Enterococcus faecium Aus0004: EFAU004_00143
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Entry
EFAU004_00143 CDS
T01772
Name
(GenBank) bifunctional glutamate--cysteine ligase/glutathione synthetase
KO
K01919
glutamate--cysteine ligase [EC:
6.3.2.2
]
Organism
efc
Enterococcus faecium Aus0004
Pathway
efc00270
Cysteine and methionine metabolism
efc00480
Glutathione metabolism
efc01100
Metabolic pathways
efc01240
Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:
efc00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
EFAU004_00143
09106 Metabolism of other amino acids
00480 Glutathione metabolism
EFAU004_00143
Enzymes [BR:
efc01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
EFAU004_00143
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Gene cluster
GFIT
Motif
Pfam:
Glu_cys_ligase
ATP-grasp_6
ATP-grasp_3
GARS_A
RimK
ATPgrasp_ST
Topo-V_HhH_2_2nd
Dala_Dala_lig_C
R2K_3
R2K_2
LUC7
Motif
Other DBs
NCBI-ProteinID:
AFC62229
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Position
137071..139338
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AA seq
755 aa
AA seq
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MMNFKQLLLHVNARPFIDQARFGIEREGQRVDLAGNLAKTDHPAIFGDRSYHPYIQTDFS
ETQTEMITPVTDSIPELFQYLAAVYDVTARSIPKEEMIWPLSMPPALPEKDEEIIIAKLK
NFEDVLYRRYLAKEYGKRKQMVSGIHFNFEFGDELLRTLFSHQEEFQDFSEFKTELYLKT
ARNFMRYRWMITYLFGASPMSEKNYFLDESHPQEPVRSIRNSALGYTNHPNVKVSYASMK
QYLADIERMIEEGKLSEEKEFYTPLRFRGGKKVADLATTGVRYIELRNIDLNPYARLGIN
PEQVRFLQLFLMYMLWTEEKEDCDQWVAEGTTRNNKVALEQPSDQTEFHQEGREILEGMK
QMLVELDWLDSLYLVEEALTQMDHPEQTLAAKLYQEAQLSSQQEVAVALGHQYYKESHER
PYQLAGFREMELSTQIFMFDAIQKGVQVKVLDESDQFLRLQFQDHVEYVKNANMTSKDSY
IVPLIMENKTVTKKVLKEAGFRVPGGAEFSSMEEAVKAYPRFAEQAFVIKPKSTNYGLGI
TIFKEGASLEDYQAGLAIAFREDSSVLVEEFMPGTEYRFFVIDGEVQAIMLRVPANVIGD
SIRTVKELVEEKNSDPLRGTNHRAPLELIQLGELEQLMLKEQGLTIESVPQANQIVYLRE
NSNISTGGDSIDMTDEFSEAYKKIAVSAVEALGAKISGIDLIIPDKEIDPTTDKKAYGII
EANFNPAMHMHVYPFAGKGRRLTMNVLKLLYPEVF
NT seq
2268 nt
NT seq
+upstream
nt +downstream
nt
atgatgaattttaagcaattattattgcatgtcaatgcgcgcccttttatcgaccaagct
cgatttggtatagaacgggaaggacagcgggttgatcttgcaggaaatctagcaaaaacc
gatcatccagcaatctttggcgatcgatcctatcacccctatatccaaacagattttagc
gaaacacaaacagagatgatcacccctgttaccgattctattcccgaattatttcagtat
ctcgctgctgtttatgatgtgactgctcgttctataccgaaagaagagatgatctggcca
ttaagtatgccacctgccttaccggaaaaagacgaagagatcattattgcaaaattaaaa
aatttcgaagatgtcttgtatcgacgttatttagcaaaagaatacgggaagcgaaaacag
atggtaagcggtattcatttcaattttgaatttggcgatgagttgctaagaacattgttc
agccatcaggaagaatttcaagatttttccgaattcaaaacagaactttatttgaaaaca
gcgagaaactttatgcgctatcgctggatgatcacttatttattcggtgcttcaccaatg
agtgagaagaactactttttagatgaatcacatccgcaagaacctgttcgcagtattcgc
aacagtgcgctgggctatacgaatcatccaaatgtgaaagtttcctatgcttctatgaaa
cagtatttagcagatatcgagcgaatgatcgaagaagggaaactttcggaggagaaagaa
ttttatacaccgcttcgtttccgaggcggaaagaaagtcgcagatttagcaacaacaggt
gttcgttatattgaattgcggaatatcgatttgaatccttatgcaagattgggtatcaat
ccagagcaagttcggttcttacaattattcctgatgtacatgttatggacagaagaaaaa
gaagactgtgaccaatgggtagcagaaggtacgactcgaaataacaaagtagcactagaa
caaccatcagatcaaacagaatttcatcaagaaggtagagaaattcttgaaggaatgaag
caaatgctggttgaattggattggttggattctctttatttagtagaggaagcattgact
caaatggatcatcctgaacaaacgttagcagcgaaactctatcaagaagcacagctatcg
agtcagcaagaagttgctgtggcattgggacatcaatattataaagaaagccatgaacgt
ccctatcagttggccggttttcgcgaaatggaactttctactcagatatttatgttcgat
gccatccaaaaaggtgtccaagtcaaagtattagatgagtcggatcaatttttgcgtctg
caattccaagaccatgtagaatatgtgaaaaatgcaaacatgacaagtaaggacagctat
atcgtcccacttatcatggaaaacaaaacagtaacgaaaaaagtcttaaaagaagctggg
ttccgggtaccaggaggcgcagaattttcatccatggaagaagcggtaaaagcttatccg
agatttgccgagcaggcatttgtgatcaaacctaaatcaaccaattacgggttaggtatc
acgattttcaaggaaggagctagtctggaagattatcaagcaggtttagccattgctttt
cgtgaagacagttcggttttagtagaagaatttatgccgggaacggaatatcgtttcttt
gtgatcgacggagaagtccaagccatcatgttgcgagtccctgctaatgttattggtgac
agtatccgaacagtgaaagaacttgttgaagaaaaaaatagtgaccctttgcgtggaacg
aatcatcgtgcacctttagaattgatccaattaggtgaattagaacaattgatgttgaaa
gaacaagggttgacgatcgaatcagttccccaagccaatcaaattgtttatctaagggag
aactcaaatatcagtacaggtggtgattcgatcgatatgactgatgaattttctgaagct
tacaaaaaaatcgccgtttctgcggtagaagcactaggagctaagattagtggtatcgat
ttgattataccagataaagaaatcgatcctacaactgataaaaaagcatatgggatcatc
gaagcaaatttcaatccagccatgcatatgcatgtttatccttttgcaggaaaaggcaga
agattgacgatgaatgtattgaaattgttatatcctgaagtattttaa
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