Eptesicus fuscus (big brown bat): 103294231
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Entry
103294231 CDS
T09083
Symbol
MAP2K2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2
KO
K04369
mitogen-activated protein kinase kinase 2 [EC:
2.7.12.2
]
Organism
efus
Eptesicus fuscus (big brown bat)
Pathway
efus01521
EGFR tyrosine kinase inhibitor resistance
efus01522
Endocrine resistance
efus04010
MAPK signaling pathway
efus04012
ErbB signaling pathway
efus04014
Ras signaling pathway
efus04015
Rap1 signaling pathway
efus04022
cGMP-PKG signaling pathway
efus04024
cAMP signaling pathway
efus04066
HIF-1 signaling pathway
efus04068
FoxO signaling pathway
efus04071
Sphingolipid signaling pathway
efus04072
Phospholipase D signaling pathway
efus04140
Autophagy - animal
efus04148
Efferocytosis
efus04150
mTOR signaling pathway
efus04151
PI3K-Akt signaling pathway
efus04210
Apoptosis
efus04218
Cellular senescence
efus04270
Vascular smooth muscle contraction
efus04370
VEGF signaling pathway
efus04371
Apelin signaling pathway
efus04540
Gap junction
efus04550
Signaling pathways regulating pluripotency of stem cells
efus04613
Neutrophil extracellular trap formation
efus04620
Toll-like receptor signaling pathway
efus04650
Natural killer cell mediated cytotoxicity
efus04660
T cell receptor signaling pathway
efus04662
B cell receptor signaling pathway
efus04664
Fc epsilon RI signaling pathway
efus04720
Long-term potentiation
efus04722
Neurotrophin signaling pathway
efus04730
Long-term depression
efus04810
Regulation of actin cytoskeleton
efus04910
Insulin signaling pathway
efus04912
GnRH signaling pathway
efus04915
Estrogen signaling pathway
efus04916
Melanogenesis
efus04917
Prolactin signaling pathway
efus04919
Thyroid hormone signaling pathway
efus04921
Oxytocin signaling pathway
efus04926
Relaxin signaling pathway
efus04929
GnRH secretion
efus04934
Cushing syndrome
efus04935
Growth hormone synthesis, secretion and action
efus05010
Alzheimer disease
efus05022
Pathways of neurodegeneration - multiple diseases
efus05132
Salmonella infection
efus05135
Yersinia infection
efus05160
Hepatitis C
efus05161
Hepatitis B
efus05163
Human cytomegalovirus infection
efus05164
Influenza A
efus05165
Human papillomavirus infection
efus05166
Human T-cell leukemia virus 1 infection
efus05167
Kaposi sarcoma-associated herpesvirus infection
efus05170
Human immunodeficiency virus 1 infection
efus05200
Pathways in cancer
efus05205
Proteoglycans in cancer
efus05206
MicroRNAs in cancer
efus05207
Chemical carcinogenesis - receptor activation
efus05208
Chemical carcinogenesis - reactive oxygen species
efus05210
Colorectal cancer
efus05211
Renal cell carcinoma
efus05213
Endometrial cancer
efus05214
Glioma
efus05215
Prostate cancer
efus05216
Thyroid cancer
efus05218
Melanoma
efus05219
Bladder cancer
efus05220
Chronic myeloid leukemia
efus05221
Acute myeloid leukemia
efus05223
Non-small cell lung cancer
efus05224
Breast cancer
efus05225
Hepatocellular carcinoma
efus05226
Gastric cancer
efus05230
Central carbon metabolism in cancer
efus05231
Choline metabolism in cancer
efus05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
efus00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
