Etheostoma cragini (Arkansas darter): 117938068 Help Entry 117938068         CDS       T07493                                  Symbol ryr1b Name (RefSeq) ryanodine receptor 1b isoform X1   KO K04961   ryanodine receptor 1 Organism ecra  Etheostoma cragini (Arkansas darter) Pathway ecra04020   Calcium signaling pathway ecra04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:ecra00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     117938068 (ryr1b)    04020 Calcium signaling pathway     117938068 (ryr1b)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:ecra01009]     117938068 (ryr1b)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:ecra04147]     117938068 (ryr1b)    04040 Ion channels [BR:ecra04040]     117938068 (ryr1b) Protein phosphatases and associated proteins [BR:ecra01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      117938068 (ryr1b) Exosome [BR:ecra04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    117938068 (ryr1b) Ion channels [BR:ecra04040]  Voltage-gated cation channels   Ryanodine receptor    117938068 (ryr1b) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 YebO Peroxin-3 Motif Other DBs NCBI-GeneID:  117938068 NCBI-ProteinID:  XP_034718290 LinkDB All DBs Position 3:26458172..26537519 Genome browser AA seq 5093 aa AA seqDB search MAEGGEGEEEIQFLRTDDQVCLQCTASVLKEQQIKLCLCCEGFGNRLCYLETTSNAQNVP PDLAISAFILEQSLSVRALQEMLANRVEMTESSQGGGHRTLLYGHAILLRHYHSGMYLSC LTTSRSLTDKLAFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSYASGDLMVDASFMQTLWNMNPISSGCELAEGFLTGGHVLRLFHGHMDECLAISTPEE GEEKRRMAHYEGGAVCSQARSLWRLEPLRICWSGGHMKWGQSFRIRHITTGRYLCMDEEK GLLVVDPEKANTKLSAFCFRASKDKVEVAPKRDVEGMGIPEIKYGESMCFVQHVSTGLWL TYAALDAKAARLGMMKRRVILHQEGHMDDALTVSRSQTEESQAARMIFSTMGLFRQFNKG LDSLNAKNKSPGAASLPLEGVILSLQDLIFYFRPPEEELEHEEKQTKLRSLRNRQNLFQE EGMITIVLECIDRLNVYNTAAHFSEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALF CDNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVL DVLRSLCVCNGVAVRSNQNLITENLLPGRDLLLQTNIVNYVTSVRPNIFLGTCEGSTQYK KWYFEMMVDYVEPFVTGQASHLRVGWAMTEGYSPYPGGGEGWGGNGVGDDLYSYGYDGLN LWSGTVPRQVAAPSAHSLSADDVVSCCLDLSVPSISFRINGHPVQGMFENFNVDGLFFPV ISFSAGVKARFLLGGRHGDFKFMPPPGYAPCYEAVLPRERMRIEPIKEYKHDFHGVRNLL GPTLSLTHTSFTPCPVDTVQIVLPPHLERIREKLAENIHELWAVTRIEQGWTYGSFRDDN KKLHPCLVDFQSLPEPERNYNLQMSGETLKTLLALGCHVGMGDEKAEENLKKIKLPKTYV MINGYKPAPLDLSHVKLTPNQNQLVEKLAENGHNVWARDRVRQGWTYSIVQDIMNKRNPR LVPYNLLDERTKKTNRDSVNNAVRTLIGYGYNIEPPDQESTGHGLENTRGDKVRIFRAEK SYAITQGKWYFEFEAVTTGEMRVGWARPSVRSDTELGADELAYVFNGNKAQRWHVGNEPF GRQWQSGDVVGCMIDLTDMNIMFTLNGEMLISDSGSDMAFKDIEIGEGFIPVCTLGLSQV GRINLGQNVSSLRYFAICGLQEGFEPFAINMKRDITMWFSKSLPQFVPVPNEHNHIEVSR VDGTVDSAPCLKLTHKTFGSQNANTDMLFLRLSMPVQFHETFKITAGTTPLTRSLTIPEE EVVVVEPDSEFEVLKKSAGRKEQDDEKKEPSVPKEISMENEKDTMSEKGKKKGFFSKAKK AAMTPLSPPPAPPTVPRLVEDVVPDDRDDPDTILNTTTYYYSVRIFAGQEPSGVWVGWVT