Eumetopias jubatus (Steller sea lion): 114210848 Help Entry 114210848         CDS       T07240                                  Symbol IRS1 Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism eju  Eumetopias jubatus (Steller sea lion) Pathway eju04022   cGMP-PKG signaling pathway eju04068   FoxO signaling pathway eju04081   Hormone signaling eju04140   Autophagy - animal eju04150   mTOR signaling pathway eju04151   PI3K-Akt signaling pathway eju04152   AMPK signaling pathway eju04211   Longevity regulating pathway eju04213   Longevity regulating pathway - multiple species eju04722   Neurotrophin signaling pathway eju04910   Insulin signaling pathway eju04920   Adipocytokine signaling pathway eju04923   Regulation of lipolysis in adipocytes eju04930   Type II diabetes mellitus eju04931   Insulin resistance eju04932   Non-alcoholic fatty liver disease eju04935   Growth hormone synthesis, secretion and action eju04960   Aldosterone-regulated sodium reabsorption eju05010   Alzheimer disease eju05206   MicroRNAs in cancer eju05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:eju00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     114210848 (IRS1)    04022 cGMP-PKG signaling pathway     114210848 (IRS1)    04151 PI3K-Akt signaling pathway     114210848 (IRS1)    04152 AMPK signaling pathway     114210848 (IRS1)    04150 mTOR signaling pathway     114210848 (IRS1)   09133 Signaling molecules and interaction    04081 Hormone signaling     114210848 (IRS1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     114210848 (IRS1)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     114210848 (IRS1)    04923 Regulation of lipolysis in adipocytes     114210848 (IRS1)    04920 Adipocytokine signaling pathway     114210848 (IRS1)    04935 Growth hormone synthesis, secretion and action     114210848 (IRS1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     114210848 (IRS1)   09156 Nervous system    04722 Neurotrophin signaling pathway     114210848 (IRS1)   09149 Aging    04211 Longevity regulating pathway     114210848 (IRS1)    04213 Longevity regulating pathway - multiple species     114210848 (IRS1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     114210848 (IRS1)   09164 Neurodegenerative disease    05010 Alzheimer disease     114210848 (IRS1)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     114210848 (IRS1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     114210848 (IRS1)    04932 Non-alcoholic fatty liver disease     114210848 (IRS1)    04931 Insulin resistance     114210848 (IRS1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  114210848 NCBI-ProteinID:  XP_027961079 LinkDB All DBs Position Unknown AA seq 1233 aa AA seqDB search MASPPETDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH HDGAAAPGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT RRSRTESITATSPASMVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGSSTLTAPN GHYILPRGGNGHRCVPGAGLGTSPALAGDEAASAADLDNRFRKRTHSAGTSPTISHQKTP SQSSVASIEEYTEMMMPAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHPLDRRGGHH RPDSSTLHTDDGYMPMSPGVAPVPSSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDP NGYMMMSPSSSCSPDTGGGPSSSAAPSGSCYSKLWTNGVGGHHTHALPHPKLPMESGSGK LLSCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGELEEGA RHLRLSSSSGRLLYATTAEDSSSSTSSDSLGGGYCGVRPDPGLPHVHHQVLQPHLPRKVD TAAQTHSRLARPTRLSLGDPKASTLPRVREQQQLPPLLRPPEPKSPGEYVNIEFGSDQPA YLSGPVASCSSPSVRCPSQLQPAPREDETGTEEYMNMDLGPGRRATWQESAGVQPGSAGP APPGAASMCRPTRAVPSSRGDYMTMQMGCPGQGYVDTSPVAPVSYADMRTGIVVEEASLP GATAAAPSSSSAASASPTAPQKAGELVARSSLLGAPQGPGGMSAFTRVNLSPNRTQSAKV IRADPQGCRRRHSSETFSSTPSATRAGNAVPFGGGAAVGGSGAGSSSTEDMKRHSSASFE NVWLRPGELGGAPKEPAQVCGAAGGLENGLNYIDLDLVKDFKQRPQERPPQLPSPPPPHQ PLGSRESRSSSRSSEDLSAYASISFQKQPEDLQ NT seq 3702 nt NT seq  +upstreamnt  +downstreamnt