Danio rerio (zebrafish): 323733 Help Entry 323733            CDS       T01004                                  Symbol top2a Name (RefSeq) DNA topoisomerase 2-alpha   KO K03164   DNA topoisomerase II [EC:5.6.2.2] Organism dre  Danio rerio (zebrafish) Brite KEGG Orthology (KO) [BR:dre00001]  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03032 DNA replication proteins [BR:dre03032]     323733 (top2a)    03036 Chromosome and associated proteins [BR:dre03036]     323733 (top2a) Enzymes [BR:dre01000]  5. Isomerases   5.6  Isomerases altering macromolecular conformation    5.6.2  Enzymes altering nucleic acid conformation     5.6.2.2  DNA topoisomerase (ATP-hydrolysing)      323733 (top2a) DNA replication proteins [BR:dre03032]  Eukaryotic type   DNA Topoisomerases    323733 (top2a) Chromosome and associated proteins [BR:dre03036]  Eukaryotic type   Chromosome condensation proteins    Other regulators of chromosome condensation     323733 (top2a)   Centrosome formation proteins    Centriole proteins     323733 (top2a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  DNA_topoisoIV TOPRIM_C DNA_gyraseB DTHCT HATPase_c Toprim Motif Other DBs NCBI-GeneID:  323733 NCBI-ProteinID:  NP_001296944 ZFIN:  ZDB-GENE-030131-2453 Ensembl:  ENSDARG00000024488 UniProt:  A0A0R4IUF0 LinkDB All DBs Position 12:10706772..10740236 Genome browser AA seq 1570 aa AA seqDB search MAGTEGPLKSLFENKALSKPKKDEKRLSVERIYQKKTQLEHILLRPDTYIGSVEPVTQQM WVFDEDTGMNCRDITFVPGLYKIFDEILVNAADNKQRDKTMNCIKVNIDPENNTISVWNN GKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSLKFTVET ACRESKRCFKQTWFDNMGRAGESKIKPFDGDDYTCITFQPDLAKFKMQALDKDTVALLTR RAYDIAGSTKGVRVLLNGKRLPINNFRTYVDLYVKDKVDETGSPLTVVHEMVNERWEVCL TLSEKGFQQVSFVNSIATTKGGRHTDYVADQIVSKLIEVVKKKNKAGVAVKPFQVKNHMW LFVNCLIENPSFDSQTKENMTLQQKNFGSACSLSDKFVKQANGCGIVESIMNWVKFKAQA QLNKKCSAVKHTKIKGVPKLDDANDAGGKNSNSCTLILTEGDSAKTLAVSGLGVVGRDRY GVFPLRGKMLNVREASHKQIMENAEINNIIKILGLQYKKNYSDPESLKSLRYGKLMIMTD QDQDGSHIKGLLINFIHHNWPSLLRHNFLEEFITPIIKASNKKQEISFYSIPEFTEWKEK QSSIKSWKIKYYKGLGTSTSKEAKEYFSDMTRHRIPFKYSGPADDEAITLAFSKKMIEER KEWLTSFMINRRQRREHNLPEEYLYGQETKSLSYHDFINKELVLFSNSDNERSIPCMVDG LKPGQRKVVFCCFKRNDKREVKVAQLAGSVAEMSAYHHGEVSLMMTIVGLAQNFVGSNNL NLLQPLGQFGTRLHGGKDSASPRYIFTMLSTLARLLFPVVDDNLLKYNYDDNLRVEPEWY MPIIPLVLANGGEGIGTGWASRIPNYDVREIINNIHRMLNGEEPLPMLPSYKGFKGTIDE LAKNQYVNNGEVAIIDSTTIEITELPVKTWTQTYKENVLEVMLNGTEKVPALITDYKEYH TDTTVRFVVKMTEERLREAEAAGLHKVFKLQNLLTCNSMVLFDHVGSLKKYESVQDILKE FFELRMKYYVLRKDWLVGMLGAESAKLSNQARFILEKIQGTLVIENKPKKELIRMLQQMG YDSDPVKAWKDAQEKEEEEDAEDDDEKEKEDTSGPDYNYLLSMPMWYLTKEKKDELCKQR DAKMTELNTLKMKAPADLWKEDLAAFTEELERVEQKEKESQNAMPLVKGKVGKPKVVKVK