PDYHQYDPTFDLSKVRTVTVTVGDDKGNIHDSMKHSNCYMVWGGDLVSNQQTRFSQEDMV VGCLVDLATGLMTFTANGKEINTFYQVEPNTKLFPAVFVQPSNQNLVQLELGKLKNIMPI SAAMFRSERKNPVPQCPPRLDVQMLTPVIWSRMPNHFLNPEVGRVSERLGWMVECTEPLI MMALHIPEENRCIDILELSERQDLMKFHYHTLMLYCAVCALGNNRVAHALCSHVDESQLF YAIENTYLPGPLRSGFYDLLISIHLESAKRARLGTNREFIVPMTKETLSIHLYPDAKKAH SLPGVGLTTCLRPKLHFSSINFVGTDPDLYTLSPVFPLQELKTRAISMLTEAVLDGSQAM RDPVGGSVEFHFVPILKLISTLLIMGIFNDEDTKHILKMIDPNVFSGKEEEEEEEKEGEK AEEGGAAEISEEEKEEETEADLEDEGVGDEGEDELQDLEGEPKEEGEQEEKEEEEAKEGK MEGEKEEEEKEEMEAELVEAEVKEEEDGLEEGLLQMKLPESVKLQMCTLLQYFCDCELRH RVEGIVAYSDSFVNSVQKNQRVRYNLLMRAFTMSAAETARKTREFRSPPQDQVLLLTNFK HSPEDELSPVPEEVRDSLVEFHTDLLLHCGIHIEEEAEEEEVDSSLRGRLISLVDKIRSL RKKEEEEKPEVEEDPKPSSLQELISHTMIHWAQESFIQNPELVRMMFSLLHRQYDGIGEL IRALPKAYAINAVSVQDTMDLLECLGQIRSLLIVQMGPEEERLMIQSIGNIMNNKVFYQH PNLMRALGMHETVMEVMVNVLGGGGDSKEIRFPQMVTNCCRFLCYFCRISRQNQRSMFDH LSYLLQNSGIGLGMRGSTPLDVAAASCIDNNELALALQEQDLEMVVTYLAGCGLQTCPML LSKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRRPECFGPALRGEGG NGLLAAMEEAIKISEDPARDGPTVKKDRRFMFGGEEQHEENRVHLGNAIMSFYSALIDLL GRCAPEMHLIQAGKGEALRIRAILRSLVPIEDLVGVISLSVQIPAFGKDGQVMEPKMSAS FVPDHKASMVLFLDRVYGIDNQDFLLHVLEVGFLPDMRAAASLDTVAFSTTEMALALNRY LCSAVLPLLTKCAPLFAGTEHRAIMIDSMLHTIYRLSRGRALTKAQRDVIEECLMSLCKY LRPSMLQHLLRRLVFDVPILNEYAKMPLKLLTNHYERCWKYYCLPNGWANFGVTSEEELH LTRKLFWGIFESLAHKKYDLELFKIAMPCLCAIAGAIPPDYVDATYSSHTEKKASVDAEG NFDPKPVETTNTIIPERLDAFMNKYAEHTHDRWAFEKIQNNWTYGEVLDENAKTHPMLRP YKTFSEKDKEIYRWPIKESIKAMLAWEWTLDKARDGEVEVDKKAATRKISQTAQATYDPS HGYNPQPIDITGMALSRELQSMAEQLAENYHNTWGRKKKLELQSKGGGTHPLLVPYDTLT AKEKARDREKAQDLLKFLQLNGYAVTRGLKDMEQDISSIEKRFAYGFLQKLLKWMDIAQE FIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLVNQYFKNHCLYFLSTPAKVLGSGGLSS NKEKEMIASIFCKLAALVRHRVALFGTDASAVVNCLHILSRSLDARTVMKSGPEIVKAVL RQFFESAADDIEKMVENLKLGKVSSRNQVKGVSQNINYTTTALMPVLTSLFDHIAQHQFG DDVMLDDLQISCYRLMCSIYSLGTVKTPHVEKQRPALGECLAHLAAAMPVAFLEPALNEF NMFSVYTTKTPRERTILGLPNNVEELCPDIPELDILMKEIHDLAESGARYTEMPHVIEIT LPMLCNYLPRWWERGPDNFPEQEGQLCTAVTSEQLNKLLGSIMKIVVNNLGIDEASWMKR LAVFAQPIVSRAKPEMLKSHFIPTMEKLKKRSGKVVAEEEQLRMEGKGELDSEDGTIKDE FAVLCRDLYALYPLLIRYVDNNRARWLTCPDPDAEELFRMVGEVFIFWSKSHNFKREEQN FVVMNEINNMSFLTADSKSKMTKAGDGESGGSEQERTKKKRRGDRYSVQTSLIVAALKKM LPIGLNMCSPADQELINLAKIRYSLKDTDEEVREFLHNNLHLQGKVEDPAMRWQMSLYKE MSGKAEDAEDPEKVVKRVQEVSAVLYHIEVTEHPYKSKKMVWHKLLSKQRRRAVVACFRM TPLYNIPAHRATNMFLDAYKRNWLETEGYSFEDKMIDDLSKALEEEEDEEEETETKPDPL HQLILHFSRTALTEKTKLDVDHLYMSYADIMAKSCHIGEDDEGGEQEGDEPSFEVRQTEM DKEMEKQRLLYQQSRLHNRGAAEMVLQMISACKGVPGAMVSSTLKLGISILNGGNSDVQQ RMLDYLKDKKDVGFFLGLQALMQTCSVLDLNAFERQNKAEGLGMVSEEGTNKKLERDEKV MADNEFTCDLFRFVQLLCEGHNNDFQNYLRTQTGSTTTINIIICTVDYLLRLQESISDFY WYYSGKEIIDEPGKRNFSKAMTVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLH VFAHMMMKLAQMHPDPGPRNGDHFWSRAHSEDSSQIGLLKELLDLQKDMVVMLLSLLEGN VVNGTIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVASDAFRDYVTDPRGLISKKDFS KAMDSQKQYSSSEIQFLLSCSEADENEMINFEEFADRFQEPAKDIGFNIAVLLTNLSEHV PHDTRLQNFLEQAESVLNYFRPFLGRIEIMGASRKIERIYFEISEANRNQWEMPQVRESK RQFIFDVVNEGGESEKMEMFVNFCEDTIFEMNIAASISEPEGDGAEEEDDEEEEEGAGEQ GESGEGDEGNGDEMPPESASAFADFLKSVFEFFNMFTFRNLRRRYRKLRKMTIKEMVIGL ATFIYTIVFGILMFVYGICKGFFTLIWKVLFGGGLVEGAKKITVTEILASMPDPTQDEVH EDLPPDPGAREVQDADGVSDLLDNVGGEEEEEDSEEREGGRLPGFNTPGGLGDFGETTAE EPPTPEGTPLLKRKLLEAAVGGPEENEQPVQTEEEAPQETEKADTEKEEKSEKAEPEPKP EVKEEEAEAKEEPTVQTKTKKEKKQVEEGFELWNELEVQRIKFMNYLSRNFYNLRFLALF IAFALNFLLLFYKVSDNPPGEEEFDDPGLFEASGLFEGSGAEEDGSGLDEEGGGEDDEEE GPMYYFLEESTGYMTPAMAFFGIIHTIISFLCIIGYNCLKVPLVIFKREKELARKLEFDG LYVTEQPEDDDIKGQWDRLVLNTPSFPNNYWDKFVKRKVLDKYGDIYGRERIAELLGMDL ASLDVSAMTHEKKPEPDTSMLSWVTSIDIKYQIWKFGVIFTDNTFLYLVWYLLMSLLGHY NNFFYAAHLLDIAMGVKTLRTILSSVTHNGKQLMMTVGLLAVVVYLYTVVAFNFFRKFYN MSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFV IVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGSDYFDSTPHGFETHTLEEHN LANYMFFLMYLINKDETEHTGQESYVWKLYQERCWDFFPAGDCFRKQYEDQLG NT seq 15282 nt NT seq  +upstreamnt  +downstreamnt atggcagaagggggagagggagaggaggagattcagttcctgcgaacggatgaccaggtc tgtctgcagtgcactgcctccgtcctgaaggagcagcagattaagctatgtctgtgctgc gagggcttcgggaaccgtctctgctacttggaaaccacatccaatgctcagaatgtgccc ccggacctggccataagtgccttcattctggagcagtccctgtcggtccgtgctctgcag gagatgttggccaacagggtggagatgacagagtcatcccaaggtggaggtcatcgtacc ttactgtacggtcatgccatccttctgagacactaccactcaggcatgtacctgagctgt ttgactacatctcggtcactcacggacaagctggcctttgacgtgggcttacaagaggat tccactggtgaggcatgttggtggaccattcatccagcctccaagcaaaggtcagaaggt gaaaaggtcagggtgggtgacgacctaatccttgtcagcgtgtcctctgagagatacctg cacctgtcctacgccagtggggatctgatggtggatgcctctttcatgcagactctgtgg aacatgaatccaattagttccggatgcgaactagctgaggggtttctgacaggaggtcac gttctcaggctgttccacggccacatggacgagtgtctggccatctctacaccagaggaa ggagaagaaaagcgcaggatggctcactatgaaggcggtgctgtgtgcagtcaggctcga tccctgtggaggttggagcccctcagaatctgctggagtggtggccacatgaagtggggg cagtctttccgtattcgccacatcaccacaggcaggtacctgtgtatggatgaggagaag ggtctgttggtggtcgacccagaaaaggcaaacaccaaactttctgctttctgcttccgt gcttcaaaggataaggtggaggtggctccaaagcgtgatgttgaggggatgggcattcca gagataaagtatggggagtccatgtgcttcgtccagcatgtgtccacaggcctgtggctc acatatgccgccctggatgccaaagctgcccgtttgggaatgatgaagagaagggtcatt ctgcaccaggagggtcacatggacgatgccctaactgtatcccgctcccaaactgaagaa tctcaggctgctcgaatgattttcagcaccatgggccttttcaggcagttcaacaagggt ttggactctctgaatgcaaagaacaagtcacctggggctgcctcgcttcctctggagggc gtcatcctgtctcttcaggatctcatcttctacttccgtcctcctgaggaggaactggag cacgaagagaagcagaccaaacttcgctccctccgcaaccgacagaacctcttccaagag gagggaatgatcaccatcgtgctggagtgcatcgaccgcctgaatgtgtacaacacggct gcacacttttctgaatttgccggggaggaagctgctgagtcctggaaggagattgtcaac cttctttatgagctgctggcttctctaattagaggaaaccgctctaattgcgcgttgttc tgtgacaacctggactggctggtcagcaagttggaccgtctggaggcttcttcaggtatt