KEGG Orthology (KO) [BR:dro00001]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
112307502 (DHFR)
00670 One carbon pool by folate
112307502 (DHFR)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
112307502 (DHFR)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
112307502 (DHFR)
Enzymes [BR:dro01000]
1. Oxidoreductases
1.5 Acting on the CH-NH group of donors
1.5.1 With NAD+ or NADP+ as acceptor
1.5.1.3 dihydrofolate reductase
112307502 (DHFR)
150 aa
MTSTTSAEGKQNMVIMGRKTWFSIPEKNRPLKDRINVVLSRELKEPPEGAHFLARSLDDA
LNLTEEPELTNKVDMVWIMGGSSVYKEAMNRPGPLRLFVTWIMQEFESDTFLPEIDLERY
KLIPEYPGVLSDVQEEKGIKFKFEVYERNN