103294231 (MAP2K2)
04012 ErbB signaling pathway
103294231 (MAP2K2)
04014 Ras signaling pathway
103294231 (MAP2K2)
04015 Rap1 signaling pathway
103294231 (MAP2K2)
04370 VEGF signaling pathway
103294231 (MAP2K2)
04371 Apelin signaling pathway
103294231 (MAP2K2)
04066 HIF-1 signaling pathway
103294231 (MAP2K2)
04068 FoxO signaling pathway
103294231 (MAP2K2)
04072 Phospholipase D signaling pathway
103294231 (MAP2K2)
04071 Sphingolipid signaling pathway
103294231 (MAP2K2)
04024 cAMP signaling pathway
103294231 (MAP2K2)
04022 cGMP-PKG signaling pathway
103294231 (MAP2K2)
04151 PI3K-Akt signaling pathway
103294231 (MAP2K2)
04150 mTOR signaling pathway
103294231 (MAP2K2)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
103294231 (MAP2K2)
04148 Efferocytosis
103294231 (MAP2K2)
09143 Cell growth and death
04210 Apoptosis
103294231 (MAP2K2)
04218 Cellular senescence
103294231 (MAP2K2)
09144 Cellular community - eukaryotes
04540 Gap junction
103294231 (MAP2K2)
04550 Signaling pathways regulating pluripotency of stem cells
103294231 (MAP2K2)
09142 Cell motility
04810 Regulation of actin cytoskeleton
103294231 (MAP2K2)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
103294231 (MAP2K2)
04620 Toll-like receptor signaling pathway
103294231 (MAP2K2)
04650 Natural killer cell mediated cytotoxicity
103294231 (MAP2K2)
04660 T cell receptor signaling pathway
103294231 (MAP2K2)
04662 B cell receptor signaling pathway
103294231 (MAP2K2)
04664 Fc epsilon RI signaling pathway
103294231 (MAP2K2)
09152 Endocrine system
04910 Insulin signaling pathway
103294231 (MAP2K2)
04929 GnRH secretion
103294231 (MAP2K2)
04912 GnRH signaling pathway
103294231 (MAP2K2)
04915 Estrogen signaling pathway
103294231 (MAP2K2)
04917 Prolactin signaling pathway
103294231 (MAP2K2)
04921 Oxytocin signaling pathway
103294231 (MAP2K2)
04926 Relaxin signaling pathway
103294231 (MAP2K2)
04935 Growth hormone synthesis, secretion and action
103294231 (MAP2K2)
04919 Thyroid hormone signaling pathway
103294231 (MAP2K2)
04916 Melanogenesis
103294231 (MAP2K2)
09153 Circulatory system
04270 Vascular smooth muscle contraction
103294231 (MAP2K2)
09156 Nervous system
04720 Long-term potentiation
103294231 (MAP2K2)
04730 Long-term depression
103294231 (MAP2K2)
04722 Neurotrophin signaling pathway
103294231 (MAP2K2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
103294231 (MAP2K2)
05206 MicroRNAs in cancer
103294231 (MAP2K2)
05205 Proteoglycans in cancer
103294231 (MAP2K2)
05207 Chemical carcinogenesis - receptor activation
103294231 (MAP2K2)
05208 Chemical carcinogenesis - reactive oxygen species
103294231 (MAP2K2)
05230 Central carbon metabolism in cancer
103294231 (MAP2K2)
05231 Choline metabolism in cancer
103294231 (MAP2K2)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
103294231 (MAP2K2)
09162 Cancer: specific types
05210 Colorectal cancer
103294231 (MAP2K2)
05225 Hepatocellular carcinoma
103294231 (MAP2K2)
05226 Gastric cancer
103294231 (MAP2K2)
05214 Glioma
103294231 (MAP2K2)
05216 Thyroid cancer
103294231 (MAP2K2)
05221 Acute myeloid leukemia
103294231 (MAP2K2)
05220 Chronic myeloid leukemia
103294231 (MAP2K2)
05218 Melanoma
103294231 (MAP2K2)
05211 Renal cell carcinoma
