Electrophorus electricus (electric eel): 113575434 Help Entry 113575434         CDS       T05787                                  Name (RefSeq) ryanodine receptor 1-like   KO K04961   ryanodine receptor 1 Organism eee  Electrophorus electricus (electric eel) Pathway eee04020   Calcium signaling pathway eee04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:eee00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     113575434    04020 Calcium signaling pathway     113575434  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:eee01009]     113575434   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:eee04147]     113575434    04040 Ion channels [BR:eee04040]     113575434 Protein phosphatases and associated proteins [BR:eee01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      113575434 Exosome [BR:eee04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    113575434 Ion channels [BR:eee04040]  Voltage-gated cation channels   Ryanodine receptor    113575434 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec SPRY MIR RIH_assoc Ion_trans EF-hand_7 DUF3671 Motif Other DBs NCBI-GeneID:  113575434 NCBI-ProteinID:  XP_026862739 LinkDB All DBs Position Unknown AA seq 5089 aa AA seqDB search MAEGGEGEEEIQFLRTEDQVVLQCTATILKEQIKLCLSCEGFGNRLCFLETTSNAQNVPP DLAICCFILEQSLSVRALQEMLSHTSEAVDLDKWSSQGGGHRTLLYGHAILLRHTHSGMY LSCLTTSRSLTDKLAFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSE RYLHLSYASGDLMVDASFMQTLWTMSPVCSGCELAEGYLTGGYVIRLYHGHMDECLAIPT ADQGSDQRKNAHYEGGAVCSHARSLWRLEPLRIGWSGCHIKWGQAFRVRHITTGRYLCLN DDKGLLLVDPEKANTNGSAFCFRVSKEKTEVVQKRDVEGMGTPEIKYGESMCFVQHVATG LWLTYASVDAKSARLGPLKRKAILHQEGHMDDALTVARSQTEESQAARMIFSTAGLFTQF IKGLDSLSGKVKSPAPPLPLPLDSVVLSLQDLIFYFRPPEEDLEHEEKQSKLRSLKNRQN LFQEEGMITLVLECIDRLNVYNTAAHFSEFAGEEATELWKEIVNLLYELLASLIRGNRAN CALFCDNLDWLVSKLDRLEASSGILEVLYCILIESPEVLNIIQENHIKSIIALLDKHGRN HKVLDVLCSLCVCNGVAVRSNQNLITENLLPRRDLLLQTNIINYVSSIRPNIFLGTCEGS TQYKKWYYELIVDHVEPFLTPQPGHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSYGF DGLHLWSGRVPQQAASPNQHILAAGDVVSCCLDLSVPSISFRINGHPVQGMFENFNLDGL FFPVVSFSAGIKVCFLLGGRHGDFKFVPPPGYAPCYEAVLPKDKLRIEPIKEYKHDFNGV RNLLGPTQSLSHTAFTPNPVDTVQIVLPPHLERIREKLAENSHELWAVTRIEQGWTYGPV RDDNKKLHPCLVDFYSLPEPERNYNLAMSGETLKTLLALGCHVGMGDEKAEENLKKIKLP KTYTQSNGYKPAPLDLNHVKLTPNQNTMVERLAENSHNVWARDRVRQNWTYXTSHNVWAR DRVRQNWTYSIVQDILNKRNPRLVPYNLLDEKTKKTNRETVCAAVRTLIGYGYNIEPPDQ ESSGHGVGDGSGNKIRVFRVEKSYSVTQGKWYFEFEAVTVGEMRVGWARPSVHADKDLGS DDLAYVFNGFKAQRWHVGSEPFGRQWQPGDVVGCMIDLSEQNIMFTLNGEMLISDSGSEM AFKDIEIGEGFIPVCSLGLSQVGRINLGQNVSSLRYFTICGLQEGFEPFAINMKRDITMW FSKSLPQFVPVPSDHAHFEVSRIDGTVDSAPCLKLNHKTFGSQNANTDLLFFRLSMPIEF HETFKVPAGAPPLTRPLTIPEDMALEVDPNSDYELLKKSATRKEQEEKEKEPLVSKEVAG NKEGENEKDTTTEKSKKKGFFSKAKKAAFVAPPPVVLVPRLVEDVVPDDRDDVDIISNTT TYYYAVRVFAGQEPSGVWAGWVTPDYHQYDLHFDLSKVRHVTVTVGDDKGNIHHSIKRSN