KEGG   Equus caballus (horse): 100146348
Entry
100146348         CDS       T01058                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
ecb  Equus caballus (horse)
Pathway
ecb01521  EGFR tyrosine kinase inhibitor resistance
ecb01522  Endocrine resistance
ecb01524  Platinum drug resistance
ecb04012  ErbB signaling pathway
ecb04014  Ras signaling pathway
ecb04015  Rap1 signaling pathway
ecb04024  cAMP signaling pathway
ecb04062  Chemokine signaling pathway
ecb04066  HIF-1 signaling pathway
ecb04068  FoxO signaling pathway
ecb04070  Phosphatidylinositol signaling system
ecb04071  Sphingolipid signaling pathway
ecb04072  Phospholipase D signaling pathway
ecb04081  Hormone signaling
ecb04140  Autophagy - animal
ecb04150  mTOR signaling pathway
ecb04151  PI3K-Akt signaling pathway
ecb04152  AMPK signaling pathway
ecb04210  Apoptosis
ecb04211  Longevity regulating pathway
ecb04213  Longevity regulating pathway - multiple species
ecb04218  Cellular senescence
ecb04360  Axon guidance
ecb04370  VEGF signaling pathway
ecb04380  Osteoclast differentiation
ecb04510  Focal adhesion
ecb04550  Signaling pathways regulating pluripotency of stem cells
ecb04611  Platelet activation
ecb04613  Neutrophil extracellular trap formation
ecb04620  Toll-like receptor signaling pathway
ecb04625  C-type lectin receptor signaling pathway
ecb04630  JAK-STAT signaling pathway
ecb04650  Natural killer cell mediated cytotoxicity
ecb04660  T cell receptor signaling pathway
ecb04662  B cell receptor signaling pathway
ecb04664  Fc epsilon RI signaling pathway
ecb04666  Fc gamma R-mediated phagocytosis
ecb04668  TNF signaling pathway
ecb04670  Leukocyte transendothelial migration
ecb04722  Neurotrophin signaling pathway
ecb04725  Cholinergic synapse
ecb04750  Inflammatory mediator regulation of TRP channels
ecb04810  Regulation of actin cytoskeleton
ecb04910  Insulin signaling pathway
ecb04914  Progesterone-mediated oocyte maturation
ecb04915  Estrogen signaling pathway
ecb04917  Prolactin signaling pathway
ecb04919  Thyroid hormone signaling pathway
ecb04923  Regulation of lipolysis in adipocytes
ecb04926  Relaxin signaling pathway
ecb04929  GnRH secretion
ecb04930  Type II diabetes mellitus
ecb04931  Insulin resistance
ecb04932  Non-alcoholic fatty liver disease
ecb04933  AGE-RAGE signaling pathway in diabetic complications
ecb04935  Growth hormone synthesis, secretion and action
ecb04960  Aldosterone-regulated sodium reabsorption
ecb04973  Carbohydrate digestion and absorption
ecb05010  Alzheimer disease
ecb05017  Spinocerebellar ataxia
ecb05020  Prion disease
ecb05100  Bacterial invasion of epithelial cells
ecb05135  Yersinia infection
ecb05142  Chagas disease
ecb05146  Amoebiasis
ecb05160  Hepatitis C
ecb05161  Hepatitis B
ecb05162  Measles
ecb05163  Human cytomegalovirus infection
ecb05164  Influenza A
ecb05165  Human papillomavirus infection
ecb05166  Human T-cell leukemia virus 1 infection
ecb05167  Kaposi sarcoma-associated herpesvirus infection
ecb05168  Herpes simplex virus 1 infection
ecb05169  Epstein-Barr virus infection
ecb05170  Human immunodeficiency virus 1 infection
ecb05171  Coronavirus disease - COVID-19
ecb05200  Pathways in cancer
ecb05203  Viral carcinogenesis
ecb05205  Proteoglycans in cancer
ecb05206  MicroRNAs in cancer
ecb05207  Chemical carcinogenesis - receptor activation
ecb05208  Chemical carcinogenesis - reactive oxygen species
ecb05210  Colorectal cancer
ecb05211  Renal cell carcinoma
ecb05212  Pancreatic cancer
ecb05213  Endometrial cancer
ecb05214  Glioma
ecb05215  Prostate cancer
ecb05218  Melanoma
ecb05220  Chronic myeloid leukemia
ecb05221  Acute myeloid leukemia
ecb05222  Small cell lung cancer
ecb05223  Non-small cell lung cancer
ecb05224  Breast cancer
ecb05225  Hepatocellular carcinoma
ecb05226  Gastric cancer
ecb05230  Central carbon metabolism in cancer
ecb05231  Choline metabolism in cancer
ecb05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ecb05415  Diabetic cardiomyopathy
ecb05417  Lipid and atherosclerosis
ecb05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ecb00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100146348 (PIK3R2)
   04014 Ras signaling pathway
    100146348 (PIK3R2)
   04015 Rap1 signaling pathway
    100146348 (PIK3R2)
   04370 VEGF signaling pathway
    100146348 (PIK3R2)
   04630 JAK-STAT signaling pathway
    100146348 (PIK3R2)
   04668 TNF signaling pathway
    100146348 (PIK3R2)
   04066 HIF-1 signaling pathway
    100146348 (PIK3R2)
   04068 FoxO signaling pathway
    100146348 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    100146348 (PIK3R2)
