Escherichia fergusonii: EFER_4072
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Entry
EFER_4072 CDS
T00811
Symbol
metH
Name
(GenBank) homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent
KO
K00548
5-methyltetrahydrofolate--homocysteine methyltransferase [EC:
2.1.1.13
]
Organism
efe
Escherichia fergusonii
Pathway
efe00270
Cysteine and methionine metabolism
efe00450
Selenocompound metabolism
efe00670
One carbon pool by folate
efe01100
Metabolic pathways
efe01110
Biosynthesis of secondary metabolites
efe01230
Biosynthesis of amino acids
efe04981
Folate transport and metabolism
Module
efe_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:
efe00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
EFER_4072 (metH)
09106 Metabolism of other amino acids
00450 Selenocompound metabolism
EFER_4072 (metH)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
EFER_4072 (metH)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
EFER_4072 (metH)
04980 Cobalamin transport and metabolism
EFER_4072 (metH)
Enzymes [BR:
efe01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.13 methionine synthase
EFER_4072 (metH)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Met_synt_B12
S-methyl_trans
Pterin_bind
B12-binding_2
B12-binding
Motif
Other DBs
NCBI-ProteinID:
CAQ91495
UniProt:
B7LKA7
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All DBs
Position
4175546..4179229
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AA seq
1227 aa
AA seq
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MSSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSK
PEVIAAIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTA
RTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILI
ETVFDTLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA
LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAE
AGFLNIVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVG
ERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLI
AGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAV
VVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQ
DFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAG
QLAIYDDLPAELRDAVEDVILNRRDDGTERLLELAEKYRGSKTDDTANAQQAEWRSWEVN
KRLEYSLVKGITEFIEQDTEEARQQATRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
SARVMKQAVAYLEPFIEASKEQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDL
GVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKA
HTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPR
TPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKY
PRILEDEVVGEEAKRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIEIYRDETRT
HVINVSHHLRQQTEKTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQH
DDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYP
ACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQV
EDYARRKGMSVSDVERWLAPNLGYDAE
NT seq
3684 nt
NT seq
+upstream
nt +downstream
nt
gtgagcagcaaagtggaacaactgcgtgcgcagttaaatgaacgtattctggtgctggat
ggcggtatgggcactatgatccagagctatcgactgaacgaagccgattttcgtggtgaa
cgctttgccgactggccatgcgatctcaaaggcaacaacgacctactggtgctcagcaaa
ccggaagtgatcgccgctatccacaacgcctactttgaagcgggtgcggatatcatcgaa
accaacaccttcaactccacgactattgcgatggcggattaccagatggaatccctgtcg
gcggaaatcaactttgcggcggcgaagctggcgcgtgcctgtgctgacgagtggaccgcc
cgtacgccagagaaaccgcgctacgttgccggtgttctcggcccgaccaaccgcacggcg
tctatttctccggacgtgaacgatccagcattccgcaacatcacttttgaccagctggtg