CYMVWGGEFSSSQQTRISQEDFVIGCLVDLVTGLMTFTANGKEVNTFYQVEPNTKLFPAV FCLPSSQNMLQVELGKLKNIMPISAAMFRSDRRNPVPQCPPRLDVQVLAPVIWSRMPNHF LLPDTWRVSERLGWMVQCTEPLSMMALHIPEENRCIDILELSERTELMKFHYHTLKLYGS VCALGNNRVAHALCGHVDQSQLFYAIENTYLPGPIRSGYYDLLISMHLESAKRNRLMTNR EFILPMTDDTRSITLYSDAEKTHALPGVGLSTCLRPKHYFSPTGFVGTNADLYTLSPVIP LETLKDHALSMLTEAVQDAGQAMRDPVGGSVESHFVPILKLISTLLIMGVFEDEDVKHIL KLIEPSVFSDADPPSQEEIKEGDRDQQLVRKEQGAGKQEQADPETNEGVDEEEEEEEEEE LEDEEELDEEDDEQTEKEDEEKHVAVEKTDREKLVDGGVEQEEEPMLRKEETKEQEDVWE GLLHMKLPESVKLQMCTLLQYFCDCELRHRVEAIVAFSDRFVNQVQTNQKLRYNELMQAF TMSAAETARKTREFRSPPQEQVNMLMNFKMCLEQNCPVPENCRTELQTFHNDLLAHCGVH LEEEEEEEQVDSSVRGRFFRLVEKVKNLRKKNQEAESEPQEERQPSTLQELISHTMIHWA QESFIQTAELVRVMFSLLHRQYDALGELIRALPRAYTINSVSEQDTMELLESLSQIRSLL IVQMGPEEERLMIQSIGNIMSNKVFYQHPNLMRALGMHETVMEVMVNVLGGGDSKEIRFP RMVTNCCRFLCYFCRISRQNQRSMFDHLSYLLQNSSVGLGMRGSTPLDVAAASCIDNNEL ALALQEQDLEQVVKYLAGCGLQTCPMLLSKGYPDIGWNPCGGEKYLDFLRFAVFVNGESV EENANVVVRLLIRRPECFGPALRGEGGSGLLAAIEEAIKISEDPARDGPSVKKDRRFPMF GGEEQHEENRVHLGNAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPIED LVGVISLPVQIPALGKDNSVIEPKMSASFVPDHKAPMVLFLDRVYGIDNQDFLLHVLEVG FLPDMRAAASLDTAAFSTTEMALALNRYLCSAVLPLITKCAPLFAGTDHRAIMIDSMLHT IYRLSRGRSLTKAQRDVIEECLMSLCRYLRPSMLQHLLRRLVFDVPILNEYAKMPLKLLT NHYERCWKYYCLPNGWANFGVSSEEELHLTRKLFWGIFESLAHKKYDAELFKIAMPCLSA IAGAIPPDYVDASYSSKAEKKASVDAEGNFDPKPVDTTNTIIPEKLDGFINRYAEYTHDK WAFEKIQNNWTFGEVLDENAKTHPMLRPYKTFSEKDKEIYRWPIKESIKAMIAWEWMLDK TRDGDEDRAEKKAARKISQTAQATYDPSHGYNPQPIDVSGMTLSRELQSMAEQLAENYHN TWGRKKKLELHAKGGGTHPLLVPYDTLTAKEKARDREKAYELLRFLQLNGYAVTRGLKDM EGDVSSIEKRFAYGFLQKLLKWMDIAQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILMP LINQYFKNHCLYFLSTPAKILGSGGHASNKEKEMIASIFCKMSALVRHRVFLFGTDAPAI VNCLHILARSLDARTVMKSGPEIVKAGLRSFFESAADDIEKMVENLKLGKMSKGNQPVKG VSQNINYTTVALLPVLTSLFDHIAQHQFGDDVILDDLQMSCYRIMCSIYSLGTVKTPHAE RHRPALGECLAHLAAAMPVAYLEPHLNEFNAFSVYTTKTPRERAILGLPNEVQELCLDIP ELDVLMKEISHLAESGARYTEMPHVIEITLPMLCNYLPRWWERGEENFPEQEGRLCTEVT SAHLNQLLGSIMKIVVNNLGIDDAPWMKRLAVXTQPIVSRARPEMLKSHFIPTMEKLKKR TAKVVAEEEHLRMEGKTEGEQEEGTIRDEFAVLCRDLYALYPLLIRYVDNNRARWLTCPN PDAEELFRMVGEVFIFWSKSHNFKREEQNFVVMNEINNMSFLTADSMSKMSKAGSAEAGG SDVERTKKKRRGDRYSVQTSLIVAALKKLLPIGLNMCSPADHELINLAKIRYSLKDTHEE VREFLQSNLHLQGKVEDPSMRWQMALYKEMAGKAEDADAPEKVVKRVQEVSAVLYHLELM EHPFKSKKMVWYKLLSKQRRRAVVACFRMTPLYNLPRHRASNMFLDSYKRNWLETEGLSF EDRMINDLSKVMEQEEEEEEETEAKPDPLHQLVLHFSRTALTEKSKLDMDYLYIAYADIM AKSCHMGEEDEGGEEEQGCNSEEMTFEEKEMEKQRLLYQQSRLHNRGAAEMVLQMISACK GEKGWMVCSTLKLGISILNGGNSEVQRKMLEYLKDKKDVGFFVSLQTLMQTCSVLDLNAF ERQNKAEGLGMVSEEGTNMKLERGEKVMADDEFTCDLFRFLQLVCEGHNNDFQNYLRTQI GSTTTINIIICTVDYLLRLQESISDFYWYYSGKEIIDEPGKRNFSKAMTVAKQVFNSLTE YIQGPCTGNQQSLAHSRLWDAIVGFLHVFAHMMMKLAQDSSQIDLLKELLDLQKDMVVML LSLLEGNVVNGTIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVASGAFRDYVTDPRGL