccagcgtgcaatgggatcctctgagcggctccagctctcggcccgtcactgtt cactttgtgctggaggagagcagcggctacatggagcccacgctgaggatccttgccatc ctgcacaccgtcatctccttcttctgcatcatcggctactactgcttaaaggttcctctg gtgattttcaagcgtgagaaggaagtggccaggaagctggagtttgacggcctgtacatc actgaacagccgtcagaagatgatattaaaggccagtgggaccgactggtcatcaacaca cagtccttcccaaacaattactgggataaatttgtgaagcggaaggtgatggataagtat ggagagttttatggacatgatcggatcagcgagctgcttgggatggataaagcggcgctg gacttcagtgatgcacacgagaagaagaagccaaagagagacagttcactggccgcagta ctgaactctgtcgatgtgaagtatcagatctggaagctcggcgtggtcttcacagataac tcgttcctgtatctggcctggtacatgagcatgtccatcctcggacactacaacaacttc ttcttcgctgctcatctgctggacattgccatgggcttcaagaccctcaggaccatccta tcctccgtcacacacaacggcaaacagctggtcctgacggtgggtctgctggcggttgta gtctatctctacactgtagtggcttttaacttcttccgcaagttctacaataagagtgaa gatggagaatcgccagacatgaagtgtgacgacatgctaacgtgctacatgtttcacatg tatgtgggcgttcgtgccggtggaggcatcggggatcagattgaagatccagccggagac gagtacgagatctaccgcatcatcttcgacatcaccttcttcttcttcgtcatcgtcatt ctcctggccatcattcagggtctgatcatagacgcgtttggtgaactgagggaccagcaa gagcaggtgaaagaggacatggagacgaagtgcttcatctgtggaatcgggaacgattat ttcgacactgttcctcatggcttcgagacgcacacactgcaggaacacaacctggccaac tatctatttttcttcatgtatctcatcaacaaggatgaaacagagcacacaggccaggag tcgtacgtttggaaaatgtaccaggaacgctgctgggaattctttcctgctggcgactgt ttccggaaacaatacgaggaccagctcaattag

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