KEGG   Eptesicus fuscus (big brown bat): 103299551
Entry
103299551         CDS       T09083                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
efus  Eptesicus fuscus (big brown bat)
Pathway
efus01521  EGFR tyrosine kinase inhibitor resistance
efus01522  Endocrine resistance
efus01524  Platinum drug resistance
efus04012  ErbB signaling pathway
efus04014  Ras signaling pathway
efus04015  Rap1 signaling pathway
efus04024  cAMP signaling pathway
efus04062  Chemokine signaling pathway
efus04066  HIF-1 signaling pathway
efus04068  FoxO signaling pathway
efus04070  Phosphatidylinositol signaling system
efus04071  Sphingolipid signaling pathway
efus04072  Phospholipase D signaling pathway
efus04081  Hormone signaling
efus04140  Autophagy - animal
efus04150  mTOR signaling pathway
efus04151  PI3K-Akt signaling pathway
efus04152  AMPK signaling pathway
efus04210  Apoptosis
efus04211  Longevity regulating pathway
efus04213  Longevity regulating pathway - multiple species
efus04218  Cellular senescence
efus04360  Axon guidance
efus04370  VEGF signaling pathway
efus04380  Osteoclast differentiation
efus04510  Focal adhesion
efus04550  Signaling pathways regulating pluripotency of stem cells
efus04611  Platelet activation
efus04613  Neutrophil extracellular trap formation
efus04620  Toll-like receptor signaling pathway
efus04625  C-type lectin receptor signaling pathway
efus04630  JAK-STAT signaling pathway
efus04650  Natural killer cell mediated cytotoxicity
efus04660  T cell receptor signaling pathway
efus04662  B cell receptor signaling pathway
efus04664  Fc epsilon RI signaling pathway
efus04666  Fc gamma R-mediated phagocytosis
efus04668  TNF signaling pathway
efus04670  Leukocyte transendothelial migration
efus04722  Neurotrophin signaling pathway
efus04725  Cholinergic synapse
efus04750  Inflammatory mediator regulation of TRP channels
efus04810  Regulation of actin cytoskeleton
efus04910  Insulin signaling pathway
efus04914  Progesterone-mediated oocyte maturation
efus04915  Estrogen signaling pathway
efus04917  Prolactin signaling pathway
efus04919  Thyroid hormone signaling pathway
efus04923  Regulation of lipolysis in adipocytes
efus04926  Relaxin signaling pathway
efus04929  GnRH secretion
efus04930  Type II diabetes mellitus
efus04931  Insulin resistance
efus04932  Non-alcoholic fatty liver disease
efus04933  AGE-RAGE signaling pathway in diabetic complications
efus04935  Growth hormone synthesis, secretion and action
efus04960  Aldosterone-regulated sodium reabsorption
efus04973  Carbohydrate digestion and absorption
efus05010  Alzheimer disease
efus05017  Spinocerebellar ataxia
efus05020  Prion disease
efus05100  Bacterial invasion of epithelial cells
efus05135  Yersinia infection
efus05142  Chagas disease
efus05146  Amoebiasis
efus05160  Hepatitis C
efus05161  Hepatitis B
efus05162  Measles
efus05163  Human cytomegalovirus infection
efus05164  Influenza A
efus05165  Human papillomavirus infection
efus05166  Human T-cell leukemia virus 1 infection
efus05167  Kaposi sarcoma-associated herpesvirus infection
efus05168  Herpes simplex virus 1 infection
efus05169  Epstein-Barr virus infection
efus05170  Human immunodeficiency virus 1 infection
efus05171  Coronavirus disease - COVID-19
efus05200  Pathways in cancer
efus05203  Viral carcinogenesis
efus05205  Proteoglycans in cancer
efus05206  MicroRNAs in cancer
efus05207  Chemical carcinogenesis - receptor activation
efus05208  Chemical carcinogenesis - reactive oxygen species
efus05210  Colorectal cancer
efus05211  Renal cell carcinoma
efus05212  Pancreatic cancer
efus05213  Endometrial cancer
efus05214  Glioma
efus05215  Prostate cancer
efus05218  Melanoma
efus05220  Chronic myeloid leukemia
efus05221  Acute myeloid leukemia
efus05222  Small cell lung cancer
efus05223  Non-small cell lung cancer
efus05224  Breast cancer
efus05225  Hepatocellular carcinoma
efus05226  Gastric cancer
efus05230  Central carbon metabolism in cancer
efus05231  Choline metabolism in cancer
efus05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
efus05415  Diabetic cardiomyopathy
efus05417  Lipid and atherosclerosis
efus05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:efus00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    103299551 (PIK3R2)
   04014 Ras signaling pathway
    103299551 (PIK3R2)
   04015 Rap1 signaling pathway
    103299551 (PIK3R2)
   04370 VEGF signaling pathway
    103299551 (PIK3R2)
   04630 JAK-STAT signaling pathway
    103299551 (PIK3R2)
   04668 TNF signaling pathway
    103299551 (PIK3R2)
   04066 HIF-1 signaling pathway
    103299551 (PIK3R2)
