Fetomaternal alloimmune thrombocytopenia (FMAIT), also known as neonatal alloimmune thrombocytopenia (NAIT), is a relatively uncommon disease, but is the leading cause of severe thrombocytopenia in the newborn. Neonatal intracranial hemorrhage is a severe complication of this disease, resulting in irreversible damage to cranial nerves and potential neonatal death. It has been reported that FMAIT is caused by maternal alloantibodies against paternally-inherited platelet antigens, most frequently HPA-1a on integrin beta 3. Many other antibodies have been identified, but are rare.
Santoso S, Amrhein J, Hofmann HA, Sachs UJ, Walka MM, Kroll H, Kiefel V
タイトル
A point mutation Thr(799)Met on the alpha(2) integrin leads to the formation of new human platelet alloantigen Sit(a) and affects collagen-induced aggregation.
