Escherichia coli JJ1886: P423_22260
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Entry
P423_22260 CDS
T02896
Symbol
metH
Name
(GenBank) B12-dependent methionine synthase
KO
K00548
5-methyltetrahydrofolate--homocysteine methyltransferase [EC:
2.1.1.13
]
Organism
ecoj
Escherichia coli JJ1886
Pathway
ecoj00270
Cysteine and methionine metabolism
ecoj00450
Selenocompound metabolism
ecoj00670
One carbon pool by folate
ecoj01100
Metabolic pathways
ecoj01110
Biosynthesis of secondary metabolites
ecoj01230
Biosynthesis of amino acids
ecoj04980
Cobalamin transport and metabolism
ecoj04981
Folate transport and metabolism
Module
ecoj_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:
ecoj00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
P423_22260 (metH)
09106 Metabolism of other amino acids
00450 Selenocompound metabolism
P423_22260 (metH)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
P423_22260 (metH)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
P423_22260 (metH)
04980 Cobalamin transport and metabolism
P423_22260 (metH)
Enzymes [BR:
ecoj01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.13 methionine synthase
P423_22260 (metH)
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Gene cluster
GFIT
Motif
Pfam:
Met_synt_B12
S-methyl_trans
Pterin_bind
B12-binding_2
B12-binding
Motif
Other DBs
NCBI-ProteinID:
AGY86644
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Position
4577285..4580968
Genome browser
AA seq
1227 aa
AA seq
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MSSKVEQLCAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSK
PEVISAIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTA
RTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILI
ETVFDTLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA
LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAE
AGFLNIVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGEDSLFVNVG
ERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLI
AGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAV
VVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPAEDIIFDPNIFAVATGIEEHNNYAQ
DFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAG
QLAIYDDLPTELRDAVEDVILNRRDDGTERLLELAEKYRGSKTDDTANTQQAEWRSWEVN
KRLEYSLVKGITEFIEQDTEEARQQATRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
SARVMKQAVAYLEPFIEASKEQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDL
GVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKA
HTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPR
TPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKY
PRILEDEVVGVEAQRLFKDANDMLDKLSAEKMLNPRGVVGLFPANRVGDDIEIYRDETRT
HVINVSHHLRQQTEKTGFANYCLADFVAPKVSGKADYIGAFAVTGGLEEDALADAFEAQH
DDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYP
ACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQV
EDYAHRKGMSVTEVERWLAPNLGYDAE
NT seq
3684 nt
NT seq
+upstream
nt +downstream
nt
gtgagcagcaaagtggaacaactgtgtgcgcagttaaatgaacgtattctggtgctggac
ggcggtatgggcaccatgatccagagctatcgactgaacgaagccgattttcgtggtgaa
cgctttgccgactggccatgcgatctcaaaggcaacaacgacctgctggtgctcagcaaa
ccggaagtgatctccgccatccacaacgcttactttgaagcgggtgcggatatcatcgaa
accaacaccttcaactccacgactattgcgatggcggattaccagatggaatccctgtcg
gcggaaatcaactttgcggcggcgaaactggcgcgcgcctgtgccgacgagtggactgcc
cgcacgccggagaaaccgcgctacgttgccggtgttctcggcccgaccaaccgcacggcg
tctatttctccggacgtcaacgatccggcattccgcaacatcacttttgaccagctggtg