   04068 FoxO signaling pathway
    103299551 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    103299551 (PIK3R2)
   04072 Phospholipase D signaling pathway
    103299551 (PIK3R2)
   04071 Sphingolipid signaling pathway
    103299551 (PIK3R2)
   04024 cAMP signaling pathway
    103299551 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    103299551 (PIK3R2)
   04152 AMPK signaling pathway
    103299551 (PIK3R2)
   04150 mTOR signaling pathway
    103299551 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    103299551 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    103299551 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    103299551 (PIK3R2)
   04218 Cellular senescence
    103299551 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    103299551 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    103299551 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    103299551 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    103299551 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    103299551 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    103299551 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    103299551 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    103299551 (PIK3R2)
   04660 T cell receptor signaling pathway
    103299551 (PIK3R2)
   04662 B cell receptor signaling pathway
    103299551 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    103299551 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    103299551 (PIK3R2)
   04670 Leukocyte transendothelial migration
    103299551 (PIK3R2)
   04062 Chemokine signaling pathway
    103299551 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    103299551 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    103299551 (PIK3R2)
   04929 GnRH secretion
    103299551 (PIK3R2)
   04915 Estrogen signaling pathway
    103299551 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    103299551 (PIK3R2)
   04917 Prolactin signaling pathway
    103299551 (PIK3R2)
   04926 Relaxin signaling pathway
    103299551 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    103299551 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    103299551 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    103299551 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    103299551 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    103299551 (PIK3R2)
   04722 Neurotrophin signaling pathway
    103299551 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    103299551 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    103299551 (PIK3R2)
   04380 Osteoclast differentiation
    103299551 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    103299551 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    103299551 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103299551 (PIK3R2)
   05206 MicroRNAs in cancer
    103299551 (PIK3R2)
   05205 Proteoglycans in cancer
    103299551 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    103299551 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    103299551 (PIK3R2)
   05203 Viral carcinogenesis
    103299551 (PIK3R2)
   05230 Central carbon metabolism in cancer
    103299551 (PIK3R2)
   05231 Choline metabolism in cancer
    103299551 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103299551 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    103299551 (PIK3R2)
   05212 Pancreatic cancer
    103299551 (PIK3R2)
   05225 Hepatocellular carcinoma
    103299551 (PIK3R2)
   05226 Gastric cancer
    103299551 (PIK3R2)
   05214 Glioma
    103299551 (PIK3R2)
   05221 Acute myeloid leukemia
    103299551 (PIK3R2)
   05220 Chronic myeloid leukemia
    103299551 (PIK3R2)
   05218 Melanoma
    103299551 (PIK3R2)
   05211 Renal cell carcinoma
    103299551 (PIK3R2)
   05215 Prostate cancer
    103299551 (PIK3R2)
   05213 Endometrial cancer
    103299551 (PIK3R2)
   05224 Breast cancer
    103299551 (PIK3R2)
   05222 Small cell lung cancer
    103299551 (PIK3R2)
   05223 Non-small cell lung cancer
    103299551 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    103299551 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    103299551 (PIK3R2)
   05161 Hepatitis B
    103299551 (PIK3R2)
   05160 Hepatitis C
    103299551 (PIK3R2)
   05171 Coronavirus disease - COVID-19
    103299551 (PIK3R2)
   05164 Influenza A
    103299551 (PIK3R2)
   05162 Measles
    103299551 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    103299551 (PIK3R2)
   05163 Human cytomegalovirus infection
    103299551 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103299551 (PIK3R2)