ISKKDFQKAMDTQKQYTPSEIQFLLSCSEADENEMINYEEFANRFQEPAKDIGFNIAVLL TNLSEHVPHDMRLQNFLGQAESVLNYFRPFLGRIEIMGMSRKIERIYFEISEVNRRQWEM PQVRESKRQFIFDVVNEGGESEKMELFVNFCEDTIFEMKIASEISEQEEEEKEEDDEEGD EGGEGGGQRADEEGGVENSQPESSSAFADFLNSMFSFLEMFTFRNLRRQYRRLRKMTLKE ITVGIAVFLWTILLGIFHFIYSVCKGFFLLMWHTLFGGGLVEGAKNITVTEILASMPDPT QDEVHGDLPGESGGGEELDAGGVSDPMEATGGEEEDEDSTEQDVGKIPGIDTPGGLGDMG DTTPVDPPTPEGSPLTKRKMQPEEAGAEKATVDVAPPEPEKADTENVEKAEKESEVKVEE PQEKEQVVKASKAKKEKKEKKPAMKARFDLWNELDIQRNKFMNYLSRNFYNLRFLALFLA FALNFILLFYRVSDSPPGDDEFEGSGVFDGSFDSNGEDMDGLGAADVGGDENDEEGPVYY FLEESTGYMQPTLVFLSVIHTIISFICIIGYYCLKIPLVIFKREKELARKLEFAGLYITE QPEDDDIKGQWDRLVLNTPSYPNNYWDKFVKRKVLDKYGDIYGRERIAELLGMDVASLDF SKQQNYKKTEEPDNSLLAWITAIDIKYQIWKFGVVFTDNTFLYLVWYTVMSLLGHYNRFF FACHLLDIAMGVKTLRTILSSVTHNGKQLMMTVGLLAVVVYLYTVVAFNFFRKFYNKSED EDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVIL LAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANY LFFLMYLINKDETEHTGQESFVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 15270 nt NT seq  +upstreamnt  +downstreamnt atggcagaaggtggcgagggagaagaggagatccagttcttacgcacagaggaccaggta gtcctccagtgcacagctaccatactgaaggagcagattaagctctgcttgtcctgcgag ggatttgggaatcgtctgtgcttcctggagaccacatctaacgcacagaatgttccaccg gatctggccatatgctgcttcatcctggagcagtcactgtctgtgcgagcactgcaggag atgctgtcccacactagtgaggcagtggatttggacaaatggtcatcacagggaggaggc catcgtacactgctgtacgggcatgctatactgctcagacacacacactctggcatgtac ctgagctgtctgaccacatcgcggtcactcacagacaagctagcctttgatgtgggctta caggaggactcaacaggtgaggcatgctggtggaccatccaccctgcttctaagcagagg tcagaaggtgagaaggtcagggtgggtgatgatctcatcttggttagtgtatcttctgaa cgatatttgcatctctcctatgccagtggagacctcatggtggacgcctctttcatgcag accctgtggaccatgagcccagtctgttctgggtgtgagctcgctgaagggtatctgact ggagggtatgtgatcagactttatcacggtcacatggatgagtgcctggccatccctact gcggatcagggcagtgaccaacgaaaaaatgcccattatgaggggggtgctgtatgtagt catgcacggtctctgtggagactggagcctcttcgcattgggtggagtggctgccacatt aaatggggtcaggccttccgtgtacgccacatcaccacagggaggtacctgtgtttgaac gatgacaaggggctcctactggtggatccagagaaggcaaatacaaatggctctgccttc tgcttccgggtatcaaaggagaagacagaggttgttcagaagagggatgtggaggggatg ggaaccccggagataaagtatggcgagtccatgtgcttcgtgcagcatgtcgctacaggc ctgtggctcacctacgcatccgtagacgccaaatctgcccgtctcggccctctcaagagg aaggcgattcttcaccaggagggccacatggacgatgccctgactgtagcccgctcgcag acggaggagtcacaggctgcgaggatgatcttcagcacagccggcctcttcacacagttc atcaaggggctggactctctgagcgggaaggtgaagagccctgcccctcccctgcccctg ccgctggactctgtcgtcctctcactgcaagacctcatcttctacttccggcctcctgag gaggatctggagcacgaggaaaaacagagcaaactgagatctctgaaaaaccgacaaaac ctgtttcaagaagagggtatgattacccttgtgctggaatgtatcgaccgtctaaacgtg tataacacagctgctcacttctctgagttcgctggagaagaggctactgagttgtggaag gagattgttaacctgctctatgagctgctggcatctctgatccgcggtaacagggctaat tgtgctctgttctgcgataatctagactggctggtcagcaaactggaccgattagaagct tcttcaggtatcctggaggtgttatactgcatccttattgaaagccctgaggtgctgaac