Eptesicus fuscus (big brown bat): 103289256 Help Entry 103289256         CDS       T09083                                  Symbol IRS1 Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism efus  Eptesicus fuscus (big brown bat) Pathway efus04022   cGMP-PKG signaling pathway efus04068   FoxO signaling pathway efus04081   Hormone signaling efus04140   Autophagy - animal efus04150   mTOR signaling pathway efus04151   PI3K-Akt signaling pathway efus04152   AMPK signaling pathway efus04211   Longevity regulating pathway efus04213   Longevity regulating pathway - multiple species efus04722   Neurotrophin signaling pathway efus04910   Insulin signaling pathway efus04920   Adipocytokine signaling pathway efus04923   Regulation of lipolysis in adipocytes efus04930   Type II diabetes mellitus efus04931   Insulin resistance efus04932   Non-alcoholic fatty liver disease efus04935   Growth hormone synthesis, secretion and action efus04960   Aldosterone-regulated sodium reabsorption efus05010   Alzheimer disease efus05206   MicroRNAs in cancer efus05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:efus00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     103289256 (IRS1)    04022 cGMP-PKG signaling pathway     103289256 (IRS1)    04151 PI3K-Akt signaling pathway     103289256 (IRS1)    04152 AMPK signaling pathway     103289256 (IRS1)    04150 mTOR signaling pathway     103289256 (IRS1)   09133 Signaling molecules and interaction    04081 Hormone signaling     103289256 (IRS1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     103289256 (IRS1)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     103289256 (IRS1)    04923 Regulation of lipolysis in adipocytes     103289256 (IRS1)    04920 Adipocytokine signaling pathway     103289256 (IRS1)    04935 Growth hormone synthesis, secretion and action     103289256 (IRS1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     103289256 (IRS1)   09156 Nervous system    04722 Neurotrophin signaling pathway     103289256 (IRS1)   09149 Aging    04211 Longevity regulating pathway     103289256 (IRS1)    04213 Longevity regulating pathway - multiple species     103289256 (IRS1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     103289256 (IRS1)   09164 Neurodegenerative disease    05010 Alzheimer disease     103289256 (IRS1)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     103289256 (IRS1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     103289256 (IRS1)    04932 Non-alcoholic fatty liver disease     103289256 (IRS1)    04931 Insulin resistance     103289256 (IRS1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  103289256 NCBI-ProteinID:  XP_008143315 LinkDB All DBs Position 11:66776110..66835541 Genome browser AA seq 1233 aa AA seqDB search MASPTETEGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKSH HDGASAPGTGGGGGSCSGSSGVGEAGEDLSFGDSNPGPAFKEVWQVVLKPKGLGQTKNLI GIYRLCLTSKTISFVKLNTEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV DDSVVAQSMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT RRSRTESITATSPASLVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR GCSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLAAPN GHYILPRGGNGHRYLPAAGLGTNSALAGEEAAGAADLDNRFRKRTHSAGTSPTISHQKTP SQSSVASIEEYTEMMPACPPGGGSGGRLPGYRHSAFLPTQSYPEEGLEMHPLERRGGHSR PDTSTLHTDDGYMPMTPGVAPVPGSRKGSGDYMPMSPKSVSSPQQIINPLRRHPQRVDPN GYMMMSPSGSCSPDTAGGPSSSSNSAAPSRSSYGKLWTNGVGGHHAHPLPPSSKLPSESS GGKLLPCTGDYMNMSPVGDSNTSSPSDCYCGPEDPQHKPVLSYYSLPRSFKHTQRPGDLE ETARHQHLRLSSSSGRLLYAAAAEDSSSSTSNDSLGGGYCGVRPEPSLPHHLHHQVLQSH LPRKVDSAAQTNSRLARPTRLSLGDPKASTLPRAREQQQPALLLPPEPKSPGEYVNIEFG SDQPGYLSGPVASHSSPSVRCPSQLQPAPREEESGTEEYMNMDLGPGRRATWQESPVVQP SRVGPAPPGTASTCRPTRAVPSTSTRGDYMTMQMGCPHQSYVDTSPVAPVSYADIRTGIV EEASLPGAAAAAPSSSSTASASPTAPQGAGELVAPQGSGGTSAFTRVNLSPSGNQSAKVI RADPQGCRRRHSSETFSSMPSTPRAGNTVPSAGAAVGGSSGGSSSIEDVKRHSSASFENV WLRPGELGGAPKEQAPVCGAAGGLENGLNYIDLDLVKDFKQHPQEHPPQGQHPQPPTLHR