Equus caballus (horse): 100070498 Help Entry 100070498         CDS       T01058                                  Symbol ADCY5 Name (RefSeq) adenylate cyclase type 5   KO K08045   adenylate cyclase 5 [EC:4.6.1.1] Organism ecb  Equus caballus (horse) Pathway ecb00230   Purine metabolism ecb01100   Metabolic pathways ecb01522   Endocrine resistance ecb04015   Rap1 signaling pathway ecb04022   cGMP-PKG signaling pathway ecb04024   cAMP signaling pathway ecb04062   Chemokine signaling pathway ecb04072   Phospholipase D signaling pathway ecb04081   Hormone signaling ecb04082   Neuroactive ligand signaling ecb04114   Oocyte meiosis ecb04211   Longevity regulating pathway ecb04213   Longevity regulating pathway - multiple species ecb04261   Adrenergic signaling in cardiomyocytes ecb04270   Vascular smooth muscle contraction ecb04371   Apelin signaling pathway ecb04540   Gap junction ecb04611   Platelet activation ecb04713   Circadian entrainment ecb04714   Thermogenesis ecb04723   Retrograde endocannabinoid signaling ecb04724   Glutamatergic synapse ecb04725   Cholinergic synapse ecb04726   Serotonergic synapse ecb04727   GABAergic synapse ecb04728   Dopaminergic synapse ecb04750   Inflammatory mediator regulation of TRP channels ecb04911   Insulin secretion ecb04912   GnRH signaling pathway ecb04913   Ovarian steroidogenesis ecb04914   Progesterone-mediated oocyte maturation ecb04915   Estrogen signaling pathway ecb04916   Melanogenesis ecb04918   Thyroid hormone synthesis ecb04921   Oxytocin signaling pathway ecb04923   Regulation of lipolysis in adipocytes ecb04924   Renin secretion ecb04925   Aldosterone synthesis and secretion ecb04926   Relaxin signaling pathway ecb04927   Cortisol synthesis and secretion ecb04928   Parathyroid hormone synthesis, secretion and action ecb04934   Cushing syndrome ecb04935   Growth hormone synthesis, secretion and action ecb04970   Salivary secretion ecb04971   Gastric acid secretion ecb04972   Pancreatic secretion ecb04976   Bile secretion ecb05012   Parkinson disease ecb05030   Cocaine addiction ecb05031   Amphetamine addiction ecb05032   Morphine addiction ecb05034   Alcoholism ecb05163   Human cytomegalovirus infection ecb05166   Human T-cell leukemia virus 1 infection ecb05200   Pathways in cancer ecb05207   Chemical carcinogenesis - receptor activation ecb05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:ecb00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     100070498 (ADCY5)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     100070498 (ADCY5)    04371 Apelin signaling pathway     100070498 (ADCY5)    04072 Phospholipase D signaling pathway     100070498 (ADCY5)    04024 cAMP signaling pathway     100070498 (ADCY5)    04022 cGMP-PKG signaling pathway     100070498 (ADCY5)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     100070498 (ADCY5)    04081 Hormone signaling     100070498 (ADCY5)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     100070498 (ADCY5)   09144 Cellular community - eukaryotes    04540 Gap junction     100070498 (ADCY5)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     100070498 (ADCY5)    04062 Chemokine signaling pathway     100070498 (ADCY5)   09152 Endocrine system    04911 Insulin secretion     100070498 (ADCY5)    04923 Regulation of lipolysis in adipocytes     100070498 (ADCY5)    04912 GnRH signaling pathway     100070498 (ADCY5)    04913 Ovarian steroidogenesis     100070498 (ADCY5)    04915 Estrogen signaling pathway     100070498 (ADCY5)    04914 Progesterone-mediated oocyte maturation     100070498 (ADCY5)    04921 Oxytocin signaling pathway     100070498 (ADCY5)    04926 Relaxin signaling pathway     100070498 (ADCY5)    04935 Growth hormone synthesis, secretion and action     100070498 (ADCY5)    04918 Thyroid hormone synthesis     100070498 (ADCY5)    04928 Parathyroid hormone synthesis, secretion and action     100070498 (ADCY5)    04916 Melanogenesis     100070498 (ADCY5)    04924 Renin secretion     100070498 (ADCY5)    04925 Aldosterone synthesis and secretion     100070498 (ADCY5)    04927 Cortisol synthesis and secretion     100070498 (ADCY5)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     100070498 (ADCY5)    04270 Vascular smooth muscle contraction     100070498 (ADCY5)   09154 Digestive system    04970 Salivary secretion     100070498 (ADCY5)    04971 Gastric acid secretion     100070498 (ADCY5)    04972 Pancreatic secretion     100070498 (ADCY5)    04976 Bile secretion     100070498 (ADCY5)   09156 Nervous system    04724 Glutamatergic synapse     100070498 (ADCY5)    04727 GABAergic synapse     100070498 (ADCY5)    04725 Cholinergic synapse     100070498 (ADCY5)    04728 Dopaminergic synapse     100070498 (ADCY5)    04726 Serotonergic synapse     100070498 (ADCY5)    04723 Retrograde endocannabinoid signaling     100070498 (ADCY5)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     100070498 (ADCY5)   09149 Aging    04211 Longevity regulating pathway     100070498 (ADCY5)    04213 Longevity regulating pathway - multiple species     100070498 (ADCY5)   09159 Environmental adaptation    04713 Circadian entrainment     100070498 (ADCY5)    04714 Thermogenesis     100070498 (ADCY5)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100070498 (ADCY5)    05207 Chemical carcinogenesis - receptor activation     100070498 (ADCY5)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     100070498 (ADCY5)    05163 Human cytomegalovirus infection     100070498 (ADCY5)   09164 Neurodegenerative disease    05012 Parkinson disease     100070498 (ADCY5)   09165 Substance dependence    05030 Cocaine addiction     100070498 (ADCY5)    05031 Amphetamine addiction     100070498 (ADCY5)    05032 Morphine addiction     100070498 (ADCY5)    05034 Alcoholism     100070498 (ADCY5)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     100070498 (ADCY5)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     100070498 (ADCY5)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     100070498 (ADCY5) Enzymes [BR:ecb01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      100070498 (ADCY5) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  AC_N Guanylate_cyc Adcy_cons_dom TBK1_ULD GBR2_CC Motif Other DBs NCBI-GeneID:  100070498 NCBI-ProteinID:  XP_001917101 Ensembl:  ENSECAG00000009948 VGNC:  15090 UniProt:  F6R9N4 LinkDB All DBs Position 19:38689973..38839402 Genome browser AA seq 1259 aa AA seqDB search MSSSKSVSPPGYAAQTAAAPASRGGPEHRSAWGEADSRANGYPHAPGGSARSSTKKPGGA VTPQQQQRLASRWRSDDDDDPPLSGDDPLVGGFGFSFRSKSAWQERGGDDCGRGSRRQRR GAAGGGSTRAPPAGGGGGSAAAAAAAGGREVRPRSVELGLEERRGKGRAADELEAGAVEG DEGSGDGGSSAGSDAGPGPVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQSSL TMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILVMAVLCNRAAFHQDHMGLAC YALIAVVLAVQVVGLLMPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHL AIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQ RENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLA SQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGM DMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAG RIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQ RTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFLGR AIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQVTI VPHSVFMLSFYLTCFLLLTLAVFVSVIYSCVKLFPVPLQTLSRKIVRSKMNSTLLGVFSI ILVFLSAFVNMFMCNSRDLFSCLAEEHNISASQVNACHVVESAVNYSLGDEQGFCGSPWP NCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLV TANAIEFNNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQA TEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSE FYVELEANNEGVECLRLLNEIIADFDEIISEDRFKQLEKIKTIGSTYMAASGLNDSTYDK VGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNT VNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS NT seq 3780 nt NT seq  +upstreamnt  +downstreamnt