attatccaggaaaaccacatcaagtccatcattgctctactggacaaacatggtcgcaat cacaaggttctggatgtactctgctctctctgtgtatgcaatggtgtggctgtgaggtcc aatcagaatctcatcacagagaatctactgccacgtcgtgacctcctactccaaaccaac atcattaattatgtctcaagcataaggccgaacatcttcctgggaacttgtgagggatcc actcagtataagaagtggtactatgagttgatagtggaccatgtagagcctttccttacc ccccagccgggccatctcagagtgggctgggctctgaccgagggctacagcccctaccct ggaggaggtgaggggtgggggggtaatggcgtaggggatgacctctactcctatggcttt gacgggctgcacctgtggtcagggcgtgtgcctcagcaggcggcctcgcccaatcagcac attctggcggctggggatgtggtgagctgctgtctggatctgagcgtgcccagtatctcc ttccgcattaatggccacccagtacagggaatgtttgagaacttcaacttggatggcctc ttcttccctgtagtcagcttctctgctggcatcaaggtttgcttcctcctgggcggtcgg catggagactttaagttcgtcccgccccctggctatgctccgtgctatgaggccgtcttg cccaaagacaagttgcgcattgagccgattaaagagtacaagcatgactttaatggtgtg cgtaacctgctgggcccgacgcagtctctctctcacaccgccttcactcccaaccccgtt gacacagtgcagattgttcttcctcctcatctggagcggatcagagagaaactggccgag aacagtcatgagctgtgggcagttacccgcatcgagcagggctggacatacggaccagtc cgtgatgacaataagaagctgcacccatgtctggtggacttctatagcctcccagagcca gagaggaactacaatctggccatgtctggagagacactcaagactctcctggcactaggg tgccatgttggtatgggagatgagaaggctgaagaaaacctgaagaagatcaaacttcct aaaacctacacacagagcaatggatacaaacctgcccctctggatctcaaccacgtcaaa ttgacacccaatcagaacacaatggtggagcgtctggctgaaaacagccacaacgtttgg gctcgagaccgagttcgccagaattggacttacnaaaccagccacaacgtttgggctcga gaccgagttcgccagaattggacttacagcattgtacaggacatcttgaacaagcggaac ccacgccttgtgccgtataacctcctagatgaaaaaaccaaaaagaccaacagagaaaca gtgtgtgctgcagttcgcactctgattggctatggctacaacattgagcctccagatcag gagagcagtggccatggggttggagatggcagcgggaataagatccgggtgtttcgggtg gaaaagtcctactctgtgacccagggcaagtggtactttgagtttgaagcagtgacggtt ggagagatgagggtgggctgggccagacccagtgtccacgctgacaaggatctgggctct gacgacctggcttatgtcttcaatggcttcaaggctcaacgttggcatgtgggtagtgag ccgtttggccgccagtggcaaccaggcgatgtggtcggctgcatgattgacctcagcgag cagaatatcatgttcaccctgaatggagagatgctgatcagtgactcgggctcagagatg gccttcaaagacattgagatcggagaggggttcattcctgtgtgtagtctcggcctctct caggttggccggattaacttgggccaaaatgtcagcagtctgcgttatttcaccatctgt ggccttcaggaaggctttgaaccttttgctatcaacatgaagagagacatcaccatgtgg ttcagcaaaagcctccctcagtttgtgcctgttccatctgaccatgctcattttgaggtg tctcgtatagatggcacagtggacagcgctccctgtctgaagctaaaccataagacattt ggatcccagaatgccaacacagacctgctcttcttcaggctgagcatgcccattgagttc catgagactttcaaagtcccagcgggtgcgccccctctcacccggcccctaaccatccca gaggatatggcccttgaggtggaccccaactcggactacgaactgctgaaaaagtctgcc acccgcaaagagcaggaagagaaagagaaggagccactagtgtccaaagaagtagctggc aacaaggagggagagaatgagaaagacacaactacagagaagagtaagaagaaagggttc ttctccaaagccaagaaggcagcttttgttgctccgccacctgttgtcctggtgccccgg ctggtggaagacgttgtcccagatgatcgagatgatgtggacatcatttcaaatacaact acatattactatgcagtgcgtgtctttgctggccaggagcccagtggagtgtgggcaggc tgggttactccagactaccaccagtatgacctccattttgatctcagtaaagtgaggcat