Eptesicus fuscus (big brown bat): 103302409 Help Entry 103302409         CDS       T09083                                  Symbol ADCY8 Name (RefSeq) adenylate cyclase type 8   KO K08048   adenylate cyclase 8 [EC:4.6.1.1] Organism efus  Eptesicus fuscus (big brown bat) Pathway efus00230   Purine metabolism efus01100   Metabolic pathways efus01522   Endocrine resistance efus04015   Rap1 signaling pathway efus04020   Calcium signaling pathway efus04022   cGMP-PKG signaling pathway efus04024   cAMP signaling pathway efus04062   Chemokine signaling pathway efus04072   Phospholipase D signaling pathway efus04081   Hormone signaling efus04082   Neuroactive ligand signaling efus04114   Oocyte meiosis efus04211   Longevity regulating pathway efus04213   Longevity regulating pathway - multiple species efus04261   Adrenergic signaling in cardiomyocytes efus04270   Vascular smooth muscle contraction efus04371   Apelin signaling pathway efus04540   Gap junction efus04611   Platelet activation efus04713   Circadian entrainment efus04714   Thermogenesis efus04720   Long-term potentiation efus04723   Retrograde endocannabinoid signaling efus04724   Glutamatergic synapse efus04725   Cholinergic synapse efus04727   GABAergic synapse efus04742   Taste transduction efus04750   Inflammatory mediator regulation of TRP channels efus04911   Insulin secretion efus04912   GnRH signaling pathway efus04913   Ovarian steroidogenesis efus04914   Progesterone-mediated oocyte maturation efus04915   Estrogen signaling pathway efus04916   Melanogenesis efus04918   Thyroid hormone synthesis efus04921   Oxytocin signaling pathway efus04923   Regulation of lipolysis in adipocytes efus04925   Aldosterone synthesis and secretion efus04926   Relaxin signaling pathway efus04927   Cortisol synthesis and secretion efus04928   Parathyroid hormone synthesis, secretion and action efus04934   Cushing syndrome efus04935   Growth hormone synthesis, secretion and action efus04970   Salivary secretion efus04971   Gastric acid secretion efus04972   Pancreatic secretion efus04976   Bile secretion efus05032   Morphine addiction efus05163   Human cytomegalovirus infection efus05166   Human T-cell leukemia virus 1 infection efus05200   Pathways in cancer efus05207   Chemical carcinogenesis - receptor activation efus05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:efus00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     103302409 (ADCY8)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     103302409 (ADCY8)    04371 Apelin signaling pathway     103302409 (ADCY8)    04020 Calcium signaling pathway     103302409 (ADCY8)    04072 Phospholipase D signaling pathway     103302409 (ADCY8)    04024 cAMP signaling pathway     103302409 (ADCY8)    04022 cGMP-PKG signaling pathway     103302409 (ADCY8)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     103302409 (ADCY8)    04081 Hormone signaling     103302409 (ADCY8)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     103302409 (ADCY8)   09144 Cellular community - eukaryotes    04540 Gap junction     103302409 (ADCY8)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     103302409 (ADCY8)    04062 Chemokine signaling pathway     103302409 (ADCY8)   09152 Endocrine system    04911 Insulin secretion     103302409 (ADCY8)    04923 Regulation of lipolysis in adipocytes     103302409 (ADCY8)    04912 GnRH signaling pathway     103302409 (ADCY8)    04913 Ovarian steroidogenesis     103302409 (ADCY8)    04915 Estrogen signaling pathway     103302409 (ADCY8)    04914 Progesterone-mediated oocyte maturation     103302409 (ADCY8)    04921 Oxytocin signaling pathway     103302409 (ADCY8)    04926 Relaxin signaling pathway     103302409 (ADCY8)    04935 Growth hormone synthesis, secretion and action     103302409 (ADCY8)    04918 Thyroid hormone synthesis     103302409 (ADCY8)    04928 Parathyroid hormone synthesis, secretion and action     103302409 (ADCY8)    04916 Melanogenesis     103302409 (ADCY8)    04925 Aldosterone synthesis and secretion     103302409 (ADCY8)    04927 Cortisol synthesis and secretion     103302409 (ADCY8)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     103302409 (ADCY8)    04270 Vascular smooth muscle contraction     103302409 (ADCY8)   09154 Digestive system    04970 Salivary secretion     103302409 (ADCY8)    04971 Gastric acid secretion     103302409 (ADCY8)    04972 Pancreatic secretion     103302409 (ADCY8)    04976 Bile secretion     103302409 (ADCY8)   09156 Nervous system    04724 Glutamatergic synapse     103302409 (ADCY8)    04727 GABAergic synapse     103302409 (ADCY8)    04725 Cholinergic synapse     103302409 (ADCY8)    04720 Long-term potentiation     103302409 (ADCY8)    04723 Retrograde endocannabinoid signaling     103302409 (ADCY8)   09157 Sensory system    04742 Taste transduction     103302409 (ADCY8)    04750 Inflammatory mediator regulation of TRP channels     103302409 (ADCY8)   09149 Aging    04211 Longevity regulating pathway     103302409 (ADCY8)    04213 Longevity regulating pathway - multiple species     103302409 (ADCY8)   09159 Environmental adaptation    04713 Circadian entrainment     103302409 (ADCY8)    04714 Thermogenesis     103302409 (ADCY8)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103302409 (ADCY8)    05207 Chemical carcinogenesis - receptor activation     103302409 (ADCY8)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103302409 (ADCY8)    05163 Human cytomegalovirus infection     103302409 (ADCY8)   09165 Substance dependence    05032 Morphine addiction     103302409 (ADCY8)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     103302409 (ADCY8)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     103302409 (ADCY8)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     103302409 (ADCY8) Enzymes [BR:efus01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      103302409 (ADCY8) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Guanylate_cyc AC_N Adcy_cons_dom TBK1_ULD Motif Other DBs NCBI-GeneID:  103302409 NCBI-ProteinID:  XP_008157689 LinkDB All DBs Position 19:4661405..4803234 Genome browser AA seq 1249 aa AA seqDB search MELSDVRCLGGSEELYTIHPTPPAGDGGSGSRPQRLLWQTAVRHITEQRFIHGHRGGGGS GGSGKGSDPAGGGPNHHASQLSGDLALPLYSLGTSERAHGGTSGTKVFPERSGSGSASGS GGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKS EVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHTY LQYSGLVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTSL LQVVLQVVIPRLAVIAVNQVVAQVVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARL RLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVK GFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHC CVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLE SGGIPGRIHISKATLDCLNGDYDVEEGHGKERNEFLRKHNIETYLIQQPEESLLSLPEDI VKEAVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQ SGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFI VLLFITAIQSLLPSSRAMPMAIQFSILIMLHAALVLITTAEDYKCLPLVLRKTCCWINET YLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGV LAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETIYSGLFLRYDNLNHSGEDFLGTKEAS LLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVAR HFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDEL LGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHS FNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETFLILK DQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQ SLNRQRQKQLLNENNSSGIKGHYARRTLLTPGGPEPGAQAEGPDKSDLP NT seq 3750 nt NT seq  +upstreamnt  +downstreamnt atggagctctccgatgtgcgctgcctcggcggcagcgaggaactctacaccatccacccg