Escherichia coli O145 H28 RM13514 (EHEC): ECRM13514_5141
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Entry
ECRM13514_5141 CDS
T03010
Symbol
metH
Name
(GenBank) 5-methyltetrahydrofolate--homocysteine methyltransferase
KO
K00548
5-methyltetrahydrofolate--homocysteine methyltransferase [EC:
2.1.1.13
]
Organism
ecoo
Escherichia coli O145:H28 RM13514 (EHEC)
Pathway
ecoo00270
Cysteine and methionine metabolism
ecoo00450
Selenocompound metabolism
ecoo00670
One carbon pool by folate
ecoo01100
Metabolic pathways
ecoo01110
Biosynthesis of secondary metabolites
ecoo01230
Biosynthesis of amino acids
ecoo04980
Cobalamin transport and metabolism
ecoo04981
Folate transport and metabolism
Module
ecoo_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:
ecoo00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
ECRM13514_5141 (metH)
09106 Metabolism of other amino acids
00450 Selenocompound metabolism
ECRM13514_5141 (metH)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
ECRM13514_5141 (metH)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
ECRM13514_5141 (metH)
04980 Cobalamin transport and metabolism
ECRM13514_5141 (metH)
Enzymes [BR:
ecoo01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.13 methionine synthase
ECRM13514_5141 (metH)
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Gene cluster
GFIT
Motif
Pfam:
Met_synt_B12
S-methyl_trans
Pterin_bind
B12-binding_2
B12-binding
Motif
Other DBs
NCBI-ProteinID:
AHG11764
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Position
5026095..5029778
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AA seq
1227 aa
AA seq
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MSSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSK
PEVIAAIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTA
RTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILI
ETVFDTLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA
LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQ
AGFLNIVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVG
ERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLKLI
AGEPDIARVPIMIDSSKWEVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAV
VVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQ
DFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAG
QLAIYDDLPAELRDAVEDVILNRRDDGTERLLELAEKYRGSKTDDTANAQQAEWRSWEVN
KRLEYSLVKGITEFIEQDTEEARQQATRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
SARVMKQAVAYLEPFIEASKEQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDL
GVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKA
HTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPR
TPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKY
PRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIEIYRDETRT
HVIKVSHHLRQQTEKTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALAESFEAQH
DDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYP
ACPEHTEKATIWELLDVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQV
EDYARRKGMSVSDVERWLAPNLGYDAD
NT seq
3684 nt
NT seq
+upstream
nt +downstream
nt
gtgagcagcaaagtggaacaactgcgtgcgcagttaaatgaacgtattctggtgctggac
ggcggtatgggcaccatgatccagagctatcgactgaacgaagccgattttcgtggtgaa
cgctttgccgactggccatgcgacctcaaaggcaacaacgacctgctggtactcagtaaa
ccggaagtgatcgccgctatccacaacgcctactttgaagcgggcgcggatatcatcgaa
accaacaccttcaactccacgaccattgcgatggcggattaccagatggaatccctgtcg
gcggaaatcaactttgcggcggcgaaactggcgcgcgcctgtgctgatgagtggaccgcg
