Equus caballus (horse): 100061987 Help Entry 100061987         CDS       T01058                                  Symbol IRS1 Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism ecb  Equus caballus (horse) Pathway ecb04022   cGMP-PKG signaling pathway ecb04068   FoxO signaling pathway ecb04081   Hormone signaling ecb04140   Autophagy - animal ecb04150   mTOR signaling pathway ecb04151   PI3K-Akt signaling pathway ecb04152   AMPK signaling pathway ecb04211   Longevity regulating pathway ecb04213   Longevity regulating pathway - multiple species ecb04722   Neurotrophin signaling pathway ecb04910   Insulin signaling pathway ecb04920   Adipocytokine signaling pathway ecb04923   Regulation of lipolysis in adipocytes ecb04930   Type II diabetes mellitus ecb04931   Insulin resistance ecb04932   Non-alcoholic fatty liver disease ecb04935   Growth hormone synthesis, secretion and action ecb04960   Aldosterone-regulated sodium reabsorption ecb05010   Alzheimer disease ecb05206   MicroRNAs in cancer ecb05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:ecb00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     100061987 (IRS1)    04022 cGMP-PKG signaling pathway     100061987 (IRS1)    04151 PI3K-Akt signaling pathway     100061987 (IRS1)    04152 AMPK signaling pathway     100061987 (IRS1)    04150 mTOR signaling pathway     100061987 (IRS1)   09133 Signaling molecules and interaction    04081 Hormone signaling     100061987 (IRS1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     100061987 (IRS1)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     100061987 (IRS1)    04923 Regulation of lipolysis in adipocytes     100061987 (IRS1)    04920 Adipocytokine signaling pathway     100061987 (IRS1)    04935 Growth hormone synthesis, secretion and action     100061987 (IRS1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     100061987 (IRS1)   09156 Nervous system    04722 Neurotrophin signaling pathway     100061987 (IRS1)   09149 Aging    04211 Longevity regulating pathway     100061987 (IRS1)    04213 Longevity regulating pathway - multiple species     100061987 (IRS1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     100061987 (IRS1)   09164 Neurodegenerative disease    05010 Alzheimer disease     100061987 (IRS1)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     100061987 (IRS1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     100061987 (IRS1)    04932 Non-alcoholic fatty liver disease     100061987 (IRS1)    04931 Insulin resistance     100061987 (IRS1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  100061987 NCBI-ProteinID:  XP_023498214 VGNC:  19141 UniProt:  F7DIR1 LinkDB All DBs Position 6:complement(14941947..15004566) Genome browser AA seq 1239 aa AA seqDB search MASPPETDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH HDGAAAPGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT RRSRTESITATSPASMVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLTAPN GHYILPRGGNGHRYVPGAGLGTSPALAGDEAASAADLDNRFRKRTHSAGTSPTISHQKTP SQSSVASIEEYTEMMPAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHPLERGGGHHR PDTSTLHTDDGYMPMSPGVAPVPGSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN GYMMMSPSGSCSPDIGGGSSSSSSAAPSGSSYGKLWTNGVGGHYSHALPHPKLPMESSGS KLLSCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGELEET ARHQHLRLSSSSGRLLYAAAAEDSSSSTSSDSLGGGYCGARSEPGLPHHLHHQVLQPHLP RKVDTAAQTNSRLARPTRLSLGDPKASTLPRARDQQQQPPLLHPPEPKSPGEYVNIEFGS DQPGYLSGPMAPHSSPSVRCPSQLQPAPREEETGPEEYMNMDLGPGRRAAWQESAGVQPG RVGPAPPGSASMCRPTRAVPSSRGDYMTMQMGCPRQSYVDTSPVAPISYADMRTGIVVEE VSLPGATAAAPSSTSAASASPAAPQGAGELGARSSLLGGPQGPGGMSAFTRVNLSPNRNQ SAKVIRADPQGCRRRHSSETFSSTPSATRAGNMVPFGAGAVVGSSGGGSSSTEDVKRHSS ASFENVWLRPGELGGAPKEPAQVCGAAGGLENGLNYIDLDLVKDFKQRPQERPSQQQPPP PPAPHQPLGSSESSSTSRSSEDLSAYASISFQKQPEDLQ NT seq 3720 nt NT seq  +upstreamnt  +downstreamnt