gcggcttatcgagaatccactaaagcgctggtggaaggcggtgcggatctgatcctgatt
gaaaccgttttcgacacccttaacgccaaagcggcggtctttgcggtgaaaacggagttc
gaagcgctgggcgttgaactgccgataatgatctccggcaccatcactgacgcctccggg
cgcacgctctccgggcagaccaccgaagcattttacaactcattgcgccacgccgaagcg
ctaacctttggcctgaactgtgcgctggggcccgatgaactgcgccagtacgtgcaggag
ctgtcacggattgcggagtgctacgtcaccgcgcacccgaacgctgggctgcccaacgcc
tttggtgaatacgatctcgacgccgacacgatggcaaaacaaatacgtgaatgggcagaa
gcgggattcctgaatattgttggcggctgctgcggcaccacgccacaacatattgcagcg
atgagccgtgctgtagaaggattagcgccgcgcaaactgccggaaattcctgtagcctgc
cgtttgtctggcctggagccgctgaacattggcgacgatagcctgtttgtgaacgtgggt
gaacgcaccaacgtcacaggttccgctaagttcaagcgcctgatcaaagaagagaaatac
agcgaggcgttggatgtggcgcgtcagcaggtggaaaacggcgcgcagattatcgatatc
aacatggatgaagggatgctcgacgccgaagcggcgatggtgcgttttctcaatctgatt
gccggtgaaccggatatcgctcgcgtgccgattatgatcgactcctcaaaatgggacgtc
attgaaaaaggtctgaagtgtatccagggcaaaggcattgttaactctatctcgatgaaa
gagggcgtcgacgcctttatccatcacgcgaaactgttgcgtcgctacggtgcggcagtc
gtggtaatggcctttgacgaacagggccaggccgatacccgcgcacggaaaatcgagatt
tgccgtcgggcgtacaaaatcctcaccgaagaggttggcttcccgccagaagatatcatc
tttgacccgaacatcttcgcggtcgcaactggcattgaagagcacaacaactacgcacag
gactttatcggcgcgtgtgaagacatcaaacgtgaactgccgcacgcgctgatctccggc
ggtgtttctaacgtttctttctcattccgtggcaacgatccggtgcgcgaagccattcac
gcggtgttcctctactatgccatccgtaacggtatggatatggggatagtcaacgccggg
caactggcgatttacgacgacctacccgctgaactgcgcgacgcggtggaagatgtgatt
cttaatcgtcgcgacgatggcaccgagcgtttactggagcttgccgagaaatatcgcggc
agcaaaaccgacgacaccgccaacgcccagcaggcggagtggcgctcgtgggaagtgaat
aaacgcctggagtactcgctggtcaaaggtattaccgaatttattgaacaggacaccgaa
gaagcccgtcagcaggctacgcgcccgattgaagtgattgaaggcccgttgatggacggc
atgaacgtggtcggcgatctgtttggcgaaggcaaaatgttcctgccgcaggtggtcaaa
tcggcgcgtgtgatgaagcaggcggtggcttacctcgaaccattcatagaagccagcaaa
gagcagggcaaaactaatggcaagatggtgatcgctacagtgaagggtgacgtccacgac
atcggtaaaaatatcgttggcgtggtgctgcaatgtaacaactacgaaattgttgatctc
ggcgttatggtgccggcggaaaaaattctccgcaccgccaaagaagtgaatgctgatttg
attggcctttcggggcttatcacgccgtcgctggatgaaatggttaacgtggcgaaagag
atggagcgtcagggtttcaccattccgttactgatcggcggcgcgaccacctctaaagcg
cacacggcggtgaaaatcgagcaaaactacagtggcccgacggtgtatgtgcagaacgcc
tcacgcaccgttggtgtggtggcggcgctgctttctgacactcagcgtgatgattttgtc
gctcgtacccgtaaagagtacgaaaccgtacgtattcaacatgggcgcaagaaaccgcgc
acaccgccagtcacgctggaagcggcgcgcgataacgacttcgcttttgactggcaggct
tatacgccgccggtggcgcaccgtctcggcgtgcaggaagtggaagccagcatcgaaacg
ctgcgtaattacatcgactggacgccgttctttatgacctggtcactggctgggaagtat
ccgcgcattctggaagatgaagtggtgggtgaagaggcgaagcgcctgtttaaagacgcc
aatgacatgctggataaattaagcgccgaaaaaacgctgaatccacgtggcgtggtgggc
ctgttcccggcaaaccgtgtgggcgatgacattgaaatctaccgtgacgaaacgcgtaca
catgtaatcaacgtcagccaccatctgcgtcaacagaccgaaaaaacgggcttcgctaac
tactgtctcgctgacttcgttgcgccgaagctttctggtaaagcagattacattggcgca
tttgctgtgaccggcgggctggaagaggacgcactggctgatgccttcgaagcacagcac
gatgattacaacaaaataatggtgaaagcgcttgccgaccgtttagccgaagcgtttgcg
gagtatctccatgagcgtgtgcgtaaagtctactggggctatgcgccgaacgagaacctc
agcaacgaagagctgatccgcgaaaactatcagggaatccgcccggcaccaggctacccg
gcctgccctgaacatacggaaaaagccaccatctgggagctgctggaagtggaaaaacac
accggcatgaaactcacggaatctttcgcgatgtggccgggagcttcggtttcgggttgg
tacttcagccacccggacagcaagtattacgcggtagcgcaaattcagcgcgatcaggtc
gaagactatgcccgccgtaaaggtatgagcgtctcagatgttgaacgctggctggcaccg
aatctggggtatgacgccgagtaa
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