KEGG   Enterobacter cloacae ECNIH4: ECNIH4_21595
Entry
ECNIH4_21595      CDS       T03486                                 
Symbol
metH
Name
(GenBank) B12-dependent methionine synthase
  KO
K00548  5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]
Organism
ecln  Enterobacter cloacae ECNIH4
Pathway
ecln00270  Cysteine and methionine metabolism
ecln00450  Selenocompound metabolism
ecln00670  One carbon pool by folate
ecln01100  Metabolic pathways
ecln01110  Biosynthesis of secondary metabolites
ecln01230  Biosynthesis of amino acids
ecln04980  Cobalamin transport and metabolism
ecln04981  Folate transport and metabolism
Module
ecln_M00017  Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:ecln00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    ECNIH4_21595 (metH)
  09106 Metabolism of other amino acids
   00450 Selenocompound metabolism
    ECNIH4_21595 (metH)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    ECNIH4_21595 (metH)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    ECNIH4_21595 (metH)
   04980 Cobalamin transport and metabolism
    ECNIH4_21595 (metH)
Enzymes [BR:ecln01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.13  methionine synthase
     ECNIH4_21595 (metH)
SSDB
Motif
Pfam: Met_synt_B12 S-methyl_trans Pterin_bind B12-binding_2 B12-binding
Other DBs
NCBI-ProteinID: AIX56694
UniProt: A0A6S5JDZ9
LinkDB
Position
complement(4526059..4529742)
AA seq 1227 aa
MSSKVEQLRAQLNERILVLDGGMGTMIQGYRLSEDDFRGERFADWPCDLKGNNDLLVLSK
PSVIKDIHNAYFEAGADIVETNTFNSTTIAMADYQMESLSAEINFEAAKLARACADEWTA
RTPDKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGSDLILI
ETVFDTLNAKAAIYAVKEEFEALGVDLPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA
LSFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAAQIREWAE
SGFLNIVGGCCGTTPEHIAAMSNAVAGLPPRKLPELPVACRLSGLEPLTIGDDSLFVNVG
ERTNVTGSAKFKRLIKEEKYSEALDVARQQVESGAQIIDINMDEGMLDAEAAMVRFLNLI
AGEPDIARVPIMIDSSKWEVIEKGLKCIQGKGIVNSISMKEGVDIFIHHAKMVRRYGAAV
VVMAFDEVGQADTRERKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQ
DFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAG
QLAIYDDLSAELRDAVEDVILNRRDDATERMLDLAEKYRGSKTDESANVQQAEWRSWDVK
KRLEYSLVKGITEFIEQDTEEARQQAARPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
SARVMKQAVAYLEPFIEASKEKGSSNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIIDL
GVMVPADKILKTAREVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKA
HTAVKIEQNYSGPTVYVQNASRTVGVVSALLSDTQRDDFVARTRKEYETVRIQHGRKKPR
TPPVSLQAARDNDLAFDWSSYTPPVAHRLGVQDVTASIETLRNYIDWTPFFMTWSLAGKY
PRILEDEVVGEEAKRLFKDANDMLDKLSAEKSLNPRGVVGLFPANRVGDDVEIYRDETRT
HVLTVSHHLRQQTEKVGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALAEAFEAQH
DDYNKIMVKAIADRLAEAFAEYLHERVRKVYWGYAANENLSNEELIRENYQGIRPAPGYP
ACPEHTEKGTIWKLLDVEAHTGMKLTESFAMWPGASVSGWYFSHPDSKYFAVAQLQRDQI
EDYALRKGMSVSEVERWLAPNLGYDAD
NT seq 3684 nt   +upstreamnt  +downstreamnt
gtgagcagcaaagtagagcaactgcgtgcgcagttaaatgaacgaattctggtgctggac
ggcggcatgggcacgatgatccagggctatcgtctgagtgaagacgatttccgcggcgaa
cgcttcgctgactggccttgcgatctgaaaggtaacaacgacctgctggtgctcagcaag
ccgtccgtcattaaggatatccacaatgcctacttcgaggcaggggcagatatcgttgaa
accaacacctttaactcgacaaccatcgccatggcggattaccagatggaatccctgtcg
gcggagatcaactttgaggcggctaaactggctcgtgcctgcgcagatgaatggactgcc
cgcacgccggacaaaccgcgctacgttgccggggtgcttggcccaaccaaccgcaccgca
tcaatctcaccggacgtcaacgacccggcatttcgtaatatcacctttgaccagctggtc
