KEGG   Escherichia coli DH1: ECDH1ME8569_3875
Entry
ECDH1ME8569_3875  CDS       T02102                                 
Symbol
metH
Name
(GenBank) B12-dependent methionine synthase
  KO
K00548  5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]
Organism
edj  Escherichia coli DH1
Pathway
edj00270  Cysteine and methionine metabolism
edj00450  Selenocompound metabolism
edj00670  One carbon pool by folate
edj01100  Metabolic pathways
edj01110  Biosynthesis of secondary metabolites
edj01230  Biosynthesis of amino acids
edj04980  Cobalamin transport and metabolism
edj04981  Folate transport and metabolism
Module
edj_M00017  Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:edj00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    ECDH1ME8569_3875 (metH)
  09106 Metabolism of other amino acids
   00450 Selenocompound metabolism
    ECDH1ME8569_3875 (metH)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    ECDH1ME8569_3875 (metH)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    ECDH1ME8569_3875 (metH)
   04980 Cobalamin transport and metabolism
    ECDH1ME8569_3875 (metH)
Enzymes [BR:edj01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.13  methionine synthase
     ECDH1ME8569_3875 (metH)
SSDB
Motif
Pfam: Met_synt_B12 S-methyl_trans Pterin_bind B12-binding_2 B12-binding
Other DBs
NCBI-ProteinID: BAJ45731
LinkDB
Position
4202933..4206616
AA seq 1227 aa
MSSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSK
PEVIAAIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTA
RTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDGLVAAYRESTKALVEGGADLILI
ETVFDTLNAKAAVFAVKTEFEALGVELPIMISGTITDAFGRTLSGQTTEAFYNSLRHAEA
LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQ
AGFLNIVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGEDSLFVNVG
ERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLI
AGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAV
VVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQ
DFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAG
QLAIYDDLPAELRDAVEDVILNRRDDGTERLLELAEKYRGSKTDDTANAQQAEWRSWEVN
KRLEYSLVKGITEFIEQDTEEARQQATRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
SARVMKQAVAYLEPFIEASKEQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDL
GVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKA
HTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPR
TPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKY
PRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIEIYRDETRT
HVINVSHHLRQQTEKTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQH
DDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYP
ACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQV
EDYARRKGMSVTEVERWLAPNLGYDAD
NT seq 3684 nt   +upstreamnt  +downstreamnt
gtgagcagcaaagtggaacaactgcgtgcgcagttaaatgaacgtattctggtgctggac
ggcggtatgggcaccatgatccagagttatcgactgaacgaagccgattttcgtggtgaa
cgctttgccgactggccatgcgacctcaaaggcaacaacgacctgctggtactcagtaaa
ccggaagtgatcgccgctatccacaacgcctactttgaagcgggcgcggatatcatcgaa
accaacaccttcaactccacgaccattgcgatggcggattaccagatggaatccctgtcg
gcggaaatcaactttgcggcggcgaaactggcgcgagcttgtgctgacgagtggaccgcg
cgcacgccagagaaaccgcgctacgttgccggtgttctcggcccgaccaaccgcacggcg
tctatttctccggacgtcaacgatccggcatttcgtaatatcacttttgacgggctggtg
gcggcttatcgagagtccaccaaagcgctggtggaaggtggcgcggatctgatcctgatt