atggcgagccctccggagaccgacggcttctcggacgtgcgcaaggtgggctacctgcgc aaacccaagagcatgcacaagcgcttcttcgtgctgcgggcggccagcgaggctgggggc ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc aaacgctcgatccccctcgagagctgcttcaacatcaacaagcgggcggactccaagaac aagcacctggtggccctctacacccgggacgagcactttgctatcgcggcggacagcgag gccgagcaggacagctggtaccaggccctcctgcagctgcacaaccgtgccaagggccac cacgacggggccgcggcccctggggcgggaggcggagggggcagctgcagcggcagctct ggcctcggcgaggcaggggaggacttgagctacggggacgtgcccccaggacctgcgttc aaagaggtctggcaggtgatcctgaaacccaagggcctgggtcagacaaagaacctgatt ggcatctaccgcctctgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag gcggcggccgtggtgctgcagctgatgaacatcaggcgctgtggccactcagagaacttc ttcttcattgaagtgggccgttccgcagtgacgggacccggggagttctggatgcaggtg gatgactctgtggtggctcagaacatgcacgagacaatcctggaggccatgcgggccatg agcgatgagttccgccctcgcagcaagagccagtcctcgtccaactgctccaaccccatc agcgtacccctgcgcaggcaccacctcaacaaccccccgcccagccaggtggggctgact cgccgctcgcgcaccgagagcatcaccgccacctccccggccagcatggtgggcgggaag cagggctccttccgtgtccgtgcttccagcgacggcgaaggcactatgtcccgtccagct tcggtggatggcagtcctgtgagtcctagcaccaacaggacccacgcccaccggcatcgg ggcagctctcggctgcacccccctctcaaccacagccgctccatccctatgccttcttct cgatgctcaccttcggccactagcccggtcagtctgtcgtccagcagcaccagtggccac ggctccacctcagactgtctcttcccgcggcggtctagtgcttctgtgtccggctccccc agcgatggcggtttcatctcctcggatgagtatggctccagtccctgcgatttccgaagt tccttccgcagtgtcaccccagattccctgggccacaccccaccggcccggggtgaggag gagttgagcaactacatctgcatgggaggcaagggggcctccaccctcactgcccccaat ggtcactacattttgcctcggggtggcaatggtcaccgctacgtcccaggagctggcttg ggcacgagtccagccctggctggagatgaagcagccagtgctgcagatctggataatcgg ttccgaaagcggactcactctgctggcacatctcctaccatttcccaccagaagacccca tcccagtcctctgtggcttccattgaggaatatacagagatgatgcctgcctacccacca ggaggtggcagtggaggccgactgcccggctaccggcactcggcctttgtgcccacccat tcctaccctgaggagggtctggaaatgcaccctttggagcgtggtgggggccaccaccgc ccagacacctcaactctccacactgatgatggctacatgcccatgtccccaggagtggcc ccagtgcctggcagccgaaagggcagtggggactatatgcctatgagccccaagagcgtg tctgccccgcagcaaatcatcaaccccatcagacgccatccccagagagtggaccccaat ggctacatgatgatgtccccaagcggcagctgctcccctgacattggaggtgggtccagc agcagcagcagtgctgccccttctgggagcagctatgggaagctatggacaaatggtgta gggggccactactctcacgccctcccacaccccaaactacccatggagagcagtgggagc aagctcttgtcttgtacaggtgactacatgaacatgtcgccagtgggggactccaacact agcagcccctctgactgctactacggccctgaggacccccagcacaagccagtactctcc tactactcattgccaaggtcctttaagcacacccagcgccctggggagctggaggagact gcccggcaccagcacctccgcctttcctccagctctggtcgccttctctatgctgcagca gcagaagattcctcttcctccaccagcagtgacagcctgggtgggggatactgtggggct agatccgagcccggcctcccacatcatctccaccatcaggtcctgcagcctcatctgcct cgaaaggtggacacagctgcgcagaccaacagccgccttgctcggcccacgaggctgtcc ctgggtgatcccaaggccagcaccttacctcgggcccgagaccagcagcagcagccaccc ctgctgcaccctccggagcccaagagcccaggggaatatgtgaatattgaatttgggagt gatcagccaggctacttatctggccccatggctccccacagctcgccttctgtcaggtgt ccatcccagctccagccagctcccagagaggaagagactggccctgaagaatacatgaac atggacttggggccgggccggagggcagcctggcaggagagcgctggggtccagcctggc agagtaggccctgcgcctcctgggtctgctagcatgtgcaggcctactcgggcagtgccc agcagccggggtgactacatgaccatgcagatgggttgtccccgtcagagctacgtggac acctcgccagttgcccccatcagctatgctgacatgcggacgggcattgttgtggaggag gtgagccttcccggggccacagcggctgctccttcctcaacctcagcagcctctgcttct cctgctgcacctcaaggggcaggggagctgggggcccgctcttccctgctggggggcccg cagggacctggtggcatgagcgccttcacccgggtgaacctcagccccaatcgcaaccag agtgccaaagtgatccgtgcggacccgcaagggtgccggaggcggcatagctccgagacc ttctcctcgacacctagtgccacccgggcgggcaatatggtgcccttcggagcgggggct gtggtggggagcagcggtggtggcagcagcagcactgaggatgtgaagcgccacagctct gcttcctttgagaacgtgtggctgaggcctggggagctcgggggagcccccaaggagcca gcccaagtgtgcggggctgctgggggtttggagaatggtcttaactacatagatctggat ttggtcaaggacttcaaacagcgccctcaggagcgcccctctcagcagcagcctccccca cccccggcccctcatcagcctcttggcagcagtgagagcagctccaccagccgctccagt gaggatttaagcgcctatgccagcatcagtttccagaagcagccagaggacctccagtag

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