嫌気性菌感染症 [DS:H01410]
During the early stages of the periodontal disease, saccharolytic, aerobic Streptococcus spp. and other bacteria adhere to and colonize the tooth enamel and root surface. This sets the stage for Fusobacterium nucleatum to coaggregate with these early colonizers and to permit late colonizers, including dental pathogens, to eventually form a biofilm. These complex interactions result in the release of factors that lead to tooth decay. Physical interaction is very specific among various genera in this complex microbial community. Due to the unusual length, adhesive nature, and other cell surface properties of F. nucleatum, periodontal disease-causing bacteria such as Porphyromonas gingivalis, Bacteroides forsythus, Aggregatibacter actinomycetemcomitans, Treponema denticola, and Streptococcus spp. aggregate and thrive; hence, F. nucleatum is thought of as a 'bridge bacterium'.
感染症疾患 [BR:jp08401]
   H01408  歯周疾患
ICD-11 による疾患分類 [BR:jp08403]
 13 消化器系の疾患
   DA0C  歯周疾患
    H01408  歯周疾患
Fusobacterium nucleatum [GN:fnu]
Porphyromonas gingivalis [GN:pgi pgn pgt]
Treponema denticola [GN:tde]
Treponema putidum [GN:tpk]
Treponema sp. OMZ 838 [GN:trm]
Aggregatibacter actinomycetemcomitans [GN:aat aan]
Olsenella uli [GN:ols]
Cryptobacterium curtum [GN:ccu]
クロラムフェニコール [DR:D00104]
アジスロマイシン水和物 [DR:D02134]
オフロキサシン [DR:D00453]
レボフロキサシン水和物 [DR:D00588]
トスフロキサシントシル酸塩水和物 [DR:D01996]
ジフェンヒドラミンサリチル酸塩・ヒドロコルチゾン酢酸エステル・ベンザルコニウム塩化物・クロルヘキシジン塩酸塩 [DR:D04425]
オキシテトラサイクリン塩酸塩・ヒドロコルチゾン [DR:D04776]
ミノサイクリン塩酸塩 [DR:D00850]
ヒドロコルチゾン酢酸エステル・ヒノキチオール・アミノ安息香酸エチル [DR:D04879]
アモキシシリン水和物 [DR:D00229]
バカンピシリン塩酸塩 [DR:D00927]
セファレキシン [DR:D00263]
セフジトレンピボキシル [DR:D01628]
セフテラムピボキシル [DR:D01686]
ロキシスロマイシン [DR:D01710]
クラリスロマイシン [DR:D00276]
クロラムフェニコールコハク酸エステルナトリウム [DR:D02185]
ICD-11: DA0C
ICD-10: K05
MeSH: D010510
Kapatral V, Anderson I, Ivanova N, Reznik G, Los T, Lykidis A, Bhattacharyya A, Bartman A, Gardner W, Grechkin G, Zhu L, Vasieva O, Chu L, Kogan Y, Chaga O, Goltsman E, Bernal A, Larsen N, D'Souza M, Walunas T, Pusch G, Haselkorn R, Fonstein M, Kyrpides N, Overbeek R.
Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum strain ATCC 25586.
J Bacteriol 184:2005-18 (2002)
Nelson KE, Fleischmann RD, DeBoy RT, Paulsen IT, Fouts DE, Eisen JA, Daugherty SC, Dodson RJ, Durkin AS, Gwinn M, Haft DH, Kolonay JF, Nelson WC, Mason T, Tallon L, Gray J, Granger D, Tettelin H, Dong H, Galvin JL, Duncan MJ, Dewhirst FE, Fraser CM.
Complete genome sequence of the oral pathogenic Bacterium porphyromonas gingivalis strain W83.
J Bacteriol 185:5591-601 (2003)
Naito M, Hirakawa H, Yamashita A, Ohara N, Shoji M, Yukitake H, Nakayama K, Toh H, Yoshimura F, Kuhara S, Hattori M, Hayashi T, Nakayama K.
Determination of the genome sequence of Porphyromonas gingivalis strain ATCC 33277 and genomic comparison with strain W83 revealed extensive genome rearrangements in P. gingivalis.
DNA Res 15:215-25 (2008)
Watanabe T, Maruyama F, Nozawa T, Aoki A, Okano S, Shibata Y, Oshima K, Kurokawa K, Hattori M, Nakagawa I, Abiko Y
Complete genome sequence of the bacterium Porphyromonas gingivalis TDC60, which causes periodontal disease.
J Bacteriol 193:4259-60 (2011)
Seshadri R, Myers GS, Tettelin H, Eisen JA, Heidelberg JF, Dodson RJ, Davidsen TM, DeBoy RT, Fouts DE, Haft DH, Selengut J, Ren Q, Brinkac LM, Madupu R, Kolonay J, Durkin SA, Daugherty SC, Shetty J, Shvartsbeyn A, Gebregeorgis E, Geer K, Tsegaye G, Malek J, Ayodeji B, Shatsman S, McLeod MP, Smajs D, Howell JK, Pal S, Amin A, Vashisth P, McNeill TZ, Xiang Q, Sodergren E, Baca E, Weinstock GM, Norris SJ, Fraser CM, Paulsen IT.
Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.
Proc Natl Acad Sci U S A 101:5646-51 (2004)
Thiha K, Takeuchi Y, Umeda M, Huang Y, Ohnishi M, Ishikawa I
Identification of periodontopathic bacteria in gingival tissue of Japanese periodontitis patients.
Oral Microbiol Immunol 22:201-7 (2007)

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