Desmodus rotundus (common vampire bat): 112307950 Help Entry 112307950         CDS       T05907                                  Symbol IRS1 Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism dro  Desmodus rotundus (common vampire bat) Pathway dro04022   cGMP-PKG signaling pathway dro04068   FoxO signaling pathway dro04081   Hormone signaling dro04140   Autophagy - animal dro04150   mTOR signaling pathway dro04151   PI3K-Akt signaling pathway dro04152   AMPK signaling pathway dro04211   Longevity regulating pathway dro04213   Longevity regulating pathway - multiple species dro04722   Neurotrophin signaling pathway dro04910   Insulin signaling pathway dro04920   Adipocytokine signaling pathway dro04923   Regulation of lipolysis in adipocytes dro04930   Type II diabetes mellitus dro04931   Insulin resistance dro04932   Non-alcoholic fatty liver disease dro04935   Growth hormone synthesis, secretion and action dro04960   Aldosterone-regulated sodium reabsorption dro05010   Alzheimer disease dro05206   MicroRNAs in cancer dro05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:dro00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     112307950 (IRS1)    04022 cGMP-PKG signaling pathway     112307950 (IRS1)    04151 PI3K-Akt signaling pathway     112307950 (IRS1)    04152 AMPK signaling pathway     112307950 (IRS1)    04150 mTOR signaling pathway     112307950 (IRS1)   09133 Signaling molecules and interaction    04081 Hormone signaling     112307950 (IRS1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     112307950 (IRS1)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     112307950 (IRS1)    04923 Regulation of lipolysis in adipocytes     112307950 (IRS1)    04920 Adipocytokine signaling pathway     112307950 (IRS1)    04935 Growth hormone synthesis, secretion and action     112307950 (IRS1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     112307950 (IRS1)   09156 Nervous system    04722 Neurotrophin signaling pathway     112307950 (IRS1)   09149 Aging    04211 Longevity regulating pathway     112307950 (IRS1)    04213 Longevity regulating pathway - multiple species     112307950 (IRS1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     112307950 (IRS1)   09164 Neurodegenerative disease    05010 Alzheimer disease     112307950 (IRS1)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     112307950 (IRS1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     112307950 (IRS1)    04932 Non-alcoholic fatty liver disease     112307950 (IRS1)    04931 Insulin resistance     112307950 (IRS1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  112307950 NCBI-ProteinID:  XP_024419883 LinkDB All DBs Position Unknown AA seq 1234 aa AA seqDB search MASPPETDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKAH HDGAAAPGAGGGGGSCSGSSGLGEAGEDLSYGDQLPGPAFKEVWQVILKPKGLGQTKNLI GIYRLCLTSKTISFVKLNSDAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT RRSRTESITATSPASMVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGAATLAAPN GHYILPRGGNGHRHLPGAGLGTSPALAGEEAASAADLDNRFRKRTHSAGTSPTISHQKTS SQSSVASIEEYAEMMPAYPPGGGSGGRLPGYRHSAFVPTQSYPEEGLEVHATERRGGHSR PDTSTLHTDDGYMPMSPGVAPVPSSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN GYMMMSPSGSCSPDAGGGPSGSNSAAPPGSSYGKMWTDSVGGHHSHALPHPKLPVESSGS KLLSCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGDPEET ARHQHLRLSSSSGRLLYAAATEDSSSSTSSDSLGGGYCGVRPEPGLPHHLHHQVLQPHLP RKVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQQPALPHPPEPKSPGEYVNIEFGSD QPGYLSAPMASHSSPSVRCPSQLHPAPREEETGTEEYMNMDLGPGRRATWQESPGVQPGR VGPAPPGTATMCRPTRAVPSTRGDYMTMQVGCPHQSYVDTSPVAPVSYAEIRTGIVEEAS LPGATAAAPSSSSAASASPTAPQGTGEVGACSSLLGAPQGPGGLSAFTRVNLSPNGNQSA KVIRADPQGCRRRHSSETFSSTPSTPRAGNSVPFTGGTAGGGSSGGGSSTEDVKRHSSAS FENVWLRPGELGGAPKEEPAQVCGAAGGLENGLNYIDLDLVKDFKQRPPQVQPPAPPPLH QPLGSKEGSSSSRSSEDLSAYASISFQKQPEDLQ NT seq 3705 nt NT seq  +upstreamnt  +downstreamnt atggcgagccctccggagaccgacggcttctcggacgtgcgcaaggtgggctacctgcgc aaacccaagagcatgcacaagcgctttttcgtgctgcgggcggccagcgaggcagggggc cccgcgcgcctggagtactacgagaatgagaagaagtggaggcacaagtcgagcgccccc aaacgctcgatccccctcgagagctgcttcaacatcaacaagcgcgcagactccaagaac aagcacctggtggccctctacacccgggacgagcacttcgctatcgcagcggacagcgag gccgagcaggacagctggtaccaggccctcctgcagctgcacaaccgcgccaaagcccac cacgatggggctgcggcccccggggcgggaggtggcggaggcagctgcagtggcagctct ggccttggcgaggcaggggaggacttgagctacggggaccagctcccaggacccgcgttc aaagaggtctggcaggtgatcctgaaacccaagggcctgggtcagacaaagaacctgatc ggtatctaccgcctctgcctgaccagcaagaccatcagcttcgtgaagctgaactcggat gccgcggcagtggtgctgcagctgatgaacatccggcgctgtggccactcagagaacttc ttcttcatcgaggtgggccggtccgcagtgaccggacctggggagttctggatgcaggtg gatgactcggtggtggcccagaacatgcacgagacaatcctggaggccatgcgggccatg agtgatgagttccggcctcgcagcaagagccagtcttcctccaactgctccaaccccatc agtgtgcccctgcgcaggcaccacctcaacaaccctccgcccagccaggtggggctgacc cgccgctcacgcacggagagcatcactgccacctctccagctagcatggtgggcgggaag cagggctccttccgtgtccgcgcctccagcgacggtgaaggcaccatgtcccgcccggct tcggtggacggcagccccgtgagtcctagcaccaacaggacccacgcccaccggcatcgg ggcagctcccggctgcaccccccactcaaccacagccgctccatccccatgccttcgtct cgctgctcgccttcagccaccagccctgtcagtctgtcttcgagtagcaccagtggccac ggctccacatctgactgccttttcccgcggagatctagtgcttctgtgtccggttccccc agcgatggcggtttcatctcttccgatgagtatggctccagtccctgcgatttccgaagt tccttccgcagtgtcaccccggattccctgggccatactcctccagcccgtggagaggag gagctgagcaactacatctgcatgggaggcaagggggccgccaccctcgccgcccccaat ggccactacattttgcctcggggtggcaatggtcaccgccacctcccaggcgctggcttg ggcacgagcccagccctggctggggaggaagcggccagtgctgcagatctcgataatcgg ttccgaaagcggactcactctgctggcacatcccccaccatttcccaccagaagacctca tcccagtcgtcagtggcttccattgaggaatatgcagagatgatgcctgcctacccacca ggaggtggcagtggaggccgcctgcccggctaccggcactccgccttcgtgcccacccag tcctaccctgaggagggtctggaagtgcacgccacggagcgtcgtggaggccacagccgc ccagacacctccaccctccacactgatgatggctacatgcccatgtccccaggggtagcc ccagtgcccagcagccggaaaggcagtggggactacatgcccatgagccccaagagtgtg tctgccccgcagcagatcatcaaccccatcagacgccacccccagagagtggaccccaat ggctacatgatgatgtcccccagcggcagctgctcccctgacgctgggggcgggcccagc ggcagcaacagtgctgcccctcctgggagtagctatgggaaaatgtggacagacagtgtt gggggccatcactctcacgccctgccacaccccaaactccctgtggagagtagcggtagc aagctcttgtcttgtacaggtgactacatgaacatgtctccagtgggggactccaacacc agcagcccttctgactgctactacggccctgaggacccccagcacaagccagttctctcc tactactcattgccaaggtcctttaagcacacccagcgcccgggggacccggaggagacc gcccggcaccagcacctccgcctttcctccagctctggtcgccttctctatgctgcagcc actgaagattcctcttcctctaccagcagcgacagcctgggtgggggatactgtggggtg aggcctgagcctggcctcccgcatcatctccaccatcaggtcctgcagccccatctgcct cgaaaggtggacacagctgcacagaccaacagtcgcctggctcggcccacgaggctgtcc ctgggggaccccaaggccagcaccttacctcgggcacgagagcagcagcagccggccctg ccgcaccctccagagcccaagagcccaggggaatatgtgaatattgagtttgggagtgat cagcccggctacttgtctgctcccatggcatcccatagctcgccttctgtcaggtgtcca tcccaactccacccagctcccagggaggaagagacgggcactgaagagtacatgaacatg gacctggggcctggccggagggccacctggcaggagagccctggggtccagcctggaaga gtgggccctgcacctccggggactgctaccatgtgcaggcctacccgggcagtgcctagc acccggggtgactacatgaccatgcaggtgggttgtccccatcagagctacgtggacacc tctccagttgcccctgtcagctatgctgaaattcggacgggcattgtggaggaggcgagc cttcctggggccacagcggcggctccctcctcatcctcagcagcctctgcttcccctact gcgcctcaaggaacgggggaggtgggggcctgctcttccctgctgggggccccacaggga cccgggggcctgagtgccttcactcgggtgaacctcagccccaacggcaaccagagtgcc aaagtgatccgagcagacccgcaagggtgccggaggcggcatagctctgagaccttctct tctacaccgagcaccccccgggcaggcaactcagtgcccttcactggggggactgcagga gggggcagcagtggtggcggcagcagcactgaggatgtgaaacgtcacagctctgcttcc tttgagaacgtgtggctgaggcctggggagctcgggggagccccaaaggaggagcctgct caagtgtgtggggctgctggggggttggagaatggtctcaactacatagacctggatttg gtcaaggacttcaagcagcgcccccctcaagtgcagcctcccgcacccccgcccctgcat cagcccctgggcagcaaagagggcagctccagcagccgctccagcgaggatttaagcgcc tatgccagcatcagtttccagaagcagccagaggatctccagtag

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