KEGG T01001: 3674

Homo sapiens (human): 3674

Entry

3674              CDS       T01001

Symbol

ITGA2B, BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GT1, GTA, HPA3, PPP1R93

Name

(RefSeq) integrin subunit alpha 2b

K06476

integrin alpha 2B

Organism

hsa Homo sapiens (human)

Pathway

hsa04015

Rap1 signaling pathway

hsa04151

PI3K-Akt signaling pathway

hsa04510

Focal adhesion

hsa04512

ECM-receptor interaction

hsa04611

Platelet activation

hsa04613

Neutrophil extracellular trap formation

hsa04640

Hematopoietic cell lineage

hsa04810

Regulation of actin cytoskeleton

hsa04820

Cytoskeleton in muscle cells

hsa05165

Human papillomavirus infection

hsa05200

Pathways in cancer

hsa05222

Small cell lung cancer

hsa05410

Hypertrophic cardiomyopathy

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

hsa05414

Dilated cardiomyopathy

hsa05418

Fluid shear stress and atherosclerosis

Network

nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06182  Shigella
nt06183  Yersinia

Element

N00393

ITGA/B-RhoGAP-RhoA signaling pathway

N00951

ITGA/B-RHOG-RAC signaling pathway

N01068

ITGA/B-FAK-RAC signaling pathway

N01070

ITGA/B-FAK-CDC42 signaling pathway

N01072

ITGA/B-RhoGEF-RhoA signaling pathway

N01080

ITGA/B-TALIN/VINCULIN signaling pathway

Disease

H00226

Glanzmann thrombasthenia

H01235

Bleeding disorder platelet-type

H01740

Macrothrombocytopenia

Drug target

Abciximab:

D02778

Elarofiban:

D03971

Eptifibatide:

D06888<US>

Lamifiban (DG01420):

D04659 D04660

Lotrafiban hydrochloride:

Orbofiban acetate:

Roxifiban acetate:

Sibrafiban:

Tadocizumab:

Tirofiban (DG00159):

D01029<US> D08607

Xemilofiban hydrochloride:

D06335

Zalunfiban (DG03167):

D12051 D12163

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    3674 (ITGA2B)
   04151 PI3K-Akt signaling pathway
    3674 (ITGA2B)
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    3674 (ITGA2B)
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    3674 (ITGA2B)
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    3674 (ITGA2B)
   04810 Regulation of actin cytoskeleton
    3674 (ITGA2B)
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    3674 (ITGA2B)
   04611 Platelet activation
    3674 (ITGA2B)
   04613 Neutrophil extracellular trap formation
    3674 (ITGA2B)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3674 (ITGA2B)
  09162 Cancer: specific types
   05222 Small cell lung cancer
    3674 (ITGA2B)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    3674 (ITGA2B)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    3674 (ITGA2B)
   05410 Hypertrophic cardiomyopathy
    3674 (ITGA2B)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    3674 (ITGA2B)
   05414 Dilated cardiomyopathy
    3674 (ITGA2B)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    3674 (ITGA2B)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3674 (ITGA2B)
   04515 Cell adhesion molecules [BR:hsa04515]
    3674 (ITGA2B)
   04090 CD molecules [BR:hsa04090]
    3674 (ITGA2B)
Protein phosphatases and associated proteins [BR:hsa01009]
Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     3674 (ITGA2B)
Exosome [BR:hsa04147]
Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   3674 (ITGA2B)
Cell adhesion molecules [BR:hsa04515]
Integrins
  Integrin alpha subunits
   3674 (ITGA2B)
CD molecules [BR:hsa04090]
Proteins
  3674 (ITGA2B)

SSDB

Motif

Pfam:

Integrin_A_Ig_3 Integrin_A_Ig_2 Integrin_A_Ig_1 FG-GAP FG-GAP_3 Integrin_alpha ITGAX-like_Ig_3

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

17:complement(44372181..44389649)

AA seq 1039 aa
MARALCPLQALWLLEWVLLLLGPCAAPPAWALNLDPVQLTFYAGPNGSQFGFSLDFHKDS
HGRVAIVVGAPRTLGPSQEETGGVFLCPWRAEGGQCPSLLFDLRDETRNVGSQTLQTFKA
RQGLGASVVSWSDVIVACAPWQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGN
TLSRIYVENDFSWDKRYCEAGFSSVVTQAGELVLGAPGGYYFLGLLAQAPVADIFSSYRP
GILLWHVSSQSLSFDSSNPEYFDGYWGYSVAVGEFDGDLNTTEYVVGAPTWSWTLGAVEI
LDSYYQRLHRLRGEQMASYFGHSVAVTDVNGDGRHDLLVGAPLYMESRADRKLAEVGRVY
LFLQPRGPHALGAPSLLLTGTQLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQV
LVFLGQSEGLRSRPSQVLDSPFPTGSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYR
AQPVVKASVQLLVQDSLNPAVKSCVLPQTKTPVSCFNIQMCVGATGHNIPQKLSLNAELQ
LDRQKPRQGRRVLLLGSQQAGTTLNLDLGGKHSPICHTTMAFLRDEADFRDKLSPIVLSL
NVSLPPTEAGMAPAVVLHGDTHVQEQTRIVLDCGEDDVCVPQLQLTASVTGSPLLVGADN
VLELQMDAANEGEGAYEAELAVHLPQGAHYMRALSNVEGFERLICNQKKENETRVVLCEL
GNPMKKNAQIGIAMLVSVGNLEEAGESVSFQLQIRSKNSQNPNSKIVLLDVPVRAEAQVE
LRGNSFPASLVVAAEEGEREQNSLDSWGPKVEHTYELHNNGPGTVNGLHLSIHLPGQSQP
SDLLYILDIQPQGGLQCFPQPPVNPLKVDWGLPIPSPSPIHPAHHKRDRRQIFLPEPEQP
SRLQDPVLVSCDSAPCTVVQCDLQEMARGQRAMVTVLAFLWLPSLYQRPLDQFVLQSHAW
FNVSSLPYAVPPLSLPRGEAQVWTQLLRALEERAIPIWWVLVGVLGGLLLLTILVLAMWK
VGFFKRNRPPLEEDDEEGE