NETMPTPQGRRVIPRITSTMKVQAVKKERGKGSKKEAGLVMKMEFDDEADAAADGTGVGL AARLTKKIKKEPTKDKGSKSGKQTTLTFKPVQKKNPWSSDEGESDSDLELMSEETAPREK RERRAAVEKKYSLSSSEDEFDDFTKSSKTKRAVIEDDESFNPEPSAAPDSDVDSPPPPVV KKAPTKVAKAKAEKPEASSKSSSHSEASQEPAPKPVKKTAEGAAKKPPAKMTSAVSKKKA ADSKQPSILDVLSKASPKKSKVVKKPTAVKPLSSDSDSAGPAVTKKQAKKRKTVLSSDQS DSSDSDSGNLMSRLKGKSTAGKKAKSWEDDESFQLEETEKVVVSAAPRSRAARTTKPVTY ALDSDSDDED NT seq 4713 nt NT seq  +upstreamnt  +downstreamnt atggctggaacagaaggacctctgaagagtttatttgagaataaggctctcagtaagccc aagaaagatgagaagcgtctgtctgtggaacggatctatcagaagaagacccagctggag catatcctgcttcgacctgacacctacataggctcagtggaacctgtgactcagcaaatg tgggtgtttgatgaggatacagggatgaattgcagagacatcacatttgtgccaggactc tacaagatttttgatgagattctggtgaatgctgctgataacaaacaaagggacaagact atgaactgcatcaaggtcaacattgacccagagaataacacaatcagtgtgtggaacaat gggaagggtattcctgtggttgaacacaaggtggaaaaagtgtatgttcctgctttgatc tttggccaactcctgacctccagtaactatgatgatgatgagaagaaggtcacaggtggg cgaaatggatatggtgcaaagctgtgtaacatcttcagcctaaagtttactgtggagact gcttgcagagagtcaaaacgctgtttcaaacagacatggtttgacaacatgggacgagca ggtgaatctaagattaaacccttcgacggtgacgactacacctgcatcacattccagcca gacctggccaagttcaagatgcaagctttagataaggacactgttgcgctactgactcga cgagcatatgacattgctggatccactaaaggtgtccgtgtcttacttaatggaaagagg ctgccaattaataatttccgcacctatgtggacttgtatgtgaaggataaggtggatgaa actggttctcccctgacagtagttcacgagatggtgaatgagcgctgggaagtgtgtctt acccttagtgaaaaagggttccagcaagtcagctttgttaacagcatcgccacaactaag ggtggcagacacacagactatgttgcagatcagattgtgtccaaactgattgaagtagtg aaaaagaagaacaaggctggagtagccgtcaaacctttccaggtcaagaaccatatgtgg ttgtttgtgaactgtctgatagagaaccccagctttgactcccagacgaaagagaatatg accttgcagcagaagaattttggttctgcctgctctctgagtgacaagtttgttaagcag gctaatgggtgtggaattgtggaaagcattatgaactgggtgaagtttaaagcccaggct cagctcaataagaaatgctcagctgtcaaacacacgaagattaaaggagtacctaagctg gatgatgccaacgatgcaggtggaaagaactccaatagctgcactctaatcctgaccgaa ggagactcggccaaaactctggccgtgtcgggtctgggtgttgtgggacgtgatcgatat ggtgtcttccctctgcgtggtaaaatgctcaacgttcgagaagcttcacacaaacagatc atggaaaatgctgagatcaacaacatcattaagatcctgggtctgcagtacaaaaagaac tacagtgaccctgagtcactcaagagtctgcgctatggcaagctcatgatcatgacagat caggatcaagatggatctcacattaaaggtctgctgatcaacttcatccatcataactgg ccatcactgctgcgccataactttctagaagagttcatcacccctatcatcaaggcatcc aataagaagcaggagatttctttctacagtattcctgagttcactgagtggaaagagaag cagagtagcatcaaatcctggaaaatcaaatactacaaaggtttgggtaccagcacatca aaggaggccaaagagtatttttcggatatgacaagacatcgaatcccttttaagtactcc gggccggctgatgatgaggctatcaccctggcctttagtaagaagatgatagaggaaagg aaggaatggctgaccagctttatgatcaacagacgtcaacgtagagaacacaacctgcct gaggagtatctgtatggacaggaaaccaagtccctctcctaccatgactttatcaataaa gagcttgtgttgttctccaactctgacaacgagaggtcaatcccctgcatggtggatggg