Escherichia coli O127 H6 E2348/69 (EPEC): E2348C_4321
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Entry
E2348C_4321 CDS
T00796
Symbol
metH
Name
(GenBank) homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent
KO
K00548
5-methyltetrahydrofolate--homocysteine methyltransferase [EC:
2.1.1.13
]
Organism
ecg
Escherichia coli O127:H6 E2348/69 (EPEC)
Pathway
ecg00270
Cysteine and methionine metabolism
ecg00450
Selenocompound metabolism
ecg00670
One carbon pool by folate
ecg01100
Metabolic pathways
ecg01110
Biosynthesis of secondary metabolites
ecg01230
Biosynthesis of amino acids
ecg04981
Folate transport and metabolism
Module
ecg_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:
ecg00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
E2348C_4321 (metH)
09106 Metabolism of other amino acids
00450 Selenocompound metabolism
E2348C_4321 (metH)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
E2348C_4321 (metH)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
E2348C_4321 (metH)
04980 Cobalamin transport and metabolism
E2348C_4321 (metH)
Enzymes [BR:
ecg01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.13 methionine synthase
E2348C_4321 (metH)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Met_synt_B12
S-methyl_trans
Pterin_bind
B12-binding_2
B12-binding
Motif
Other DBs
NCBI-ProteinID:
CAS11869
UniProt:
B7UPG9
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All DBs
Position
4550737..4554420
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AA seq
1227 aa
AA seq
DB search
MSSKVEQLCAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSK
PEVISAIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTA
RTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILI
ETVFDTLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA
LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAE
AGFLNIVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVG
ERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLI
AGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAV
VVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPAEDIIFDPNIFAVATGIEEHNNYAQ
DFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAG
QLAIYDDLPTELRDAVEDVILNRRDDGTERLLELAEKYRGSKTDDTANTQQAEWRSWVVN
KRLEYSLVKGITEFIEQDTEEARQQATRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
SARVMKQAVAYLEPFIEASKEQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDL
GVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKA
HTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPR
TPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKY
PRILEDEVVGVEAQRLFKDANDMLDKLSAEKMLNPRGVVGLFPANRVGDDIEIYRDETRT
HVINVSHHLRQQTEKTGFANYCLADFVAPKVSGKADYIGAFAVTGGLEEDALADAFEAQH
DDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYP
ACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQV
EDYARRKGMSVTEVERWLAPNLGYDAE
NT seq
3684 nt
NT seq
+upstream
nt +downstream
nt
gtgagcagcaaagtggaacaactgtgtgcgcagttaaatgaacgtattctggtgctggac
ggcggtatgggcaccatgatccagagctatcgactgaacgaagccgattttcgtggtgaa
cgctttgccgactggccatgcgatctcaaaggcaacaacgacctgctggtgctcagcaaa
ccggaagtgatctctgctatccacaacgcttactttgaagcgggtgcggatatcatcgaa
accaacaccttcaactccacgaccattgcgatggcggattaccagatggaatccctgtcg
gcggaaatcaactttgcggcggcgaaactggcgcgcgcctgtgctgacgagtggactgcc
cgcacgccggagaaaccgcgctacgttgccggtgttctcggcccgaccaaccgcacggcg
tctatttctccggacgtcaacgatccggcattccgcaacatcacttttgaccagctggtg
