Desmodus rotundus (common vampire bat): 112321008 Help Entry 112321008         CDS       T05907                                  Symbol ADCY2 Name (RefSeq) adenylate cyclase type 2   KO K08042   adenylate cyclase 2 [EC:4.6.1.1] Organism dro  Desmodus rotundus (common vampire bat) Pathway dro00230   Purine metabolism dro01100   Metabolic pathways dro01522   Endocrine resistance dro04015   Rap1 signaling pathway dro04020   Calcium signaling pathway dro04022   cGMP-PKG signaling pathway dro04024   cAMP signaling pathway dro04062   Chemokine signaling pathway dro04072   Phospholipase D signaling pathway dro04081   Hormone signaling dro04082   Neuroactive ligand signaling dro04114   Oocyte meiosis dro04211   Longevity regulating pathway dro04213   Longevity regulating pathway - multiple species dro04261   Adrenergic signaling in cardiomyocytes dro04270   Vascular smooth muscle contraction dro04371   Apelin signaling pathway dro04540   Gap junction dro04611   Platelet activation dro04713   Circadian entrainment dro04714   Thermogenesis dro04723   Retrograde endocannabinoid signaling dro04724   Glutamatergic synapse dro04725   Cholinergic synapse dro04727   GABAergic synapse dro04750   Inflammatory mediator regulation of TRP channels dro04911   Insulin secretion dro04912   GnRH signaling pathway dro04913   Ovarian steroidogenesis dro04914   Progesterone-mediated oocyte maturation dro04915   Estrogen signaling pathway dro04916   Melanogenesis dro04918   Thyroid hormone synthesis dro04921   Oxytocin signaling pathway dro04922   Glucagon signaling pathway dro04923   Regulation of lipolysis in adipocytes dro04925   Aldosterone synthesis and secretion dro04926   Relaxin signaling pathway dro04927   Cortisol synthesis and secretion dro04928   Parathyroid hormone synthesis, secretion and action dro04934   Cushing syndrome dro04935   Growth hormone synthesis, secretion and action dro04970   Salivary secretion dro04971   Gastric acid secretion dro04972   Pancreatic secretion dro04976   Bile secretion dro05032   Morphine addiction dro05163   Human cytomegalovirus infection dro05166   Human T-cell leukemia virus 1 infection dro05200   Pathways in cancer dro05207   Chemical carcinogenesis - receptor activation dro05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:dro00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     112321008 (ADCY2)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     112321008 (ADCY2)    04371 Apelin signaling pathway     112321008 (ADCY2)    04020 Calcium signaling pathway     112321008 (ADCY2)    04072 Phospholipase D signaling pathway     112321008 (ADCY2)    04024 cAMP signaling pathway     112321008 (ADCY2)    04022 cGMP-PKG signaling pathway     112321008 (ADCY2)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     112321008 (ADCY2)    04081 Hormone signaling     112321008 (ADCY2)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     112321008 (ADCY2)   09144 Cellular community - eukaryotes    04540 Gap junction     112321008 (ADCY2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     112321008 (ADCY2)    04062 Chemokine signaling pathway     112321008 (ADCY2)   09152 Endocrine system    04911 Insulin secretion     112321008 (ADCY2)    04922 Glucagon signaling pathway     112321008 (ADCY2)    04923 Regulation of lipolysis in adipocytes     112321008 (ADCY2)    04912 GnRH signaling pathway     112321008 (ADCY2)    04913 Ovarian steroidogenesis     112321008 (ADCY2)    04915 Estrogen signaling pathway     112321008 (ADCY2)    04914 Progesterone-mediated oocyte maturation     112321008 (ADCY2)    04921 Oxytocin signaling pathway     112321008 (ADCY2)    04926 Relaxin signaling pathway     112321008 (ADCY2)    04935 Growth hormone synthesis, secretion and action     112321008 (ADCY2)    04918 Thyroid hormone synthesis     112321008 (ADCY2)    04928 Parathyroid hormone synthesis, secretion and action     112321008 (ADCY2)    04916 Melanogenesis     112321008 (ADCY2)    04925 Aldosterone synthesis and secretion     112321008 (ADCY2)    04927 Cortisol synthesis and secretion     112321008 (ADCY2)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     112321008 (ADCY2)    04270 Vascular smooth muscle contraction     112321008 (ADCY2)   09154 Digestive system    04970 Salivary secretion     112321008 (ADCY2)    04971 Gastric acid secretion     112321008 (ADCY2)    04972 Pancreatic secretion     112321008 (ADCY2)    04976 Bile secretion     112321008 (ADCY2)   09156 Nervous system    04724 Glutamatergic synapse     112321008 (ADCY2)    04727 GABAergic synapse     112321008 (ADCY2)    04725 Cholinergic synapse     112321008 (ADCY2)    04723 Retrograde endocannabinoid signaling     112321008 (ADCY2)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     112321008 (ADCY2)   09149 Aging    04211 Longevity regulating pathway     112321008 (ADCY2)    04213 Longevity regulating pathway - multiple species     112321008 (ADCY2)   09159 Environmental adaptation    04713 Circadian entrainment     112321008 (ADCY2)    04714 Thermogenesis     112321008 (ADCY2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     112321008 (ADCY2)    05207 Chemical carcinogenesis - receptor activation     112321008 (ADCY2)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     112321008 (ADCY2)    05163 Human cytomegalovirus infection     112321008 (ADCY2)   09165 Substance dependence    05032 Morphine addiction     112321008 (ADCY2)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     112321008 (ADCY2)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     112321008 (ADCY2)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     112321008 (ADCY2) Enzymes [BR:dro01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      112321008 (ADCY2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc Adcy_cons_dom AC_N HNOBA Motif Other DBs NCBI-GeneID:  112321008 NCBI-ProteinID:  XP_024434198 LinkDB All DBs Position Unknown AA seq 1052 aa AA seqDB search MSQQHPLIIFLLLIVMGACLALLAVFFALQLEVEDHVAFLITVPTALAIFFAIFILVCIE SVFKKLLRLFSVVIWICLVAMAYLFMCFGGTISPWDQVSFFLFIIFVVYTMLPFNMRDAI IASVLTSSSHTIVLSVCLSATPGAKEHLVWQILANVIIFVCGNLAGAYHKHLMELALQQT YQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFH NLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGD CYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQ KWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVK TYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTE NGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRI SLLFYNKILEKEYRDTALPAFKYYVTCACLIFFCIFIVQVLVLPKTSILGISFGAAFLLL AFILFLCFAGQLLQCSKKASASLLWLLKSSGIIANRPWPRISLTVITTAIILTMAVFNMF FLSDSEKTIPPSTNTSNASLSASNNQAAILRAQNLFFLPYFIYSCILGLISCSVFLRVNY ELKMLIMMAALVGYNVIFLHTHAHVLDDYSHVLLERPGIWKDLKTMGSVSLFIFFITLLV LGRQNEYYCRLDFLWKNKFNKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELY HQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIK TIGSTYMAATGLSAVPSQEHAQEPERQYMHIGTMVEFAFALVAKLDAINKHSFNDFKLRV GMNHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTC RGIINVKGKGDLKTYFVNTEMSRSLSQSNLAS NT seq 3159 nt NT seq  +upstreamnt  +downstreamnt atgagccagcagcacccgctcatcatcttcctgctgctgatcgtcatgggcgcctgtctc gccctgctcgccgtcttcttcgcgctccagctggaagttgaagaccatgtggcgttttta ataacggttcccactgcgctggcgattttctttgcgatattcatccttgtctgcattgag tctgtgtttaagaagctgctccgccttttctccgtggtgatatggatctgtctcgtggcc atggcctacctgttcatgtgttttggaggcaccatctctccctgggaccaggtgtcattc ttcctcttcatcatcttcgtggtctacaccatgctgcccttcaacatgagagatgccatc attgccagcgtgctcacctcgtcctcccacaccatcgtgctgagcgtctgcctgtctgcg acgcctggggccaaggagcacctggtttggcagatcttggccaacgtgatcatcttcgtc tgcgggaacctggcgggagcgtaccacaagcacctcatggaacttgctctgcagcaaaca tatcaggacacatgcaattgtatcaagtcccggatcaagttggagtttgaaaaacgtcag caggagcggctgctgctgtccctgctgccggcacacatagccatggagatgaaggctgag atcatccagaggctgcagggccctaaagctggccaaatggaaaacaccaacaactttcac aacctgtacgtcaagcgacacaccaacgtcagtatcctatatgctgacattgttggcttc acccggctggccagcgactgctccccaggagagctggtccacatgctgaatgaacttttt ggaaagttcgatcaaattgcaaaggagaatgaatgtatgagaataaaaattttaggggac tgctactactgtgtgtctggactcccgatatcgctccctaaccatgccaagaattgtgtg aaaatgggactggatatgtgtgaagccatcaagaaagtgagggatgctactggagttgac atcaacatgcgcgtgggagtgcactccgggaacgtcctctgtggcgtgattggtctgcag aagtggcagtatgatgtgtggtcacatgacgttaccttagccaatcacatggaagctgga ggggtcccagggcgtgttcacatctcttctgtcactctggaacacttgaatggagcttat aaagtggaggaaggagacggtgatatcagggacccgtatttaaagcagcacctggtgaaa acctactttgtaatcaaccccaagggcgaacgacggagtccccagcacctcttcaggcct cgccacaccctcgatggagccaagatgagggcctccgtgcgcatgacccggtacctggag tcctggggggcggccaagccctttgcacacctgcaccacagagacagtatgaccacggag aatggcaagatcagcaccacggatgtaccaatgggtcagcataattttcaaaatcgcact ttaagaactaagtcacaaaagaaaagatttgaagaagaattgaatgaaaggatgattcaa gcaattgatggaattaatgcacaaaagcaatggctcaagtctgaagacattcagagaatc tcactgcttttctacaataaaattctagaaaaagagtaccgagacaccgccctgccagcc ttcaagtactacgtgacctgtgcttgtctcatattcttctgcatcttcatcgtgcaggtc ctcgtgctaccaaaaacctccattctcgggatctcctttggagctgcatttctcctactg gcctttatccttttcctctgctttgctggacagcttttgcaatgcagcaaaaaggcctcc gcgtctcttctgtggcttttgaagtcctcaggcatcattgccaaccggccctggccacgg atctccctgacggtcatcaccacggccatcattttaaccatggccgtgttcaacatgttt ttcctgagtgactcagagaaaacaatccctccatctaccaatacatcaaatgcaagcctt tcggcctcaaataatcaggcagcgattctgcgtgcgcaaaacttgtttttccttccgtac tttatatacagctgcatcctggggctgatatcctgctcggttttcctgcgggtgaactac gagttgaaaatgttgatcatgatggcagcgctggtgggctacaacgtcatcttcctccac acgcacgcccacgtcctggatgactacagccacgtcttgcttgagagaccaggcatttgg aaggacctgaagaccatgggctcagtgtctctctttatattcttcatcacgctgcttgtt ctaggtagacagaatgaatattactgtaggttagacttcttatggaagaacaaattcaat aaagagcgggaggagatagaaaccatggagaacctgaaccgcgtgctgctggagaacgtg cttcctgcacacgtggccgagcacttcctggccaggagcctgaagaatgaggagttatac caccagtcctatgactgtgtctgcgttatgtttgcctccattccggatttcaaggaattc tacacagaatcagacgtcaacaaggagggcttggagtgcctgcggctcctgaacgagatc atcgccgactttgatgatctgctgtccaagccaaaattcagcggagttgaaaagatcaag accatcggcagcacatacatggcagcgacaggcctgagcgccgtgcccagccaggagcac gcccaggagcccgagaggcagtacatgcacatcggcaccatggtggagttcgcttttgcg ctggtggcgaaactggacgccatcaacaagcactccttcaatgacttcaagctgcgagtg ggcatgaaccacggacctgtgatagctggtgtcattggagctcagaagccgcagtatgac atctggggcaacactgtgaatgtggccagtaggatggacagcactggagtcctggacaaa atacaggtcacggaggagacgagcctcgttctgcagaccctggggtacacgtgcacgtgt cggggaataatcaacgtgaagggaaagggggacctgaagacatactttgtgaacacagaa atgtcaaggtccctttcccagagcaacttggcttcctga

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