Escherichia coli K-12 MG1655: b3940
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Entry
b3940 CDS
T00007
Symbol
metL
Name
(RefSeq) fused aspartate kinase/homoserine dehydrogenase 2
KO
K12525
bifunctional aspartokinase / homoserine dehydrogenase 2 [EC:
2.7.2.4
1.1.1.3
]
Organism
eco
Escherichia coli K-12 MG1655
Pathway
eco00260
Glycine, serine and threonine metabolism
eco00261
Monobactam biosynthesis
eco00270
Cysteine and methionine metabolism
eco00300
Lysine biosynthesis
eco01100
Metabolic pathways
eco01110
Biosynthesis of secondary metabolites
eco01120
Microbial metabolism in diverse environments
eco01230
Biosynthesis of amino acids
Module
eco_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
eco_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
eco_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
eco00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
b3940 (metL)
00270 Cysteine and methionine metabolism
b3940 (metL)
00300 Lysine biosynthesis
b3940 (metL)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
b3940 (metL)
Enzymes [BR:
eco01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
b3940 (metL)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
b3940 (metL)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
NAD_binding_3
HTH_11
Motif
Other DBs
NCBI-GeneID:
948433
NCBI-ProteinID:
NP_418375
Pasteur:
metL
RegulonDB:
RDBECOLIGNC00582
ECOCYC:
EG10590
ASAP:
ABE-0012889
UniProt:
P00562
LinkDB
All DBs
Position
4129835..4132267
Genome browser
AA seq
810 aa
AA seq
DB search
MSVIAQAGAKGRQLHKFGGSSLADVKCYLRVAGIMAEYSQPDDMMVVSAAGSTTNQLINW
LKLSQTDRLSAHQVQQTLRRYQCDLISGLLPAEEADSLISAFVSDLERLAALLDSGINDA
VYAEVVGHGEVWSARLMSAVLNQQGLPAAWLDAREFLRAERAAQPQVDEGLSYPLLQQLL
VQHPGKRLVVTGFISRNNAGETVLLGRNGSDYSATQIGALAGVSRVTIWSDVAGVYSADP
RKVKDACLLPLLRLDEASELARLAAPVLHARTLQPVSGSEIDLQLRCSYTPDQGSTRIER
VLASGTGARIVTSHDDVCLIEFQVPASQDFKLAHKEIDQILKRAQVRPLAVGVHNDRQLL
QFCYTSEVADSALKILDEAGLPGELRLRQGLALVAMVGAGVTRNPLHCHRFWQQLKGQPV
EFTWQSDDGISLVAVLRTGPTESLIQGLHQSVFRAEKRIGLVLFGKGNIGSRWLELFARE
QSTLSARTGFEFVLAGVVDSRRSLLSYDGLDASRALAFFNDEAVEQDEESLFLWMRAHPY
DDLVVLDVTASQQLADQYLDFASHGFHVISANKLAGASDSNKYRQIHDAFEKTGRHWLYN
ATVGAGLPINHTVRDLIDSGDTILSISGIFSGTLSWLFLQFDGSVPFTELVDQAWQQGLT
EPDPRDDLSGKDVMRKLVILAREAGYNIEPDQVRVESLVPAHCEGGSIDHFFENGDELNE
QMVQRLEAAREMGLVLRYVARFDANGKARVGVEAVREDHPLASLLPCDNVFAIESRWYRD
NPLVIRGPGAGRDVTAGAIQSDINRLAQLL
NT seq
2433 nt
NT seq
+upstream
nt +downstream
nt
atgagtgtgattgcgcaggcaggggcgaaaggtcgtcagctgcataaatttggtggcagt
