KEGG   Escherichia coli O145 H28 RM13516 (EHEC): ECRM13516_4878
Entry
ECRM13516_4878    CDS       T03011                                 
Symbol
metH
Name
(GenBank) 5-methyltetrahydrofolate--homocysteine methyltransferase
  KO
K00548  5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]
Organism
ecoh  Escherichia coli O145:H28 RM13516 (EHEC)
Pathway
ecoh00270  Cysteine and methionine metabolism
ecoh00450  Selenocompound metabolism
ecoh00670  One carbon pool by folate
ecoh01100  Metabolic pathways
ecoh01110  Biosynthesis of secondary metabolites
ecoh01230  Biosynthesis of amino acids
ecoh04980  Cobalamin transport and metabolism
ecoh04981  Folate transport and metabolism
Module
ecoh_M00017  Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:ecoh00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    ECRM13516_4878 (metH)
  09106 Metabolism of other amino acids
   00450 Selenocompound metabolism
    ECRM13516_4878 (metH)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    ECRM13516_4878 (metH)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    ECRM13516_4878 (metH)
   04980 Cobalamin transport and metabolism
    ECRM13516_4878 (metH)
Enzymes [BR:ecoh01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.13  methionine synthase
     ECRM13516_4878 (metH)
SSDB
Motif
Pfam: Met_synt_B12 S-methyl_trans Pterin_bind B12-binding_2 B12-binding
Other DBs
NCBI-ProteinID: AHG17464
LinkDB
Position
4844179..4847862
AA seq 1227 aa
MSSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSK
PEVIAAIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTA
RTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILI
ETVFDTLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA
LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQ
AGFLNIVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVG
ERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLKLI
AGEPDIARVPIMIDSSKWEVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAV
VVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQ
DFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAG
QLAIYDDLPAELRDAVEDVILNRRDDGTERLLELAEKYRGSKTDDTANAQQAEWRSWEVN
KRLEYSLVKGITEFIEQDTEEARQQATRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
SARVMKQAVAYLEPFIEASKEQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDL
GVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKA
HTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPR
TPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKY
PRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIEIYRDETRT
HVIKVSHHLRQQTEKTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALAESFEAQH
DDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYP
ACPEHTEKATIWELLDVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQV
EDYARRKGMSVSDVERWLAPNLGYDAD
NT seq 3684 nt   +upstreamnt  +downstreamnt
gtgagcagcaaagtggaacaactgcgtgcgcagttaaatgaacgtattctggtgctggac
ggcggtatgggcaccatgatccagagctatcgactgaacgaagccgattttcgtggtgaa
cgctttgccgactggccatgcgacctcaaaggcaacaacgacctgctggtactcagtaaa
ccggaagtgatcgccgctatccacaacgcctactttgaagcgggcgcggatatcatcgaa
accaacaccttcaactccacgaccattgcgatggcggattaccagatggaatccctgtcg
gcggaaatcaactttgcggcggcgaaactggcgcgcgcctgtgctgatgagtggaccgcg
cgcacgccagagaaaccgcgctacgttgccggtgttctcggcccgaccaaccgcacggcg
tctatttctccggacgtcaacgatccggcattccgcaacatcacttttgaccagctggtg