gttactgtcactgtgggagacgataaaggaaacatacaccacagtataaagcgcagtaac tgctacatggtgtggggcggagagttcagcagctcacagcaaactcgcatcagtcaagag gactttgtgattggctgtctcgtggacctggttacaggcctcatgactttcacagccaat gggaaagaagttaacacattctaccaggtggagcccaacaccaagctcttccctgctgtc ttctgtctgccctccagtcagaacatgcttcaggtggagctgggcaagctaaagaacatc atgcccatctcagcagccatgttccgcagtgaccgcaggaacccggtcccacagtgcccg ccacgtctcgacgtccaggttctagcccctgtcatctggagccgtatgcccaaccacttc ctgttgccggatacatggcgtgtcagtgagagattgggctggatggtacagtgcactgag cccctcagcatgatggctctgcacatcccagaagagaacaggtgtattgacatactggag ttgtcggagaggacggaactgatgaagttccactaccacacgctcaaattgtatggctcg gtgtgtgcactgggcaacaaccgcgtggcacacgccctctgcggccacgtggaccaatcg cagctcttctatgccatcgagaacacatacctgcccggccccatccgcagtggctactat gacctgctcatctctatgcacctggagtctgccaagcgcaaccgcctcatgacaaacagg gagttcatcttgccaatgacggatgacacacgcagcatcactctgtattcagacgcggag aagacccacgcgctgcctggggtgggcctctcgacctgcctgcgccccaaacactacttc tcccccactggctttgtggggaccaacgcggacctgtacaccctcagccctgttataccg ttggagacactgaaggaccatgctctgagcatgcttacagaggctgtgcaggatgccggt caggccatgcgggatcctgtagggggcagtgtggagtcccactttgttcccatcctgaaa ctgatcagcactctgctcattatgggtgtgtttgaggatgaagacgtgaagcacattctg aagctgatcgaaccgtctgtattcagcgatgctgaccctcccagccaggaggagataaag gaaggagatcgagaccagcagctcgtgagaaaagagcagggggcggggaaacaggagcag gcagatccggagacgaacgaaggtgtggatgaagaggaagaggaagaggaagaagaagaa ctggaggacgaagaggaactagatgaggaggatgatgaacaaacagagaaggaagatgag gaaaagcatgtggcagttgagaaaacagacagagagaaattagtagatggaggggtggag caagaggaggaacctatgttgaggaaggaggagacaaaggagcaggaggatgtgtgggag gggcttctacatatgaaattacctgagtctgttaaactgcagatgtgtactctgctgcag tatttctgtgactgtgagctccgtcaccgggtagaagccattgttgccttctctgatagg tttgtaaatcaggtccagaccaatcagaagctgcgttataatgagctgatgcaggccttc accatgtcagctgcagaaacagcccgcaagaccagggaatttcgttccccaccccaggaa caggttaacatgctgatgaacttcaagatgtgtcttgagcagaactgtcctgtacctgaa aactgtcgcactgaactgcagacgttccacaatgacctgctggctcactgcggtgtgcat ttagaggaagaggaggaggaagaacaggtggactcatctgtgcgtgggcggttcttccgg ctggtcgagaaagtgaaaaacctgaggaagaagaaccaggaggcggagtcagagccacag gaggagaggcagcccagcactctgcaggagctgatctcccacacgatgatccactgggcc caggagtcgttcatccagacggctgagctggtgcgggtcatgttcagcctcctccaccgg cagtatgacgccctgggcgagctgatccgtgcgctgcccagagcctataccatcaactcc gtctcggagcaggacaccatggagttgctggagagtctgagccaaatccgctcgctcctc atcgtgcaaatgggcccagaggaggagcgcctcatgatccagagcatcggaaatatcatg agtaataaggtgttctaccagcacccaaacctgatgagggctctgggtatgcacgagaca gtcatggaggtgatggttaacgtgctgggaggcggagactccaaggagatccggtttcct cgcatggtcaccaactgctgccgatttctgtgttatttctgccgaatcagtcgtcagaac cagcgctccatgttcgatcacctgagctacctgctccagaacagcagcgtgggcctggga atgcggggttccacaccgctggacgttgccgcggcatcctgcatcgataacaatgagctt gccctggcgctccaggagcaggacctggagcaggtggtaaagtacctggctggctgtggg ctgcagacttgtcccatgctcctgtcgaagggctaccccgatattggctggaacccctgt