KEGG   DISEASE: 痛風
エントリ  
H01532                                                             
名称    
痛風
  下位グループ
血清尿酸値量的形質座位 (UAQTL)
痛風を伴うD-乳酸尿症 (DLACD)
概要    
Gout is a kind of arthritis associated with hyperuricemia. It is triggered due to precipitation and deposition of inflammatory monosodium urate crystals in synovial and other tissues, accompanied by severe pain. The most common symptom include swelling, tenderness, warmth and redness. Mostly, the joint at the base of the big toe is affected, gout progresses with more frequent attacks that involve multiple joints. Joint pain that used to resolve in a week to 10 days could become a milder, but constant pain. Eventually, untreated gout can cause other comorbidities such as high blood pressure, diabetes, chronic kidney disease and cardiovascular disease. The incidence of the disease is more common in 40s men than women, but gout in women after menopause appears increased risk. Recently, the onset in 20s increases. The development of gout is not only associated with sex, age, race and genetics, but also diet and lifestyle are contributed to increasing prevalence of the disease. Epidemiology studies reported that the excessive intake of alcohol and purine rich food, which excessively produce uric acid, leads to accumulation of uric acid.
カテゴリ  
筋骨格疾患
階層分類  
ヒト疾患 [BR:jp08402]
 筋骨格疾患
  その他の筋骨格疾患
   H01532  痛風
ICD-11 による疾患分類 [BR:jp08403]
 15 筋骨格系・結合組織の疾患
  関節症
   炎症性関節症
    FA25  痛風
     H01532  痛風
病因遺伝子 
(GOUT1) ABCG2 [HSA:9429] [KO:K05681]
(GOUT2) SLC2A9 [HSA:56606] [KO:K08146]
(GOUT4) SLC17A3 [HSA:10786] [KO:K12300]
(GOUT5/DLACD) LDHD [HSA:197257] [KO:K00102]
環境要因  
Alcohol, Purine rich food, Fructose/Sugar-sweetened beverages
治療薬   
アスピリン [DR:D00109]
インドメタシン [DR:D00141]
ナプロキセン [DR:D00118]
ケトプロフェン [DR:D00132]
オキサプロジン [DR:D00463]
プラノプロフェン [DR:D01578]
ブコローム [DR:D01661]
コルヒチン [DR:D00570]
プロベネシド [DR:D00475]
アロプリノール [DR:D00224]
フェブキソスタット [DR:D01206]
ベンズブロマロン [DR:D01056]
クエン酸カリウム・クエン酸ナトリウム [DR:D05624]
トピロキソスタット [DR:D09786]
ドチヌラド [DR:D11071]
大防風湯 [DR:D07007]
リンク   
ICD-11: FA25
ICD-10: M10
MeSH: D006073
OMIM: 138900 612076 612671 245450
文献    
PMID:25151572 (description and drug)
  著者
Dalbeth N, Lauterio TJ, Wolfe HR
  タイトル
Mechanism of action of colchicine in the treatment of gout.
  雑誌
Clin Ther 36:1465-79 (2014)
DOI:10.1016/j.clinthera.2014.07.017
文献    
PMID:21894471 (description and drug)
  著者
Sunkureddi P
  タイトル
Gouty arthritis: understanding the disease state and management options in primary care.
  雑誌
Adv Ther 28:748-60 (2011)
DOI:10.1007/s12325-011-0058-5
文献    
PMID:26977282 (drug)
  著者
Bernal JA, Quilis N, Andres M, Sivera F, Pascual E
  タイトル
Gout: optimizing treatment to achieve a disease cure.
  雑誌
Ther Adv Chronic Dis 7:135-44 (2016)
DOI:10.1177/2040622315618393
文献    
  著者
MacFarlane LA, Kim SC
  タイトル
Gout: a review of nonmodifiable and modifiable risk factors.
  雑誌
Rheum Dis Clin North Am 40:581-604 (2014)
DOI:10.1016/j.rdc.2014.07.002
文献    
  著者
Dehghan A, Kottgen A, Yang Q, Hwang SJ, Kao WL, Rivadeneira F, Boerwinkle E, Levy D, Hofman A, Astor BC, Benjamin EJ, van Duijn CM, Witteman JC, Coresh J, Fox CS
  タイトル
Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study.
  雑誌
Lancet 372:1953-61 (2008)
DOI:10.1016/S0140-6736(08)61343-4
文献    
  著者
Drabkin M, Yogev Y, Zeller L, Zarivach R, Zalk R, Halperin D, Wormser O, Gurevich E, Landau D, Kadir R, Perez Y, Birk OS
  タイトル
Hyperuricemia and gout caused by missense mutation in d-lactate dehydrogenase.
  雑誌
J Clin Invest 129:5163-5168 (2019)
DOI:10.1172/JCI129057
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