gcggcttatcgagaatccaccaaagcgctggtggaaggtggcgcggacctgatcctgatt
gaaaccgttttcgacacccttaacgccaaagcggcggtctttgcggtgaaaacggagttt
gaagcgctgggcgttgaactgccgattatgatctccggcaccatcaccgacgcctccggg
cgcacgctctccgggcagaccactgaagcgttttacaactccctgcgccacgccgaagcg
ctgacctttggcctgaactgtgcgctggggccagacgaactgcgccagtacgtacaggaa
ctgtcgcgtattgcggaatgctatgtcaccgcccacccgaacgccgggctgcccaacgcc
tttggtgaatacgatctcgacgccgacacgatggcaaaacagatacgtgaatgggcagaa
gcgggctttctcaatatcgtcggcggctgctgcggcaccacgccacaacatattgcagcg
atgagtcgtgcagtagaaggattagcgccgcgcaaactaccggaaattcccgtagcctgc
cgtttgtccggcctggagccgctgaacattggcgaagatagcctgtttgtgaacgtgggt
gaacgcaccaacgtcaccggttccgctaagttcaagcgcctgatcaaagaagagaaatac
agcgaggcgctggatgtggcgcgtcagcaggtggaaaacggtgcgcagattatcgatatc
aacatggatgaagggatgctcgatgccgaagcggcgatggtgcgttttctcaatctgatt
gccggtgaaccggatatcgctcgtgtgccgataatgatcgactcctcgaaatgggacgtt
attgaaaaaggtctgaagtgtatccagggcaaaggcattgttaactctatctcgatgaaa
gagggcgtcgacgcctttatccatcacgcgaaactgttgcgtcgctacggtgcggcagta
gtggtaatggcttttgacgaacagggccaggccgatacccgcgcacggaaaatcgagatt
tgccgtcgggcgtacaaaatcctcaccgaagaggttggcttcccggctgaagatatcatc
ttcgacccgaacatcttcgcggtcgcaactggcattgaagagcacaacaattacgcacag
gactttatcggcgcgtgtgaagacatcaaacgtgaactgccgcacgcactgatttccggc
ggcgtttctaacgtgtcgttctcgtttcgtggtaacgatcctgtgcgcgaagccattcac
gcggtgttcctctactacgctattcgcaatggcatggatatggggatcgtcaacgccggg
caactggcgatttacgacgacctgcctaccgagctacgcgacgcggtggaggatgtgatc
ctcaaccgccgcgacgatggcaccgagcgtttactcgagcttgccgagaaatatcgcggc
agcaaaaccgacgacaccgctaacacccagcaggcggagtggcgctcgtgggaagtgaat
aaacgtctggaatactcgctggtcaaaggcattaccgagtttatcgagcaggataccgaa
gaagcccgccagcaggctacgcgcccgattgaagtgattgaaggcccgttgatggacggc
atgaacgtggtcggcgacctgtttggcgagggcaaaatgttcctgccgcaggtggtgaaa
tcggcgcgcgtaatgaagcaggcggtggcgtatctcgagccgtttattgaagccagcaaa
gagcagggtaaaaccaacggcaagatggtgatcgccacagtgaagggcgatgtccacgac
atcggtaaaaatatcgttggcgtggtgctgcaatgtaacaactacgaaattgtcgatctc
ggcgtgatggtgcctgcggaaaaaattctccgtaccgctaaagaagtgaatgctgatttg
attggcctttcggggctgatcacgccgtcgctggacgagatggttaacgtggcgaaagag
atggagcgccagggcttcaccattccgctattgattggcggcgcgaccacctcaaaagcg
cacacggcggtgaaaatcgagcagaactacagcggcccgacggtgtatgtgcagaacgca
tcgcgcaccgttggtgtggtggcggcgctgctttccgacactcagcgcgatgatttcgtt
gctcgtacccgcaaggagtacgaaaccgtgcgtattcagcacggacgaaagaaaccacgc
acaccaccggtcacgctggaagcggcgcgtgataacgacttcgcttttgactggcaggct
tacacgccgccggtggcgcaccgtctcggtgtgcaggaagtcgaagccagcatcgaaacg
ctgcgtaattacatcgactggacgccgttctttatgacctggtcgctggccgggaagtat
ccgcgcattctggaagatgaagtggtaggtgttgaggcgcagcggctgtttaaagacgcc
aacgacatgctggataaattaagcgccgaaaaaatgctgaacccgcgtggtgtggtgggc
ctgttcccggcaaaccgtgtgggcgatgacattgaaatctaccgtgacgaaacgcgtacc
catgtgattaatgtcagccaccatctgcgccaacagaccgaaaaaaccggcttcgctaac
tactgtctcgctgacttcgttgcgccgaaggtttccggcaaagcggattacatcggcgca
tttgccgtgactggcgggctggaagaggacgcactggctgatgcctttgaagcacagcat
gatgattacaacaaaatcatggtgaaagcgcttgccgaccgtctggcggaagcctttgcg
gagtatctccatgagcgtgtgcgtaaagtctactggggctatgcgccgaacgagaacctc
agcaacgaagagctgatccgcgaaaactaccagggcatccgtccggcaccgggctaccct
gcctgcccggaacatacggaaaaagccacaatctgggagctgctggaagtggaaaaacat
accggtatgaaactcacggaatctttcgccatgtggccgggtgcatcggtttcgggttgg
tacttcagtcatccagacagcaagtattacgcggtggcgcaaattcagcgcgatcaggtt
gaagactatgcccaccgtaaaggaatgagcgttaccgaagttgagcgttggttggcaccg
aatctggggtatgatgccgagtaa
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