ggtggggagaagtaccttgattttcttcggtttgctgtgtttgttaatggagagagtgtg gaggagaacgctaacgtggtggtgcgtctgctgatcagacggcccgaatgcttcggccct gcactcagaggagagggaggcagtggcctgcttgctgctatcgaggaggccattaaaatc tctgaggatccagctagagatggacccagcgtcaagaaagacagacgcttccccatgttt ggtggagaagagcagcatgaggagaatagggttcacctgggaaacgcaatcatgtctttc tacgctgctctcatcgacctgctgggccgctgtgcacctgagatgcacttgatccaggca gggaaaggtgaggctctgaggataagggccattctcagatctttggtgcccatcgaggac ctggttggtgttattagccttccagtccagatccctgcactagggaaagacaacagcgtt attgagccaaagatgtcagccagttttgttcctgaccacaaggctccgatggtgctgttc ctggaccgcgtctatggcatcgataaccaggacttcctattgcatgtcctggaagtgggt ttcctgccggacatgcgggcagcagcctctttggacacggctgcgttcagcaccacagag atggctctggccctgaaccgctacctgtgctctgccgtcctgcccctcatcacgaaatgc gccccgctgttcgccggcactgaccaccgagccatcatgatcgactccatgctgcacacc atctacaggctttccaggggacgctctctcaccaaggctcagagggatgtcatagaggaa tgtctgatgtcactgtgcagatacctgcgaccctctatgcttcagcatctactgagacgg ctggtgtttgatgtgccaattctcaatgagtatgccaaaatgcccctgaagttgctgacc aatcactatgagcgttgctggaaatactactgcttgcctaacggctgggcaaactttggc gtgtcatcagaggaagaactccatctgacccggaagctcttctggggaatctttgaatct ctggcacacaagaaatatgatgcagaactgttcaaaatagccatgccttgtctcagtgcc atagctggtgccatccctcctgattacgtggatgccagttactcctccaaagcagaaaag aaagcctctgttgatgctgagggcaactttgatcccaaacccgtggacaccaccaacacg atcatccctgagaagctagatggattcattaatagatacgcagaatatacgcatgataaa tgggcttttgagaagatccagaacaactggacatttggggaggtgctggatgaaaatgcc aagactcatcccatgctcagaccatacaaaacattttctgaaaaggataaagagatctac cgctggcccattaaagagtccattaaggccatgatagcctgggagtggatgctggacaaa accagagatggagacgaggacagagcagagaagaaggcggctcgcaaaatctcccagact gcacaggcaacctatgaccctagtcacggctacaacccccagcctatagatgtatcaggc atgacactgtccagagagctgcagtccatggctgagcaattggcagagaactaccacaac acctgggggcgcaagaagaagctggagctgcacgcaaagggtggtgggactcacccactg ctggtaccttacgatactctaacggctaaagagaaggctcgcgaccgtgagaaagcgtat gagctgctcagattcctgcagctcaacggctatgcggtaacaaggggactcaaagatatg gagggagacgtttcctctattgagaagcgcttcgcttacggcttcctacagaagctgctg aagtggatggacatcgcccaggagttcattgcacaccttgaggcggtggtcagcagtggc cgtgtggagaagtctcctcatgagcaggagatcaagttctttgccaagattcttatgcct ctgataaaccagtacttcaaaaaccactgcctctatttcctgtccacacctgctaaaatc ctgggcagtggtggccatgcctccaacaaagagaaagagatgattgccagtatcttctgt aagatgtctgctctagtgagacacagagtctttctctttggcactgatgctcctgccatc gtgaactgtctccatatcctcgcccgctctctcgatgccaggaccgtgatgaagtctggg cctgagatcgtgaaggcagggctgcgatctttctttgagagtgctgctgatgacatagaa aagatggtggagaatctcaaactggggaaaatgtcaaaaggcaaccagcctgtgaaaggt gtgagccagaacattaactacaccacagttgctctgctccctgtcctcacatccctgttt gaccacattgcacagcaccagtttggcgacgacgttatactggatgatctgcagatgtcc tgctacagaatcatgtgcagtatctattcccttggcactgtgaagacacctcacgctgaa agacacaggcccgctctgggagagtgcctggcccatcttgctgctgccatgcccgtggct tacctggagcctcacctgaacgagtttaatgctttctcagtgtacaccaccaagacaccc agggagagagccatcctgggtctccctaatgaggtgcaggagctgtgtttggacattcct