KEGG   Enterobacter cloacae ECNIH2: ECNIH2_02015
Entry
ECNIH2_02015      CDS       T03471                                 
Symbol
metH
Name
(GenBank) B12-dependent methionine synthase
  KO
K00548  5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]
Organism
ecle  Enterobacter cloacae ECNIH2
Pathway
ecle00270  Cysteine and methionine metabolism
ecle00450  Selenocompound metabolism
ecle00670  One carbon pool by folate
ecle01100  Metabolic pathways
ecle01110  Biosynthesis of secondary metabolites
ecle01230  Biosynthesis of amino acids
ecle04981  Folate transport and metabolism
Module
ecle_M00017  Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:ecle00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    ECNIH2_02015 (metH)
  09106 Metabolism of other amino acids
   00450 Selenocompound metabolism
    ECNIH2_02015 (metH)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    ECNIH2_02015 (metH)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    ECNIH2_02015 (metH)
   04980 Cobalamin transport and metabolism
    ECNIH2_02015 (metH)
Enzymes [BR:ecle01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.13  methionine synthase
     ECNIH2_02015 (metH)
SSDB
Motif
Pfam: Met_synt_B12 S-methyl_trans Pterin_bind B12-binding_2 B12-binding
Other DBs
NCBI-ProteinID: AIE62180
LinkDB
Position
414158..417841
AA seq 1227 aa
MSSKVEQLRAQLNERILVLDGGMGTMIQGYRLSEDDFRGERFADWPCDLKGNNDLLVLSK
PSVIRDIHNAYFEAGADIVETNTFNSTTIAMADYQMESLSAEINFEAAKLARACADEWTA
RTPDKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGSDLILI
ETVFDTLNAKAAIYAVKEEFEALGVDLPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA
LSFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAAQIREWAE
SGFLNIVGGCCGTTPEHIAAMSRAVAGLPPRKLPELPVACRLSGLEPLTIGDDSLFVNVG
ERTNVTGSAKFKRLIKEEKYSEALDVARQQVESGAQIIDINMDEGMLDAEAAMVRFLNLI
AGEPDIARVPIMIDSSKWVVIEKGLKCIQGKGIVNSISMKEGVDTFIHHAKLVRRYGAAV
VVMAFDEVGQADTRERKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQ
DFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAG
QLAIYDDLPAELRDAVEDVILNRRDDATERMLDLAEKYRGSKSDESANVQQAEWRSWDVN
KRLEYSLVKGITEFIEQDTEEARQQAARPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
SARVMKQAVAYLEPFIEASKEKGSSNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIIDL
GVMVPADKILRTAREVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKA
HTAVKIEQNYSGPTVYVQNASRTVGVVSALLSDTQRDDFVARTRKEYETVRIQHGRKKPR
TPPVSLQAARDNDLAFDWSSYTPPVAHRLGVQDVTASIETLRNYIDWTPFFMTWSLAGKY
PRILEDEVVGEEAKRLFKDANDMLDRLSAEKALNPRGVVGLFPANRVGDDVEIYRDETRT
HVLAVSHHLRQQTEKVGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAYDAQH
DDYNKIMVKAIADRLAEAFAEYLHERVRKVHWGYAANENLSNEELIRENYQGIRPAPGYP
ACPEHTEKGTIWKLLDVEAHTGMKLTESFAMWPGASVSGWYFSHPDSKYFAVAQLQRDQI
EDYALRKGMSVSEVERWLAPNLGYDAD
NT seq 3684 nt   +upstreamnt  +downstreamnt
gtgagcagcaaagtagagcaactgcgtgcgcagttaaatgaacgaattctggtgctggac
ggcggcatgggcaccatgatccagggctatcgtctgagtgaagacgatttccgcggcgag
cgctttgccgactggccttgtgacctgaaagggaacaatgacctgctggtgttaagcaaa
ccgtctgttatcagggatatccacaacgcttacttcgaagcgggtgcggatattgttgaa
accaacaccttcaactcgacaaccatcgccatggcggattaccagatggaatccctgtcg
gcggagatcaactttgaagcggcgaagctggcgcgcgcctgcgccgacgaatggacggcc
cgtacgccggacaagccgcgctacgtagccggggtgctgggcccaaccaaccgcaccgcg
tcgatttctccggacgtcaacgacccggcgtttcggaacatcacctttgaccagctggtg
gccgcgtatcgtgagtccactaaagcgctggtggaaggcggctccgacctgatcctgatt