atggcgagccctccggagaccgacggcttctcggacgtgcgcaaggtgggctacctgcgc aaacccaagagcatgcacaagcgcttcttcgtgctgcgggcggccagcgaggcggggggc ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc aaacgctcgatccccctcgagagctgcttcaacatcaacaagcgggcggactccaagaac aagcacctggtggccctttacacccgggacgagcactttgccatcgcggcggacagcgag gccgagcaggacagctggtaccaggccctcctgcagctgcacaaccgggccaagggccac cacgacggggccgcggcccccggggcaggaggcggcgggggcagctgcagcggcagctct ggccttggggaggctggggaggacttgagctacggggacgtgcccccaggacctgcgttc aaggaggtctggcaggtgatcctgaaacccaagggcctgggtcagacaaagaacctgatt ggcatctaccgtctctgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag gcggcggccgtggtgctgcagctgatgaacatcagacgctgcggccactcagagaacttc ttcttcatcgaagtgggccgttccgcagtgacaggacctggggagttctggatgcaggtg gatgactctgtggtggcccagaacatgcacgagaccatcctggaggccatgcgggccatg agcgatgagttccgtcctcgaagtaagagccagtcctcctccaactgctccaaccccatc agcgttcccctgcgcaggcaccacctcaacaaccccccgcccagccaggtggggctgacg cgccgctcacggactgagagcatcaccgccacctcaccggccagcatggtgggcggcaag cagggctctttccgtgtgcgcgcgtccagcgacggcgaaggcaccatgtcccgcccggcc tcggtggacggcagccccgtgagtcccagcaccaacaggacccacgcccaccggcatcgc ggcagctcccggctgcacccccctctcaaccacagccgctccattcccatgccttcctcc cgctgctcaccttccgccaccagcccggtcagcctgtcgtccagcagcaccagtggccac ggctccacctcggactgtctcttcccgcggcggtctagtgcttctgtgtcgggttctccc agcgatggcggcttcatctcctccgatgagtacggctccagcccttgcgatttccgaagt tccttccgcagtgtcaccccggattccctgggccacacgccaccggcccgcggtgaggag gagctgagcaactacatctgcatgggaggcaaagggtcctccaccctcaccgcccccaat ggtcactacattttacctcggggtggcaacggtcaccgctgcgtcccaggtgctggcttg ggcacgagcccagccctggctggggatgaagcagccagtgctgcagatctggataatcgg ttccgcaagcggactcactccgcgggcacatcccctaccatttcccaccagaagacccca tcccagtcgtctgtggcgtccattgaggaatacacagagatgatgatgcctgcctacccg ccaggaggtggcagtggaggccggctgcctggctaccggcactctgccttcgtgcccacc cactcctaccctgaggagggcctggaaatgcaccctttggacaggcgtgggggccaccac cgcccagactcctccactctccacacggatgatggctacatgcccatgtccccaggagtg gcgccagtgcccagcagccgaaagggcagtggcgactatatgcccatgagccccaagagc gtgtcggcgccgcagcagatcatcaaccctatcagacgccatccccagagagtggacccc aatggctacatgatgatgtccccaagcagcagctgctccccggacaccggaggcggaccc agcagcagcgctgccccttctgggagctgctacagcaagctgtggacaaatggggtcggg ggccaccacactcacgccctgccgcatcccaaactgcccatggagagcgggagtggcaag ctcttgtcttgtactggtgactacatgaacatgtcgccagtgggggactccaacaccagc agcccctccgactgctactacggcccggaggacccccagcacaagccagttctctcctac tactcgttgccaaggtcctttaagcacacccagcggcctggggagctggaggagggtgct cggcacctccgcctttcctccagctctggccgccttctctatgctacaacagcggaagat tcctcctcgtccaccagcagcgacagcctgggcgggggatactgtggggtgaggccggat cctggcctcccacatgtccaccatcaggtcctgcagccccatctgcctcgaaaggtggac acagctgcccagacccacagccgcctggctcggcccacgaggctgtccctgggggacccc aaggccagcaccttacctcgggtccgggaacaacagcagctcccgcccctgctgcgcccc ccagagcccaagagccccggcgaatatgtgaatattgaatttgggagtgatcagccagct tacttatctggtcctgtggcttcctgcagctcaccttctgtcaggtgcccatcccagctc cagccagctccccgagaggacgagactggcaccgaggaatacatgaacatggacctgggg ccaggccggagggcgacctggcaggagagcgctggggtccagcccggcagcgcgggccct gcaccacccggggctgctagcatgtgcaggcctacccgggcagtgcccagcagccggggg gactacatgaccatgcagatgggttgtcctgggcagggctacgtggacacctcaccagtt gcccccgtcagctatgccgacatgcggacaggcattgttgtggaggaggccagccttcca ggggccacggcggctgctccctcctcatcctctgcagcctctgcttctcccaccgcgcct caaaaagcaggggagctggtggcccgctcttccctgctgggggccccccagggacctggg ggcatgagcgccttcacccgggtgaacctcagtcccaaccgcacgcagagtgccaaagtg atccgtgcggacccacaagggtgccggaggcggcatagctctgagaccttctcctccaca ccgagtgccacccgggcgggcaatgcggtgccctttggagggggggctgctgtagggggc agcggtgctggtagcagcagcacggaggatatgaaacgccacagttctgcttcctttgag aatgtgtggctgaggcctggggagctcgggggagcccccaaggagccggcccaagtgtgc ggggctgctgggggtttggagaatgggcttaactacatagacctggatttggtcaaggac ttcaaacagcgccctcaggagcgcccccctcaactgccctcgcccccgccccctcatcag cctctgggcagcagggagagccgctcaagcagccgctccagcgaggatttaagcgcctat gccagcatcagtttccagaagcagccagaggacctccagtag

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