gcggcttatcgagaatccaccaaagcgctggtggaaggtggcgcggatctgatcctgatt
gaaaccgtttttgacacccttaacgccaaagcagcggtctttgcggtgaaaacagagttc
gaagcgctgggcgttgagctgccgattatgatctccggcaccatcaccgacgcctccggg
cgcacgctctccgggcagaccactgaagcattttacaattcattgcgccacgccgaagcg
ctgacctttggcctgaactgtgcgctggggccagacgaactgcgccagtacgtacaggaa
ctgtcgcgtattgcggaatgctatgtcaccgcccacccgaacgccgggctgcccaacgcc
tttggtgaatacgatctcgacgccgacacgatggcaaaacagatacgtgaatgggcagaa
gcaggctttctcaatatcgtcggcggctgctgcggcaccacgccacaacatattgcagcg
atgagtcgtgcagtagaaggattagcgccgcgcaaactgccggaaattcccgtagcctgc
cgtttgtccggcctggagccgctgaacattggcgacgatagcctgtttgtgaacgtgggt
gaacgcaccaacgtcaccggttccgctaagttcaaacgcctgatcaaagaagagaaatac
agcgaggcgctggatgtggcgcgtcagcaggtggaaaacggtgcgcagattatcgatatc
aacatggatgaagggatgctcgacgccgaagcggcgatggtgcgttttctcaatctgatt
gccggtgaaccggatatcgctcgcgtgccgataatgatcgactcctcaaaatgggacgtt
attgaaaaaggtctaaagtgtatccagggcaaaggcattgttaactctatctcgatgaaa
gagggtgtcgacgcttttatccatcacgcgaaattgttgcgtcgttacggtgcggcagtc
gtggtaatggcttttgacgaacagggccaggccgatacccgcgcacggaaaatcgagatt
tgccgtcgggcgtacaaaatcctcaccgaagaggttggcttcccggctgaagatatcatc
ttcgacccgaacatcttcgcggtcgcaactggcattgaagagcacaacaattacgcgcag
gactttatcggcgcgtgtgaagacatcaaacgtgaactgccgcacgcactgatttccggc
ggcgtttctaacgtttctttctcattccgtggcaacgatccggtgcgcgaagccattcac
gcggtgttcctctactacgctattcgcaatggcatggatatggggatcgtcaacgccggg
caactggcgatttacgacgacctgcctaccgagctacgcgacgcggtggaggatgtgatc
ctcaaccgtcgcgacgatggcaccgagcgtttactcgagcttgccgagaaatatcgcggc
agcaaaaccgacgacaccgctaacacccagcaggcggagtggcgctcgtgggtagtgaat
aaacgtctggaatactcgctggtcaaaggcattaccgagtttatcgagcaggataccgaa
gaagcccgccagcaggctacgcgtccgattgaagtgattgaaggcccgttgatggacggc
atgaacgtggtcggcgacctgtttggcgagggcaaaatgttcctgccgcaggtggtgaaa
tcggcgcgcgtcatgaaacaggcggtggcgtatctcgaaccgtttattgaagccagcaaa
gagcagggtaaaaccaacggcaagatggtgatcgccaccgtgaaaggcgatgtccacgac
atcggtaaaaatatcgttggcgtggtgctgcaatgtaacaactacgaaattgtcgatctc
ggcgtgatggtgcctgcggaaaaaattctccgtaccgctaaagaagtgaatgctgatttg
attggcctttcagggctgatcacgccgtcgctggacgagatggttaacgtggcgaaagag
atggagcgtcagggcttcaccattccgctattgattggcggcgcgaccacctcaaaagcg
cacacggcggtgaaaatcgagcagaactacagcggcccgacggtgtatgtgcagaacgca
tcgcgcaccgttggtgtggtggcggcgttgctttccgacactcagcgcgatgatttcgtt
gctcgtacccgcaaggagtacgaaaccgtgcgtattcagcacggacgaaagaaaccacgc
acaccaccggtcacgctggaagcggcgcgtgataacgacttcgcttttgactggcaggct
tacacgccgccggtggcgcaccgtctcggtgtgcaggaagtcgaagccagcatcgaaacg
ctgcgtaattacatcgactggacgccgttctttatgacctggtcgctggccgggaagtat
ccgcgcattctggaagatgaagtggtaggtgttgaggcgcagcggctgtttaaagacgcc
aacgacatgctggataaattaagcgccgaaaaaatgctgaacccgcgtggtgtggtgggc
ctgttcccggcaaaccgtgtgggcgatgacattgaaatctaccgtgacgaaacgcgtacc
catgtgattaatgtcagccaccatctacgccaacagaccgaaaaaaccggcttcgctaac
tactgtctcgctgacttcgttgcgccgaaggtttccggcaaagcggattacatcggcgca
tttgccgtgactggcgggctggaagaggacgcactggctgatgcctttgaagcacagcat
gatgattacaacaaaatcatggtgaaagcgcttgccgaccgcctggcggaagcctttgcg
gagtatctccatgagcgtgtgcgtaaagtctactggggctatgcgccgaacgagaacctc
agcaacgaagagctgatccgcgaaaactaccagggcatccgtccggcaccgggctaccct
gcctgcccggaacatacggaaaaagccacaatctgggagctgctggaagtggaaaaacat
accggtatgaaactcacggaatccttcgccatgtggccgggtgcatcggtttcgggttgg
tacttcagtcatccagacagcaagtattacgcggtggcgcaaattcagcgcgatcaggtt
gaagactatgcccgccgtaaaggaatgagcgttaccgaagtcgagcgttggttggcaccg
aatctggggtatgatgccgagtaa
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