cttaaaccaggccagaggaaagttgtcttctgttgttttaagagaaatgataagagagag gtgaaagtggctcagttggctggatcagtggctgagatgtcagcatatcaccatggagag gtctctctgatgatgaccattgtgggtcttgctcagaattttgtgggcagtaataatttg aacctgctccagcctctgggtcagtttggcacacgtctccatggcggcaaagactcagcc agccccagatacatctttactatgctcagtacacttgctcgtctactgttccctgtggtg gacgacaacctgctgaagtacaactacgatgacaatttgcgagtggaaccggagtggtac atgcccatcatccctctggtgctggctaatggaggtgaaggcattggcacaggatgggcc agccgcatccctaactatgacgtgcgagagatcatcaacaacattcaccgcatgcttaac ggagaagagcccctccccatgctgcccagctataagggcttcaagggcaccattgatgag ctggcaaagaatcagtatgtgaataatggagaagtggccatcattgactccaccaccatc gagatcacagagctgcctgtcaaaacctggacacagacctataaggagaatgtgttggag gtgatgctgaacggcacagagaaggtccctgctctgatcacagactacaaggagtatcat acagacaccacagtgcgttttgttgttaagatgacagaggagcgcctgagagaggcagag gcagctggactgcacaaagtctttaaactccagaacctgctgacctgtaactccatggtg ttatttgatcatgtgggcagtctgaagaagtatgagtctgttcaggacatcttaaaggag ttctttgagctcagaatgaaatactacgtcctcaggaaagactggcttgtaggaatgttg ggagctgaaagtgccaaactttccaaccaagcccgatttattctggagaagatccagggc acactggtcattgaaaacaaaccgaaaaaagagctgatccgcatgcttcagcagatgggc tatgactcggaccctgttaaagcatggaaagatgctcaggagaaggaagaagaagaggat gctgaggatgatgatgagaaggagaaagaggacacgtctggccctgattataactatctg ctcagcatgcccatgtggtacctaaccaaagaaaagaaagatgagttgtgcaagcagaga gatgcaaagatgactgagttgaacacactcaagatgaaggcccctgctgatctgtggaaa gaagatctggcagcttttactgaggagctggagcgtgtggaacagaaagagaaggagtca cagaatgcaatgcccctggtgaagggtaaagtgggcaaaccaaaagtggtcaaggtaaag aacgagaccatgcctacaccgcaaggccgcagagttatcccccgcatcaccagcaccatg aaggtccaggctgtaaaaaaagagcgaggcaaaggatcgaagaaagaggctggtttggtg atgaagatggagtttgatgatgaggcagacgcagcagctgatggcactggggtgggattg gctgcaagacttacaaagaagatcaagaaagagccaaccaaagacaaaggctcaaagtca ggaaagcagaccaccctcacttttaaaccagtccagaagaagaacccctggtcttctgat gagggagagtctgattctgacctagagttgatgtctgaggaaacagccccaagagaaaag agagaacgcagagccgctgttgaaaagaagtacagtctgtcaagcagtgaggatgaattt gatgactttacgaagagcagtaaaacgaagcgtgctgtgattgaggacgacgagtctttc aatccagaacccagtgctgcacctgacagtgatgtggactctcctcctccacctgttgtg aaaaaagccccaacaaaagttgccaaagcaaaggcagagaaaccagaagccagcagcaag tctagctctcattctgaagccagtcaagagccggctcctaaacctgtgaagaaaactgct gaaggagctgccaaaaaacctcctgccaagatgacaagtgccgtttcaaagaagaaagca gctgattcaaaacagccttcgatccttgacgtgctctccaaggcaagccctaagaagtcc aaagttgtcaaaaagccaactgctgtcaagccattgtccagcgactcggacagcgcaggc cctgctgtcacaaagaaacaagccaagaagaggaagactgtgctgagcagtgaccaatca gacagctccgactctgacagcggcaatctcatgtcccgcctcaagggcaagagcactgct ggaaagaaagcaaagagctgggaggatgatgaaagctttcagttggaagagactgagaag gtggtggtctctgcagcccccaggagccgagctgcccgcaccactaaacctgtgacctac gcactcgattcagactctgacgatgaagattaa

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