gaaaccgtattcgacaccctcaacgctaaagccgcgatttacgcggtgaaagaggagttc
gaggcgctgggcgtcgacctgccgatcatgatttccggcaccatcaccgacgcctcgggg
cgcacactttccggccagacaaccgaagcgttttataactccctgcgccacgccgaagcg
ctctcctttggcctcaactgtgcgctggggccggacgagctgcgccagtacgtgcaggag
ctttcgcgcatcgcagagtgctacgtcaccgcccacccgaacgccggtctgccgaacgcg
tttggtgagtacgatctggatgccgacaccatggcggcgcaaatccgcgaatgggccgaa
tctggtttcctcaacatcgtcggcggctgctgcggcaccacgccggagcatatcgccgcc
atgagccgcgccgtcgccgggcttccaccgcgcaagctacccgagcttccggtagcctgt
cgtctgtccggcctggagccgttgaccatcggcgacgacagcctgtttgtgaacgtgggt
gaacgtactaacgttaccggttctgcgaagttcaagcgcctgatcaaagaagagaagtac
agcgaagcgctggacgttgctcgccagcaggtagaaagcggggcgcagatcatcgatatc
aacatggatgaggggatgctcgatgccgaagcggcaatggtgcgtttcctcaacctgatt
gccggtgagccggatatcgcccgcgtgccgatcatgattgactcctccaagtgggtggtc
atcgaaaaagggctgaagtgcattcagggcaaaggcatcgttaactccatctcgatgaaa
gagggcgtcgatacctttatccaccacgcgaagctggtccgtcgctacggagccgccgtg
gtggtgatggccttcgatgaagtgggccaggccgatacccgcgaacgcaaaattgagatt
tgccgccgcgcgtacaaaattttgaccgaagaggtgggtttcccgccggaagacatcatc
ttcgacccgaacatcttcgccgtcgcgaccggcatcgaagagcacaacaactacgctcag
gacttcatcggcgcgtgtgaagacattaaacgcgagctaccgcatgcgctgatctccggc
ggcgtgtcgaacgtgtcgttctcgttccgcggcaatgacccggtgcgtgaggcgatccac
gccgtgttcctttactacgccatccgcaacgggatggacatggggatcgtcaacgctggc
cagctggcaatttacgacgatctgccagccgagctgcgcgacgccgtagaagacgtgatc
ctcaatcgtcgtgacgacgccaccgaacgcatgctggatctggcggaaaaataccgcggc
agtaaatctgacgaatcagccaacgttcaacaggccgaatggcgctcctgggatgtgaat
aagcgtctggaatactcgctggtaaaaggcattaccgagtttatcgagcaggataccgag
gaagcgcgtcagcaggccgcccgtccgattgaagtgatcgaagggccgctgatggacggc
atgaacgtggtcggcgatctgttcggcgagggcaaaatgttcctgccgcaggtggtgaaa
tccgcccgcgtcatgaagcaggcggtggcgtatctggaaccctttatcgaagccagcaaa
gagaagggctccagtaacggtaaaatggtcatcgccaccgtgaagggcgacgtacacgac
atcggcaaaaacatcgttggcgtggtgttgcagtgtaataactacgaaattatcgatctt
ggcgtgatggtcccggcggataaaatcctcaggaccgcgcgcgaagtgaatgcggatctg
attggtctttccgggctgattacgccttcgcttgacgaaatggtcaacgtggcaaaagag
atggagcgccagggctttaccattccactgctgattggcggggcaaccacctcgaaagcc
cacacggcggtgaaaatcgagcagaactacagtgggccgacggtgtatgttcaaaacgcc
tcgcgcactgtgggcgtggtctccgcgctgctgtccgacacccagcgcgatgactttgtc
gcccgcacccgcaaagagtatgaaaccgtccgcattcagcatggacgtaagaaaccgcgc
acgccgccggtttcgcttcaggcggcgcgcgataacgatctggcgttcgactggtccagc
tatacgccgccggtcgcacaccgtctgggcgtgcaggacgtgacggccagcatcgaaacg
ctgcgtaactacatcgactggacgccgttcttcatgacctggtcgctggcgggcaaatat
ccgcgcattcttgaagatgaggtggtgggcgaagaggcgaagcgcctgtttaaagatgct
aacgacatgctcgacaggctgagcgcagagaaagccctcaacccgcgcggcgtggtgggg
ctgttcccggcgaaccgcgtgggcgacgacgtggaaatctaccgcgatgaaacccgcacc
cacgtgctggccgtgagccaccacctgcgccagcaaaccgagaaagtgggctttgccaac
tactgcctggcggatttcgtcgcaccgaaactctccggtaaagccgactatatcggcgcc
tttgccgtaaccggtggtctggaagaagacgcgctggcggatgcgtacgacgcgcagcac
gatgattacaacaaaatcatggtgaaagcgatcgccgaccgtctggcggaagccttcgct
gaatatctgcatgaacgcgtacgtaaggtgcactggggctacgcggcgaatgagaatctc
agcaacgaggagctgatccgcgaaaattaccagggcattcgtccggcgccggggtatccg
gcctgcccggaacacacagaaaagggcactatctggaagttgctggacgtcgaagcgcat
actggcatgaagctcaccgagtcgttcgccatgtggccgggcgcgtccgtttccggctgg
tatttcagccacccggacagcaagtacttcgccgtggcacagcttcagcgcgatcagatt
gaggattacgccctgcgtaaaggcatgagcgtgtcagaggtggaacgctggctggcgccg
aatttgggctacgacgcagactaa

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