cttgaggtgctgtactgtgtgctaattgaaagccctgaggttctgaacatcatccaggag aaccacattaaatccataatctctcttctggacaagcatggaaggaaccacaaggtcctg gatgtcttgcgctctctctgtgtgtgtaatggtgtagctgtgaggtccaaccagaacctc atcactgaaaacctgctcccaggtcgtgacctcttgctgcagaccaacattgtaaactat gtcactagtgtaagacccaacatcttcctgggtacatgtgaggggtccacacagtataag aaatggtactttgagatgatggtagactatgtggaaccctttgtgacggggcaggccagc cacctgcgtgtgggctgggctatgaccgagggatacagcccctaccctggaggaggggaa ggctggggaggcaacggtgttggagatgacctctactcctatggctacgatggactgaat ctatggtcaggtaccgtccctcgccaggttgctgcacccagcgcacacagcctgtctgct gacgacgttgtcagctgctgtctggatctgagcgtgcctagtatctctttccgtattaac ggccacccagtccagggcatgtttgaaaactttaatgtggacggcctcttcttccctgtc atcagtttctctgctggagtcaaggctcgattcctccttggcggtcgtcatggagacttc aagttcatgccaccgcctggctacgccccgtgctatgaggctgtgttgcctagagagaga atgcgtattgaacccatcaaggagtacaagcacgacttccatggtgtacgcaacctgttg ggtcccacgctatctctcacccacacctcttttaccccctgccctgtggacactgttcag attgtgttaccaccccacttggaacgtatccgagagaagctagccgagaatattcacgag ctctgggctgtcactcgtattgagcagggctggacctatgggagtttcagggatgacaac aagaaactccatccgtgtctggtggacttccagagtctccctgaacctgagaggaactac aacctgcaaatgtctggcgagactctcaaaactctcctggcgctgggttgccatgttggt atgggtgacgagaaagcagaggagaatctcaagaagatcaagctgcccaagacctatgtg atgatcaatgggtacaagcctgccccccttgatctcagccatgtcaaactgacaccaaat cagaaccagcttgtagaaaaactggcagaaaatgggcataatgtttgggcaagggaccgg gtacgccaaggatggacctacagcattgtgcaggacatcatgaataagcgaaaccctcgt ctggtaccttacaacttgctggacgagagaactaagaaaaccaaccgagacagtgttaat aacgctgtccgcaccctcattggctatggctacaacattgagcctccagatcaggagagc actggccatggcctcgagaacactcgcggggataaggtacgaatcttcagggcagagaag tcgtacgctatcacccaagggaagtggtactttgagtttgaggctgtaaccacgggggag atgagagtgggctgggcccgtccgagtgtccgctctgacactgaactgggagcagatgaa ctcgcatacgtctttaacggcaataaggctcagagatggcatgttggcaatgaacccttc ggtcgccagtggcagtctggggatgtggttggttgtatgattgacctgactgatatgaac atcatgttcacactcaacggagaaatgttgatcagtgactcaggctcggacatggcgttc aaagacattgaaattggggaaggttttataccagtgtgcaccctgggcctgtctcaggtt ggcaggattaatcttgggcaaaatgtaagcagcctgcgatactttgccatctgtggcctg caggaaggatttgaaccttttgccatcaatatgaagcgagacattaccatgtggttcagt aaaagtttgccccagtttgtgcctgtacccaacgaacacaatcatattgaggtctcccgt gtggatgggactgtggacagcgccccctgtctaaaactgacccacaagacgtttggctcg cagaacgccaatactgatatgctgttcctcagacttagcatgcccgtccagtttcatgag actttcaagattaccgcaggcacaacccctctcacacgttccctcaccatacccgaggag gaagtggtagtggtggagcccgactcagagtttgaagttctgaagaagtctgccggccgc aaggagcaggatgatgaaaagaaggagccgtctgtacctaaggaaatctctatggaaaac gagaaggacacaatgtcagaaaagggaaagaaaaaaggattcttctcaaaggccaagaag gctgccatgacacctctctcccctcctcctgcccctccaacggtgccacgtttggtggaa gatgtggtcccggatgacagagatgaccctgacaccatcctgaataccaccacttattac tattctgtgaggatctttgctgggcaggagccttctggtgtgtgggttggctgggttact cctgattaccaccagtatgatccaacctttgacctctccaaagtccgcactgttactgtt