Eumetopias jubatus (Steller sea lion): 114196636 Help Entry 114196636         CDS       T07240                                  Symbol IRS2 Name (RefSeq) insulin receptor substrate 2   KO K07187   insulin receptor substrate 2 Organism eju  Eumetopias jubatus (Steller sea lion) Pathway eju04022   cGMP-PKG signaling pathway eju04068   FoxO signaling pathway eju04081   Hormone signaling eju04140   Autophagy - animal eju04152   AMPK signaling pathway eju04211   Longevity regulating pathway eju04213   Longevity regulating pathway - multiple species eju04910   Insulin signaling pathway eju04920   Adipocytokine signaling pathway eju04923   Regulation of lipolysis in adipocytes eju04930   Type II diabetes mellitus eju04931   Insulin resistance eju04932   Non-alcoholic fatty liver disease eju04935   Growth hormone synthesis, secretion and action eju05010   Alzheimer disease eju05206   MicroRNAs in cancer Brite KEGG Orthology (KO) [BR:eju00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     114196636 (IRS2)    04022 cGMP-PKG signaling pathway     114196636 (IRS2)    04152 AMPK signaling pathway     114196636 (IRS2)   09133 Signaling molecules and interaction    04081 Hormone signaling     114196636 (IRS2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     114196636 (IRS2)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     114196636 (IRS2)    04923 Regulation of lipolysis in adipocytes     114196636 (IRS2)    04920 Adipocytokine signaling pathway     114196636 (IRS2)    04935 Growth hormone synthesis, secretion and action     114196636 (IRS2)   09149 Aging    04211 Longevity regulating pathway     114196636 (IRS2)    04213 Longevity regulating pathway - multiple species     114196636 (IRS2)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     114196636 (IRS2)   09164 Neurodegenerative disease    05010 Alzheimer disease     114196636 (IRS2)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     114196636 (IRS2)    04932 Non-alcoholic fatty liver disease     114196636 (IRS2)    04931 Insulin resistance     114196636 (IRS2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  IRS PH PH_11 MEKK4_N Motif Other DBs NCBI-GeneID:  114196636 NCBI-ProteinID:  XP_027943172 LinkDB All DBs Position Unknown AA seq 1328 aa AA seqDB search MASPPLHGPPGPAGGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGDEATAT AGGGPAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDEY FAVAAENEQEQEGWYRALTDLVSEGRAGDAPPAAATAASCSASLPGALGGSAGAAAADDS YGLVAPATAAYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLM NIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPR SKSQSSGSSSTHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSSCRVRT ASEGDGGAAAGAAGGRPVSVAGSPLSPGPVRAPLSRSHTLSGGCGARASKVALAPAGGAL QHSRSMSMPVAHSPPAATSPSSLSSSSGHGSGSYPPPPGPHPHLQHPLHHPASQRPSSGS ASASGSPSDPGFMSLDEYGSSPGDLRAFCSHRSNTPESIAETPPARDGSGGELYGYMTMD RPLSHCGRPYRRVSGDGAQDLDRGLRKRTYSLTTPARQRPVPQPSSASLDEYTLMRATFS GSSGRLCPSCPASSPKVAYHPYPEDYGDIEIGSHRSSSSNLGADDGYMPMTPGVALLGGG SGSCKSDDYMPMSPTSVSAPKQILQPRAAAAAALPPTGAVVPAPTPTAGRAFPANAGSYK TSSPAESSPEDSGYMRMWCGSKLSMENADTKLLPNGDYLNMSPSDAGTSGTPPDFFSAAL HGSGEMLRGVPGYCYSSLPRSYKAPYTCNGDNDQYVLMSSPVGRILEEERLEPPAGPGTA PSTSALAAAGGHTQPPHPVVPSPSRPSGSLGGRPDSFLNQRCRLVRPTRLSLEGLQTLPS MHEYPLPPEPKSPGEYINIDFGEAAARLSPPAPPLLASAASSSSLLSASSPASSLGSGTP GTSSDSRQRSPLSDYMNLDFSSPKSPKPGPQSGDPVGSLDAFLSPEASSPYPPLPPRPPA PTSSLQPQPPPPPPPGELYRLPQASTSQGPSAACSSSPETGDNGDYTEMAFGVAATPPQP IAAPPKPEGARVTSPTSGLKRLSLMDQVSGVEAFLQASQPPDPHRGAKVIRADPQGGRRR HSSETFSSTTTVTPVSPSFAHNPKRHNSASVENVCLRKSSEGGGGGVLGGAEERPTSPRQ LQPPPPQQARPRVSSQPGGLVGCPGGSGSPMRRETSAGFQNGLNYIAIDVRDEPGLSPTP QQHPHPQPGDKSAWGRTRSLGGLISAVGGSSSGGVCGGPGPGALPSANTYASIDFLSHHL KEATIVKE NT seq 3987 nt NT seq  +upstreamnt  +downstreamnt atggcgagcccgccgctgcatgggccccccgggccggcgggcggcgacggccccaacctc aacaacaacaacaacaacaacaaccacagcgtgcgcaagtgcggctacctgcgcaagcag aagcacggccacaagcgcttcttcgtgctgcgcgggcccggcgacgaggcgacggcgaca