gaaaccgttttcgacacccttaacgccaaagcggcggtatttgcggtgaaaacggagttt
gaagcgctgggcgttgagctgccgattatgatctccggcaccatcaccgacgccttcggg
cgcacgctctccgggcagaccaccgaagcattttacaactcattgcgccacgccgaagct
ctgacctttggcctgaactgtgcgctggggcccgatgaactgcgccagtacgtgcaggag
ctgtcacggattgcggaatgctacgtcaccgcgcacccgaacgccgggctacccaacgcc
tttggtgagtacgatctcgacgccgacacgatggcaaaacagatacgtgaatgggcgcaa
gcgggttttctcaatatcgtcggcggctgctgtggcaccacgccacaacatattgcagcg
atgagtcgtgcagtagaaggattagcgccgcgcaaactgccggaaattcccgtagcctgc
cgtttgtccggcctggagccgctgaacattggcgaagatagcctgtttgtgaacgtgggt
gaacgcaccaacgtcaccggttccgctaagttcaagcgcctgatcaaagaagagaaatac
agcgaggcgctggatgtcgcgcgtcaacaggtggaaaacggcgcgcagattatcgatatc
aacatggatgaagggatgctcgatgccgaagcggcgatggtgcgttttctcaatctgatt
gccggtgaaccggatatcgctcgcgtgccgattatgatcgactcctcaaaatgggacgtc
attgaaaaaggtctgaagtgtatccagggcaaaggcattgttaactctatctcgatgaaa
gagggcgtcgatgcctttatccatcacgcgaaattgttgcgtcgctacggtgcggcagtg
gtggtaatggcctttgacgaacagggacaggccgatactcgcgcacggaaaatcgagatt
tgccgtcgggcgtacaaaatcctcaccgaagaggttggcttcccgccagaagatatcatc
ttcgacccaaacatcttcgcggtcgcaactggcattgaagagcacaacaactacgcgcag
gactttatcggcgcgtgtgaagacatcaaacgcgaactgccgcacgcgctgatttccggc
ggcgtatctaacgtttctttctcgttccgtggcaacgatccggtgcgcgaagccattcac
gcagtgttcctctactacgctattcgcaatggcatggatatggggatcgtcaacgccggg
caactggcgatttacgacgacctacccgctgaactgcgcgacgcggtggaagatgtgatt
cttaatcgtcgcgacgatggcaccgagcgtttactggagcttgccgagaaatatcgcggc
agcaaaaccgacgacaccgccaacgcccagcaggcggagtggcgctcgtgggaagtgaat
aaacgtctggaatactcgctggtcaaaggcattaccgagtttatcgagcaggataccgaa
gaagcccgccagcaggctacgcgcccgattgaagtgattgaaggcccgttgatggacggc
atgaatgtggtcggcgacctgtttggcgaagggaaaatgttcctgccacaggtggtcaaa
tcggcgcgcgtcatgaaacaggcggtggcctacctcgaaccgtttattgaagccagcaaa
gagcagggcaaaaccaacggcaagatggtgatcgccaccgtgaagggcgacgtccacgac
atcggtaaaaatatcgttggtgtggtgctgcaatgtaacaactacgaaattgtcgatctc
ggcgttatggtgcctgcggaaaaaattctccgtaccgctaaagaagtgaatgctgatctg
attggcctttcggggcttatcacgccgtcgctggacgagatggttaacgtggcgaaagag
atggagcgtcagggcttcactattccgttactgattggcggcgcgacgacctcaaaagcg
cacacggcggtgaaaatcgagcagaactacagcggcccgacggtgtatgtgcagaatgcc
tcgcgtaccgttggtgtggtggcggcgctgctttccgatacccagcgtgatgattttgtc
gctcgtacccgcaaggagtacgaaaccgtacgtattcagcacgggcgcaagaaaccgcgc
acaccaccggtcacgctggaagcggcgcgcgataacgatttcgcttttgactggcaggct
tacacgccgccggtggcgcaccgtctcggcgtgcaggaagtcgaagccagcatcgaaacg
ctgcgtaattacatcgactggacaccgttctttatgacctggtcgctggccgggaagtat
ccgcgcattctggaagatgaagtggtgggcgttgaggcgcagcggctgtttaaagacgcc
aacgacatgctggataaattaagcgccgagaaaacgctgaatccgcgtggcgtggtgggc
ctgttcccggcaaaccgtgtgggcgatgacattgaaatctaccgtgacgaaacgcgtacc
catgtgatcaacgtcagccaccatctgcgtcaacagaccgaaaaaacaggcttcgctaac
tactgtctcgctgacttcgttgcgccgaagctttctggtaaagcagattacatcggcgca
tttgccgtgactggcgggctggaagaggacgcactggctgatgcctttgaagcgcagcac
gatgattacaacaaaatcatggtgaaagcgcttgccgaccgtttagccgaagcctttgcg
gagtatctccatgagcgtgtgcgtaaagtctactggggctatgcgccgaacgagaacctc
agcaacgaagagctgatccgcgaaaactaccagggcatccgtccggcaccgggctatccg
gcctgcccggaacatacggaaaaagccaccatctgggagctgctggaagtggaaaaacac
actggcatgaaactcacagaatctttcgccatgtggcccggtgcatcggtttcgggttgg
tacttcagccacccggacagcaagtactacgctgtagcacaaattcagcgcgatcaggtt
gaagattatgcccgccgtaaaggtatgagcgttaccgaagttgagcgctggctggcaccg
aatctggggtatgacgcggactga

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