accgtgggagatgacaaaggcaacatacatgacagtatgaaacacagtaactgttatatg gtgtggggaggggacctggtcagcaatcagcagacccgcttcagccaggaggacatggtg gttggctgcttggtcgacctggcaactggtctgatgacctttacagccaatggaaaggag attaacacattttaccaggtggagcccaacaccaagctgttccctgccgtcttcgttcag ccctctaatcagaacttggtgcagctggagctgggaaaactcaagaacatcatgcccatc tcggcagccatgttccgcagtgaacgtaaaaacccggtcccccagtgccctcccaggcta gatgtccagatgctgaccccagttatctggagtcgtatgcctaatcactttctcaacccg gaggtgggcagagtgagtgagaggttgggctggatggtggagtgcactgaacctctcatc atgatggctctgcacatcccagaggagaacaggtgtattgatatcctcgagctgtctgag cgtcaggatctgatgaagttccactaccacactcttatgctctactgcgctgtgtgcgca cttggcaataatcgagtggctcatgctctgtgcagccatgtggatgaatcacagcttttt tatgccatcgagaacacttacctgcctggacctctccgcagtggcttctacgacctgctc atcagcattcacctggagtctgccaaacgagcgcgtctgggcaccaacagggagtttatc gtccccatgactaaagagactctcagcatccacctctatcctgatgcaaagaaggcccat tccctccccggtgtcggactgaccacctgcttacggcccaaactgcatttctcatccatc aactttgttggcacagaccctgacttgtacacccttagtcctgttttccccctgcaggag ctgaagaccagggcaattagcatgttaacagaggctgtgctagatggtagccaggctatg cgcgatcctgttggaggcagtgtggagttccactttgtcccaatcctaaagctgatcagt acattgctcattatgggcatcttcaacgatgaggacaccaagcacatcctcaagatgatt gatccaaatgttttcagtggaaaggaggaggaagaggaggaagagaaggagggagagaaa gctgaggagggtggagccgctgaaataagcgaggaagaaaaggaggaggaaactgaggcc gatcttgaggacgaaggggttggtgatgagggagaggatgagctgcaagatttagaagga gagcctaaggaggaaggagaacaggaggagaaggaggaggaagaggccaaagaaggaaaa atggaaggagagaaggaggaggaggagaaggaggagatggaggcagagttagtggaggca gaagtgaaagaagaggaggatggtctggaagagggtttactccagatgaagctaccagag tctgtcaaactgcagatgtgcacactcctgcagtacttctgcgactgtgagctgcgacac agagtggaaggcattgtggcctattcagacagctttgtcaatagtgttcagaaaaaccag cgtgttcgctacaacctgttaatgagagccttcactatgtcggctgctgagactgcacgc aagactcgcgagttccgttcaccaccccaggaccaggttcttttgctgaccaactttaag cacagtccggaggatgaattgagtccggtgcctgaggaggtgcgggacagtctggtagag ttccacactgacctcctgcttcactgcggtatacatattgaggaggaggcagaggaggaa gaggtggactcctcactgagaggcagacttatcagtctggtggataagattaggagcttg cgcaagaaggaggaggaggagaagccagaggttgaggaggatccaaaacccagctccctt caggaactgatctcccacaccatgatccactgggcccaggagtcgtttattcagaaccct gagcttgtccgtatgatgttcagcctgctccacagacagtatgacggcattggggagctg atccgagcactgcccaaagcctacgcaatcaatgctgtgtctgttcaggacaccatggac ctacttgagtgtttgggacagatacgttcgctgcttattgtccagatgggcccagaagag gagaggctcatgatccagagcattgggaacatcatgaacaacaaggtgttctaccaacac cccaatctaatgagagctcttggtatgcatgagactgtaatggaagtaatggtcaatgtg ttgggcggtggaggagactcaaaggagattcgattcccacaaatggtgaccaactgctgt cgtttcctgtgttacttctgtcgtattagccggcagaaccagcgctccatgtttgaccat ctgagctacctgctacaaaacagcggcattggcttgggcatgcgtgggtccacacctctg gatgtagctgcagcatcttgcatcgacaacaatgagctggccttagctctacaagagcag gacctggaaatggtggtgacatacctggcaggctgtggactgcagacgtgtccaatgctc ctttccaagggctaccctgacattggctggaacccctgcggaggagagagatacctggat ttcctccgctttgctgtctttgttaatggggaaagcgtggaagagaacgccaatgttgtt