   04072 Phospholipase D signaling pathway
    100146348 (PIK3R2)
   04071 Sphingolipid signaling pathway
    100146348 (PIK3R2)
   04024 cAMP signaling pathway
    100146348 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    100146348 (PIK3R2)
   04152 AMPK signaling pathway
    100146348 (PIK3R2)
   04150 mTOR signaling pathway
    100146348 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    100146348 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100146348 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    100146348 (PIK3R2)
   04218 Cellular senescence
    100146348 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100146348 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    100146348 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100146348 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100146348 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    100146348 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    100146348 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    100146348 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    100146348 (PIK3R2)
   04660 T cell receptor signaling pathway
    100146348 (PIK3R2)
   04662 B cell receptor signaling pathway
    100146348 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    100146348 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    100146348 (PIK3R2)
   04670 Leukocyte transendothelial migration
    100146348 (PIK3R2)
   04062 Chemokine signaling pathway
    100146348 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100146348 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    100146348 (PIK3R2)
   04929 GnRH secretion
    100146348 (PIK3R2)
   04915 Estrogen signaling pathway
    100146348 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    100146348 (PIK3R2)
   04917 Prolactin signaling pathway
    100146348 (PIK3R2)
   04926 Relaxin signaling pathway
    100146348 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    100146348 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    100146348 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100146348 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100146348 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    100146348 (PIK3R2)
   04722 Neurotrophin signaling pathway
    100146348 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100146348 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    100146348 (PIK3R2)
   04380 Osteoclast differentiation
    100146348 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    100146348 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    100146348 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100146348 (PIK3R2)
   05206 MicroRNAs in cancer
    100146348 (PIK3R2)
   05205 Proteoglycans in cancer
    100146348 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    100146348 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    100146348 (PIK3R2)
   05203 Viral carcinogenesis
    100146348 (PIK3R2)
   05230 Central carbon metabolism in cancer
    100146348 (PIK3R2)
   05231 Choline metabolism in cancer
    100146348 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100146348 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100146348 (PIK3R2)
   05212 Pancreatic cancer
    100146348 (PIK3R2)
   05225 Hepatocellular carcinoma
    100146348 (PIK3R2)
   05226 Gastric cancer
    100146348 (PIK3R2)
   05214 Glioma
    100146348 (PIK3R2)
   05221 Acute myeloid leukemia
    100146348 (PIK3R2)
   05220 Chronic myeloid leukemia
    100146348 (PIK3R2)
   05218 Melanoma
    100146348 (PIK3R2)
   05211 Renal cell carcinoma
    100146348 (PIK3R2)
   05215 Prostate cancer
    100146348 (PIK3R2)
   05213 Endometrial cancer
    100146348 (PIK3R2)
   05224 Breast cancer
    100146348 (PIK3R2)
   05222 Small cell lung cancer
    100146348 (PIK3R2)
   05223 Non-small cell lung cancer
    100146348 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100146348 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    100146348 (PIK3R2)
   05161 Hepatitis B
    100146348 (PIK3R2)
   05160 Hepatitis C
    100146348 (PIK3R2)
   05171 Coronavirus disease - COVID-19
    100146348 (PIK3R2)
   05164 Influenza A
    100146348 (PIK3R2)
   05162 Measles
    100146348 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    100146348 (PIK3R2)
   05163 Human cytomegalovirus infection
    100146348 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100146348 (PIK3R2)
   05169 Epstein-Barr virus infection
    100146348 (PIK3R2)
