KEGG   Escherichia coli O6 K15 H31 536 (UPEC): ECP_4228
Entry
ECP_4228          CDS       T00373                                 
Name
(GenBank) 5-methyltetrahydrofolate-homocysteine methyltransferase
  KO
K00548  5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]
Organism
ecp  Escherichia coli O6:K15:H31 536 (UPEC)
Pathway
ecp00270  Cysteine and methionine metabolism
ecp00450  Selenocompound metabolism
ecp00670  One carbon pool by folate
ecp01100  Metabolic pathways
ecp01110  Biosynthesis of secondary metabolites
ecp01230  Biosynthesis of amino acids
ecp04980  Cobalamin transport and metabolism
ecp04981  Folate transport and metabolism
Module
ecp_M00017  Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:ecp00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    ECP_4228
  09106 Metabolism of other amino acids
   00450 Selenocompound metabolism
    ECP_4228
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    ECP_4228
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    ECP_4228
   04980 Cobalamin transport and metabolism
    ECP_4228
Enzymes [BR:ecp01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.13  methionine synthase
     ECP_4228
SSDB
Motif
Pfam: Met_synt_B12 S-methyl_trans Pterin_bind B12-binding_2 B12-binding
Other DBs
NCBI-ProteinID: ABG72178
UniProt: A0A454AA41
LinkDB
Position
4432272..4435970
AA seq 1232 aa
MSGASVSSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDL
LVLSKPEVIAAIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACA
DEWTARTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGA
DLILIETVFDTLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSL
RHAEALTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQI
REWAEAGFLNIVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGEDSL
FVNVGERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVR
FLNLIAGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRR
YGAAVVVMAFDEQGQADTRARKIEICHRAYKILTEEVGFPAEDIIFDPNIFAVATGIEEH
NNYAQDFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMG
IVNAGQLAIYDDLPTELRDAVEDVILNRRDDGTERLLELAEKYRGSKTDDTANTQQAEWR
SWEVNKRLEYSLVKGITEFIEQDTEEARQQATRPIEVIEGPLMDGMNVVGDLFGEGKMFL
PQVVKSARVMKQAVAYLEPFIEASKEQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNY
EIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGA
TTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHG
RKKPRTPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWS
LAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKMLNPRGVVGLFPANRVGDDIEIYR
DETRTHVINVSHHLRQQTEKTGFANYCLADFVAPKVSGKADYIGAFAVTGGLEEDALADA
FEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRP
APGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQI
QRDQVEDYARRKGMSVTEVERWLAPNLGYDAE
NT seq 3699 nt   +upstreamnt  +downstreamnt
gtgtcgggagcaagtgtgagcagcaaagtggaacaactgcgtgcgcagttaaatgaacgt
attctggtgctggacggcggtatgggcaccatgatccagagttatcgactgaacgaggcc
gattttcgcggcgagcgttttgccgactggccgtgcgatctcaaaggcaacaacgacctg
ctggtgctcagcaaaccggaagtgatcgccgctatccacaacgcctactttgaagcgggt
gcggatatcatcgaaaccaacaccttcaactccacgaccattgcgatggcggattaccag
atggaatccctgtcggcggaaatcaactttgcagcggcgaaactggcgcgcgcctgtgcc
gacgagtggactgcccgcacgccggagaaaccgcgctacgttgccggtgttctcggcccg
accaaccgcacggcgtctatttctccggacgtcaacgatccggcattccgcaacatcact
tttgaccagctggtggcggcttatcgagaatccaccaaagcgctggtggaaggtggcgcg