gagctggatgtccttatgaaagagatcagccaccttgcagagtctggcgcacgctacacg gagatgccgcacgtgatcgagatcacgctgcccatgctgtgtaactacctgccccgctgg tgggagagaggcgaggagaacttccctgagcaggagggccgtctgtgcacagaggtcacc tctgctcaccttaaccaattgctgggcagcatcatgaagattgtggtcaacaacctgggc atcgatgatgctccctggatgaagaggctggcagtgtncacccagcccatcgtgagcagg gccaggccggagatgttgaagtcccatttcatccccaccatggagaagctgaagaagcgc acagcgaaggtggtggctgaggaggagcacctacgcatggagggcaagactgagggcgag caggaggaaggcacaatccgtgacgagtttgctgtgctctgcagagacctgtatgccctc taccctctcctcatccgctacgtcgacaacaacagggcaaggtggctgacctgccccaat ccagatgctgaggagctgtttcgcatggtgggagaggtcttcattttctggtccaaatct cacaactttaaacgtgaggagcagaactttgtagtgatgaatgagataaacaacatgtcc ttcctcacagcagacagcatgagtaagatgagcaaggccgggagcgctgaggctggcggc tcagatgtggagcgtaccaagaagaaaagaagaggggatcgttactcggtgcagacgtcc ctgatcgtggccgccctgaagaagttgctccccatcggactcaatatgtgctctcctgcc gaccatgagctcattaatctggccaagatccgctactctttgaaagatacacatgaagaa gtgagagagttcctgcagagcaacctgcatcttcagggcaaggtggaggacccttccatg cgttggcagatggctctgtataaggagatggcaggaaaggccgaggatgccgacgctcct gagaaggtggtgaagagagttcaggaggtgtctgctgtgctttatcacctggaactgatg gagcacccgttcaaatctaaaaagatggtttggtataagctgctgtccaagcagaggcgg cgcgccgtggtcgcctgtttcaggatgacacccctctacaacctgcccaggcaccgagca tccaacatgttcctggacagttacaagaggaactggcttgagactgaaggcctctccttt gaagacaggatgatcaatgacttatctaaagtcatggaacaggaagaggaggaagaggag gaaacggaggcgaagccggatcctcttcatcagctcgtccttcattttagccgcaccgct ctcaccgagaagagtaaacttgacatggactacctgtatattgcatatgctgatattatg gcaaagagttgccacatgggtgaggaggatgagggtggagaggaagagcagggttgcaac agtgaagagatgacctttgaggagaaggagatggagaaacagaggctgctctaccagcag tcccgcctacataaccgtggagctgcagagatggtcttacagatgatcagtgcctgcaag ggtgaaaagggctggatggtgtgctccactctcaagcttggcatctctattctgaatggt ggaaacagcgaagtccagcggaaaatgctggagtatctgaaggacaaaaaggacgtgggc ttctttgtgagcttgcagactctcatgcagacctgcagtgtcctggacctgaatgccttt gagaggcagaacaaggctgaaggtttgggcatggtgtctgaggagggaacaaacatgaag cttgaacgcggtgagaaagtaatggcagacgacgagttcacctgtgacctgttccgcttc ttgcagttggtgtgcgagggccataataatgacttccagaactacctgagaacccagatt ggaagcacaaccaccatcaacatcatcatctgcaccgtagactacctgctgcggctacag gaatccatcagcgatttctactggtattattctggcaaagagatcatagacgagcctggt aagaggaacttctccaaggccatgactgtagccaagcaggtgttcaactccctgacagaa tacatccagggcccctgcacaggtaaccagcagtcactggcccacagcagactctgggac gctatagtgggcttcctacatgtctttgctcatatgatgatgaaactggcccaggattcg agtcagattgacttgctgaaagaactcttggacctgcagaaagacatggtggttatgctg ctctctctgttggagggtaatgttgtgaatggcacaatagctcgtcagatggtagatatg ctggtggagtcttccagcaatgttgagatgatcctcaagttctttgacatgttcctcaaa ctaaaagatattgttgcctctggtgcattccgtgactatgtgactgaccccagaggtctg atctccaagaaggacttccaaaaggccatggacacccagaagcagtacaccccctcagag atccagttcctgctgtcctgctctgaggcagacgagaatgagatgatcaactatgaggag tttgccaaccgtttccaggagccagccaaggacattggctttaacattgctgtgctgcta