gtgcgtctgctcatccgtcggcctgagtgcttcggtccggccctgagaggagagggcggg aatggtctgctggctgccatggaggaagccatcaagatctcagaggatccagcaagggat ggacccactgtcaaaaaagacagacgcttcatgtttggtggtgaggaacagcacgaggag aaccgtgtacatctaggaaatgccatcatgtccttctactctgccctcatcgatctgctg ggtcgctgtgcccctgagatgcatctgatccaagcaggcaaaggtgaagctctaagaatc agggccatccttaggtctcttgtgcccatagaggacctggtgggagtcatcagtttatcc gtccagattcctgcctttggcaaagatggtcaggttatggagccgaagatgtcagccagt tttgtcccagaccacaaggcctctatggtgctgtttcttgacagagtttatggtattgac aaccaggacttcttgcttcatgtgctggaggttggcttcctgcctgacatgagagctgca gcctctctggacacggtggcattcagtacgactgaaatggccttggcactgaaccgctac ctctgttcggctgttctgcctttgctcaccaagtgtgctccgttgtttgctgggacggaa caccgggccatcatgatagattccatgcttcacaccatctatcgcttgtcccgtggccga gccctcaccaaggctcagagggacgtcattgaggagtgcctcatgtcgctttgcaaatac cttcgaccctccatgctgcagcatctgcttagacggctggtatttgatgtgcccatcctc aacgaatatgcaaagatgcccctcaagctgttgaccaatcactatgagcgctgctggaag tactactgcttacctaacggatgggctaattttggggtgacctcagaggaggagctacat cttactcgaaaactcttttggggaatttttgaatctttggcgcacaagaaatatgattta gaactcttcaagatcgccatgccctgcctctgtgctatagccggagccatcccgccagat tatgtggatgccacctactcctctcacactgagaagaaggcctctgtggatgctgaaggc aactttgaccccaaaccagtggagaccaccaacacaatcataccagagaggctggatgcc ttcatgaacaagtatgcagagcacactcatgacagatgggcctttgaaaagattcagaac aactggacctacggagaggtgttggatgaaaatgcgaagactcaccccatgctccggcca tacaaaacattctctgaaaaggacaaggagatttatcgttggcccatcaaagaatccatc aaagccatgttggcctgggagtggaccttggataaagctagggatggggaggtggaagtc gacaagaaggcggccactcgcaagatctcccaaactgctcaggccacttacgatccaagt cacgggtacaaccctcagccaatagatatcacaggaatggccctgtccagagagctgcag tccatggctgagcagctggctgagaactatcacaacacctggggcaggaagaagaagctg gagctacaatccaaaggtggtggcacccatcctttgcttgtgccttatgacaccctgacg gctaaggagaaggccagggacagggagaaggcccaggacctgctcaagttcctccagcta aatggatatgctgtgacaaggggactgaaagacatggagcaggacatttcctccattgag aagcgttttgcttacggcttcctccagaagcttcttaaatggatggacattgcccaggag ttcattgctcatcttgaggctgtagttagcagtgggagagtggagaagtcaccacatgaa caagagatcaaattctttgccaagattctcttgccactggtaaatcagtacttcaagaat cactgcctttacttcctctccactcctgctaaagtcttgggtagtggagggctttcctcc aacaaggagaaggagatgattgcaagtatcttttgtaagttggctgctttggtgaggcac agagtagctctttttggaacagatgcaagtgcagtggtgaactgtctgcacatcctctca cgatcactagatgccagaaccgttatgaagtcaggccctgagattgttaaggcagtcctg cggcagttctttgagagtgctgcggatgacattgagaagatggttgagaatctgaaactg ggcaaagtgtccagtcgaaaccaggttaagggtgtgtcccagaacatcaactacaccacc actgccttgatgccagtcctcacttcactgtttgaccacattgcccagcaccagtttgga gatgacgtcatgttggacgatctgcaaatatcctgctatcgtttaatgtgcagtatctac tctttgggcacagtgaagactccacatgtcgagaaacagcgaccagctcttggcgagtgc ttggcccacttagcagctgctatgccagtggccttccttgagccagcactgaatgagttc aacatgttttctgtttacaccaccaagactcccagagagagaaccattctgggtcttccc aacaatgtagaagagctgtgccctgacattccagagctggacatcctgatgaaggagatc