Desmodus rotundus (common vampire bat): 112305180 Help Entry 112305180         CDS       T05907                                  Symbol JAK3 Name (RefSeq) tyrosine-protein kinase JAK3   KO K11218   Janus kinase 3 [EC:2.7.10.2] Organism dro  Desmodus rotundus (common vampire bat) Pathway dro04062   Chemokine signaling pathway dro04151   PI3K-Akt signaling pathway dro04217   Necroptosis dro04550   Signaling pathways regulating pluripotency of stem cells dro04630   JAK-STAT signaling pathway dro04658   Th1 and Th2 cell differentiation dro04659   Th17 cell differentiation dro05161   Hepatitis B dro05162   Measles dro05166   Human T-cell leukemia virus 1 infection dro05169   Epstein-Barr virus infection dro05200   Pathways in cancer dro05203   Viral carcinogenesis dro05223   Non-small cell lung cancer dro05340   Primary immunodeficiency Brite KEGG Orthology (KO) [BR:dro00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     112305180 (JAK3)    04151 PI3K-Akt signaling pathway     112305180 (JAK3)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     112305180 (JAK3)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     112305180 (JAK3)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     112305180 (JAK3)    04659 Th17 cell differentiation     112305180 (JAK3)    04062 Chemokine signaling pathway     112305180 (JAK3)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     112305180 (JAK3)    05203 Viral carcinogenesis     112305180 (JAK3)   09162 Cancer: specific types    05223 Non-small cell lung cancer     112305180 (JAK3)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     112305180 (JAK3)    05161 Hepatitis B     112305180 (JAK3)    05162 Measles     112305180 (JAK3)    05169 Epstein-Barr virus infection     112305180 (JAK3)   09163 Immune disease    05340 Primary immunodeficiency     112305180 (JAK3)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:dro01001]     112305180 (JAK3) Enzymes [BR:dro01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      112305180 (JAK3) Protein kinases [BR:dro01001]  Non-receptor tyrosine kinases   JAK family [OT]    112305180 (JAK3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 SH2_1 FERM_F1 Jak1_Phl Kdo Kinase-like ABC1 FERM_M SH2 Haspin_kinase Motif Other DBs NCBI-GeneID:  112305180 NCBI-ProteinID:  XP_024416656 LinkDB All DBs Position Unknown AA seq 1105 aa AA seqDB search MAPPSEETPLIPQRSCSLSSSEAGALHVLLPPRGPGPPQRLSFSFGDHSAEELCVQAAKA SGILPVYHSLFALAVEDLSCWFPPSHTFSVEDVGTQVLVYRLRFYFPNWFGLEKCHRFGL RKDLASAILDLTVLEHLFAQHRNDLVNGRLPVGLSLKEQGECLSLAVLDLARMACEQAQR PEELLKTISYKTCLPPGLRDLIQGLSFVTRRRIRRRVRQALCRVAACQVDRHSLMVKYIM DLERLDPSRATETFVVGLPGVAGGQDASGLLRVSGGSGIAWSPGTQEEVFQPFCDFPEIV DISIKQAPRVGPAGEHRLVTITRTDNQILEAEFPGLPGALSFVALVDGYFRLTTDSRHYF CKEVAPPRLLEEVAQQCHGPITLDFAINKLKTEGSLPGSYVLRRSPQDFNSFLLTVCVQT PLGPDYKGCLIRCDPTGTFSLAGLGRPHSSLRELLAACLDGGLHVDGVALNLTFCCTPRP KEKSNLIVVRRGCSPPTSSPVQPHSGCQLSQMTFHKIPVDSLEWHENLGHGSFTKIYRGC RHEPVDGEPRKTEVLLKVLDAKHKSCTESFLEAASLMSQVSYQHLVLLHGVCMAGDSIMV QEFVHLGALDTYLRKSGHLVPASWKLQVIKQLAYALNYLEDKGLTHGNVSARKVLLAREG SDGSLPFIKLSDPGVSPTVLSLEMLTDRIPWVAPECLQEARILGLEADKWGFGATVWEVF SGVTMPISTMDPAKKLQFYEERQQLPAPKWMELALLIQQCMTYEPSHRPSFRAVIRDLNN LITSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELC RYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLR LVMEYLPSGCLRDFLQRHRTRLDASRLLLYASQICKGMEYLGSRRCVHRDLAARNILVES ETHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYE LFTYSDKSCSPSAEFLRMMGCERDVPALCRLLDLLAEGQRLPAPPACPGEVHELMKLCWA PSPQDRPSFSTLGPQLDALWSGSRG