acaaacctctctgagcatgtacctcatgatatgcggctgcaaaacttcctgggacaggcg gagagtgtcctgaactacttccgaccattcctgggccgcatcgagatcatgggaatgagc aggaagattgagcgaatctacttcgagatcagcgaggtgaaccgccgacagtgggagatg cctcaggtccgtgagtccaagcggcagttcatctttgatgttgtcaacgaaggcggcgag tcagaaaaaatggagctctttgtgaacttttgtgaggacaccatctttgagatgaagatc gcctctgagatctcagagcaggaagaggaagagaaagaggaggatgatgaggaaggagat gaaggaggggagggaggaggacaaagggcagacgaagagggaggcgtggaaaacagccaa ccagaatccagctcggcctttgctgacttcctgaacagcatgttcagcttcctggaaatg ttcaccttccgtaacctgcgcaggcagtatcgcaggctccggaagatgaccttaaaagag atcactgtgggcattgctgtcttcctctggacaatcctgttgggaattttccacttcatt tacagtgtgtgtaagggtttcttcctgctcatgtggcatactctgtttggaggaggttta gtggagggggccaagaacatcactgtgactgagatcctggccagcatgcctgaccccacc caggatgaggtgcacggagacctgcctggagaatcagggggtggtgaggagctggatgct ggaggagtgtcggatcccatggaggcaacgggaggggaggaagaggacgaggacagcaca gagcaagatgtgggcaaaatccctgggatcgatacccctggtggtctgggagatatggga gacactactccagtggatcccccaactccagaaggatctcctctaaccaagaggaaaatg cagccagaagaggcaggagctgagaaggctactgtagatgtggctcctcctgaaccagag aaggccgacactgaaaatgttgagaaggcggaaaaggagagtgaggtgaaggttgaggag ccccaggagaaggagcaggtggtgaaagccagcaaggccaagaaggaaaagaaagagaag aaaccagccatgaaagcaagatttgacctctggaacgagctggacattcaaagaaataag ttcatgaactatctgtctcgtaacttctacaaccttcggtttctggccttgtttctggct tttgctctcaacttcattctgcttttctatagggtgtcggacagccctccaggagatgat gagtttgagggctctggggtgtttgatggttcttttgacagcaatggagaagacatggat gggcttggagcagcagatgttggtggtgatgaaaatgatgaggaaggccctgtgtattac tttctggaggagagtaccggctacatgcagccaactctagtcttcctgtctgtgatccac accatcatctcctttatctgtattattggctactactgcctcaagatccccttggtgatc tttaagagggagaaagagctggcaaggaagctggagtttgctggactttacatcaccgaa cagcctgaagatgatgatatcaaagggcaatgggacagactggtgctaaacaccccatcc tacccaaacaactactgggataagtttgtcaaacgaaaggtcctggataaatatggtgac atttacggtcgagagaggatcgctgagttactgggaatggatgtggcctcactggatttt agcaaacagcagaactataagaaaacggaggaaccggacaactccctattggcctggatc acagcaatcgatatcaaatatcagatctggaaatttggagttgtattcacagacaatact ttcctctacctggtctggtacactgtgatgtctctgcttggccactacaaccgtttcttc tttgcatgtcacctgctggacattgccatgggtgtgaagacgctacgcaccattctgtct tctgtcacacacaatgggaaacagctgatgatgacggtgggcttgctggcagtggtggtg tacctctacactgtggtggccttcaacttcttccgcaagttctacaacaagagcgaggac gaggacgagccagacatgaaatgcgatgacatgatgacgtgctatttgtttcacatgtat gtgggagtgcgagctggtggagggattggtgatgagattgaggatccagcaggtgatgag tatgagctctatcgggtcgtctttgacatcaccttcttcttctttgtcatcgtcattctg ctggccatcatccagggtctgatcattgatgcttttggtgagctgagagaccagcaagaa caagtgaaagaagacatggagaccaaatgctttatatgtgggatagggagcgattacttc gatacaactccacatggttttgagacccacactttagaggaacacaacttggccaattac ttgttcttcctgatgtacctcataaacaaggatgagactgagcacacaggtcaggagtcg ttcgtgtggaaaatgtaccaagaacgctgctgggatttctttcctgctggtgactgcttt cgaaaacaatatgaggaccagctgggctag

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