NT seq 3120 nt +upstreamnt +downstreamnt
atggccagagctttgtgtccactgcaagccctctggcttctggagtgggtgctgctgctc
ttgggaccttgtgctgcccctccagcctgggccttgaacctggacccagtgcagctcacc
ttctatgcaggccccaatggcagccagtttggattttcactggacttccacaaggacagc
catgggagagtggccatcgtggtgggcgccccgcggaccctgggccccagccaggaggag
acgggcggcgtgttcctgtgcccctggagggccgagggcggccagtgcccctcgctgctc
tttgacctccgtgatgagacccgaaatgtaggctcccaaactttacaaaccttcaaggcc
cgccaaggactgggggcgtcggtcgtcagctggagcgacgtcattgtggcctgcgccccc
tggcagcactggaacgtcctagaaaagactgaggaggctgagaagacgcccgtaggtagc
tgctttttggctcagccagagagcggccgccgcgccgagtactccccctgtcgcgggaac
accctgagccgcatttacgtggaaaatgattttagctgggacaagcgttactgtgaagcg
ggcttcagctccgtggtcactcaggccggagagctggtgcttggggctcctggcggctat
tatttcttaggtctcctggcccaggctccagttgcggatattttctcgagttaccgccca
ggcatccttttgtggcacgtgtcctcccagagcctctcctttgactccagcaacccagag
tacttcgacggctactgggggtactcggtggccgtgggcgagttcgacggggatctcaac
actacagaatatgtcgtcggtgcccccacttggagctggaccctgggagcggtggaaatt
ttggattcctactaccagaggctgcatcggctgcgcggagagcagatggcgtcgtatttt
gggcattcagtggctgtcactgacgtcaacggggatgggaggcatgatctgctggtgggc
gctccactgtatatggagagccgggcagaccgaaaactggccgaagtggggcgtgtgtat
ttgttcctgcagccgcgaggcccccacgcgctgggtgcccccagcctcctgctgactggc
acacagctctatgggcgattcggctctgccatcgcacccctgggcgacctcgaccgggat
ggctacaatgacattgcagtggctgccccctacgggggtcccagtggccggggccaagtg
ctggtgttcctgggtcagagtgaggggctgaggtcacgtccctcccaggtcctggacagc
cccttccccacaggctctgcctttggcttctcccttcgaggtgccgtagacatcgatgac
aacggatacccagacctgatcgtgggagcttacggggccaaccaggtggctgtgtacaga
gctcagccagtggtgaaggcctctgtccagctactggtgcaagattcactgaatcctgct
gtgaagagctgtgtcctacctcagaccaagacacccgtgagctgcttcaacatccagatg
tgtgttggagccactgggcacaacattcctcagaagctatccctaaatgccgagctgcag
ctggaccggcagaagccccgccagggccggcgggtgctgctgctgggctctcaacaggca
ggcaccaccctgaacctggatctgggcggaaagcacagccccatctgccacaccaccatg
gccttccttcgagatgaggcagacttccgggacaagctgagccccattgtgctcagcctc
aatgtgtccctaccgcccacggaggctggaatggcccctgctgtcgtgctgcatggagac
acccatgtgcaggagcagacacgaatcgtcctggactgtggggaagatgacgtatgtgtg
ccccagcttcagctcactgccagcgtgacgggctccccgctcctagttggggcagataat
gtcctggagctgcagatggacgcagccaacgagggcgagggggcctatgaagcagagctg
gccgtgcacctgccccagggcgcccactacatgcgggccctaagcaatgtcgagggcttt
gagagactcatctgtaatcagaagaaggagaatgagaccagggtggtgctgtgtgagctg
ggcaaccccatgaagaagaacgcccagataggaatcgcgatgttggtgagcgtggggaat
ctggaagaggctggggagtctgtgtccttccagctgcagatacggagcaagaacagccag
aatccaaacagcaagattgtgctgctggacgtgccggtccgggcagaggcccaagtggag
ctgcgagggaactcctttccagcctccctggtggtggcagcagaagaaggtgagagggag
cagaacagcttggacagctggggacccaaagtggagcacacctatgagctccacaacaat
ggccctgggactgtgaatggtcttcacctcagcatccaccttccgggacagtcccagccc
tccgacctgctctacatcctggatatacagccccaggggggccttcagtgcttcccacag
cctcctgtcaaccctctcaaggtggactgggggctgcccatccccagcccctcccccatt
cacccggcccatcacaagcgggatcgcagacagatcttcctgccagagcccgagcagccc
tcgaggcttcaggatccagttctcgtaagctgcgactcggcgccctgtactgtggtgcag
tgtgacctgcaggagatggcgcgcgggcagcgggccatggtcacggtgctggccttcctg
tggctgcccagcctctaccagaggcctctggatcagtttgtgctgcagtcgcacgcatgg
ttcaacgtgtcctccctcccctatgcggtgcccccgctcagcctgccccgaggggaagct
caggtgtggacacagctgctccgggccttggaggagagggccattccaatctggtgggtg
ctggtgggtgtgctgggtggcctgctgctgctcaccatcctggtcctggccatgtggaag
gtcggcttcttcaagcggaaccggccacccctggaagaagatgatgaagagggggagtga

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