Escherichia coli O7 K1 IAI39 (ExPEC): ECIAI39_4406
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Entry
ECIAI39_4406 CDS
T00829
Symbol
metH
Name
(GenBank) homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent
KO
K00548
5-methyltetrahydrofolate--homocysteine methyltransferase [EC:
2.1.1.13
]
Organism
ect
Escherichia coli O7:K1 IAI39 (ExPEC)
Pathway
ect00270
Cysteine and methionine metabolism
ect00450
Selenocompound metabolism
ect00670
One carbon pool by folate
ect01100
Metabolic pathways
ect01110
Biosynthesis of secondary metabolites
ect01230
Biosynthesis of amino acids
ect04980
Cobalamin transport and metabolism
ect04981
Folate transport and metabolism
Module
ect_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:
ect00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
ECIAI39_4406 (metH)
09106 Metabolism of other amino acids
00450 Selenocompound metabolism
ECIAI39_4406 (metH)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
ECIAI39_4406 (metH)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
ECIAI39_4406 (metH)
04980 Cobalamin transport and metabolism
ECIAI39_4406 (metH)
Enzymes [BR:
ect01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.13 methionine synthase
ECIAI39_4406 (metH)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Met_synt_B12
S-methyl_trans
Pterin_bind
B12-binding_2
B12-binding
Motif
Other DBs
NCBI-ProteinID:
CAR20512
UniProt:
A0A0H3MS15
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All DBs
Position
4607551..4611234
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AA seq
1227 aa
AA seq
DB search
MSSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSK
PEVIAAIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTA
RTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILI
ETVFDTLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA
LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQ
AGFLNIVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGEDSLFVNVG
ERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLI
AGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAV
VVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQ
DFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAG
QLAIYDDLPTELRDAVEDVILNRRDDGTERLLELAEKYRGSKTDDTANTQQAEWRSWEVN
KRLEYSLVKGITEFIEQDTEEARQQATRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
SARVMKQAVAYLEPFIEASKEQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDL
GVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKA
HTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPR
TPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKY
PRILEDEVVGVEAQRLFKDANDMLDKLSAEKMLNPRGVVGLFPANRVGDDIEIYRDETRT
HVINVSHHLRQQTEKTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQH
DDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYP
ACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQV
EDYARRKGMSVSDVERWLAPNLGYDAE
NT seq
3684 nt
NT seq
+upstream
nt +downstream
nt
gtgagcagcaaagtggaacaactgcgtgcgcagttaaatgaacgtattctggtgctggac
ggcggtatgggcaccatgatccagagctatcgactgaacgaagccgattttcgtggtgaa
cgctttgccgactggccatgcgacctcaaaggcaacaacgacctgctggtactcagtaaa
ccggaagtgatcgccgctatccacaacgcctactttgaagcgggcgcggatatcatcgaa
accaacaccttcaactccacaaccattgcgatggcggattaccagatggaatccctgtcg
gcggaaatcaactttgcggcggcgaaactggcgcgcgcctgtgctgatgagtggaccgcg
cgcacgccggagaaaccgcgctacgttgccggtgttctcggcccgaccaaccgcacggcg