catgacctggctgagtctggggctcgctacacagaaatgccccatgtgattgagatcacc ctgcccatgttgtgtaactacctcccacgctggtgggaaaggggcccagacaatttcccc gagcaggagggccagctctgcaccgctgtcacttcggagcagcttaacaagctgctgggc agcatcatgaagattgtggttaacaacctgggtatagatgaggcctcctggatgaagaga ttggcagtgtttgcccagcccattgtcagtagggctaaaccagagatgctaaaatcccac ttcatccccaccatggaaaagctaaagaagcgctcaggaaaggtggtggccgaggaggaa caactgcgcatggagggcaaaggggagctggacagcgaagatgggaccatcaaagatgag tttgctgtgctgtgtcgggacctgtatgctctctaccccttgctcatccgctatgtggac aataacagggcaagatggttgacctgtccagacccagatgcagaggaacttttcaggatg gtgggagaggtcttcattttctggtccaaatcccacaactttaagagagaggagcagaac tttgtggttatgaatgagatcaacaacatgtccttcctgactgctgacagtaaaagcaag atgaccaaggccggagatggagagtctggaggctcagagcaggagcgtaccaagaagaag cggcgaggggatcgctactctgtgcagacctcccttatcgttgcggcattaaagaagatg cttcctatcggcctcaatatgtgctctcctgcagaccaggagctcatcaatcttgccaag atcagatactcactgaaagatacggatgaagaggtgagggagttcttacacaacaatctg catctgcagggcaaggtggaggacccagctatgcgctggcaaatgtctctctataaggag atgtcaggcaaggcggaagatgctgaagaccctgagaaggttgtaaaaagggtgcaagag gtgtctgctgtcctttaccacattgaggtgacggagcatccctacaagtcaaagaaaatg gtgtggcacaagctgctgtctaaacagcgtcgcagggctgtggtggcctgtttcaggatg acacccctgtacaacatccctgcgcacagggcaaccaacatgttcttggatgcctacaaa cgcaactggttagagactgagggttactcatttgaggacaagatgatcgacgacttatca aaagccctagaggaagaagaggacgaggaagaggagacagagacaaagcctgaccccctt catcagctgattcttcatttcagccgcacagctctcacagaaaagactaaacttgacgtt gatcatctttatatgtcttatgctgatattatggcaaagagctgccacattggtgaggat gacgaagggggagaacaggagggggatgagccatcctttgaggtgcgacagacagagatg gataaggagatggagaaacagaggcttctgtaccagcagtcccgtctacacaaccgtggg gctgcagagatggtgctgcagatgatcagtgcctgtaaaggcgtacctggagccatggtt tcttccacgcttaaactgggaatctccatcctcaatggaggcaacagtgatgtacagcag agaatgctggactatctgaaggataaaaaggatgtgggattcttccttggccttcaggct ctgatgcagacctgcagtgttttggacttgaatgcttttgagagacaaaacaaggccgag ggacttgggatggtttcagaggaaggaactaataagaagctagaacgtgatgagaaagtg atggcggataatgaatttacgtgtgacctcttccgctttgtgcagcttctttgtgagggc cataataacgattttcagaactacttaagaactcagacaggcagtaccactaccatcaat atcatcatctgcactgtggactacctgctgcgactacaggagtcgatcagtgacttttac tggtactactcaggaaaagaaattattgatgaacctggaaagaggaatttctccaaagca atgactgtggccaagcaggtcttcaatagcttgactgagtacatccagggtccctgtact ggtaaccagcagtctttggcccacagccggttgtgggatgctgttgtgggcttcctgcac gtctttgctcatatgatgatgaaacttgctcagatgcaccccgatcctggacctcgaaat ggcgatcatttttggagtagagcacactctgaggactccagtcaaattggactgttgaag gagctgttggacctgcagaaggacatggtggtgatgcttctgtctctgcttgaaggcaat gttgtaaatggcaccattgccaggcagatggttgacatgctggtggaatcctccagcaac gtggagatgatccttaagttcttcgacatgttccttaagctcaaagacatagtggcatct gacgccttccgagactatgtgaccgacccccgtgggttaatctccaagaaggacttctcc aaggccatggacagccagaagcaatactcttcttcagaaatccagttcctcctctcttgc tcagaagctgatgaaaacgagatgatcaacttcgaggagtttgctgatcgtttccaagag ccagccaaagacattggtttcaatattgccgttctgctcacaaacctgtccgagcacgta