PPGSSESSSSSRSREDVSAYASISFQKQPEDLQ NT seq 3702 nt NT seq  +upstreamnt  +downstreamnt atggcgagccctacggagaccgagggcttctcggacgtgcgcaaggtgggctacctgcgc aaacctaagagcatgcacaagcgcttcttcgtgctgcgggcggccagcgaggcggggggc ccggcgcgcctggagtactacgagaatgagaagaagtggcggcacaagtcgagcgccccc aaacgctcgatccccctcgagagctgtttcaacatcaacaagcgggctgactccaagaat aagcacctggtggccctctatacccgggacgagcactttgctatcgcagcggacagcgag gccgagcaggacagctggtaccaggccctcctgcagctgcataaccgtgccaagagccac cacgatggggcttcggcccccgggacaggaggcggcgggggcagctgcagtggcagctcc ggcgtgggcgaggctggggaggacctgagcttcggggacagcaacccggggcccgcattc aaggaggtctggcaggtggtcttgaaacccaagggcctgggtcagacaaagaacctgatt ggtatctaccgcctctgcctgaccagcaagaccatcagcttcgtgaagctgaacacagag gcggctgcagtggtgctgcagctgatgaacatccggcgctgtggtcactcggagaacttc ttcttcatcgaagtgggccgttccgccgtgaccggacccggggagttctggatgcaggtg gatgactcggtggtggcccagagcatgcacgagacaatcctggaggccatgcgggctatg agcgatgaattccggcctcgcagcaagagccagtcttcctccaactgctccaaccccatc agtgtccccctgcgcaggcaccacctaaacaaccctccgcccagccaggtggggctgacc cgccgttcacgcacggagagcatcacggccacctctccagccagcctggtgggcgggaag cagggctccttccgcgtccgtgcctccagcgacggggaaggcaccatgtcccgcccggct tcggtggacggcagccccgtgagtcctagcaccaacaggacgcacgcccaccggcatcgg ggctgctcgcggctgcaccccccactcaaccacagccgatccatccccatgccttcttct cgctgctcgccttcggccaccagccctgtcagcctgtcctcaagcagcaccagtggccac ggctccacctcggactgtcttttcccgcggagatccagtgcttctgtgtctggttccccc agcgatggcggtttcatctcttcggatgagtatggctccagcccctgcgatttccgaagt tccttccgcagtgtcaccccagattccctgggccacaccccaccggcccgcggggaggag gagctgagcaactacatctgcatgggaggcaagggggcctccactctcgccgcccccaat ggccactacattttgcctcggggtggcaatggtcaccgctacctcccggccgctggcctg ggcacgaactcggccctggctggggaggaagcagccggtgctgcggatctggataaccgg tttcgcaagcggactcactcggctggcacttcccccaccatttcccaccagaagaccccg tcgcagtcctccgtggcttccattgaggaatatacagagatgatgcctgcctgcccacca ggaggtggcagtggaggccgactgcccggctaccggcactccgccttcctgcccacccag tcctaccccgaggagggtctggaaatgcaccccctggagcgccgcggaggccacagccgc ccggacacctccaccctccacacggatgatggctacatgcccatgaccccaggagtggcc ccagtgcctggcagccggaaaggcagtggggactacatgcctatgagccccaagagtgtg tcttccccgcagcagatcatcaaccccctcaggcgccatccccagagagtggaccccaat ggctacatgatgatgtccccaagtggcagctgctccccggacactgcgggtgggcccagc agcagcagcaacagtgctgccccttctaggagtagctatgggaagctgtggacaaatggg gtcgggggccaccacgcccaccccctgccaccctcctccaaactcccctcggagagcagt ggtgggaagctcttgccttgtacaggtgactacatgaacatgtcaccggtgggggactcc aacaccagcagcccctctgactgctactgcggccctgaggacccccagcacaagccagtt ctctcctactactcattgccaaggtcctttaagcacacccagcggccgggggacctggag gagaccgcccggcaccagcacctccgcctttcctccagctctggtcgccttctctatgct gcagcagccgaagattcctcttcctccaccagcaacgacagcctgggtgggggatactgt ggggtgaggcccgagcccagcctcccgcatcatctgcaccatcaggtcctgcagtcccat ctgcctcgaaaggtggactcagctgcgcagaccaacagccgcctggctcggcccacgagg ctttccctgggggaccccaaggccagcaccttaccccgggctcgagagcagcagcagccg gccctcctgcttcctccggagcccaagagcccaggggaatatgtgaatatagaatttggg agtgatcagcctggctacttatctggtcccgtggcatcccacagctcaccttcggtcagg tgtccatcccagctccagccggctcccagggaggaagagtctggcactgaagagtacatg aacatggacctggggcctggccggagggctacctggcaggagagccctgtggtccagccg agcagagtgggtcctgcacctccagggactgccagcacctgcaggcctacccgggcagtg cctagcactagcactcggggtgactacatgaccatgcagatggggtgtccccatcagagc tatgtggacacctctccggttgcccctgtcagctatgctgatattcggacaggcattgtg gaggaggcgagccttcccggggctgcagcggctgctccctcctcatcctctacagcctct gcttcccccactgcgcctcaaggagcaggggagctggtggccccgcaggggtccgggggc acgagtgccttcacccgggtgaacctcagtcccagtggcaaccagagtgccaaagtgatc cgtgcagacccgcaagggtgccggaggcggcatagctccgagaccttctcctccatgcct agtaccccccgggccggcaacacggtgccctcagcgggggctgcggtagggggcagcagt ggtggcagcagcagcattgaggatgtgaagcgtcacagctctgcttcatttgagaacgtg tggctgaggcctggggagctcgggggagcacccaaagagcaggctccagtgtgtggggct gcagggggtttggagaatggtctgaactacatagacctggatttggtcaaggacttcaaa cagcacccccaggagcacccccctcaagggcagcatccccaacccccaacccttcatcgt cctccgggcagcagtgagagcagctcctccagccgctccagggaggatgtaagcgcctac gccagcatcagttttcagaagcagccagaggacctccagtag

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