gcgggcggggggccggcgccgcagccgccgcggctcgagtactacgagagcgagaagaag tggcggagcaaggcgggcgccccgaagcgggtcatcgcgctcgactgctgcctgaacatc aacaagcgcgccgacgccaagcacaagtacctgatcgcgctctacaccaaggacgagtac ttcgcggtggcggccgagaacgagcaggagcaggagggctggtaccgcgcgctcaccgac ctggtcagcgagggccgcgccggcgacgcgccccccgccgccgccaccgctgcgtcctgc agcgcctccctgcccggcgccctgggcggctcggccggcgccgccgcggccgatgacagc tacgggctggtggcgcccgccacggccgcctaccgcgaggtgtggcaggtgaacctgaag cccaagggcctgggccagagcaagaatctgacgggcgtgtaccgcctgtgcctgtcggcg cgcaccatcggcttcgtgaagctcaactgtgagcagccgtcggtgacgctgcagctcatg aacatccgccgctgcggccactcggacagctttttcttcattgaggtgggccggtcggcc gtcacgggcccaggtgagctgtggatgcaggccgacgactcggtggtggcgcagaacatc cacgagaccatcctggaggccatgaaggcactcaaggagctcttcgagttccggccgcgc agtaagagccagtcgtcgggctcgtcctccacacaccccatcagcgtccccggcgcgcgc cgccaccaccacctggtcaacctcccccccagccagacgggcctggtgcgtcgctcgcgc accgacagcctggccgccactccgccggccgcgaagtgcagctcgtgtcgggtgcgcacg gccagcgagggcgacggcggcgcggcggcgggggcggcgggcggcaggccagtgtcggtg gccgggagtcccctgagccccgggccggtgcgcgcgcccctgagccgctcacacaccctg agcggcggctgcggcgcccgcgcgagcaaggtggcgctggcgccggcagggggcgccctg caacacagccgctccatgtccatgccggtggcgcactcgcccccagccgccaccagcccc agcagcctgtcgtccagcagcgggcacggctccggctcctacccgccgcctccaggcccg catccgcacctgcagcaccccctgcaccaccccgcgagccagcggccctccagcggcagc gcctcggcctcgggctcccccagcgatcctggcttcatgtctctggatgagtacggctcc agccctggggacctcagagccttctgcagccaccggagcaacacgcccgagtctatcgct gagacacccccggccagggacggcagcgggggcgagctctacgggtacatgactatggac aggcccctgagccactgtggccgcccctaccgcagagtctcgggggacggggcccaggac ttggaccgagggctgaggaagaggacttactccctgaccacacctgcccggcagcggccg gtaccccagccctcctctgcgtccctggatgaatacaccctgatgcgggccaccttctct ggcagctccggccgcctctgcccgtcttgtcccgcgtcgtctcccaaagtggcctaccac ccctatcccgaggactacggcgacatcgagatcgggtcccataggagctccagcagtaac ctgggtgccgacgatggctacatgcccatgacccctggcgtggccctcctgggtggtggc agcggtagctgtaagagtgatgactacatgcccatgagccccactagcgtgtcggccccg aagcagatcctgcagcctcgagccgccgccgccgcagccctgccccccacgggagccgta gtgccggcgcccacccccacggccggcagggcctttccagccaacgccggcagctacaag acgagctccccagccgagagctcccccgaggacagtgggtacatgcgcatgtggtgtggc tccaagctgtccatggagaacgcggacaccaagctgctacccaacggggactacctcaac atgtcccccagcgacgcgggtacctcggggacccctcccgacttcttctcggccgccttg catggcagcggggagatgctcaggggagtccctggctattgctacagctccctgccccgc tcctacaaggctccctacacgtgcaacggggacaacgaccagtatgtgctcatgagctcc cccgtggggcgcatcctggaagaagagaggctggaaccgccggccggcccggggaccgcg ccgtccactagcgctctcgcggcagcaggcggccacacccagcctcctcacccagtagtg ccttcgcccagcaggccgagtggcagcctcggtggccgccccgacagcttcctgaaccag cgctgccggttagtgcggcccacacgcctgtccctggaggggcttcagaccctgcccagc atgcacgagtaccctctgccgcccgagcccaagagccccggcgagtacatcaacattgac ttcggcgaggccgcagcgcgcctgtctccgcccgcgcccccgctgctggcttcggcggcc tcctcgtcctcgctgctgtcggccagcagcccggcctcatccctgggctcaggcaccccg ggcaccagcagcgacagcaggcagcgctccccactctccgactacatgaacctcgacttc agctcgcccaagtcacccaagccgggcccccagagcggggaccccgtgggctccctggat gccttcctgtcccccgaggcctcgtccccctacccgccgctgcccccacgccctcccgcc cccacctcctccctgcagccgcagccgcccccgccgccccccccaggggagctgtaccgc ctgccccaggcgtccacttcccagggccccagcgctgcctgctcttcgtccccggagact ggggacaatggggactacaccgagatggcctttggcgtagctgccaccccgccacaaccc atcgcggcccccccgaagccggaaggtgcccgcgtgaccagccccacgtccggcctgaag aggctgagtctcatggatcaggtgtcgggagtggaggccttcctgcaggcgagccagccc ccagacccgcaccggggagccaaggtcatccgcgcagacccacaggggggccgccgccgc cacagctccgagaccttctcctcgaccaccactgtgacccccgtgtccccgtccttcgcc cataaccctaagcgccacaactcggcctctgtggaaaacgtctgtctcaggaaaagcagc gaagggggcggtggcggcgtcctgggtggggccgaggagcgccccacctccccccgccag ttgcagccaccgcccccccagcaggcgcgcccaagggtatcgagtcagcctgggggcttg gttggctgcccagggggcagtggctctccaatgcgcagggagacctctgccggcttccag aacggcctcaattacatcgccatcgacgtaagggacgagcctgggctgtcacccaccccg cagcagcatccgcatccacagcccggagacaagagcgcctggggccggacccgcagcctc gggggtctcatcagcgctgtggggggcagcagcagcggtggggtgtgtggggggccgggc cctggcgccctcccctccgccaacacctatgccagcattgacttcttgtcccatcacctg aaggaggccaccattgtgaaagagtga

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