NT seq 3318 nt NT seq  +upstreamnt  +downstreamnt atggcgcctccgagtgaggagacgcccctgatccctcagcgatcttgcagcctctcatct tcagaggctggtgccttgcacgtgctgcttccccctcggggccctggcccccctcagcgc ctctccttctcctttggggaccactcggctgaagaactgtgtgttcaggctgctaaggcc agtggcatcctgcccgtgtaccactccctctttgctctggccgtggaggacctgtcctgc tggtttcccccaagccacaccttctccgtggaggatgtgggcacccaggtcctcgtctac aggctccgcttttacttccccaactggtttgggctagagaagtgtcaccgattcgggctt cgaaaggacttggccagtgccatccttgacctgacagtcctggagcacttattcgcccag caccgcaacgacttggtgaacggccgtctccccgtgggccttagcctcaaggagcagggc gaatgtctcagcctggctgtgctggacctggcccggatggcctgtgagcaggcccagcga ccagaggagctgctgaagaccatcagctacaagacctgcctacctcccggcctgcgcgac ctgatccagggcctgagctttgtaacacggaggcgcatccggaggagggtgcgccaggcg ctgtgccgtgtggccgcctgtcaggttgacaggcactcactcatggtcaagtacatcatg gacctggagcgcctggacccctccagggccaccgagaccttcgtcgtgggcctccccggg gttgctggtggtcaggacgcgtcggggctgctccgtgtgtctggtggtagcggcattgcc tggagtccaggaacacaggaggaggtcttccagcctttctgcgactttccagaaatcgtg gacatcagcattaagcaggcgccgcgcgttggcccggccggggaacaccgtcttgtcact atcaccaggacagacaaccagatcctggaggctgagttcccggggctgccaggcgcgttg tccttcgtggcgctggtcgacggctacttccggctgaccacggactcccggcactacttc tgcaaggaggtggcgcctccgcggctcctggaggaggtggcgcagcagtgccacggcccc atcaccctggattttgccatcaacaagctcaagactgagggctcccttcccggttcctat gttctccgtcgcagcccccaggatttcaacagcttcctcctcactgtttgtgtccagacg cccctgggccccgattacaagggctgcctcatccggtgcgaccccacaggaaccttctcc ctggctggccttggccggccccacagcagtcttcgagagctcctggcagcctgcctggat ggtgggctgcatgtagatggggttgcactgaacctcaccttctgttgcacccctagaccc aaagaaaagtccaatctgatcgtggtccggaggggttgcagtccacccacatcgtcccct gttcagccccactcgggatgccagctgagtcagatgacatttcacaagatccctgttgat agcctggagtggcatgagaatctgggtcatggatccttcaccaagatttaccggggctgt cgccacgagcccgtggacggggagcctcgaaagacagaggtgctgctcaaagtgttagat gcgaagcataagagctgcacagagtcattcctggaagcggcgagcttgatgagccaagtg tcataccagcatcttgtgttgcttcatggcgtgtgcatggccggagacagcatcatggtg caggaatttgtacacctgggagcactggacacatacctacggaagtctggccatctggtg ccggccagctggaagctgcaggtgatcaaacagctggcctatgccctcaactatctggag gacaaaggcctcacccatggcaatgtctcagcccgtaaggtgctcttggcccgggagggg tctgacgggagcctacccttcatcaagctgagtgaccctggtgtcagtcctactgtgcta agccttgagatgctcactgacaggatcccctgggtggcccctgaatgtctccaggaggcc cggatacttggcttggaagctgacaagtggggcttcggtgccacagtctgggaggtgttc agcggtgtcacaatgccaatcagtaccatggaccctgccaagaagctccagttttatgag gagcggcagcaactgcctgcccccaagtggatggagctggccctgctgatccaacagtgc atgacctatgagccaagccacaggccctccttccgtgctgtcatccgggacctgaacaac ctcattacgtcagattacgaactcctctcggaccccacacctggtgccctggcgccccgc gatgggctgtggaatggcgctcagctctatgcctgccaggaccctaccatctttgaggag agacaccttaagtacatttcacagctgggcaagggcaactttggcagcgtggaactgtgc cgctatgaccccttgggagacaacacaggagccctggtggctgtgaagcagctgcagcac agtgggccagaccagcagagggacttccagcgggagatccagatcctcaaagccctgcac agtgacttcatcgtcaagtatcgcggtgtcagctatggcccaggccgccagagtctgaga ctcgtcatggaatacctgcccagcggctgcctgcgtgacttcctgcagcggcaccgcacg cgcctggatgccagccgcctgctcctctacgcctcgcagatctgcaagggcatggagtac ctgggctcccgccgctgtgtgcaccgcgacctggcagcacgtaacatcctggtggagagc gagacccacgtcaagatcgctgactttggccttgccaagctgttgccactggataaagac tattacgttgtccgggagccgggccaaagccccatcttctggtacgccccggagtccctc tcggacaacatcttctcgcgccagtcggatgtctggagttttggggtcgttctgtatgag ctgttcacctacagcgacaagagctgcagcccctctgctgagttcctgcggatgatggga tgtgagcgagatgtcccggctctttgccgcctcctggacctgctggcagagggccagagg ctgcccgcacctccagcctgccctggtgaggttcacgagctcatgaagctgtgctgggct cctagcccacaagaccggccatccttcagcaccctgggcccccagctggatgcgctgtgg agtggaagccgggggtag

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