tctatttctccggacgtcaacgatccggcattccgcaacatcacttttgaccagctggtg
gcggcctatcgcgaatccaccaaagcgctggtggaaggtggtgcggatctgatcctgatc
gaaaccgttttcgacacccttaacgccaaagcggcggtttttgcggtgaaaacggagttt
gaagcgctgggcgttgagctgccgattatgatctccggcaccatcaccgacgcctccggg
cgcacgctctccgggcagaccaccgaagcgttttataactctctgcgccacgccgaagcg
ctgactttcggccttaactgtgcgctggggccagacgaactgcgccagtacgtgcaggag
ctgtcacggattgcggaatgctacgtcaccgcgcacccgaacgccgggctacccaacgcc
tttggtgagtacgatctcgacgccgacacgatggcaaaacagatacgtgaatgggcgcaa
gcgggttttctcaatatcgtcggcggctgctgtggcaccacgccacaacatattgcagcg
atgagtcgtgcagtagaaggattagcgccgcgcaaactgccggaaatccccgtagcctgc
cgtttgtccggcctggagccgctgaacattggcgaagatagcctgtttgtgaacgtgggt
gaacgcaccaacgtcaccggttccgctaagttcaagcgcctgatcaaagaagagaaatac
agcgaggcactggatgtggcccgccagcaggtggaaaacggcgcgcagattatcgatatc
aatatggatgaagggatgctcgacgccgaagcggcgatggtgcgttttctcaatctgatt
gccggtgaaccggatatcgctcgcgtgccgattatgatcgactcctcaaaatgggatgtc
attgaaaaaggtctgaagtgtatccagggcaaaggcattgttaactctatttcgatgaaa
gaaggcgtcgacgcttttatccatcacgcgaaattgttgcgtcgttacggtgcggcagtg
gtggtaatggcctttgacgaacagggccaggccgatacccgcgcacggaaaatcgagatt
tgccgtcgggcgtacaaaatcctcaccgaagaggttggcttcccgccagaagatatcatc
tttgacccgaacatcttcgcggtcgcaactggcattgaagagcacaacaattacgcgcag
gactttatcggcgcgtgtgaagacatcaaacgtgaactgccgcacgcactgatttccggc
ggcgtttctaacgtttctttctcattccgtggcaacgatccggtgcgcgaagccattcac
gcggtgttcctctactacgctattcgcaatggcatggatatggggatcgtcaacgccggg
caactggcgatttacgacgacctgcctaccgagctacgcgacgcggtggaggatgtgatc
ctcaaccgtcgcgacgatggcaccgagcgtttactcgagcttgccgagaaatatcgcggc
agcaaaaccgacgacaccgctaacacccagcaggcagagtggcgttcgtgggaagtgaat
aaacgtctggaatactcgctggtcaaaggcattaccgagtttatcgagcaggataccgaa
gaagcccgccagcaggctacgcgtccgattgaagtgattgaaggcccgttgatggacggc
atgaacgtggtcggcgacctgtttggcgagggcaaaatgttcctgccgcaggtggtgaaa
tcggcgcgcgtgatgaagcaggcggtggcctacctcgaaccgtttattgaagccagcaaa
gagcagggtaaaaccaacggcaagatggtgatcgccacagtgaagggcgatgtccacgac
atcggtaaaaatatcgttggcgtggtgctgcaatgtaacaactacgaaattgtcgatctc
ggcgtgatggtgcctgcggaaaaaattctccgtaccgctaaagaagtgaatgctgatttg
attggcctttcggggctgatcacgccgtcgctggacgagatggttaacgtggcgaaagag
atggagcgtcagggcttcaccattccgctattgattggcggcgcgaccacctcaaaagcg
cacacggcggtgaaaattgagcagaactacagcggcccgacggtgtatgtgcagaacgct
tcacgcaccgttggtgtggtggcggcgctgctttccgatactcagcgtgatgattttgtc
gctcgtacccgcaaggagtacgaaaccgtacgtattcagcacgggcgcaagaaaccgcgc
acaccaccggtcacgctggaagcggcgcgtgataacgacttcgcttttgactggcaggct
tatacgccgccggtggcgcaccgtctcggcgtgcaggaagtcgaagccagcatcgaaacg
ctgcgtaattacatcgactggacaccgttctttatgacctggtcactggccgggaagtat
ccgcgcattctggaagatgaagtggtaggcgttgaggcgcagcggctgtttaaagacgcc
aacgacatgctggataaattaagcgccgaaaaaatgctgaacccgcgtggcgtggtgggc
ctgttcccggcaaaccgtgtgggcgatgacattgaaatctaccgtgacgaaacgcgtacc
catgtgatcaacgtcagccaccatctgcgccaacagaccgaaaaaaccggcttcgctaac
tactgtctcgctgacttcgttgcgccgaagctttctggtaaagcagattacatcggcgca
tttgccgtgactggcgggctggaagaggacgcactggctgatgcctttgaagcgcagcac
gatgattacaacaaaatcatggtgaaagcccttgcagaccgtctggcggaagcctttgcg
gagtatctccatgagcgtgtgcgtaaagtctactggggctatgcgccgaacgagaacctc
agcaacgaagagctgatccgcgaaaactaccagggcatccgtccggcaccgggctaccct
gcctgcccggaacatacggaaaaagccaccatctgggagctgctggaagtggaaaaacat
accggtatgaaactcacggaatccttcgccatgtggccgggtgcatcggtttcgggttgg
tacttcagtcatccagacagcaagtattacgcggtggcgcaaattcagcgcgaccaggtc
gaagactatgcccgccgtaaaggaatgagcgtctcagatgttgagcgctggctggcaccg
aatctggggtatgatgccgagtaa
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