KEGG   DISEASE: 劇症肝炎
エントリ  
H01712                                                             
名称    
劇症肝炎
  下位グループ
ウイルス性肝炎 [DS:H02162]
概要    
Fulminant hepatic failure (FHF) is a life-threatening condition characterized by the rapid deterioration of liver functions and hepatic encephalopathy. FHF is with the basic definition of the onset of hepatic encephalopathy within 8 weeks of the appearance of the first symptoms like jaundice, fever, nausea, and vomiting. The prothrombin time is prolonged by 4-6 seconds or more. While the etiologies of FHF are multiple and varied, viral hepatitis is the most frequent cause. Around 40-60% of patients with FHF are thought to be due to some viral infection. The prognosis is dependent on several factors, including the underlying cause of liver failure. For instance, it is well known that the spontaneous recovery rates from FHF from such etiologies as hepatitis A and acetaminophen toxicity are high, whereas those same rates for other types of viral hepatitis and idiosyncratic drug reactions are quite low. Identification of the cause of FHF is important because some causes have specific treatment interventions or antidotes. Specific therapies include N-acetylcysteine for acetaminophen overdose, and acyclovir for herpesvirus infection. Different therapeutic options such as complete exchange blood transfusion, corticosteroids, and plasma pheresis, have been tried. However, the overall prognosis for patients with FHF is quite poor, with survival rates usually reported between 10% and 30% without liver transplantation.
カテゴリ  
肝疾患
階層分類  
ヒト疾患 [BR:jp08402]
 消化器系疾患
  肝疾患
   H01712  劇症肝炎
ICD-11 による疾患分類 [BR:jp08403]
 13 消化器系の疾患
  肝疾患
   DB91  急性または亜急性肝不全
    H01712  劇症肝炎
治療薬   
デキサメタゾン [DR:D00292]
デキサメタゾンリン酸エステルナトリウム [DR:D00975]
ベタメタゾンリン酸エステルナトリウム [DR:D00972]
ベタメタゾン [DR:D00244]
プレドニゾロン [DR:D00472]
メチルプレドニゾロン [DR:D00407]
メチルプレドニゾロン酢酸エステル [DR:D00979]
リンク   
ICD-11: DB91.1
ICD-10: K72
MeSH: D017114
文献    
  著者
Younis BB, Arshad R, Khurhsid S, Masood J, Nazir F, Tahira M
  タイトル
Fulminant hepatic failure (FHF) due to acute hepatitis C.
  雑誌
Pak J Med Sci 31:1009-11 (2015)
DOI:10.12669/pjms.314.7618
文献    
  著者
Farmer DG, Anselmo DM, Ghobrial RM, Yersiz H, McDiarmid SV, Cao C, Weaver M, Figueroa J, Khan K, Vargas J, Saab S, Han S, Durazo F, Goldstein L, Holt C, Busuttil RW
  タイトル
Liver transplantation for fulminant hepatic failure: experience with more than 200 patients over a 17-year period.
  雑誌
Ann Surg 237:666-75; discussion 675-6 (2003)
DOI:10.1097/01.SLA.0000064365.54197.9E
LinkDB    

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