gacctgatcctgattgaaaccgttttcgacacccttaacgccaaagcggcggtctttgcg
gtgaaaacggagtttgaagcgctgggcgttgaactgccgattatgatctccggcaccatc
accgacgcctccgggcgcacgctctccgggcagactactgaagcgttttacaactccctg
cgccacgccgaagcgctgacctttggcctgaactgtgcgctggggccagacgaactgcgc
cagtacgtacaggaactgtcgcgtattgcggaatgctacgtcaccgcccacccgaacgcc
gggctgcccaacgcctttggtgaatacgatctcgacgccgacacgatggcaaaacagata
cgtgaatgggcagaagcaggctttctcaatatcgtcggcggctgctgcggcaccacgcca
caacatattgcagcgatgagtcgtgcagtagaaggattagcgccgcgcaaactaccggaa
attcccgtagcctgccgtttgtccggcctggagccgctgaacattggcgaagatagcctg
tttgtgaacgtgggtgaacgcaccaacgtcaccggttccgctaagttcaagcgactgatc
aaagaagagaaatacagcgaggcgctggatgtggcgcgtcagcaggtggaaaacggtgcg
cagattatcgatatcaacatggatgaagggatgctcgacgccgaagcggcgatggtgcgt
tttctcaatctgattgccggtgaaccggatatcgctcgcgtgccgattatgatcgactcc
tcaaaatgggacgttattgaaaaaggtctgaagtgtatccagggcaaaggcattgttaac
tctatctcgatgaaagagggtgtcgacgcctttatccatcacgcgaaactgttgcgtcgc
tacggtgcggcagtcgtggtaatggcttttgacgaacagggccaggccgatacccgcgca
cggaaaatcgagatttgccatcgggcgtacaaaatcctcaccgaagaggttggcttcccg
gctgaagatatcatcttcgacccgaacatcttcgcggtcgcaactggcattgaagagcac
aacaattacgcgcaggactttatcggcgcgtgtgaagacatcaaacgtgaactgccgcac
gcactgatttccggcggcgtttctaacgtttctttctcattccgtggcaacgatccggtg
cgcgaagccattcacgcggtgttcctctactacgctattcgcaatggcatggatatgggg
atcgtcaacgccgggcaactggcgatttacgacgacctgcctaccgagctacgcgacgcg
gtggaggatgtgatcctcaaccgtcgcgacgatggcaccgagcgtttactcgagcttgcc
gagaaatatcgcggcagcaaaaccgacgacaccgctaacacccagcaggcggagtggcgc
tcgtgggaagtgaataaacgtctggaatactcgctggtcaaaggcattaccgagtttatc
gagcaggataccgaagaagcccgccagcaggctacgcgtccgattgaagtgattgaaggc
ccgttgatggacggcatgaacgtggtcggcgacctgtttggcgagggcaaaatgttcctg
ccgcaggtggtgaaatcggcgcgcgtaatgaagcaggcggtggcgtatctcgaaccgttt
attgaagccagcaaagagcagggtaaaaccaacggcaagatggtgatcgccaccgtgaaa
ggcgatgtccacgacatcggtaaaaatatcgttggcgtggtgctgcaatgtaacaactac
gaaattgtcgatctcggcgtgatggtgcctgcggaaaaaattctccgtaccgctaaagaa
gtgaatgctgatttgattggcctttcagggctgatcacgccgtcgctggacgagatggtt
aacgtggcgaaagagatggagcgtcagggcttcaccattccgctattgattggcggcgcg
accacctcaaaagcgcacacggcggtgaaaatcgagcagaactacagcggcccgacggtg
tatgtgcagaacgcatcgcgcaccgttggtgtggtggcggcgctgctttccgacactcag
cgcgatgatttcgttgctcgtacccgcaaggagtacgaaaccgtgcgtattcagcacgga
cgaaagaaaccacgcacaccaccggtcacgctggaagcggcgcgtgataacgacttcgct
tttgactggcaggcttacacgccgccggtggcgcaccgtctcggtgtgcaggaagtcgaa
gccagcatcgaaacgctgcgtaattacatcgactggacgccgttctttatgacctggtcg
ctggccgggaagtatccgcgcattctggaagatgaagtggtaggtgttgaggcgcagcgg
ctgtttaaagacgccaacgacatgctggataaattaagcgccgaaaaaatgctgaacccg
cgtggtgtggtgggcctgttcccggcaaaccgtgtgggcgatgacattgaaatctaccgt
gacgaaacgcgtacccatgtgattaatgtcagccaccatctacgccaacagaccgaaaaa
accggcttcgctaactactgtctcgctgacttcgttgcgccgaaggtttccggcaaagcg
gattacatcggcgcatttgccgtgactggcgggctggaagaggacgcactggctgatgcc
tttgaagcacagcatgatgattacaacaaaatcatggtgaaagcgcttgccgaccgtctg
gcggaagcctttgcggagtatctccatgagcgtgtgcgtaaagtctactggggctatgcg
ccgaacgagaacctcagcaacgaagagctgatccgcgaaaactaccagggcatccgtccg
gcaccgggctaccctgcctgcccggaacatacggaaaaagccacaatctgggagctgctg
gaagtggaaaaacataccggtatgaaactcacggaatccttcgccatgtggccgggtgca
tcggtttcgggttggtacttcagtcatccagacagcaagtattacgcggtggcgcaaatt
cagcgcgatcaggttgaagactatgcccgccgtaaaggaatgagcgttaccgaagtcgag
cgttggttggcaccgaatctggggtatgatgccgagtaa

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