gcggcctatcgcgaatccaccaaagcgctggtggaaggtggtgcggatctgatcctgatt
gaaaccgttttcgacacccttaacgccaaagcggcggtttttgcggtgaaaacggagttt
gaagcgctgggcgttgagctgccgattatgatctccggcaccatcaccgacgcctccggg
cgcacgctctccgggcagaccaccgaagcattttacaactcattgcgccacgccgaagcg
ctgacctttggcctgaactgtgcgctggggccagatgaactgcgccagtacgtgcaggag
ctgtcacggattgcggaatgctacgtcaccgcgcacccgaacgccgggctacccaacgcc
tttggtgagtacgatctcgacgccgacacgatggcaaaacagatacgtgaatgggcgcaa
gcgggttttctcaatatcgtcggcggctgctgtggcaccacgccacaacatattgcagcg
atgagtcgtgcagtagaaggattagcgccgcgcaaactgcctgaaattcccgtagcctgc
cgtttgtccggcctggagccgctgaacattggcgacgacagcctgtttgtgaacgtcggc
gagcggactaacgtcaccggttccgctaagttcaagcgcctgatcaaagaagagaaatac
agcgaggcgctggatgtggcccgccagcaggtggaaaacggtgcgcagattatcgatatc
aacatggatgaagggatgctcgatgccgaagcggcgatggtgcgttttctcaaactgatt
gccggtgaaccggatatcgctcgcgtgccgattatgatcgactcctcaaaatgggaggtc
atcgaaaaggggctgaagtgtattcagggcaaaggcattgttaactctatctcaatgaaa
gagggcgtcgacgcctttatccatcatgcgaaactgttgcgtcgttacggtgcagcggtg
gtggtaatggcctttgacgaacagggacaggccgatacccgcgcacggaaaatcgagatt
tgccgtcgggcgtacaaaatcctcaccgaagaggttggcttcccgccagaagatatcatc
ttcgacccgaacatcttcgcggtcgccaccggcattgaagagcacaacaactatgcgcag
gactttatcggcgcctgcgaagacatcaaacgcgaactgccgcacgcgctgatttccggc
ggcgtatctaacgtttctttctcattccgtggcaacgatccggtgcgcgaagccattcac
gcggtgttcctctactacgctattcgcaatggcatggatatggggatcgtcaacgctggg
caactggcgatttacgacgacctgcccgctgaactgcgcgacgcggtggaagatgtgatt
cttaatcgtcgcgatgatggcactgagcgtttactggagcttgccgagaaatatcgcggc
agcaaaaccgacgacaccgctaacgcccagcaggcggagtggcgctcgtgggaagtgaat
aaacgtctagaatactcgctggtcaaaggcattaccgagtttatcgagcaggataccgaa
gaagcacgccagcaggctacgcgcccgattgaagtgattgaaggcccgctaatggacggc
atgaacgtggtcggcgatctgttcggcgaagggaaaatgttcctgccacaggtggtcaaa
tcggcgcgtgtgatgaagcaggcggtggcctacctcgaaccgtttattgaagccagcaaa
gagcagggcaaaaccaacggcaagatggtgatcgccaccgtgaagggcgacgtccacgac
atcggtaaaaatatcgttggtgtggtgctgcaatgtaacaactacgaaattgtcgatctc
ggcgttatggtgcctgcggaaaaaattctccgtaccgctaaagaagtgaatgctgatctg
attggactttcggggcttatcacgccgtcgctggacgagatggttaacgtggcgaaagag
atggagcgtcagggcttcaccattccgttactgatcggtggcgcgacgacctcaaaagcg
cacacggcggtgaaaattgagcagaactacagcggcccgacggtgtatgtgcagaatgcc
tcgcgcaccgttggtgtggtggcggcgctgctttccgacactcagcgcgatgatttcgtt
gctcgtacccgcaaagagtacgaaaccgtgcgtattcagcacgggcgcaagaaaccgcgc
acaccgccagtcacgctggaagcggcgcgcgataacgatttcgcttttgactggcaggct
tacacgccaccggtggcgcaccgtctcggcgtgcaggaagttgaagccagcatcgaaacg
ctgcgtaattacatcgactggacgccgttctttatgacctggtcgctggccgggaagtat
ccgcgcattctggaagatgaagtggttggcgttgaggcgcagcgcctgtttaaagacgcc
aacgacatgctggataaattaagcgccgagaaaacgctgaatccacgcggcgtggtgggg
ctgttcccggcaaaccgtgtgggtgatgacattgaaatctaccgtgatgaaacgcgcacc
catgtgatcaaagtcagccaccatctgcgtcaacagacggaaaaaaccggcttcgctaac
tactgtctcgctgacttcgtggcaccgaagctctccggtaaagcggattacatcggcgca
tttgctgtgactggcgggctggaagaggacgcgctggcagaatcgttcgaagcacagcac
gatgattacaacaaaatcatggtcaaagcccttgccgaccgtttagccgaagcctttgcg
gaatatcttcatgagcgcgtgcgtaaagtttactggggctatgcaccaaacgagaacctc
agcaacgaagagctgatccgcgaaaactatcaaggcatccgtccggcaccaggctacccg
gcctgcccggaacatacggaaaaagccaccatctgggagctgctggacgtagaaaaacac
accggcatgaaacttacggaatctttcgcgatgtggcctggagcgtcggtttcaggttgg
tatttcagccacccggacagcaagtattacgccgtggcgcaaattcagcgcgatcaggtt
gaagactatgcccgccgtaaaggtatgagcgtctcagatgttgagcgctggctggcaccg
aatctggggtatgacgcggactga

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