103294231 (MAP2K2)
05219 Bladder cancer
103294231 (MAP2K2)
05215 Prostate cancer
103294231 (MAP2K2)
05213 Endometrial cancer
103294231 (MAP2K2)
05224 Breast cancer
103294231 (MAP2K2)
05223 Non-small cell lung cancer
103294231 (MAP2K2)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
103294231 (MAP2K2)
05170 Human immunodeficiency virus 1 infection
103294231 (MAP2K2)
05161 Hepatitis B
103294231 (MAP2K2)
05160 Hepatitis C
103294231 (MAP2K2)
05164 Influenza A
103294231 (MAP2K2)
05163 Human cytomegalovirus infection
103294231 (MAP2K2)
05167 Kaposi sarcoma-associated herpesvirus infection
103294231 (MAP2K2)
05165 Human papillomavirus infection
103294231 (MAP2K2)
09171 Infectious disease: bacterial
05132 Salmonella infection
103294231 (MAP2K2)
05135 Yersinia infection
103294231 (MAP2K2)
09164 Neurodegenerative disease
05010 Alzheimer disease
103294231 (MAP2K2)
05022 Pathways of neurodegeneration - multiple diseases
103294231 (MAP2K2)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
103294231 (MAP2K2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
103294231 (MAP2K2)
01522 Endocrine resistance
103294231 (MAP2K2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
efus01001
]
103294231 (MAP2K2)
Enzymes [BR:
efus01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
103294231 (MAP2K2)
Protein kinases [BR:
efus01001
]
Serine/threonine kinases: STE group
STE7 family
103294231 (MAP2K2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Kinase-like
Haspin_kinase
Seadorna_VP7
CAMSAP_CC1
Kdo
APH
Motif
Other DBs
NCBI-GeneID:
103294231
NCBI-ProteinID:
XP_008148838
LinkDB
All DBs
Position
6:28004931..28030791
Genome browser
AA seq
400 aa
AA seq
DB search
MLARRKPVLPALTINPAIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDAKELEAIFGRPMVDGAEGEPHSISPRPRP
PGRPISGHGVDSRPAMAIFELLDYIVNEPPPKLPSGVFTQDFQEFVNKCLIKNPAERADL
KMLMNHGFIKRSEVEEVDFAGWLCKTLRLNQPSTPTRTAV
NT seq
1203 nt
NT seq
+upstream
nt +downstream
nt
atgctggcccggaggaagccggtgctgccggcgctcaccatcaaccccgccatcgccgag
ggcccatcccccaccagcgagggcgcctccgaagcaaacttggtggacctccagaagaag
ctagaggaactagagcttgatgagcagcagaagaagcggttagaagccttcctcacccaa
aaggccaaggttggggagctcaaggatgatgacttcgaaaggatctcagagctgggagct
gggaacggcggagtggtcaccaaggtccagcacagaccttcaggcctcatcatggccaga
aagctgattcacctggagatcaagccagccatccggaaccagatcatccgagagctgcag
gtgctgcatgagtgcaactccccgtacattgtcggcttctacggggccttctacagcgac
ggggagatcagcatctgcatggagcacatggatggtggctctctggaccaggtgttgaaa
gaagccaagagaattccagaagagatcctggggaaggtcagcatcgcggttctgcggggc
ctggcgtatctccgggaaaagcaccagatcatgcaccgagatgtgaaaccatctaacatc
ctcgtcaactccagaggggagatcaagctgtgcgattttggggtgagcgggcagctcatc
gactccatggccaactccttcgtgggaactcgatcctacatgtctccagagcggctgcaa
ggcactcactactcggtgcagtcggacatctggagcatgggcttgtccctggtggagctg
tccatcggaagataccccatccccccgccggatgccaaggagctggaggccatcttcggc
cggcccatggtcgatggggcagaaggagagcctcacagcatctcaccgcggccgagaccc
cccggacgccccatcagtggtcacggggtggacagccgaccggctatggctatctttgaa
ctgctggactatattgtgaacgagcctcctcctaagctgcccagtggtgtcttcacccag
gacttccaggagtttgtgaataaatgcctcattaagaacccagctgagcgagcagatctg
aagatgctcatgaaccacggcttcatcaaacggtccgaggtggaagaagtggattttgcc
ggctggctgtgtaaaacgctgcgtctgaaccagcctagcacgcccacacgtaccgccgtg
tga
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