KEGG   Equus caballus (horse): 100057796
Entry
100057796         CDS       T01058                                 
Symbol
ADCY8
Name
(RefSeq) adenylate cyclase type 8 isoform X1
  KO
K08048  adenylate cyclase 8 [EC:4.6.1.1]
Organism
ecb  Equus caballus (horse)
Pathway
ecb00230  Purine metabolism
ecb01100  Metabolic pathways
ecb01522  Endocrine resistance
ecb04015  Rap1 signaling pathway
ecb04020  Calcium signaling pathway
ecb04022  cGMP-PKG signaling pathway
ecb04024  cAMP signaling pathway
ecb04062  Chemokine signaling pathway
ecb04072  Phospholipase D signaling pathway
ecb04081  Hormone signaling
ecb04082  Neuroactive ligand signaling
ecb04114  Oocyte meiosis
ecb04211  Longevity regulating pathway
ecb04213  Longevity regulating pathway - multiple species
ecb04261  Adrenergic signaling in cardiomyocytes
ecb04270  Vascular smooth muscle contraction
ecb04371  Apelin signaling pathway
ecb04540  Gap junction
ecb04611  Platelet activation
ecb04713  Circadian entrainment
ecb04714  Thermogenesis
ecb04720  Long-term potentiation
ecb04723  Retrograde endocannabinoid signaling
ecb04724  Glutamatergic synapse
ecb04725  Cholinergic synapse
ecb04727  GABAergic synapse
ecb04742  Taste transduction
ecb04750  Inflammatory mediator regulation of TRP channels
ecb04911  Insulin secretion
ecb04912  GnRH signaling pathway
ecb04913  Ovarian steroidogenesis
ecb04914  Progesterone-mediated oocyte maturation
ecb04915  Estrogen signaling pathway
ecb04916  Melanogenesis
ecb04918  Thyroid hormone synthesis
ecb04921  Oxytocin signaling pathway
ecb04923  Regulation of lipolysis in adipocytes
ecb04925  Aldosterone synthesis and secretion
ecb04926  Relaxin signaling pathway
ecb04927  Cortisol synthesis and secretion
ecb04928  Parathyroid hormone synthesis, secretion and action
ecb04934  Cushing syndrome
ecb04935  Growth hormone synthesis, secretion and action
ecb04970  Salivary secretion
ecb04971  Gastric acid secretion
ecb04972  Pancreatic secretion
ecb04976  Bile secretion
ecb05032  Morphine addiction
ecb05163  Human cytomegalovirus infection
ecb05166  Human T-cell leukemia virus 1 infection
ecb05200  Pathways in cancer
ecb05207  Chemical carcinogenesis - receptor activation
ecb05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ecb00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    100057796 (ADCY8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    100057796 (ADCY8)
   04371 Apelin signaling pathway
    100057796 (ADCY8)
   04020 Calcium signaling pathway
    100057796 (ADCY8)
   04072 Phospholipase D signaling pathway
    100057796 (ADCY8)
   04024 cAMP signaling pathway
    100057796 (ADCY8)
   04022 cGMP-PKG signaling pathway
    100057796 (ADCY8)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    100057796 (ADCY8)
   04081 Hormone signaling
    100057796 (ADCY8)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    100057796 (ADCY8)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    100057796 (ADCY8)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100057796 (ADCY8)
   04062 Chemokine signaling pathway
    100057796 (ADCY8)
  09152 Endocrine system
   04911 Insulin secretion
    100057796 (ADCY8)
   04923 Regulation of lipolysis in adipocytes
    100057796 (ADCY8)
   04912 GnRH signaling pathway
    100057796 (ADCY8)
   04913 Ovarian steroidogenesis
    100057796 (ADCY8)
   04915 Estrogen signaling pathway
    100057796 (ADCY8)
   04914 Progesterone-mediated oocyte maturation
    100057796 (ADCY8)
   04921 Oxytocin signaling pathway
    100057796 (ADCY8)
   04926 Relaxin signaling pathway
    100057796 (ADCY8)
   04935 Growth hormone synthesis, secretion and action
    100057796 (ADCY8)
   04918 Thyroid hormone synthesis
    100057796 (ADCY8)