   05165 Human papillomavirus infection
    100146348 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100146348 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    100146348 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100146348 (PIK3R2)
   05142 Chagas disease
    100146348 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100146348 (PIK3R2)
   05017 Spinocerebellar ataxia
    100146348 (PIK3R2)
   05020 Prion disease
    100146348 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100146348 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    100146348 (PIK3R2)
   05415 Diabetic cardiomyopathy
    100146348 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100146348 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    100146348 (PIK3R2)
   04931 Insulin resistance
    100146348 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100146348 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100146348 (PIK3R2)
   01524 Platinum drug resistance
    100146348 (PIK3R2)
   01522 Endocrine resistance
    100146348 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ecb04131]
    100146348 (PIK3R2)
Membrane trafficking [BR:ecb04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100146348 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 Ribosomal_L22e ATG11 SH3_1 SH3_9
Other DBs
NCBI-GeneID: 100146348
NCBI-ProteinID: XP_023481250
UniProt: A0A3Q2KJF6
LinkDB
Position
21:3494066..3503917
AA seq 723 aa
MAGAEGFQYRALYRFRRERPEDLELLPGDVLVVSRAALQALGVAEGSERCPQSVGWMPGF
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGPPEPGLTLPDLPEQFSP
PDAAPPILVKLVEAIEQTGLDGDSLYRPEPPAPRTDWSLSDVEQWDAAALSDGVKGFLLA
LPAPLVTPEAAAEAHRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRLARRAPAPG
PAVRALGAAFGPLLLRAPPPSPPPGGAPDGTEPGPDFPGLLVEKLLQEHLEEQEVAPPAL
PPKPPKAKPAPTGVANGGSLPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQ
GEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFGSVVDLITHYRHESLAQYNAKLDTRLL
YPVSKYQQDQIVKEDSVEAVGAQLRVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIE
AFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKL
EQELRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETE
DQYALMEDEEDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVD
GDTKHCVIYRTATGFGFAEPYNLYGSLRELVLHYQHTSLLQHNDALAVTLAHPVRAPAPA
PAR
NT seq 2172 nt   +upstreamnt  +downstreamnt
atggctggtgctgaaggcttccaataccgggcgctttaccggttccgccgggagcggccc
gaggacctagagctgctgccgggcgacgtgctggtggtgagccgggcagccttgcaggcg
ctgggcgtggcggagggcagtgagcgctgcccgcagagtgtgggctggatgcctggcttc
aacgagcgcacgcggcagcgtggcgacttccccggcacctacgttgagttcctggggccc
gtggccctggcccggcctggccctcgcccccgaggcccccgcccactgcctgccaggccc
cgagatggacccccggagccaggcctcacactccccgacctgcctgagcagttctcccca
cctgatgcggctcctcccatcctggtgaagctcgtggaagccattgagcagacagggcta
gacggtgactccctctacaggccggagccgcccgccccgcgcacagactggtccctgagc
gacgtggagcagtgggacgcggccgctctgtcagacggcgtcaagggtttcctgctggcg
ctgcccgcgcccctcgtgacgcccgaggcggcggccgaggcgcaccgggccctgagggag
gccgcggggcccgtgggaccggcgctggagccgccgacgctgccgctgcaccgcgcgctc
acgctgcgcttcctgctccagcacctgggccgcctggcgcggcgcgcccccgccccgggc
cccgccgtgcgcgcgctgggcgcggccttcgggccgctgctgctgcgcgcgccgccgccc
tcgccgccgccagggggcgcgcccgacggcactgagcccggcccagacttcccagggctg
ctggtggagaagttgcttcaggagcatctggaggagcaggaggtggcacccccagcacta
ccacctaaaccccccaaggcaaagccggcccccacaggtgtggccaatggggggagcctg
ccctccctgcaggatgctgagtggtactggggcgacatctccagggaggaggtgaatgag
aaactccgggacacgcctgatggcacctttctggtccgagatgcctccagcaagatccag
ggggagtacacgctgaccctcaggaaaggcgggaacaacaagctgattaaagttttccac
cgtgacgggcactatggcttctcggagccgctgaccttcggctccgtggtggatctcatc
acccactaccgccatgagtcgttggcccagtacaacgccaaactggacacgcggctcctc
taccccgtgtccaagtaccagcaggaccagatcgtcaaggaggacagcgtggaggcggtg
ggtgctcagctcagggtctaccaccagcagtaccaggacaagagccgcgagtacgaccag
ctgtacgaggagtacacgcgcacctcccaggaactgcagatgaagcgcacagcaattgaa
gctttcaatgagacgattaagatctttgaagagcagggccagacacaagagaagtgcagc
aaggaatatctggagcgcttccggcgtgagggcaatgagaaggagatgcaaaggatcctg
ctgaactcagagcggctcaagtctcgcatcgctgagatccacgagagccgcacaaagctg
gagcaggagctgcgtgcacaggcctcagacaaccgggagattgacaagcgcatgaacagc
ctcaagccagacctcatgcagctgcgcaagatccgagaccagtacctcgtgtggcttacc
cagaaaggcgcccggcagaagaaaatcaacgagtggttggggatcaaaaacgagactgag
gaccaatatgcgctgatggaggatgaggaggacctcccccaccatgaggagcgcacgtgg
tatgtgggcaagatcaaccgcacgcaggccgaagaaatgctgagtggcaagcgggatggc
accttcctcatccgcgagagcagccagcggggctgctatgcctgctcggtggtggtggac
ggcgacaccaagcactgcgtcatctaccgcacggccacgggcttcggcttcgcggagccc
tacaacctgtacggctcgctgcgggagctggtgctgcactaccagcacacgtcgctgctg
cagcacaacgacgcgctcgccgtcacgctcgcccacccggtgcgcgcgcccgcgcccgcg
cccgcgcgctga

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