gctgcctaccgtgaatcgaccaaagcgctggtggaaggcggttccgacctgatcctgatt
gaaacggttttcgacaccctcaacgccaaagccgcgatttacgcggtgaaagaggagttc
gaggcactgggcgttgacctgccgatcatgatttccggcaccattaccgacgcctccggc
cgtaccctgtccggccagaccaccgaagcgttttataactccctgcgccacgcggaagcg
ctctcctttggcctgaactgtgctctggggccagatgaactgcgccagtacgtgcaggag
ttatcgcgcatcgcagaatgctatgtcaccgcgcacccgaacgccggtctgcccaatgcc
tttggtgaatacgatctggatgccgacaccatggcggcgcaaatccgcgagtgggctgaa
tctggcttcctgaacattgttggcggctgctgcggcaccacgccggaacacattgccgcc
atgagcaacgccgtggccgggctgccgccgcgtaagctgcctgagcttcccgttgcctgt
cgtctttctggtctcgagccgttgaccattggtgacgacagcctgtttgtgaacgtgggt
gagcggactaacgttaccggttccgcgaagttcaaacgtctgatcaaagaagagaaatac
agcgaagcgctggacgtcgcccgccagcaggtggaaagcggcgcacagattattgatatc
aacatggacgaggggatgctcgacgccgaagcggcgatggtgcgtttcctcaacctgatt
gccggcgagccggacattgcccgcgtgccgatcatgatcgactcctccaagtgggaggtc
atcgaaaaagggctgaagtgcattcagggtaaaggcatcgtcaactctatctcgatgaaa
gagggcgttgatatctttatccaccacgcgaagatggtccgccgctacggtgccgccgtg
gtggtcatggccttcgacgaagtgggccaggcggatacccgcgagcgtaaaattgagata
tgccgccgcgcgtacaagattttgaccgaagaggtgggtttcccgccggaagacatcatc
ttcgatccgaacattttcgccgtcgcgaccgggattgaagagcataacaactatgcccag
gactttatcggcgcatgtgaagacattaaacgtgaattgccgcatgcgttaatctccggc
ggcgtgtcgaacgtgtcgttctcgttccgcggcaacgacccggtgcgtgaagcgatccac
gccgtgttcctctactacgccatccgcaacgggatggacatggggatcgttaacgctggc
cagctggcgatttacgatgacctctctgccgagcttcgcgacgcggtagaagatgtcatc
cttaaccgtcgcgacgacgccaccgagcgcatgctggacctcgcggagaaataccgcggc
agcaaaacggatgaatcggccaacgttcagcaggccgagtggcgttcctgggacgtgaaa
aagcgtctggaatattcgctggtgaaaggcatcaccgagtttattgagcaggacaccgaa
gaagcgcgccagcaggcagcccgcccgattgaggtgatcgaaggcccgctgatggacggc
atgaacgtggtcggcgatctgttcggcgagggaaaaatgttcctgccgcaggtggtgaaa
tctgcccgcgtgatgaagcaggccgtggcctatctggagccgtttatcgaggccagcaaa
gagaaaggctccagcaacggcaagatggtcatcgccaccgtgaagggcgacgtgcacgac
atcggcaagaatatcgtcggcgtggtgctgcagtgcaataactacgaaattatcgacctc
ggggtaatggtcccggcggataaaatcctcaaaaccgcgcgtgaggtgaatgccgacctg
attggcctttccgggctgatcacgccgtcgctggacgagatggtcaacgtggcgaaagag
atggagcgtcagggcttcactattccgctgctgattggcggagcgaccacctcgaaagcc
catactgcggtgaaaatcgagcagaactacagcggcccgacggtctatgtgcagaacgcc
tcgcgcaccgtaggcgtggtgtccgcgctgctctccgacacccagcgcgatgacttcgtg
gcgcgcacccgcaaagagtacgaaaccgtccgcatccagcacggtcgtaagaaaccgcgc
acgccgccggtttcacttcaggcggcgcgcgataacgatctggcgtttgactggtcgagt
tataccccgccggtcgcgcatcgtctgggcgtgcaggacgtcaccgccagcatcgaaacg
ctgcgtaactacatcgactggacgccgttcttcatgacatggtcgctggcgggcaaatat
ccgcgcatcctcgaggatgaggtggtaggtgaagaggcgaagcggttgtttaaagatgcc
aatgacatgctcgacaagctgagtgcagagaaatccctcaatccgcgcggcgtggtgggg
ctgttcccggcgaaccgcgtgggtgacgatgtggaaatctaccgcgatgaaacccgcacg
catgtgctgaccgtgagccatcacctgcgtcagcaaacggagaaagtgggcttcgccaac
tactgtctggcggatttcgtcgcaccgaaactgagtggcaaagccgactatatcggcgcc
tttgcggtaaccggcggcctggaagaagatgcgctggcggaggcattcgaagcgcagcat
gatgattacaacaaaatcatggtcaaagcgattgccgaccgcctggcggaagccttcgct
gagtatctgcatgagcgcgtacgtaaggtgtactggggctacgcggccaatgaaaacctc
agcaacgaggagctgatccgcgaaaactaccagggcattcgcccggccccgggctatccg
gcctgcccggagcacaccgaaaaaggcaccatctggaaacttctcgatgttgaggcccat
acggggatgaaactcaccgagtcgtttgccatgtggccgggtgcctccgtctcaggctgg
tacttcagccacccggacagcaagtactttgccgtggcgcagctacagcgcgatcagatc
gaagattacgccctgcgcaaaggcatgagcgtgtcagaagtcgagcgctggctggcgcct
aatctcggctacgacgccgactaa

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