   04928 Parathyroid hormone synthesis, secretion and action
    100057796 (ADCY8)
   04916 Melanogenesis
    100057796 (ADCY8)
   04925 Aldosterone synthesis and secretion
    100057796 (ADCY8)
   04927 Cortisol synthesis and secretion
    100057796 (ADCY8)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100057796 (ADCY8)
   04270 Vascular smooth muscle contraction
    100057796 (ADCY8)
  09154 Digestive system
   04970 Salivary secretion
    100057796 (ADCY8)
   04971 Gastric acid secretion
    100057796 (ADCY8)
   04972 Pancreatic secretion
    100057796 (ADCY8)
   04976 Bile secretion
    100057796 (ADCY8)
  09156 Nervous system
   04724 Glutamatergic synapse
    100057796 (ADCY8)
   04727 GABAergic synapse
    100057796 (ADCY8)
   04725 Cholinergic synapse
    100057796 (ADCY8)
   04720 Long-term potentiation
    100057796 (ADCY8)
   04723 Retrograde endocannabinoid signaling
    100057796 (ADCY8)
  09157 Sensory system
   04742 Taste transduction
    100057796 (ADCY8)
   04750 Inflammatory mediator regulation of TRP channels
    100057796 (ADCY8)
  09149 Aging
   04211 Longevity regulating pathway
    100057796 (ADCY8)
   04213 Longevity regulating pathway - multiple species
    100057796 (ADCY8)
  09159 Environmental adaptation
   04713 Circadian entrainment
    100057796 (ADCY8)
   04714 Thermogenesis
    100057796 (ADCY8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100057796 (ADCY8)
   05207 Chemical carcinogenesis - receptor activation
    100057796 (ADCY8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100057796 (ADCY8)
   05163 Human cytomegalovirus infection
    100057796 (ADCY8)
  09165 Substance dependence
   05032 Morphine addiction
    100057796 (ADCY8)
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    100057796 (ADCY8)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100057796 (ADCY8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    100057796 (ADCY8)
Enzymes [BR:ecb01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     100057796 (ADCY8)
SSDB
Motif
Pfam: Guanylate_cyc AC_N Adcy_cons_dom TBK1_ULD
Other DBs
NCBI-GeneID: 100057796
NCBI-ProteinID: XP_001916535
Ensembl: ENSECAG00000024601
VGNC: 15092
UniProt: F6R859
LinkDB
Position
9:complement(73995376..74211578)
AA seq 1252 aa
MELSDVRCLSGSEELYTIHPTPPAGDGGSASRPQRLLWQTAVRHITEQRFIHGHRGSGGG
GGSGGSGKASDPTGGGPNHHASQLSSDSALPLYSLGPGERAHSSGGTKVFPERSGSGSGS
GSGGGGDLGFLHLDCAPSNSDFFLSGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRR
KSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSH
TYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGT
SLLQVILQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEA
RLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFAD
VKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHA
HCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANK
LESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEESLLSLPE
DIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALH
VQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCA
FIVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLVLRKTCCWIN
ETYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFT
GVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETIYAGLFLRYDNLNHSGEDFLGTKE
ASLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHV
ARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFD
ELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQHCEDKWGHLCALADFSLALTESIQEINK
HSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLI
LKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRMPGQYSLAAVVLGL
VQSLNRQRQKQLLNENNNTGIIKGHYNRRTLLTPSGPEPGTQAEGTDKSDLP
NT seq 3759 nt   +upstreamnt  +downstreamnt
atggagctctccgatgtgcgctgccttagcggcagcgaggaactctacaccatccacccg
acgcccccggccggcgacggcgggagcgcctctcggccgcagcggctgctgtggcagacg