agtctggctgatgtgaagtgttatttgcgtgtcgcgggcattatggcggagtactctcag
cctgacgatatgatggtggtttccgccgccggtagcaccactaaccagttgattaactgg
ttgaaactaagccagaccgatcgtctctctgcgcatcaggttcaacaaacgctgcgtcgc
tatcagtgcgatctgattagcggtctgctacccgctgaagaagccgatagcctcattagc
gcttttgtcagcgaccttgagcgcctggcggcgctgctcgacagcggtattaacgacgca
gtgtatgcggaagtggtgggccacggggaagtatggtcggcacgtctgatgtctgcggta
cttaatcaacaagggctgccagcggcctggcttgatgcccgcgagtttttacgcgctgaa
cgcgccgcacaaccgcaggttgatgaagggctttcttacccgttgctgcaacagctgctg
gtgcaacatccgggcaaacgtctggtggtgaccggatttatcagccgcaacaacgccggt
gaaacggtgctgctggggcgtaacggttccgactattccgcgacacaaatcggtgcgctg
gcgggtgtttctcgcgtaaccatctggagcgacgtcgccggggtatacagtgccgacccg
cgtaaagtgaaagatgcctgcctgctgccgttgctgcgtctggatgaggccagcgaactg
gcgcgcctggcggctcccgttcttcacgcccgtactttacagccggtttctggcagcgaa
atcgacctgcaactgcgctgtagctacacgccggatcaaggttccacgcgcattgaacgc
gtgctggcctccggtactggtgcgcgtattgtcaccagccacgatgatgtctgtttgatt
gagtttcaggtgcccgccagtcaggatttcaaactggcgcataaagagatcgaccaaatc
ctgaaacgcgcgcaggtacgcccgctggcggttggcgtacataacgatcgccagttgctg
caattttgctacacctcagaagtggccgacagtgcgctgaaaatcctcgacgaagcggga
ttacctggcgaactgcgcctgcgtcaggggctggcgctggtggcgatggtcggtgcaggc
gtcacccgtaacccgctgcattgccaccgcttctggcagcaactgaaaggccagccggtc
gaatttacctggcagtccgatgacggcatcagcctggtggcagtactgcgcaccggcccg
accgaaagcctgattcaggggctgcatcagtccgtcttccgcgcagaaaaacgcatcggc
ctggtattgttcggtaagggcaatatcggttcccgttggctggaactgttcgcccgtgag
cagagcacgctttcggcacgtaccggctttgagtttgtgctggcaggtgtggtggacagc
cgccgcagcctgttgagctatgacgggctggacgccagccgcgcgttagccttcttcaac
gatgaagcggttgagcaggatgaagagtcgttgttcctgtggatgcgcgcccatccgtat
gatgatttagtggtgctggacgttaccgccagccagcagcttgctgatcagtatcttgat
ttcgccagccacggtttccacgttatcagcgccaacaaactggcgggagccagcgacagc
aataaatatcgccagatccacgacgccttcgaaaaaaccgggcgtcactggctgtacaat
gccaccgtcggtgcgggcttgccgatcaaccacaccgtgcgcgatctgatcgacagcggc
gatactattttgtcgatcagcgggatcttctccggcacgctctcctggctgttcctgcaa
ttcgacggtagcgtgccgtttaccgagctggtggatcaggcgtggcagcagggcttaacc
gaacctgacccgcgtgacgatctctctggcaaagacgtgatgcgcaagctggtgattctg
gcgcgtgaagcaggttacaacatcgaaccggatcaggtacgtgtggaatcgctggtgcct
gctcattgcgaaggcggcagcatcgaccatttctttgaaaatggcgatgaactgaacgag
cagatggtgcaacggctggaagcggcccgcgaaatggggctggtgctgcgctacgtggcg
cgtttcgatgccaacggtaaagcgcgtgtaggcgtggaagcggtgcgtgaagatcatccg
ttggcatcactgctgccgtgcgataacgtctttgccatcgaaagccgctggtatcgcgat
aaccctctggtgatccgcggacctggcgctgggcgcgacgtcaccgccggggcgattcag
tcggatatcaaccggctggcacagttgttgtaa
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