ccccacgacacgcgccttcagaacttcctggagcaggccgagagcgtgctgaactacttc cgccctttcctcggccgcattgagatcatgggagccagcaggaagattgagcgcatttac tttgaaatcagcgaggcgaaccgcaaccagtgggaaatgccacaagtccgagagtccaag cggcagttcatatttgatgtggtcaatgagggcggggagagtgagaaaatggagatgttt gtgaacttctgcgaggacaccatctttgagatgaacattgctgcgtctatctctgagccc gagggtgatggcgctgaagaggaagatgacgaggaagaggaggagggcgcgggagaacaa ggagagtctggagaaggagacgaaggcaatggagacgaaatgcctccagagtccgcttca gcctttgcagactttctaaagagtgtgttcgaattcttcaacatgttcaccttccgtaac ctgcggcgtcggtaccgcaaactaagaaaaatgacgataaaggagatggtgatcggtctg gctacatttatctacaccattgtgtttggtatcctgatgtttgtttatggcatatgtaag ggcttcttcacactcatatggaaggtgctgtttggtggaggcctagtggagggtgccaag aagataacggtgacagagatcctagccagtatgccagatcccacacaggacgaagttcac gaggacctgccacctgaccctggggctagagaggttcaagatgcagacggagtgtcagac ctcttagataacgtgggaggagaggaggaggaggaggatagcgaggagagggaaggtgga cgcctacctggtttcaatacacccgggggacttggagactttggtgagacgacagctgaa gagcctccgactccagagggcacgccgctgctgaagaggaaattgttggaagccgcagtg ggaggaccagaagagaacgaacaacctgttcaaactgaagaagaggctcctcaggagact gagaaagcagacaccgagaaggaagagaagtcagagaaggcagagcctgaacctaaacct gaggtaaaggaggaagaggctgaggcgaaagaggagccgactgtgcagaccaagacaaag aaggagaagaaacaagttgaggagggctttgagctgtggaatgagctggaggttcagagg attaaattcatgaactacctttctcgcaacttctacaaccttcggttcttggccctgttt attgccttcgctctcaatttcctcctgctcttctacaaggtgtctgacaatcctccaggc gaggaagagtttgacgatcctggtctgtttgaggcctctggcctgtttgaaggctccggc gctgaggaggatgggtccggattagatgaagaaggaggaggagaagatgatgaagaagaa ggtcccatgtactacttcttggaagagagcacaggctacatgacaccagccatggccttc tttggtatcatccacaccatcatctccttcctctgcatcattggctacaactgcctcaag gtccctctggttatcttcaagagagagaaggagctggccagaaagctagagtttgatggt ctctatgtcactgagcagcctgaggacgatgacatcaagggccagtgggacaggctggtg ctcaacactccatctttccctaacaattactgggacaagtttgtgaaaagaaaggtgctg gataaatatggtgacatctacggcagagagaggattgcggagttgctcggtatggacttg gcttctctagacgtcagtgccatgacccacgagaagaagcctgaaccagacacctcaatg ttgagttgggtcacatctattgacatcaagtaccagatctggaagtttggtgttattttc accgacaataccttcctctacctggtttggtacttgttaatgtctctgctcggacactac aacaacttcttctatgccgctcatcttctggacattgccatgggtgttaaaaccctgcgc accattctgtcctctgttactcacaacggcaaacagttgatgatgacagtgggtttgctg gctgtggtggtgtacctgtacaccgtggtggccttcaacttcttccgcaagttctacaac atgagtgaggatgaggacgaaccggacatgaagtgtgatgacatgatgacttgctacctg ttccacatgtatgttggcgtgcgtgctggcggtggcataggagatgaaattgaggaccca gccggggatgaatacgagctctaccgagtggtctttgacattaccttcttcttctttgtc attgtcatcctgctggctatcatccagggtttgatcattgatgcctttggagagctgaga gatcagcaggagcaggtccgagaggacatggagacaaagtgtttcatctgtggaattgga agtgactactttgactctacgccacacggcttcgagacacacaccttagaagagcataac ttagccaactacatgttcttcctgatgtatctcatcaacaaagacgaaacagaacacaca ggacaggaatcatacgtgtggaagctgtaccaggagcgatgctgggactttttccctgct ggagactgcttcaggaagcagtatgaggatcagctcggataa

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