gcggtgaggcacatcaccgagcagcgcttcattcacgggcaccggggcagcggcggcggc
ggcggaagcggaggctccggcaaagcctcggaccctacaggcggcggccccaatcaccat
gcgtcgcagctgtccagcgactccgcgctgcccctctactcgctgggccccggggagaga
gcgcacagcagcggcggcaccaaagtcttcccggaacgcagcgggagcgggagcggcagc
ggcagcgggggcgggggcgacctgggcttcctgcacctcgactgcgccccgagcaactcg
gatttcttcctcagtgggggctatagctaccgaggggtcatttttcctaccctgcgcaac
tccttcaagtcccgggatctggagcgcctctaccagcgctatttcctgggccagagacgc
aaatctgaggtggtgatgaacgtgctggacgtgctcaccaaactcaccctcttggttctc
cacttgagcctggcctcagcccccatggacccgctcaagggtatcctgctgggtttcttc
actggcatcgaggtcgtgatttgcgccctggtggtggtcaggaaggacaccacctcgcac
acgtacctgcaatacagcggcgtggtcacctgggtggccatgaccacccagatcctggca
gcaggcctgggctacgggctcctgggtgatggcatcggctacgtgctctttacactcttc
gccacctacagcatgctgccactgcccctcacctgggccatcctggccggcctgggcacc
tcgctgctgcaggtcatcctccaagtggtcatcccccggctggcggtcatttccatcaac
caggttgtggcccaggcagtgttattcatgtgtatgaacacagctggaatctttatcagt
tacctgtcagaccgggcccagcgccaagccttcctggagacacggaggtgtgtggaggcc
aggctgcgcctggaaacggaaaaccaaagacaggagcggctggtgctatctgtgctcccc
cggtttgtcgtcctggaaatgatcaacgacatgaccaatgtggaagacgagcacctgcag
caccagttccatcggatctacatccatcgctacgagaacgtcagtattctttttgcagat
gttaaaggatttaccaacctctccacgaccttgtccgctcaggagctggtcaggatgctc
aacgagctctttgccagatttgatcgactagcccatgagcatcactgccttcgcatcaaa
atcctgggagactgctactactgtgtttccggacttcctgagccccgccaggaccacgcc
cactgctgcgtggaaatgggcctcagcatgatcaaaaccatcaggtatgtacggtcaagg
acaaagcatgatgttgacatgaggatcggaattcactcaggctcagtgctatgtggcgtt
ttgggactacggaagtggcagtttgatgtctggtcttgggatgtggacattgcaaacaaa
cttgaatctggaggaatcccggggaggattcacatttccaaagccacgctggactgtctc
aacggtgactataacgtggaagagggtcacgggaaagagaggaacgaattcttgaggaag
cataatatagagacctatttaattaagcagcctgaagagagtctgctgtccttgcccgaa
gacattgtcaaggagtctgtgagctcctcagacaggagaaacagtggggcgacgttcacg
gaaggatcttggagccccgaactgcccttcgataacatagtggggaaacagaacactctg
gctgccctaacaagaaattcaataaatctacttccaaaccatcttgcacaagctttgcat
gtccagtctgggcctgaggaaattaacaagagaatagaacataccatcgacttgcggagt
ggcgataaattgagaagagagcatatcaagccattctcactgatgtttaaagactccagc
ctggagcacaagtattctcaaatgagagatgaagtattcaagtcaaacttggtctgtgcg
ttcatcgttcttctatttatcacggcaatacaaagtttgcttccttcttcaagggtgatg
ccaatgaccatccagttttccatcctgattatgctgcactcagctctggtcctcatcacc
acagcagaggactataagtgtttgcccctcgtcctccggaaaacttgctgttggattaac
gagacttatttggcccggaatgtcatcatctttgcatccatcttgattaatttcctggga
gccatcctaaatattctgtggtgtgattttgacaagtcgatacccttgaagaacctgact
ttcaattcctcagctgtgtttacagatatctgctcctacccagagtactttgtcttcact
ggggtgctggccatggtgacctgtgcggttttcctccgactgaactctgtcctgaagctg
gccgtgctgctgatcatgatcgccatctacgccctgctgaccgagaccatctatgcaggt
ctctttctgcgctacgacaacctgaaccacagtggagaagatttcctggggaccaaggag
gcgtcgctgctgctgatggccatgttcctccttgctgtgttctaccacggacagcagctg
gagtacacagcccgcctggacttcctttggcgagtacaggccaaagaggagatcaatgag
atgaaggagctgagggaacacaatgagaacatgctccggaacatcttacccagtcacgtg
gcccgccatttcctggagaaagaccgagacaatgaggagctgtattctcaatcctatgat
gccgttggggtgatgttcgcctccatcccagggtttgcagacttttactctcagaccgaa
atgaataaccaaggagtggaatgcctgcgcctcctgaatgagatcattgctgactttgat
gagctgctcggcgaagaccggtttcaagacattgaaaaaattaagaccattggcagcacc
tacatggctgtgtcaggcttgtcacctgaaaaacagcactgtgaagacaagtggggccat
ctgtgtgctctggctgacttctccctcgccctgaccgaaagcatacaggagatcaacaag
cattccttcaacaactttgaactccggattggcatcagccacggctcagtggtagctggt
gtaattggcgctaagaaacctcagtatgacatttggggcaaaaccgtgaacctggcaagt
cgaatggacagcacgggggtcagcggcaggatccaagtcccagaggagacctatctcatc
ctgaaggaccagggctttgcctttgactaccgaggggagatctacgtgaaaggtatcagc
gaacaggagggaaagatcaaaacgtactttctcctgggaagagtccagcccaacccgttc
atcttgcccccgagaagaatgcccgggcagtactccttggccgcggtcgtcctgggcctc
gtccagtccctcaacaggcaaaggcagaagcagctactcaacgagaacaacaacacgggc
atcatcaagggccattacaaccggcggactttgttgacacccagtgggccagagcctgga
acccaagccgaaggcaccgacaagtccgatttgccataa

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