acgcccccggccggcgacggcgggagcggctcccggccgcagcggctgctgtggcagacg gcggtgcggcacatcaccgagcagcgcttcattcacgggcaccgaggcggcggcgggagc gggggctcgggcaaaggctcggacccggcgggcggaggccccaaccaccacgcctcgcag ctgtccggcgacttggcgctgcccctctattcgctgggcacctcggagagagcgcacggc ggcaccagcggcaccaaagtcttccctgaacgcagcgggagcggcagcgccagcggcagc gggggagggggcgacctggggttcctgcacctggactgcgccccgagcaactcggatttc ttcctcaatgggggctacagctaccgaggggtgattttccccaccctgcgcaactccttc aagtcacgggatctggagcgcctctaccagcgctatttcctgggccagaggcgcaaatcc gaggtggtgatgaatgtgctggacgtgctgaccaagctcacgctcctggttctccacctg agcctggcctcggcccccatggacccgctcaagggcatcctgctgggcttcttcaccggc atcgaggtggtcatctgcgccctggtggtggtcaggaaggacaccacctcgcacacgtac ctgcagtacagcggcctggtcacctgggtggccatgaccacccagatcttggccgcgggc ctgggctatgggctcctgggcgacggcatcggctacgtgctcttcacgctgttcgccacc tacagcatgctgccgctgccgctcacctgggccatcctggccggcctgggcacgtcgctg ctgcaggtggtcctccaagtggtgatcccccgactggcggtcattgccgtcaaccaggtg gtggcccaggtggtgttattcatgtgcatgaacacggctgggatcttcatcagttacctg tcagaccgcgcccagcgccaggccttcctggagactcggaggtgtgtggaggccaggctg cgcctggagacggaaaaccaaagacaggagcggctcgtgctgtccgtgctgccccgcttt gtcgtcctggagatgatcaacgacatgaccaacgtggaagatgagcacctgcagcaccag ttccaccggatctacatccatcgctacgagaacgtcagtattctttttgcagatgttaaa ggatttaccaacctctccacgaccttgtccgctcaggagctggtcaggatgctcaacgag ctctttgcccgattcgatcgcctggcccacgagcatcactgtcttcgcatcaagatcctg ggggactgctactactgcgtctccggacttcctgagccccgccaggaccacgcccactgc tgcgtggaaatgggcctcagcatgatcaaaaccatcaggtatgtgcggtcaaggacgaag catgacgttgacatgcgaatcggaatccactcgggctcagtgctgtgtggtgtgttgggc ctgcggaagtggcagtttgacgtctggtcttgggacgtggatattgcgaacaaacttgaa tctggagggatccctgggaggattcacatttccaaagccaccctcgactgcctcaacggt gactatgatgtggaagagggccacgggaaagagaggaatgagttcctgaggaagcataac atagagacctatttaattcagcagccggaggagagcctgctgtcgctgcccgaagacatt gtcaaggaggcagtgagctcctcggaccggaggaacagcggggcgacgttcacggagggg tcctggagccccgagctgcccttcgacaacatcgtgggcaaacagaacactctggctgcc ctaacaagaaattcaataaatctacttccaaaccatcttgcacaagctttgcatgtccag tcggggcctgaggaaattaacaagcgaatagaacataccatcgacttgcggagtggcgat aaattgagaagagagcatatcaagccattctcactgatgtttaaagactccagcctggag cacaagtattctcaaatgagggacgaagtgttcaagtcaaacttggtgtgtgcgttcatc gttcttctgtttatcacggcaatacagagcttgcttccttcttcaagggctatgccgatg gccatccagttctccatcctcatcatgctgcacgcggccctggtcctcatcaccacggcg gaggattacaagtgtttaccactcgtcctgcggaagacttgctgctggatcaacgagacc tatttggcccggaacgtcatcatcttcgcatccatcctgatcaatttcctgggcgccatc ctcaatatcctgtggtgtgattttgacaagtcgatacccttgaagaacctgactttcaat tcctcagctgtgtttacagatatctgctcctacccagagtacttcgtcttcacgggcgtg ttggccatggtgacctgtgcggttttcctccgactcaactctgtcctgaagctggccgtg ctgctcattatgatcgccatctatgccctgctgaccgagaccatctactcaggtctcttc ctgcgctatgacaacctgaaccacagtggagaagatttcctggggaccaaggaggcgtcg ctgctgctgatggccatgttcctcctcgctgtgttctaccacggacagcagctggagtac acagcccgcctggacttcctgtggcgggttcaggccaaagaggagatcaacgagatgaag gagctgagggagcacaatgagaacatgctccggaacatcctgcccagccacgtggcccgc cacttcctggagaaggaccgagacaacgaggagctgtattctcaatcctacgatgccgtc ggggtgatgttcgcctccatcccggggtttgcggacttttactctcagaccgaaatgaat aaccaaggagtggagtgcctgcgcctgctgaatgagatcattgcggacttcgatgagctg ctcggcgaagaccggtttcaagacattgaaaagatcaagaccattggcagcacctacatg gctgtctcgggcctgtctcccgaaaagcagcaatgtgaagacaagtggggacacctgtgc gccctggccgacttctcgctggccctgacggagagcatccaggagatcaacaagcactcg ttcaacaacttcgagctccggattggcatcagccacggctcggtggtcgccggcgtcatc ggcgccaagaagccgcagtacgacatctggggtaaaaccgtgaacctggccagccgcatg gacagcacgggggtcagcggcaggatccaggtcccggaggagacgttcctcatcctgaag gaccagggcttcgccttcgactaccgcggggagatctacgtgaagggcatcagcgagcag gaggggaagatcaagacgtacttcctcctgggcagggtccagcccaacccgttcatcctg cccccgaggaggctgccgggccagtactcgctggccgccgtggtcctgggcctcgtccag tccctcaacaggcagcggcagaagcagctcctcaacgagaacaacagctcgggcatcaag ggccactacgcccggcggactctgctgacgcccggcggcccggagcccggcgcccaggcc gagggccccgacaagtccgacttgccataa

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