atgtccagctccaaaagcgtgagccccccgggctacgcggcgcagacagcggcggcgccg gcgtcccggggaggcccggaacaccgctccgcgtggggggaggccgattcccgcgccaat ggctacccccacgcccccgggggttcggcccgcagctccaccaagaaacccgggggggcg gtgaccccgcaacagcagcagcgcctggccagccgctggcgcagcgacgacgatgacgat cctccgctgagtggcgacgaccccctggtcgggggcttcggcttcagcttccgctccaag tcagcctggcaggagcgcggcggcgacgactgcggtcgcggcagccgccggcagcggcgg ggcgcggccggcgggggcagcacccgggcgccccctgcgggcggcggcggcggctcggcg gccgcggcggccgcagcgggcgggagggaggtgcgcccccgctcggtggagctgggcctg gaggagcggcggggcaagggccgcgcggccgacgagctggaggccggcgccgtcgagggc gatgagggctccggggatggcggcagctcggcgggctcggacgcgggtcccggcccggtg ctgtcgctgggcgcctgctgcctggcgctgctgcagatattccgctccaagaagttcccg tcggacaagctggagcggctgtaccagcgctactttttccgtctgaaccagagcagcctc accatgctcatggccgtgctggtgctcgtgtgcctcgtcatgttggccttccacgcggcg cggcccccgctccagctgccctacctggccgtgctggcggccgccgtgggcgtgatcctg gtcatggcggtgctctgcaaccgcgccgccttccaccaggaccacatgggcctggcctgc tacgcgctcatcgccgtggtgctggccgtccaggtggtgggcctgctgatgccccagccg cgcagcgcctccgagggcatctggtggaccgtgttcttcatctacaccatctacacgctg ctgcctgtgcgcatgcgggccgcggtactaagcggggtgctcctgtctgccctgcatctg gccattgccctgcgcaccaacgcccaggaccagttcctgctcaagcagcttgtctccaat gtcctcattttctcctgcaccaacatcgtgggtgtctgcacccactacccggccgaggtc tcccagagacaggccttccaggagacccgggagtgcatccaggcgcggctccactcacag cgggagaaccagcagcaggagcggcttctgctgtctgtccttccccgtcatgttgccatg gagatgaaagcagacatcaatgccaaacaggaggatatgatgttccacaagatttacatc cagaaacatgacaacgtgagcatcctgtttgctgacatcgagggcttcaccagcctggcg tcccagtgcactgcccaggagctggtcatgaccctcaacgagctcttcgcccgcttcgac aagctggccgcggagaaccactgtttacgtattaagatcctgggggattgttattactgt gtttcggggctgcctgaagcgagggctgaccatgcccactgctgcgtggagatgggcatg gacatgattgaggccatctcgttggtccgggaggtgacaggggtgaacgtgaacatgcgc gtgggaatccacagcgggcgagtacactgcggtgtccttggtctcaggaagtggcagttc gacgtctggtctaacgacgtcacgctagccaaccacatggaggctggaggcaaggcggga cgcatccacatcaccaaggccacactcaactacctgaacggtgactacgaggtggagcca ggctgtgggggcgagcgcaacgcctacctcaaggagcacagcatcgagaccttcctcatc ctgcgctgcacccagaagcggaaagaagagaaggccatgatcgccaagatgaatcgccag agaaccaattccatcgggcacaacccgccacactggggggccgaacgccccttctacaac cacctgggtggcaaccaggtgtccaaggagatgaagcggatgggctttgaagaccccaag gacaagaacgcccaggaaagtgcaaaccctgaggatgaagtggacgaatttctgggccgt gccattgacgccaggagcatcgacaggctgcgatctgagcatgtccgcaagttcctcttg actttcagggaacctgacttagagaagaagtactccaagcaggtggatgaccgattcggt gcctacgtggcgtgtgcctcgctggtcttcctcttcatctgctttgtccaggtcaccatc gtgccccactccgtgttcatgttgagtttctacctgacgtgtttcctgctgctgaccttg gcggtgtttgtgtccgtgatctactcctgcgtgaagctcttcccggtgcccctgcagacc ctgtccaggaaaatcgtgcggtccaagatgaacagcaccctgctcggggtgttcagcatc atcctggtgttcctgtcggcttttgtcaacatgttcatgtgcaactccagggacctgttc agctgcctggcggaggagcacaacatcagtgccagccaggtcaacgcgtgccacgtggtg gagtccgccgtcaactacagcctgggcgatgaacagggcttctgcggcagcccctggccc aactgcaacttccccgagtacttcacctacagcgtgctgctcagcctgctggcctgctcc gtgttcctgcagatcagctgcatcgggaagctggtgctcatgctggccatcgagctcatc tacgtgctcatcgtcgaggtgcccggtgtcacactctttgacaatgccgacctgctggtc accgccaacgccatcgagttcaacaacaacgggacctcccagtgccctgagcatgccacc aaggtggcgctgaaggtggtgacgcccatcatcatctcagtcttcgtgctggccctgtac ctgcacgcccagcaggtggagtccaccgcccgccttgacttcctctggaaactgcaggcc acagaggagaaggaggagatggaagagctgcaggcctacaaccgccggctgctgcacaac atcctgcccaaggacgtggccgcccacttcctggcccgcgagcggcgcaacgatgagctg tactatcagtcgtgcgagtgcgtggccgtcatgttcgcctccatcgccaacttctccgag ttctacgtggagctggaggccaacaacgagggcgtcgagtgcctgcggctgctcaacgag atcatcgccgactttgatgagatcatcagcgaggatcggttcaagcagctggaaaagatc aagaccatcggcagcacctacatggccgcctcgggcctcaacgactccacctacgacaaa gtgggcaagacccacatcaaggctctggccgacttcgccatgaagctgatggaccagatg aagtacatcaacgagcactccttcaacaacttccagatgaagatcgggctcaatatcggc cccgtggtggctggggtgatcggggcccgcaagcctcagtatgacatctggggcaatacg gtgaatgtggccagccgcatggacagcaccggtgtgcccgaccgcatccaggtcaccaca gacatgtaccaggtgctggccgccaacacttaccagctggagtgccggggtgtggtcaag gtcaagggcaaaggcgagatgatgacctacttcctcaatggagggcccccgctcagttag

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