Eumetopias jubatus (Steller sea lion): 114200877 Help Entry 114200877         CDS       T07240                                  Symbol INSR Name (RefSeq) insulin receptor isoform X1   KO K04527   insulin receptor [EC:2.7.10.1] Organism eju  Eumetopias jubatus (Steller sea lion) Pathway eju04010   MAPK signaling pathway eju04014   Ras signaling pathway eju04015   Rap1 signaling pathway eju04022   cGMP-PKG signaling pathway eju04066   HIF-1 signaling pathway eju04068   FoxO signaling pathway eju04072   Phospholipase D signaling pathway eju04081   Hormone signaling eju04150   mTOR signaling pathway eju04151   PI3K-Akt signaling pathway eju04152   AMPK signaling pathway eju04211   Longevity regulating pathway eju04213   Longevity regulating pathway - multiple species eju04520   Adherens junction eju04910   Insulin signaling pathway eju04913   Ovarian steroidogenesis eju04923   Regulation of lipolysis in adipocytes eju04930   Type II diabetes mellitus eju04931   Insulin resistance eju04932   Non-alcoholic fatty liver disease eju04960   Aldosterone-regulated sodium reabsorption eju05010   Alzheimer disease eju05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:eju00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     114200877 (INSR)    04014 Ras signaling pathway     114200877 (INSR)    04015 Rap1 signaling pathway     114200877 (INSR)    04066 HIF-1 signaling pathway     114200877 (INSR)    04068 FoxO signaling pathway     114200877 (INSR)    04072 Phospholipase D signaling pathway     114200877 (INSR)    04022 cGMP-PKG signaling pathway     114200877 (INSR)    04151 PI3K-Akt signaling pathway     114200877 (INSR)    04152 AMPK signaling pathway     114200877 (INSR)    04150 mTOR signaling pathway     114200877 (INSR)   09133 Signaling molecules and interaction    04081 Hormone signaling     114200877 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     114200877 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     114200877 (INSR)    04923 Regulation of lipolysis in adipocytes     114200877 (INSR)    04913 Ovarian steroidogenesis     114200877 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     114200877 (INSR)   09149 Aging    04211 Longevity regulating pathway     114200877 (INSR)    04213 Longevity regulating pathway - multiple species     114200877 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     114200877 (INSR)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     114200877 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     114200877 (INSR)    04932 Non-alcoholic fatty liver disease     114200877 (INSR)    04931 Insulin resistance     114200877 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:eju01001]     114200877 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:eju04090]     114200877 (INSR) Enzymes [BR:eju01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      114200877 (INSR) Protein kinases [BR:eju01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    114200877 (INSR) CD molecules [BR:eju04090]  Proteins   114200877 (INSR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Ig_DSCAM-DSCAML_C Kinase-like B2 DUF4476 Motif Other DBs NCBI-GeneID:  114200877 NCBI-ProteinID:  XP_027949017 LinkDB All DBs Position Unknown AA seq 1369 aa AA seqDB search MGAGAGRGAASAPLLLAVAALLLGATGHLYPGEVCPGMDIRNNLTRLHELANCSVIEGHL QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL VIFEMVHLKELGLYSLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE ECGDICPGTAKGKTSCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSQCL GNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHNRCKNSRRQG CHQYAIHNSKCIPECPSGYTMNSSNLMCTPCLGPCPKVCHILEGEKTIDSVTSAQELRGC TVVNGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE RNDIALKTNGDQASCENELLKFSYIRTSYDKILLKWEPYWPPDFRDLLGFMLFYKEAPYQ NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE RQVEDSELYELDYCLKGLKLPSRTWSPPFEAEGSQKHNQSEYEESAGECCSCPKTDSQIL KELEESSFRKTFEDYLHNVVFVPRPSRKRRALGDVANVTAAAPTVPGFPNTSTSAPTSPE EHKPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPEERCSVAAYVSARTMPEAKADDI VGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRRHFALERGCRL RGLPPGNYSVRVRATSLAGNGSWTEATYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIG SIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVPREKITLLRELGQGS FGMVYEGNARDIVKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVV SKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAK KFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVF TTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCW QFNPKMRPTFLEIVELLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMESVPLDRAS HSQREEAGGRDGGSSLGLKRNYEEHIPYTHMNGGKKNGRILTLPRSNPS NT seq 4110 nt NT seq  +upstreamnt  +downstreamnt atgggcgccggggctgggcggggggcggcgtccgcgccgctgctgctggcggtggccgcg ctgctgctgggtgccacgggccacctgtaccccggagaagtgtgccctggcatggatatc cggaacaacctcacgaggttgcatgagctggccaactgctcggtcattgaaggacatttg cagatactgttgatgttcaaaacgaggcccgaggatttccgagacctcagtttccccaaa ctcatcatgatcactgattacttgctgctcttccgggtctatgggctggagagcctgaag gacctgttccccaacctcacggtcatccggggctcgcgtctcttcttcaactatgcgctg gtcatcttcgagatggttcacctgaaggagcttggcctctacagcttgatgaacattacc cggggctccgtccgcattgagaagaacaatgagctctgctacctggccaccattgactgg tcgcgcatcctggattctgtggaggataattacattgtgctgaacaaagacgacaacgag gagtgtggggacatttgtccaggcaccgcaaagggcaagaccagctgccccgccactgtc atcaacgggcagtttgtcgagcggtgttggacacacagccactgccagaaagtttgtccc accatctgcaagtcacacggctgtaccgccgagggtctctgctgccacagccagtgttta ggcaattgctccgagcccgacgaccccaccaagtgcgtggcctgtcgcaacttctacctg gatggcaggtgcgtggagacctgcccgcccccgtactaccacttccaagactggcgctgc gtgaacttcagcttctgccaggacctgcacaacagatgcaagaactcccggagacagggc tgccaccagtatgccattcacaatagcaagtgtatccctgagtgcccctctggctacacg atgaattccagcaacctgatgtgcactccatgcctgggcccctgtcccaaggtctgccac atcctggagggcgagaaaaccattgactcggtgacgtctgcccaggagcttcgaggctgc actgttgtcaacggaagcctcatcatcaacatccgagggggcaacaacctggcagctgag ctggaggccaacctaggactcattgaagaaatttccgggtatctgaaaatccggagatcc tacgctcttgtgtcactttcttttttccggaagttacggctgattcgaggagagaccttg gaaatcgggaactactctttctacgccttggacaaccagaacctaaggcagctctgggac tggagcaaacacaacctcaccatcactcaggggaaactcttcttccactacaatcccaaa ctctgcttgtcagaaattcacaagatggaggaagtttcaggaaccaaggggcgccaggag aggaacgacattgccctgaagaccaatggggaccaggcgtcttgtgaaaatgaactcctt aaattttcttacattcggacatcgtatgacaagatcttgctgaaatgggagccgtactgg ccccctgacttccgagacctcctggggttcatgcttttctacaaagaggccccttaccag aatgtgaccgagttcgacgggcaggatgcgtgtggttccaacagctggacggtggtggac atcgacccacctctgcggtccaacgaccccaagtcgcagaaccacccagggtggctgatg cggggtctcaagccctggacccagtatgccatctttgtcaagaccttggtcaccttttct gatgaacgccgcacgtatggggccaagagtgatatcatctatgtacagacggatgccact aacccttccgtccccctggatccaatctccgtttctaactcctcgtcccagattattctg aagtggaagcctccctctgatcccaatggcaacatcacacactacctggttttctgggag aggcaggtggaagacagtgagctgtatgagctggattactgcctcaaagggttgaaactg ccgtcccggacctggtctccgccgttcgaggccgagggctcccagaagcacaaccagagt gaatacgaggagtctgccggcgaatgttgctcctgccccaagacggactctcagatcctc aaggagctggaggagtcctcttttaggaagacctttgaggattacctgcacaatgtggtg ttcgtccccaggccatcgcggaaacgccgggccctcggggacgttgccaatgtgacggca gccgcgcccacggttccaggtttccccaacacctcgaccagcgcgcccacgagcccggag gagcacaagcccttcgagaaagtggtgaacaaagaatccctggtcatctctgggctgcgc cacttcactggctaccgcatcgagctgcaggcttgcaaccaagactcccccgaggagagg tgcagcgtggccgcctacgtcagcgccaggaccatgcccgaagccaaggcagatgacatt gttggccccgtgacccacgaaatcttcgagaacaatgtcgttcacttgatgtggcaggag ccaaaggaacccaacggtctgatcgtgctgtatgaagtgagttaccgacgctatggtgat gaggagctgcacctctgtgtctcccgcagacattttgctctggagcggggctgcaggctg cgcgggctgccgccagggaattacagtgtgcgagtccgggccacctccctggcaggcaac ggctcatggacagaagctacctatttctacgtgacagactatttagatgtcccgtcgaat attgcaaaaatcatcatcggccccctcatctttgtctttctcttcagtgttgtgattgga agtatttacctgttcctgagaaagaggcagccggatgggccactgggaccactgtatgcg tcttcaaaccccgagtacctcagtgccagtgatgtctttccatgttctgtgtatgtgccg gatgagtgggaggtgcctcgggagaagatcacgctcctgcgtgagctggggcagggctcc ttcggcatggtgtacgaaggcaacgccagggacatcgtcaagggcgaggcggagacccgc gtggcggtgaagacagtcaacgagtcggccagtctgcgggagaggatcgagtttctcaac gaggcctcagtcatgaagggcttcacctgtcatcacgtggtccgcctcctgggggtggtg tccaaaggccagccaacgctggtggtgatggagctgatggctcacggtgacctgaagagc tatctccgctccctgcggccggaggctgagaataaccccggccgccctccccctaccctg caagagatgattcagatggcggcagagatcgccgatgggatggcctacctgaatgccaag aagtttgtgcaccgggatctcgcagcccgaaactgcatggtcgcccacgatttcactgtc aaaattggagactttgggatgaccagagacatctatgaaacggattactaccggaaagga ggcaagggtctgctccccgtgcggtggatggcaccggaatccctgaaggacggggtcttt accacttcttctgacatgtggtccttcggcgtggtcctttgggaaatcaccagcttggca gaacagccttaccaaggtctgtctaatgaacaggtgttgaaatttgtcatggatggaggg tatctggatcaacccgacaattgtccagagagagtcaccgacctgatgcgtatgtgctgg cagttcaatcccaagatgcggcccaccttcctagagatcgtcgaactgctcaaggacgac ctgcaccccagctttccagaagtttccttcttccacagcgaggagaacaaggcgcctgag agcgaggagctggagatggagttcgaggacatggagagtgtccccctggatcgggcctca cactctcagagggaggaggccgggggccgggatggagggtcctcgctgggcctaaaacgg aactacgaggagcacatcccctacacccacatgaacgggggcaagaaaaatggacggatt ctgactctgccgaggtcaaatccttcctaa

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