   05169 Epstein-Barr virus infection
    103299551 (PIK3R2)
   05165 Human papillomavirus infection
    103299551 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    103299551 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    103299551 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    103299551 (PIK3R2)
   05142 Chagas disease
    103299551 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103299551 (PIK3R2)
   05017 Spinocerebellar ataxia
    103299551 (PIK3R2)
   05020 Prion disease
    103299551 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    103299551 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    103299551 (PIK3R2)
   05415 Diabetic cardiomyopathy
    103299551 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    103299551 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    103299551 (PIK3R2)
   04931 Insulin resistance
    103299551 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    103299551 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103299551 (PIK3R2)
   01524 Platinum drug resistance
    103299551 (PIK3R2)
   01522 Endocrine resistance
    103299551 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:efus04131]
    103299551 (PIK3R2)
Membrane trafficking [BR:efus04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    103299551 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH3_9 Ribosomal_L22e
Other DBs
NCBI-GeneID: 103299551
NCBI-ProteinID: XP_008154628
LinkDB
Position
6:complement(16847317..16859549)
AA seq 725 aa
MAGAEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQGLGVAEGSERCPQNVGWIPGL
NERTRQRGDFPGTYVEFLGPVTLARPGPRPRGPRPLPARPQEGPPEPGLTLPDLPEQFSP
PDVAPPLLVKLVEAIERTGLDSESLYRPELPPPCTDWSLSDLEQWDSAALADGIKGFLLA
LPAPLVPLEAAAEACRALREAAGPVGPTLEPPTLPLHHALTLRFLLQHLSRVARRAPAPG
PAVRALGVAFGPLLLRAPPSPPPGVAPVGTEPNPDFPALLVEKLLQEHLEEQEVAPPALP
PKPPKVKPAPAGLANGGSQPALQDAEWYWGDISREEVNDKLRDTPDGTFLVRDASSKIQG
EYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLITHYRHESLAQYNAKLDTRLLY
PVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEA
FNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLE
QELRTQALDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETED
QYALMEDEDDLPHHEERTWYVGKINRTQAEEMLNGKRDGTFLIRESSQRGCYACSVVVDG
DTKHCVIYRTATGLGFAEPYNLYGSLKELVLHYQHTSLVQHNDALTVTLAHPVRAPGPGP
PPTAR
NT seq 2178 nt   +upstreamnt  +downstreamnt
atggctggcgctgagggcttccaatatcgtgcactgtacccgttccgccgggagcggcca
gaggacctggaactgctgcccggtgacgtgctggtggtaagccgggcagccctgcagggc
ctgggtgtggccgagggcagcgagcgctgcccgcagaacgtgggctggatacctggcctc
aatgagcgaactcggcagcgcggtgacttccctggtacctacgtggagttcctggggccg
gtgaccctggcccggcctggccctcgtccccgcggcccccgcccactgcctgccaggccc
caagaggggccccctgagccaggcctcacactccctgacctacctgagcagttctcccca
cctgatgtggctcccccactgctggtaaagcttgtggaggccattgagcggacaggtcta
gacagcgaatccctctacaggcctgagctgccgcccccatgcacagactggtccctgagc
gacctagagcagtgggactcggcagccctggccgatggcatcaagggcttcctcctggca
ctgcctgcgccccttgtgccgctggaagccgctgcagaggcctgccgcgccctgcgagag
gccgcggggcccgtggggccaactcttgagcccccgacgctgccactgcaccacgcgctc
acgctgcgcttcctgctccagcacctgagccgggtggcccggcgcgcccctgccccgggt
cctgctgtgcgagccctgggcgttgcgttcgggcctctgctgctgcgtgcgcctccctcg
ccgccaccaggggtcgcacctgtcgggactgagcccaaccccgacttcccagctctgctg
gtggagaagttgcttcaggagcacctggaggagcaggaggtcgcacccccagctctgcca
cctaaaccgcctaaagtaaagccggccccagcagggctggctaatggggggagccagccc
gctctgcaggatgctgagtggtactggggtgacatttccagggaggaggtgaatgacaaa
ctccgggacacacctgatggcaccttcctggtccgagatgcctccagcaagatccaggga
gagtataccctgacccttaggaaaggtggaaacaacaagctgattaaggtcttccaccgt
gacgggcattacggcttctcagagccgctcaccttctgctccgtcgtggacctcatcact
cactaccgccatgagtcactggcccagtacaatgccaaactggacacacggctcctgtac
cccgtgtccaagtaccagcaggaccagattgtcaaggaagatagcgtggaggcagtgggt
gcccagctcaaagtctaccaccagcagtaccaggacaagagccgcgagtacgaccagctc
tacgaggagtacacacgaacctcccaggaactgcagatgaagcgcaccgcaatcgaggcc
ttcaatgaaaccatcaagatcttcgaagagcagggccagactcaagagaagtgcagcaag
gagtatctggagcgcttccggcgtgagggcaatgaaaaagagatgcagaggatcctgctg
aactcagaacggctcaagtctcgcatcgcggagatccacgagagccgcacgaagctggag
caggagctgcggacgcaggccttggacaaccgggagatcgataagcgcatgaacagcctg
aagccagacctcatgcagctgcgcaagatccgagaccagtacctggtctggctcacccag
aaaggcgcccggcagaagaaaatcaacgagtggctgggaatcaaaaatgagactgaagac
cagtatgcactgatggaggacgaggatgacctcccccaccatgaggaacgaacctggtat
gtgggcaagatcaaccgcacgcaggctgaggaaatgctgaacggcaagcgggatgggacc
ttcctcatccgtgagagcagccagcggggctgctacgcctgctctgtggtggtggacggc
gataccaagcactgtgtcatctaccgcacggccaccggcctgggctttgcggagccctac
aacctgtacgggtccctgaaggagctggtgctgcattatcagcacacctccctcgtgcaa
cacaacgatgccctcaccgtcacactggcacaccccgtgcgggccccgggccccgggccc
ccccccaccgcccgctga

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