cgcacgccagagaaaccgcgctacgttgccggtgttctcggcccgaccaaccgcacggcg
tctatttctccggacgtcaacgatccggcattccgcaacatcacttttgaccagctggtg
gcggcctatcgcgaatccaccaaagcgctggtggaaggtggtgcggatctgatcctgatt
gaaaccgttttcgacacccttaacgccaaagcggcggtttttgcggtgaaaacggagttt
gaagcgctgggcgttgagctgccgattatgatctccggcaccatcaccgacgcctccggg
cgcacgctctccgggcagaccaccgaagcattttacaactcattgcgccacgccgaagcg
ctgacctttggcctgaactgtgcgctggggccagatgaactgcgccagtacgtgcaggag
ctgtcacggattgcggaatgctacgtcaccgcgcacccgaacgccgggctacccaacgcc
tttggtgagtacgatctcgacgccgacacgatggcaaaacagatacgtgaatgggcgcaa
gcgggttttctcaatatcgtcggcggctgctgtggcaccacgccacaacatattgcagcg
atgagtcgtgcagtagaaggattagcgccgcgcaaactgcctgaaattcccgtagcctgc
cgtttgtccggcctggagccgctgaacattggcgacgacagcctgtttgtgaacgtcggc
gagcggactaacgtcaccggttccgctaagttcaagcgcctgatcaaagaagagaaatac
agcgaggcgctggatgtggcccgccagcaggtggaaaacggtgcgcagattatcgatatc
aacatggatgaagggatgctcgatgccgaagcggcgatggtgcgttttctcaaactgatt
gccggtgaaccggatatcgctcgcgtgccgattatgatcgactcctcaaaatgggaggtc
atcgaaaaggggctgaagtgtattcagggcaaaggcattgttaactctatctcaatgaaa
gagggcgtcgacgcctttatccatcatgcgaaactgttgcgtcgttacggtgcagcggtg
gtggtaatggcctttgacgaacagggacaggccgatacccgcgcacggaaaatcgagatt
tgccgtcgggcgtacaaaatcctcaccgaagaggttggcttcccgccagaagatatcatc
ttcgacccgaacatcttcgcggtcgccaccggcattgaagagcacaacaactatgcgcag
gactttatcggcgcctgcgaagacatcaaacgcgaactgccgcacgcgctgatttccggc
ggcgtatctaacgtttctttctcattccgtggcaacgatccggtgcgcgaagccattcac
gcggtgttcctctactacgctattcgcaatggcatggatatggggatcgtcaacgctggg
caactggcgatttacgacgacctgcccgctgaactgcgcgacgcggtggaagatgtgatt
cttaatcgtcgcgatgatggcactgagcgtttactggagcttgccgagaaatatcgcggc
agcaaaaccgacgacaccgctaacgcccagcaggcggagtggcgctcgtgggaagtgaat
aaacgtctagaatactcgctggtcaaaggcattaccgagtttatcgagcaggataccgaa
gaagcacgccagcaggctacgcgcccgattgaagtgattgaaggcccgctaatggacggc
atgaacgtggtcggcgatctgttcggcgaagggaaaatgttcctgccacaggtggtcaaa
tcggcgcgtgtgatgaagcaggcggtggcctacctcgaaccgtttattgaagccagcaaa
gagcagggcaaaaccaacggcaagatggtgatcgccaccgtgaagggcgacgtccacgac
atcggtaaaaatatcgttggtgtggtgctgcaatgtaacaactacgaaattgtcgatctc
ggcgttatggtgcctgcggaaaaaattctccgtaccgctaaagaagtgaatgctgatctg
attggactttcggggcttatcacgccgtcgctggacgagatggttaacgtggcgaaagag
atggagcgtcagggcttcaccattccgttactgatcggtggcgcgacgacctcaaaagcg
cacacggcggtgaaaattgagcagaactacagcggcccgacggtgtatgtgcagaatgcc
tcgcgcaccgttggtgtggtggcggcgctgctttccgacactcagcgcgatgatttcgtt
gctcgtacccgcaaagagtacgaaaccgtgcgtattcagcacgggcgcaagaaaccgcgc
acaccgccagtcacgctggaagcggcgcgcgataacgatttcgcttttgactggcaggct
tacacgccaccggtggcgcaccgtctcggcgtgcaggaagttgaagccagcatcgaaacg
ctgcgtaattacatcgactggacgccgttctttatgacctggtcgctggccgggaagtat
ccgcgcattctggaagatgaagtggttggcgttgaggcgcagcgcctgtttaaagacgcc
aacgacatgctggataaattaagcgccgagaaaacgctgaatccacgcggcgtggtgggg
ctgttcccggcaaaccgtgtgggtgatgacattgaaatctaccgtgatgaaacgcgcacc
catgtgatcaaagtcagccaccatctgcgtcaacagacggaaaaaaccggcttcgctaac
tactgtctcgctgacttcgtggcaccgaagctctccggtaaagcggattacatcggcgca
tttgctgtgactggcgggctggaagaggacgcgctggcagaatcgttcgaagcacagcac
gatgattacaacaaaatcatggtcaaagcccttgccgaccgtttagccgaagcctttgcg
gaatatcttcatgagcgcgtgcgtaaagtttactggggctatgcaccaaacgagaacctc
agcaacgaagagctgatccgcgaaaactatcaaggcatccgtccggcaccaggctacccg
gcctgcccggaacatacggaaaaagccaccatctgggagctgctggacgtagaaaaacac
accggcatgaaacttacggaatctttcgcgatgtggcctggagcgtcggtttcaggttgg
tatttcagccacccggacagcaagtattacgccgtggcgcaaattcagcgcgatcaggtt
gaagactatgcccgccgtaaaggtatgagcgtctcagatgttgagcgctggctggcaccg
aatctggggtatgacgcggactga
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